MetaADEDB 2.0 @ LMMD
Hydrocodone
(LLPOLZWFYMWNKH-CMKMFDCUSA-N)
Structure
SMILES
COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4CCC1=O)C
Type(s)
Approved; Illicit; Investigational
ATC code(s)
R05DA03
Molecular Formula:
C18H21NO3
Molecular Weight:
299.364
Log P:
1.8712
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
38.77
CAS Number(s):
125-29-1; 50678-79-0
Synonym(s)
1.
Hydrocodone
2.
Dihydrocodeinone
3.
Hydrocodeinonebitartrate
4.
Hydrocon
5.
Codinovo
6.
Dicodid
7.
Hycodan
8.
Hycon
9.
Hydrocodon
10.
Hydrocodone Bitartrate
11.
Hydrocodone Tartrate (1:1), Hydrate (2:5)
12.
Robidone
External Link(s)
MeSHD006853
PubChem Compound5284569
BindingDB50386689
ChEBI5779
CHEMBLCHEMBL1457
DrugBankDB00956
DrugCentral1386
IUPHAR/BPS Guide to PHARMACOLOGY7081
KEGGcpd:C08024
dr:D08045
Therapeutic Target DatabaseD0C2DS
D0X5KF
ZINC1280665
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 59OFFSIDES
US FAERS
2NauseaFAERS: 20OFFSIDES
SIDER
US FAERS
3PainFAERS: 207562497CTD
OFFSIDES
US FAERS
4HeadacheFAERS: 18SIDER
US FAERS
5VomitingFAERS: 18SIDER
US FAERS
6PruritusFAERS: 16SIDER
US FAERS
7DizzinessFAERS: 12OFFSIDES
SIDER
US FAERS
8AnxietyFAERS: 11OFFSIDES
SIDER
US FAERS
9Drug toxicityFAERS: 10OFFSIDES
US FAERS
10Product quality issueFAERS: 10US FAERS
11HypersensitivityFAERS: 9SIDER
US FAERS
12SomnolenceFAERS: 9SIDER
US FAERS
13UrticariaFAERS: 9US FAERS
14Feeling abnormalFAERS: 8OFFSIDES
US FAERS
15Product substitution issueFAERS: 8US FAERS
16OverdoseFAERS: 7OFFSIDES
US FAERS
17Product formulation issueFAERS: 7US FAERS
18Abdominal discomfortFAERS: 6OFFSIDES
SIDER
US FAERS
19Breakthrough PainFAERS: 6US FAERS
20ConstipationFAERS: 6SIDER
US FAERS
21MalaiseFAERS: 6US FAERS
22Drug level increasedFAERS: 5US FAERS
23TremorFAERS: 5SIDER
US FAERS
24AgitationFAERS: 4US FAERS
25Drug DependenceFAERS: 4US FAERS
26Product dispensing errorFAERS: 4US FAERS
27Abdominal PainFAERS: 3OFFSIDES
SIDER
US FAERS
28ArthralgiaFAERS: 3SIDER
US FAERS
29AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
30Drug abuseFAERS: 3US FAERS
31Drug withdrawal syndromeFAERS: 3US FAERS
32Incorrect dose administeredFAERS: 3US FAERS
33Product physical issueFAERS: 3US FAERS
34SwellingFAERS: 3US FAERS
35Back PainFAERS: 2SIDER
US FAERS
36Chest PainFAERS: 2OFFSIDES
US FAERS
37Completed SuicideFAERS: 2US FAERS
38Drug dispensed to wrong patientFAERS: 2US FAERS
39Drug diversionFAERS: 2US FAERS
40Drug effect incompleteFAERS: 2US FAERS
41Drug effect variableFAERS: 2US FAERS
42Ear congestionFAERS: 2US FAERS
43FatigueFAERS: 2OFFSIDES
SIDER
US FAERS
44Inadequate analgesiaFAERS: 2US FAERS
45Inappropriate schedule of drug administrationFAERS: 2OFFSIDES
US FAERS
46Medication ErrorFAERS: 2US FAERS
47Musculoskeletal PainFAERS: 2OFFSIDES
SIDER
US FAERS
48MyalgiaFAERS: 2SIDER
US FAERS
49No adverse eventFAERS: 2US FAERS
50PalpitationsFAERS: 2US FAERS
51ParanoiaFAERS: 2US FAERS
52Pharmaceutical product complaintFAERS: 2US FAERS
53Product dose omissionFAERS: 2US FAERS
54ScreamingFAERS: 2US FAERS
55Skin lesionFAERS: 2US FAERS
56Unevaluable eventFAERS: 2US FAERS
57Weight decreasedFAERS: 2US FAERS
58AbasiaFAERS: 1OFFSIDES
US FAERS
59Accidental deathFAERS: 1US FAERS
60Accidental exposure to product by childFAERS: 1US FAERS
61Accidental overdoseFAERS: 1OFFSIDES
US FAERS
62AngerFAERS: 1OFFSIDES
US FAERS
63Autoimmune thyroiditisFAERS: 1US FAERS
64BlindnessFAERS: 1US FAERS
65BronchopneumoniaFAERS: 1US FAERS
66Burning sensationFAERS: 1OFFSIDES
US FAERS
67CachexiaFAERS: 1US FAERS
68Cerebrovascular accidentFAERS: 1US FAERS
69Cervix carcinomaFAERS: 1US FAERS
70ChokingFAERS: 1US FAERS
71CryingFAERS: 1US FAERS
72Deep Vein ThrombosisFAERS: 1US FAERS
73DependenceFAERS: 1US FAERS
74DiscomfortFAERS: 1US FAERS
75Documented hypersensitivity to administered productFAERS: 1US FAERS
76Drug dose omissionFAERS: 1OFFSIDES
US FAERS
77Drug screen positiveFAERS: 1OFFSIDES
US FAERS
78DyspepsiaFAERS: 1OFFSIDES
US FAERS
79DysphoniaFAERS: 1OFFSIDES
US FAERS
80Economic problemFAERS: 1OFFSIDES
US FAERS
81Emotional disorderFAERS: 1US FAERS
82Emotional distressFAERS: 1OFFSIDES
US FAERS
83EructationFAERS: 1US FAERS
84Euphoric moodFAERS: 1US FAERS
85Extra dose administeredFAERS: 1US FAERS
86Feeling ColdFAERS: 1US FAERS
87Feeling jitteryFAERS: 1US FAERS
88Gastric BypassFAERS: 1US FAERS
89GastritisFAERS: 1US FAERS
90HyperphagiaFAERS: 1US FAERS
91HypersomniaFAERS: 1US FAERS
92Hypertrophic CardiomyopathyFAERS: 1US FAERS
93HyperventilationFAERS: 1US FAERS
94HypopituitarismFAERS: 1US FAERS
95Impaired work abilityFAERS: 1US FAERS
96Incorrect drug administration durationFAERS: 1US FAERS
97Incorrect route of drug administrationFAERS: 1US FAERS
98InflammationFAERS: 1US FAERS
99Intentional product misuseFAERS: 1US FAERS
100Intentional product use issueFAERS: 1US FAERS
101Joint swellingFAERS: 1US FAERS
102Loss of personal independence in daily activitiesFAERS: 1US FAERS
103Middle insomniaFAERS: 1US FAERS
104Multi-organ disorderFAERS: 1US FAERS
105Musculoskeletal chest painFAERS: 1OFFSIDES
US FAERS
106Neck PainFAERS: 1SIDER
US FAERS
107PancreatitisFAERS: 1OFFSIDES
US FAERS
108PneumoniaFAERS: 1US FAERS
109Portal triaditisFAERS: 1US FAERS
110Product availability issueFAERS: 1US FAERS
111Product complaintFAERS: 1US FAERS
112Product difficult to swallowFAERS: 1US FAERS
113Product distribution issueFAERS: 1US FAERS
114Product measured potency issueFAERS: 1US FAERS
115Product packaging quantity issueFAERS: 1US FAERS
116Product selection errorFAERS: 1US FAERS
117Product solubility abnormalFAERS: 1US FAERS
118Product tamperingFAERS: 1US FAERS
119Pulmonary congestionFAERS: 1OFFSIDES
US FAERS
120Skin UlcerFAERS: 1US FAERS
121SomnambulismFAERS: 1US FAERS
122Sperm concentration increasedFAERS: 1US FAERS
123Spinal fusion surgeryFAERS: 1US FAERS
124Tablet physical issueFAERS: 1US FAERS
125Therapeutic product ineffectiveFAERS: 1US FAERS
126Therapy cessationFAERS: 1US FAERS
127Throat irritationFAERS: 1US FAERS
128ThrombosisFAERS: 1US FAERS
129Ventricular hypertrophyFAERS: 1US FAERS
130VertigoFAERS: 1US FAERS
131Visual ImpairmentFAERS: 1US FAERS
132WheezingFAERS: 1US FAERS
133Wrong drug administeredFAERS: 1US FAERS
134Wrong product administeredFAERS: 1US FAERS
135nervous system disorderFAERS: 1SIDER
US FAERS
136Abdominal AbscessOFFSIDES
137Abdominal adhesionsOFFSIDES
138Abdominal tendernessOFFSIDES
139Abnormal visionOFFSIDES
140Accidental exposureOFFSIDES
141Acid refluxOFFSIDES
142Acquired Protein S DeficiencyOFFSIDES
143ActinomycosisOFFSIDES
144Acute endocarditisOFFSIDES
145Acute respiratory failureOFFSIDES
146AdenocarcinomaOFFSIDES
147Adrenal gland cancer metastaticOFFSIDES
148AgeusiaOFFSIDES
149AgranulocytosisSIDER
150Alanine aminotransferase abnormalOFFSIDES
151AlopeciaOFFSIDES
152AmnesiaOFFSIDES
153AneurysmOFFSIDES
154AnhedoniaOFFSIDES
155Animal scratchOFFSIDES
156AnorexiaOFFSIDES
157AnosmiaOFFSIDES
158AphoniaOFFSIDES
159Application site burnOFFSIDES
160Application site rashOFFSIDES
161Application site reactionOFFSIDES
162Arterial thrombosisOFFSIDES
163ArteriosclerosisOFFSIDES
164ArthritisOFFSIDES
165ArthropathyOFFSIDES
166AsbestosisOFFSIDES
167AscitesOFFSIDES
168Aspartate aminotransferase abnormalOFFSIDES
169AtelectasisOFFSIDES
170Atrial tachycardiaOFFSIDES
171AuraOFFSIDES
172Back disorderOFFSIDES
173Benign bone neoplasmOFFSIDES
174Biliary sepsisOFFSIDES
175Bipolar DisorderOFFSIDES
176Blood GlucoseOFFSIDES
177Blood albumin abnormalOFFSIDES
178Blood albumin decreasedOFFSIDES
179Blood albuminOFFSIDES
180Blood alkaline phosphatase increasedOFFSIDES
181Blood alkaline phosphataseOFFSIDES
182Blood cholesterolOFFSIDES
183Blood creatinine decreasedOFFSIDES
184Blood magnesium decreasedOFFSIDES
185Blood pH decreasedOFFSIDES
186Blood phosphorusOFFSIDES
187Blood potassium decreasedOFFSIDES
188Blood potassiumOFFSIDES
189Blood pressure immeasurableOFFSIDES
190Blood sodium abnormalOFFSIDES
191Blood testosterone decreasedOFFSIDES
192Body TemperatureOFFSIDES
193Bone density decreasedOFFSIDES
194Bowel movement irregularityOFFSIDES
195Brain DeathOFFSIDES
196BronchitisOFFSIDES
197BronchoscopyOFFSIDES
198Cardiac ablationOFFSIDES
199Cardiac enzymes increasedOFFSIDES
200Cardiac valve vegetationOFFSIDES
201Cardioactive drug level increasedOFFSIDES
202Carotid artery occlusionOFFSIDES
203CataractOFFSIDES
204Catheter related infectionOFFSIDES
205CellulitisOFFSIDES
206Central nervous system lesionOFFSIDES
207Cerebellar infarctionOFFSIDES
208Cervical cord compressionOFFSIDES
209Choking sensationOFFSIDES
210ChromaturiaOFFSIDES
211Chronic Obstructive Airway DiseaseOFFSIDES
212Circumstance or information capable of leading to medication errorOFFSIDES
213Colon adenomaOFFSIDES
214ConfabulationOFFSIDES
215Congenital tricuspid valve incompetenceOFFSIDES
216Culture positiveOFFSIDES
217Culture wound positiveOFFSIDES
218CystOFFSIDES
219DeafnessSIDER
220DebridementOFFSIDES
221DehydrationOFFSIDES
SIDER
222DemyelinationOFFSIDES
223Dental FistulaOFFSIDES
224Dental abscessOFFSIDES
225Dental cariesOFFSIDES
226DermatitisSIDER
227Device leakageOFFSIDES
228DiabetesOFFSIDES
229Diabetic RetinopathyOFFSIDES
230DiarrheaOFFSIDES
231Disseminated Intravascular CoagulationOFFSIDES
232DiverticulumOFFSIDES
233Documented hypersensitivity to administered drugOFFSIDES
234DrowningOFFSIDES
235DrowsinessOFFSIDES
SIDER
236Drug addictOFFSIDES
237Drug administered at inappropriate siteOFFSIDES
238Drug prescribing errorOFFSIDES
239Drug therapy changedOFFSIDES
240Drug withdrawal headacheOFFSIDES
241DysgeusiaOFFSIDES
242Dysthymic DisorderOFFSIDES
243DysuriaOFFSIDES
244Early satietyOFFSIDES
245Echocardiogram abnormalOFFSIDES
246Ejection Fraction DecreasedOFFSIDES
247Embolic strokeOFFSIDES
248EndocarditisOFFSIDES
249EnterocolitisOFFSIDES
250EpistaxisOFFSIDES
251EscharOFFSIDES
252Expired drug administeredOFFSIDES
253Eyelid DiseasesOFFSIDES
254Factor V Leiden mutationOFFSIDES
255Failure to ThriveOFFSIDES
256Fatty LiverOFFSIDES
257FibromyalgiaOFFSIDES
258Flat affectOFFSIDES
259Fluid overloadOFFSIDES
260Foaming at mouthOFFSIDES
261FormicationOFFSIDES
262GangreneOFFSIDES
263Gastrointestinal PainSIDER
264Gastrointestinal obstructionOFFSIDES
265Gastrointestinal perforationOFFSIDES
266Genital burning sensationOFFSIDES
267GlaucomaOFFSIDES
268GlobulinuriaOFFSIDES
269GoutOFFSIDES
270GranulocytosisOFFSIDES
271Hallucinations15027567CTD
272Hearing Loss10733182
17525781		CTD
273Heparin-induced thrombocytopeniaOFFSIDES
274Hepatitis COFFSIDES
275HerniaOFFSIDES
276Histiocytosis haematophagicOFFSIDES
277Hyperemesis GravidarumOFFSIDES
278Hypoaesthesia facialOFFSIDES
279HypokinesiaOFFSIDES
280HypomaniaOFFSIDES
281HypotensionSIDER
282HypotensiveSIDER
283ImmunosuppressionOFFSIDES
284Impaired driving abilityOFFSIDES
285IncoherentOFFSIDES
286InfectionOFFSIDES
287Injection site irritationOFFSIDES
288Injection site pruritusOFFSIDES
289Inspiratory capacity decreasedOFFSIDES
290Insulin-requiring type 2 diabetes mellitusOFFSIDES
291Intention tremorOFFSIDES
292Intentional drug misuseOFFSIDES
293IntertrigoOFFSIDES
294Intervertebral Disc DegenerationOFFSIDES
295Intervertebral disc disorderOFFSIDES
296Intestinal PerforationOFFSIDES
297Irritable Bowel Syndrome17956996CTD
298Joint abscessOFFSIDES
299Joint injurySIDER
300Joint sprainSIDER
301Kidney FailureOFFSIDES
302LacerationSIDER
303Left Ventricular HypertrophyOFFSIDES
304Left atrial dilatationOFFSIDES
305LethargyOFFSIDES
SIDER
306Leukopenia neonatalOFFSIDES
307Ligament injuryOFFSIDES
308LightheadednessSIDER
309Loose toothOFFSIDES
310Loss of proprioceptionOFFSIDES
311Low Back PainSIDER
312Lumbar radiculopathyOFFSIDES
313Lung cystOFFSIDES
314Lung infection pseudomonalOFFSIDES
315Malignant neoplasm progressionOFFSIDES
316MalnutritionSIDER
317Mastication disorderOFFSIDES
318MegacolonOFFSIDES
319Mental status changesOFFSIDES
320Metabolic acidosisOFFSIDES
321Mood swingsSIDER
322Mucosal atrophyOFFSIDES
323Multiple MyelomaOFFSIDES
324Multiple drug overdoseOFFSIDES
325Multiple sclerosis relapseOFFSIDES
326Muscle strainSIDER
327Musculoskeletal discomfortOFFSIDES
SIDER
328Musculoskeletal stiffnessOFFSIDES
329MyelodysplasiaOFFSIDES
330NephrectomyOFFSIDES
331Nephrogenic Fibrosing DermopathyOFFSIDES
332NephrolithiasisOFFSIDES
333Nervous tensionOFFSIDES
334NeuralgiaOFFSIDES
335Night sweatsSIDER
336Non-cardiac chest painOFFSIDES
SIDER
337Nutritional condition abnormalOFFSIDES
338ObstructionOFFSIDES
339Occult blood positiveOFFSIDES
340Oral dischargeOFFSIDES
341Oral fungal infectionOFFSIDES
342Oral infectionOFFSIDES
343Oral mucosal exfoliationOFFSIDES
344Oropharyngeal painOFFSIDES
345OsteomyelitisOFFSIDES
346OsteoporosisOFFSIDES
347Ovarian enlargementOFFSIDES
348Pancreatic PseudocystOFFSIDES
349ParaplegiaOFFSIDES
350Pelvic fluid collectionOFFSIDES
351Performance status decreasedOFFSIDES
352PericarditisOFFSIDES
353PeriodontitisOFFSIDES
354Peripheral nerve lesionOFFSIDES
355PeritonitisOFFSIDES
356Phantom painOFFSIDES
357PleurisyOFFSIDES
358Protein total decreasedOFFSIDES
359PterygiumOFFSIDES
360Pulmonary HypertensionOFFSIDES
361Pulmonary function test decreasedSIDER
362Radiation PneumonitisOFFSIDES
363RalesOFFSIDES
364Rectal polypOFFSIDES
365Renal cancer metastaticOFFSIDES
366Respiratory DepressionSIDER
367Respiratory FailureOFFSIDES
368Rheumatoid factor increasedOFFSIDES
369RhinorrheaOFFSIDES
370ScabOFFSIDES
371SclerodermaOFFSIDES
372ScotomaOFFSIDES
373Septic ShockOFFSIDES
374Shoulder PainOFFSIDES
375SinusitisOFFSIDES
376Skeletal injuryOFFSIDES
377Skin lacerationSIDER
378Skin necrosisOFFSIDES
379Spinal column stenosisOFFSIDES
380SpondylolisthesisOFFSIDES
381Stasis dermatitisOFFSIDES
382Sudden Cardiac DeathOFFSIDES
383Synovial CystOFFSIDES
384TachyphreniaOFFSIDES
385Terminal stateOFFSIDES
386Thoracic vertebral fractureOFFSIDES
387ThrombocytopeniaSIDER
388Thrombosis in deviceOFFSIDES
389Tinea PedisOFFSIDES
390TinnitusOFFSIDES
391Tongue bitingOFFSIDES
392Tooth ExtractionOFFSIDES
393Tooth LossOFFSIDES
394Tooth ResorptionOFFSIDES
395Umbilical herniaOFFSIDES
396Unresponsive to stimuliOFFSIDES
397Ureteral spasmSIDER
398Urinary RetentionSIDER
399Urinary tract infectionSIDER
400Vascular insufficiencyOFFSIDES
401Venous InsufficiencyOFFSIDES
402VertebroplastyOFFSIDES
403Weight GainOFFSIDES
404Wrong technique in drug usage processOFFSIDES
405effusionOFFSIDES
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