Mibefradil
(HBNPJJILLOYFJU-VMPREFPWSA-N)
Structure
- SMILES
- COCC(=O)O[C@]1(CCN(CCCc2nc3c([nH]2)cccc3)C)CCc2c([C@@H]1C(C)C)ccc(c2)F
- Type(s)
- Investigational; Withdrawn
- ATC code(s)
- C08CX01
- Molecular Formula:
- C29H38FN3O3
- Molecular Weight:
- 495.629
- Log P:
- 5.2709
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 1
- TPSA:
- 67.45
- CAS Number(s):
- 116644-53-2
Synonym(s)
1.
Mibefradil
2.
Mibefradil Dihydrochloride
3.
Posicor
4.
Ro 40-5967
5.
Ro 40 5967
6.
Ro 405967
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Chest Pain | FAERS: 1 | US FAERS | |
| 2 | Headache | FAERS: 1 | 12078937 | CTD US FAERS |
| 3 | muscle injury | FAERS: 1 | US FAERS | |
| 4 | Abnormalities, Drug-Induced | 9100294 | CTD | |
| 5 | Angina Pectoris | 9360062 9818470 10378820 | CTD | |
| 6 | Bradycardia | 12078937 | CTD | |
| 7 | Cardiomegaly | 8934362 | CTD | |
| 8 | Cardiovascular Abnormalities | 9100294 | CTD | |
| 9 | Chemical and Drug Induced Liver Injury | 22166485 | CTD | |
| 10 | Dizziness | 10378820 12078937 | CTD | |
| 11 | Dyspnea | 12078937 | CTD | |
| 12 | Edema | 9444446 12078937 | CTD | |
| 13 | Fatigue | 12078937 | CTD | |
| 14 | Heart Diseases | 22166485 | CTD | |
| 15 | Ischemia | 9360062 | CTD | |
| 16 | Lysosomal Storage Diseases | 28551711 | CTD | |
| 17 | Myocardial Infarction | 8001041 | CTD | |
| 18 | Necrosis | 12130671 | CTD | |
| 19 | Renal Insufficiency | 22166485 | CTD | |
| 20 | Syncope | 12078937 | CTD | |
| 21 | Torsades de Pointes | 11595612 | CTD | |
| 22 | Ventricular Fibrillation | 8331569 | CTD |
Powered by :
Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.