MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Cortisone

(MFYSYFVPBJMHGN-ZPOLXVRWSA-N)

Structure

SMILES: OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)CC(=O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
Type(s): Experimental
ATC code(s): H02AB10; S01BA03
Molecular Formula:: C21H28O5
Molecular Weight:: 360.444
Log P:: 1.9898
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 91.67
CAS Number(s):: 53-06-5; 19515

Synonym(s)

Cortisone

17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate

Adreson

Cortisone Acetate

Cortone Acetate

External Link(s)

MeSH	D003348
PubChem Compound	222786
BindingDB	22452 13739 28362
ChEBI	16962
CHEMBL	CHEMBL1499
DrugBank	DB14681
IUPHAR/BPS Guide to PHARMACOLOGY	5171
KEGG	cpd:C00762 dr:D07749
Therapeutic Target Database	D0IX6I
ZINC	4083557

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 18 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
2	Headache	FAERS: 5 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
3	Erythema	FAERS: 4 Canada Vigilance: 4		Canada Vigilance OFFSIDES SIDER US FAERS
4	Swelling	FAERS: 4		US FAERS
5	Drug ineffective for unapproved indication	FAERS: 3		US FAERS
6	Malaise	FAERS: 3		SIDER US FAERS
7	Burning sensation	FAERS: 2		US FAERS
8	Constipation	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
9	Feeling abnormal	FAERS: 2		OFFSIDES SIDER US FAERS
10	Flushing	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
11	Gait inability	FAERS: 2		US FAERS
12	Impaired work ability	FAERS: 2		US FAERS
13	Joint swelling	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
14	Nausea	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
15	Oropharyngeal pain	FAERS: 2		OFFSIDES US FAERS
16	Pain	FAERS: 2 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
17	Peripheral swelling	FAERS: 2		US FAERS
18	Urticaria	FAERS: 2		SIDER US FAERS
19	Abasia	FAERS: 1		OFFSIDES US FAERS
20	Amnesia	FAERS: 1		OFFSIDES US FAERS
21	Arthralgia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
22	Arthritis	FAERS: 1		OFFSIDES US FAERS
23	Arthropathy	FAERS: 1		OFFSIDES US FAERS
24	Atrial Fibrillation	FAERS: 1		US FAERS
25	Blood cortisol increased	FAERS: 1		US FAERS
26	Chest Pain	FAERS: 1		US FAERS
27	Dehydration	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
28	Drug effect delayed	FAERS: 1		OFFSIDES US FAERS
29	Drug effect incomplete	FAERS: 1		US FAERS
30	Drug withdrawal syndrome	FAERS: 1		US FAERS
31	Epidural lipomatosis	FAERS: 1		US FAERS
32	Exfoliative rash	FAERS: 1		US FAERS
33	Eye pain	FAERS: 1		US FAERS
34	Fatigue	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
35	General physical health deterioration	FAERS: 1		OFFSIDES US FAERS
36	Hemiparesis	FAERS: 1		OFFSIDES US FAERS
37	Infection	FAERS: 1		US FAERS
38	Meningitis	FAERS: 1		US FAERS
39	Menorrhagia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
40	Mental status changes	FAERS: 1		US FAERS
41	Musculoskeletal Pain	FAERS: 1		OFFSIDES US FAERS
42	Osteopenia	FAERS: 1		OFFSIDES US FAERS
43	Palpitations	FAERS: 1		US FAERS
44	Paraparesis	FAERS: 1		US FAERS
45	Poor quality drug administered	FAERS: 1		US FAERS
46	Product contamination	FAERS: 1		US FAERS
47	Pruritus	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
48	Psoriasis	FAERS: 1		OFFSIDES US FAERS
49	Rheumatoid Arthritis	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
50	Soft tissue inflammation	FAERS: 1		US FAERS
51	Stasis dermatitis	FAERS: 1		US FAERS
52	Tinnitus	FAERS: 1		US FAERS
53	Toxicity to various agents	FAERS: 1		US FAERS
54	Unevaluable event	FAERS: 1		US FAERS
55	Vertigo	FAERS: 1		SIDER US FAERS
56	Visual Impairment	FAERS: 1		US FAERS
57	Weight decreased	FAERS: 1		US FAERS
58	Wheelchair user	FAERS: 1		US FAERS
59	treatment failure	FAERS: 1		US FAERS
60	Abdominal Pain			OFFSIDES
61	Abdominal discomfort			OFFSIDES
62	Abdominal symptom			OFFSIDES
63	Abnormal vision			OFFSIDES
64	Abscess			OFFSIDES
65	Acid reflux			OFFSIDES
66	Actinomycosis			OFFSIDES
67	Activities of daily living impaired			OFFSIDES
68	Acute Coronary Syndrome			OFFSIDES SIDER
69	Adenocarcinoma		4856713	CTD
70	Adverse event			OFFSIDES
71	Alanine Aminotransferase Increased			SIDER
72	Allergy to animal			OFFSIDES
73	Alopecia			OFFSIDES
74	Amblyopia			OFFSIDES
75	Anger			OFFSIDES
76	Angioedema			SIDER
77	Angle Closure Glaucoma			OFFSIDES
78	Anhidrosis			OFFSIDES
79	Ankylosing spondylitis			OFFSIDES
80	Anosmia			OFFSIDES
81	Antimicrobial susceptibility test resistant			OFFSIDES
82	Anxiety			OFFSIDES
83	Aortic Aneurysm			OFFSIDES
84	Apathy			OFFSIDES
85	Aphagia			OFFSIDES
86	Aphonia			OFFSIDES
87	Appendectomy			OFFSIDES
88	Appendicitis			OFFSIDES
89	Application site pain			OFFSIDES
90	Arteriosclerosis			OFFSIDES
91	Arthrodesis			OFFSIDES
92	Arthroscopy			OFFSIDES
93	Artificial crown procedure			OFFSIDES
94	Aseptic necrosis			SIDER
95	Asthenia			OFFSIDES
96	Asthma			OFFSIDES
97	Atelectasis			OFFSIDES
98	Atrial tachycardia			OFFSIDES
99	Aura			OFFSIDES
100	Aversion			OFFSIDES
101	Bacteria stool identified			OFFSIDES
102	Bacterial disease carrier			OFFSIDES
103	Bed rest			OFFSIDES
104	Biopsy			OFFSIDES
105	Bladder Diverticulum			OFFSIDES
106	Blood Glucose			OFFSIDES
107	Blood cortisol abnormal			OFFSIDES
108	Blood count abnormal			OFFSIDES
109	Blood glucose decreased	Canada Vigilance: 1		Canada Vigilance OFFSIDES
110	Blood glucose fluctuation			OFFSIDES
111	Blood glucose increased	Canada Vigilance: 2		Canada Vigilance
112	Blood thyroid stimulating hormone			OFFSIDES
113	Bone erosion			OFFSIDES
114	Bone fragmentation			OFFSIDES
115	Bone lesion			OFFSIDES
116	Bone marrow depression			OFFSIDES
117	Bone pain			OFFSIDES
118	Bronchiolitis			OFFSIDES
119	Bronchitis			OFFSIDES
120	Bronchopleural Fistula			OFFSIDES
121	Bronchopneumonia			OFFSIDES
122	Bulbar palsy			OFFSIDES
123	Bursitis			OFFSIDES
124	Carbohydrate tolerance decreased			SIDER
125	Carbon Monoxide Poisoning			OFFSIDES
126	Cartilage injury			OFFSIDES
127	Cataract			OFFSIDES
128	Catheter placement			OFFSIDES
129	Catheter site related reaction			OFFSIDES
130	Cellulitis			OFFSIDES
131	Central line infection			OFFSIDES
132	Cheilitis			OFFSIDES
133	Choking sensation			OFFSIDES
134	Chondromalacia			OFFSIDES
135	Chronic Obstructive Airway Disease			OFFSIDES
136	Chronic ulcerative colitis			OFFSIDES
137	Circumstance or information capable of leading to medication error			OFFSIDES
138	Colectomy			OFFSIDES
139	Congenital hypertrichosis			OFFSIDES
140	Congenital pyelocaliectasis			OFFSIDES
141	Congenital tricuspid valve incompetence			OFFSIDES
142	Cyanosis			OFFSIDES
143	Cyst			OFFSIDES
144	Debridement			OFFSIDES
145	Decreased immune responsiveness			OFFSIDES
146	Dementia		3237266 6703100	CTD
147	Demyelination			OFFSIDES
148	Dental abscess			OFFSIDES
149	Dental caries			OFFSIDES
150	Depressed mood			OFFSIDES
151	Depressive disorder		3237266	CTD
152	Dermatomyositis			OFFSIDES
153	Device Failure			OFFSIDES
154	Diabetes Mellitus			SIDER
155	Diabetic			SIDER
156	Diarrhea			OFFSIDES
157	Discomfort	Canada Vigilance: 1		Canada Vigilance SIDER
158	Disease Progression			OFFSIDES
159	Diverticulosis			OFFSIDES
160	Dizziness			OFFSIDES
161	Drowsiness			OFFSIDES
162	Drug exposure during pregnancy			OFFSIDES
163	Drug withdrawal headache			OFFSIDES
164	Duodenal ulcer perforation			OFFSIDES
165	Dyspareunia			OFFSIDES
166	Dyspepsia			OFFSIDES
167	Dysphonia			OFFSIDES
168	Dysuria			OFFSIDES
169	Ear congestion			OFFSIDES
170	Ear discomfort			OFFSIDES
171	Ecchymosis			SIDER
172	Eczema			OFFSIDES
173	Embolism			SIDER
174	Emotional disorder			OFFSIDES
175	Empyema			OFFSIDES
176	Encephalitis			OFFSIDES
177	Endocarditis			OFFSIDES
178	Endodontic procedure			OFFSIDES
179	Endometrial Neoplasms		4856713	CTD
180	Endomyocardial Fibrosis		20014201	CTD
181	Enteritis			OFFSIDES
182	Enterococcal infection			OFFSIDES
183	Enuresis			OFFSIDES
184	Epilepsy			OFFSIDES
185	Erythema Multiforme			OFFSIDES
186	Eschar			OFFSIDES
187	Escherichia infection			OFFSIDES
188	Euphoric mood			OFFSIDES
189	Exophthalmos			SIDER
190	Eye laser surgery			OFFSIDES
191	Eyelid Diseases			OFFSIDES
192	Facial Neuralgia			OFFSIDES
193	Feeling Cold			OFFSIDES
194	Fibromyalgia			OFFSIDES
195	Fistula discharge			OFFSIDES
196	Formication			OFFSIDES
197	Frustration			OFFSIDES
198	Gallbladder necrosis	Canada Vigilance: 1		Canada Vigilance
199	Gastric Bypass			OFFSIDES
200	Gastroduodenitis			OFFSIDES
201	Gastrointestinal infection			OFFSIDES
202	Gastrointestinal inflammation			OFFSIDES
203	Gastrointestinal perforation			OFFSIDES
204	Gingival blister			OFFSIDES
205	Glaucoma		6225374	CTD SIDER
206	Glomerulonephritis			OFFSIDES
207	Graft infection			OFFSIDES
208	Granuloma			OFFSIDES
209	Hallucinations		3237266	CTD
210	Heart Diseases		914349	CTD
211	Hepatitis			OFFSIDES
212	Hepatotoxicity			OFFSIDES
213	High frequency ablation			OFFSIDES
214	Hip surgery			OFFSIDES
215	Hirsutism			SIDER
216	Hoarseness			OFFSIDES
217	Hormone level abnormal			OFFSIDES
218	Hydropneumothorax			OFFSIDES
219	Hyperkeratosis			OFFSIDES
220	Hyperplasia		4856713	CTD
221	Hypersensitivity	Canada Vigilance: 1		Canada Vigilance SIDER
222	Hypertrichosis			OFFSIDES
223	Hypervigilance			OFFSIDES
224	Hypokinesia	Canada Vigilance: 1		Canada Vigilance OFFSIDES
225	Hypopituitarism		48615	CTD
226	Hysterectomy			OFFSIDES
227	Incontinence			OFFSIDES
228	Increased insulin requirement			SIDER
229	Induration			OFFSIDES
230	Infusion site mobility decreased			OFFSIDES
231	Injection site erythema			OFFSIDES
232	Injection site infection			OFFSIDES
233	Injection site inflammation			OFFSIDES
234	Injection site joint pain	Canada Vigilance: 1		Canada Vigilance
235	Injection site mass			OFFSIDES
236	Injection site pain	Canada Vigilance: 1		Canada Vigilance
237	Injection site warmth			OFFSIDES
238	Intention tremor			OFFSIDES
239	Intentional self-injury			OFFSIDES
240	Intervertebral disc disorder			OFFSIDES
241	Intestinal Fistula			OFFSIDES
242	Intestinal resection			OFFSIDES
243	Intraspinal abscess			OFFSIDES
244	JC virus infection			OFFSIDES
245	Joint Range of Motion Decreased			OFFSIDES
246	Joint injury			OFFSIDES
247	Joint stiffness	Canada Vigilance: 1		Canada Vigilance
248	Kidney Failure			OFFSIDES
249	Laryngocele			OFFSIDES
250	Legionella			OFFSIDES
251	Lenticular pigmentation			OFFSIDES
252	Lesion excision			OFFSIDES
253	Limb discomfort			OFFSIDES
254	Limb operation			OFFSIDES
255	Lordosis			OFFSIDES
256	Lupus-like syndrome			OFFSIDES
257	Malocclusion			OFFSIDES
258	Markedly reduced dietary intake			OFFSIDES
259	Mastectomy			OFFSIDES
260	Mastication disorder			OFFSIDES
261	Meniscus removal			OFFSIDES
262	Mental disorders		4327030	CTD
263	Mental impairment			OFFSIDES
264	Metastases to thorax			OFFSIDES
265	Metastatic Neoplasm			OFFSIDES
266	Monoplegia			OFFSIDES
267	Multiple sclerosis relapse			OFFSIDES
268	Muscle flap operation			OFFSIDES
269	Muscle necrosis			OFFSIDES
270	Muscle tightness			OFFSIDES
271	Musculoskeletal chest pain			OFFSIDES
272	Musculoskeletal stiffness			OFFSIDES
273	Myelodysplasia			OFFSIDES
274	Myocardial Infarction			SIDER
275	Myocardial rupture			SIDER
276	Myopathy			SIDER
277	Myopia			OFFSIDES
278	Nasopharyngitis			OFFSIDES
279	Neck Pain	Canada Vigilance: 1	12672838	CTD Canada Vigilance
280	Nervous tension			OFFSIDES
281	Neuroma			OFFSIDES
282	Neuromuscular Diseases		6063856	CTD
283	Nicotine Dependence			OFFSIDES
284	Nitrogen balance negative			SIDER
285	Non-cardiac chest pain			OFFSIDES
286	Occult blood positive			OFFSIDES
287	Oliguria			OFFSIDES
288	Open wound			OFFSIDES
289	Optic Neuritis			OFFSIDES SIDER
290	Oropharyngeal discomfort			OFFSIDES
291	Osteitis Deformans			OFFSIDES
292	Osteochondrosis			OFFSIDES
293	Osteolysis			OFFSIDES
294	Osteomyelitis			OFFSIDES
295	Osteoporosis			OFFSIDES SIDER
296	Osteoradionecrosis			OFFSIDES
297	Pancreatic Cyst			OFFSIDES
298	Pancreatitis			SIDER
299	Paranasal sinus hypersecretion			OFFSIDES
300	Peptic Ulcer			SIDER
301	Periodontitis			OFFSIDES
302	Periostitis			OFFSIDES
303	Peritonitis			OFFSIDES
304	Petechiae			SIDER
305	Pharmaceutical product complaint			OFFSIDES
306	Platelet count abnormal			OFFSIDES
307	Pneumothorax			OFFSIDES
308	Polymyalgia Rheumatica			OFFSIDES
309	Polyneuropathy			OFFSIDES
310	Poor dental condition			OFFSIDES
311	Postmenopausal bleeding			OFFSIDES
312	Productive Cough			OFFSIDES
313	Propofol Infusion Syndrome			OFFSIDES
314	Pseudotumor			SIDER
315	Psychomotor Agitation		3237266	CTD
316	Psychoses, Substance-Induced		3237266 6703100	CTD
317	Pulmonary congestion			OFFSIDES
318	Pulmonary sepsis			OFFSIDES
319	Pustular psoriasis			OFFSIDES
320	Radiotherapy to brain			OFFSIDES
321	Rash erythematous	Canada Vigilance: 1		Canada Vigilance
322	Reflux laryngitis			OFFSIDES
323	Renal embolism	Canada Vigilance: 1		Canada Vigilance
324	Respiratory Failure			OFFSIDES
325	Rheumatoid Nodule			OFFSIDES
326	Rhinitis perennial			OFFSIDES
327	Rhinitis			OFFSIDES
328	Rhinorrhea			OFFSIDES
329	Scab			OFFSIDES
330	Scan bone marrow abnormal			OFFSIDES
331	Scleroderma			OFFSIDES
332	Sensorimotor disorder			OFFSIDES
333	Septic Shock			OFFSIDES
334	Severe Acute Respiratory Syndrome			OFFSIDES
335	Sinus operation			OFFSIDES
336	Sinusitis			OFFSIDES
337	Skin laceration			OFFSIDES
338	Skin lesion			OFFSIDES
339	Skin reaction	Canada Vigilance: 1		Canada Vigilance
340	Sleep Talking			OFFSIDES
341	Smoker			OFFSIDES
342	Splenectomy			OFFSIDES
343	Spondylitis			OFFSIDES
344	Sputum retention			OFFSIDES
345	Stem cell transplant			OFFSIDES
346	Stress			OFFSIDES
347	Sudden Cardiac Death			OFFSIDES
348	Teeth brittle			OFFSIDES
349	Tendinitis			OFFSIDES
350	Thoracotomy			OFFSIDES
351	Thromboembolism			SIDER
352	Tobacco user			OFFSIDES
353	Tooth Extraction			OFFSIDES
354	Tooth Infection			OFFSIDES
355	Toxoplasmosis			OFFSIDES
356	Trauma			SIDER
357	Type III immune complex mediated reaction			OFFSIDES
358	Urine flow decreased			OFFSIDES
359	Vascular anomaly			OFFSIDES
360	Vascular encephalopathy			OFFSIDES
361	Ventricular Dysfunction, Left		20014201	CTD
362	Ventricular Outflow Obstruction		20014201	CTD
363	Vitreous Detachment			OFFSIDES
364	Vomiting	Canada Vigilance: 1		Canada Vigilance
365	Vulvovaginal burning sensation			OFFSIDES
366	Vulvovaginal dryness			OFFSIDES
367	Vulvovaginal pruritus			OFFSIDES
368	Walking aid user			OFFSIDES
369	Weight Gain			OFFSIDES
370	Wound infection staphylococcal			OFFSIDES
371	colonoscopy			OFFSIDES
372	effusion			OFFSIDES

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