MetaADEDB 2.0 @ LMMD
azelastine
(MBUVEWMHONZEQD-UHFFFAOYSA-N)
Structure
SMILES
CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2
Type(s)
Approved
ATC code(s)
R01AC03; R06AX19; S01GX07
Molecular Formula:
C22H24ClN3O
Molecular Weight:
381.898
Log P:
4.2354
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
38.13
CAS Number(s):
58581-89-8
Synonym(s)
1.
azelastine
2.
4-((4-chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCl
3.
4-(p-chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone
4.
A 5610
5.
A-5610
6.
Afluon
7.
Allergodil
8.
Astelin
9.
Azeptin
10.
Corifina
11.
Loxin
12.
Optilast
13.
Optivar
14.
Rhinolast
15.
Vividrin akut Azelastin
16.
azelastine hydrochloride
External Link(s)
MeSHC020976
PubChem Compound2267
BindingDB50341448
ChEBI2950
CHEMBLCHEMBL639
DrugBankDB00972
DrugCentral271
IUPHAR/BPS Guide to PHARMACOLOGY7121
KEGGcpd:C07768
dr:D07483
Therapeutic Target DatabaseD00JVR
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 8US FAERS
2HeadacheFAERS: 5SIDER
US FAERS
3Product quality issueFAERS: 5OFFSIDES
US FAERS
4Product substitution issueFAERS: 5US FAERS
5Drug dose omissionFAERS: 4US FAERS
6Eye painFAERS: 4SIDER
US FAERS
7Product container issueFAERS: 4US FAERS
8Burning sensationFAERS: 3US FAERS
9DysgeusiaFAERS: 3OFFSIDES
SIDER
US FAERS
10Eye irritationFAERS: 3US FAERS
11Incorrect dose administeredFAERS: 3US FAERS
12Throat irritationFAERS: 3SIDER
US FAERS
13AmnesiaFAERS: 2OFFSIDES
US FAERS
14EpistaxisFAERS: 2OFFSIDES
SIDER
US FAERS
15MyalgiaFAERS: 2SIDER
US FAERS
16Product physical issueFAERS: 2US FAERS
17Product taste abnormalFAERS: 2US FAERS
18Rash erythematousFAERS: 2US FAERS
19Upper-airway cough syndromeFAERS: 2US FAERS
20Accidental exposure to productFAERS: 1US FAERS
21ArthralgiaFAERS: 1US FAERS
22ArthritisFAERS: 1OFFSIDES
SIDER
US FAERS
23Back PainFAERS: 1SIDER
US FAERS
24ChillsFAERS: 1US FAERS
25Circumstance or information capable of leading to medication errorFAERS: 1OFFSIDES
US FAERS
26Device FailureFAERS: 1OFFSIDES
US FAERS
27Device defectiveFAERS: 1US FAERS
28Device difficult to useFAERS: 1US FAERS
29DizzinessFAERS: 1OFFSIDES
SIDER
US FAERS
30HypersensitivityFAERS: 1SIDER
US FAERS
31Incorrect dose administered by deviceFAERS: 1US FAERS
32Incorrect product storageFAERS: 1US FAERS
33Medication ErrorFAERS: 1US FAERS
34Nasal discomfortFAERS: 1OFFSIDES
SIDER
US FAERS
35NauseaFAERS: 1OFFSIDES
SIDER
US FAERS
36Oropharyngeal painFAERS: 1OFFSIDES
US FAERS
37Product packaging quantity issueFAERS: 1US FAERS
38SneezingFAERS: 18100058CTD
SIDER
US FAERS
39Therapeutic product effect decreasedFAERS: 1US FAERS
40Toxicity to various agentsFAERS: 1US FAERS
41Urinary RetentionFAERS: 1SIDER
US FAERS
42UrticariaFAERS: 1US FAERS
43VertigoFAERS: 1SIDER
US FAERS
44WheezingFAERS: 1US FAERS
45AbasiaOFFSIDES
46Abdominal PainOFFSIDES
SIDER
47Abdominal discomfortOFFSIDES
48Abnormal clotting factorOFFSIDES
49Abnormal visionOFFSIDES
SIDER
50Abscess managementOFFSIDES
51AbscessOFFSIDES
52AbuseOFFSIDES
53Acid refluxOFFSIDES
54ActinomycosisOFFSIDES
55Activities of daily living impairedOFFSIDES
56Acute bronchitisOFFSIDES
57Acute myocardial infarctionOFFSIDES
58Acute prerenal failureOFFSIDES
59Acute respiratory failureOFFSIDES
60Acute sinusitisOFFSIDES
61Adnexa uteri cystOFFSIDES
62Adverse eventOFFSIDES
63AgeusiaOFFSIDES
SIDER
64AgitationSIDER
65Alanine Aminotransferase IncreasedSIDER
66AlbuminuriaSIDER
67Allergy to chemicalsOFFSIDES
68AlveoloplastyOFFSIDES
69Amaurosis FugaxOFFSIDES
70Anal sphincterotomyOFFSIDES
71Anaphylactic shockSIDER
72Anaphylactoid ReactionSIDER
73AngerOFFSIDES
74AngiomyolipomaOFFSIDES
75AnhedoniaOFFSIDES
76AnhidrosisOFFSIDES
77AnosmiaOFFSIDES
SIDER
78Anti-platelet antibody positiveOFFSIDES
79Antimicrobial susceptibility test resistantOFFSIDES
80Antithrombin III increasedOFFSIDES
81AnxietyOFFSIDES
SIDER
82Aortic AneurysmOFFSIDES
83Aortic occlusionOFFSIDES
84Aphthous StomatitisSIDER
85Application site irritationSIDER
86ArteriosclerosisOFFSIDES
87ArthropathyOFFSIDES
88Artificial crown procedureOFFSIDES
89AsterixisOFFSIDES
90AstheniaOFFSIDES
SIDER
91AsthenopiaOFFSIDES
92AsthmaOFFSIDES
SIDER
93AtelectasisOFFSIDES
94Atrial FibrillationSIDER
95Atrophic vulvovaginitisOFFSIDES
96AuraOFFSIDES
97Back disorderOFFSIDES
98Bacterial disease carrierOFFSIDES
99Basal cell carcinomaOFFSIDES
100Benign neoplasm of adrenal glandOFFSIDES
101Benign neoplasm of thyroid glandOFFSIDES
102Beta-2 glycoprotein antibody positiveOFFSIDES
103Bile Duct StenosisOFFSIDES
104Biliary dilatationOFFSIDES
105BiopsyOFFSIDES
106BlepharoptosisOFFSIDES
107Blood GlucoseOFFSIDES
108Blood alkaline phosphatase increasedOFFSIDES
109Blood blisterOFFSIDES
110Blood cholesterol abnormalOFFSIDES
111Blood cholesterolOFFSIDES
112Blood iron decreasedOFFSIDES
113Blood pressure fluctuationOFFSIDES
114Blood urea abnormalOFFSIDES
115Blurred visionOFFSIDES
116Bone density decreasedOFFSIDES
117Bone erosionOFFSIDES
118Bone fragmentationOFFSIDES
119Bone lesionOFFSIDES
120Bone painOFFSIDES
121Bone swellingOFFSIDES
122BronchitisOFFSIDES
SIDER
123Bronchopleural FistulaOFFSIDES
124BronchospasmSIDER
125BursitisOFFSIDES
126Cataract operationOFFSIDES
127CataractOFFSIDES
128Catheter related complicationOFFSIDES
129Caustic injuryOFFSIDES
130Central nervous system lesionOFFSIDES
131Cerebral atrophyOFFSIDES
132Cerebral ventricle dilatationOFFSIDES
133Cervical myelopathyOFFSIDES
134Chemical burns of eyeOFFSIDES
135Chest PainOFFSIDES
SIDER
136Choking sensationOFFSIDES
137CholecystitisOFFSIDES
138ChondromalaciaOFFSIDES
139Chorea20108362CTD
140ChromaturiaOFFSIDES
141Chronic Fatigue SyndromeOFFSIDES
142Chronic Obstructive Airway DiseaseOFFSIDES
143Clostridium colitisOFFSIDES
144Clostridium difficile toxin test positiveOFFSIDES
145Cold symptomsSIDER
146ColectomyOFFSIDES
147ColitisOFFSIDES
148Compression fractureOFFSIDES
149Congenital cystic kidney diseaseOFFSIDES
150Congenital heart valve disorderOFFSIDES
151Congenital tricuspid valve incompetenceOFFSIDES
152Conjunctival depositOFFSIDES
153ConjunctivitisSIDER
154ConstipationSIDER
155Contact DermatitisOFFSIDES
156Contact lens intoleranceOFFSIDES
157Corneal ScarOFFSIDES
158Corneal degenerationOFFSIDES
159Corneal epithelium defectOFFSIDES
160CraniectomyOFFSIDES
161CraniotomyOFFSIDES
162CryingOFFSIDES
163CyanosisOFFSIDES
164CystOFFSIDES
165DeafnessOFFSIDES
166DebridementOFFSIDES
167DehydrationOFFSIDES
168DemyelinationOFFSIDES
169Dental FistulaOFFSIDES
170Dental abscessOFFSIDES
171Denture wearerOFFSIDES
172DependenceOFFSIDES
173Depressed moodOFFSIDES
174DermatitisSIDER
175DiabetesOFFSIDES
176DiarrheaOFFSIDES
177DiplopiaOFFSIDES
178DiscomfortSIDER
179Disorders of Excessive Somnolence3057041CTD
180DiverticulitisOFFSIDES
181DiverticulosisOFFSIDES
182DiverticulumOFFSIDES
183DrowsinessOFFSIDES
184Drug toxicityOFFSIDES
185Drug withdrawal headacheOFFSIDES
186DyscheziaOFFSIDES
187DysgraphiaOFFSIDES
188DysmenorrheaOFFSIDES
189DysphoniaOFFSIDES
190Dysthymic DisorderOFFSIDES
191DysuriaOFFSIDES
192Ear dischargeOFFSIDES
193Ear discomfortOFFSIDES
194Economic problemOFFSIDES
195EczemaOFFSIDES
SIDER
196Ejection Fraction DecreasedOFFSIDES
197Electrocardiogram ST segment abnormalOFFSIDES
198Emotional disorderOFFSIDES
199Emotional distressOFFSIDES
200EmpyemaOFFSIDES
201EncephalomalaciaOFFSIDES
202Endodontic procedureOFFSIDES
203Enterococcal sepsisOFFSIDES
204Eosinophilia1355641CTD
205ErythemaOFFSIDES
206Escherichia urinary tract infectionOFFSIDES
207Eustachian tube disorderOFFSIDES
208Expired drug administeredOFFSIDES
209Eye BurnsSIDER
210Eye InfectionOFFSIDES
211False positive laboratory resultOFFSIDES
212Familial Mediterranean Fever15805719CTD
213FatigueOFFSIDES
SIDER
214Feeling abnormalSIDER
215FibromyalgiaOFFSIDES
216Flank PainOFFSIDES
217Fluid overloadOFFSIDES
218FlushingSIDER
219FurunculosisSIDER
220GamblingOFFSIDES
221Gastric BypassOFFSIDES
222GastroenteritisOFFSIDES
SIDER
223Gastrointestinal PainSIDER
224Gingival erythemaOFFSIDES
225Gingival graftOFFSIDES
226GlaucomaOFFSIDES
227GlossitisOFFSIDES
SIDER
228GoiterOFFSIDES
229HemiparesisOFFSIDES
230Hepatic Vein ThrombosisOFFSIDES
231Hepatitis C RNAOFFSIDES
232HiccoughOFFSIDES
233High frequency ablationOFFSIDES
234Hip surgeryOFFSIDES
235HistoplasmosisOFFSIDES
236HoarsenessOFFSIDES
237Hungry bone syndromeOFFSIDES
238HydropneumothoraxOFFSIDES
239HyperkeratosisOFFSIDES
240HyperkinesiaSIDER
241Hypertensive heart diseaseOFFSIDES
242Hypertrophic CardiomyopathyOFFSIDES
243Hypoaesthesia facialOFFSIDES
244Hypocoagulable stateOFFSIDES
245HypophagiaOFFSIDES
246HyporeflexiaOFFSIDES
247Impaired driving abilityOFFSIDES
248Implantable defibrillator insertionOFFSIDES
249IncontinenceOFFSIDES
250Increased upper airway secretionOFFSIDES
251InfectionSIDER
252Influenza-like symptomsSIDER
253Infusion site pruritusOFFSIDES
254Initial insomniaOFFSIDES
255Injection site burningOFFSIDES
256Injection site discomfortOFFSIDES
257Injection site erythemaOFFSIDES
258Injection site stingingOFFSIDES
259Injection site urticariaOFFSIDES
260Intention tremorOFFSIDES
261Intentional drug misuseOFFSIDES
262Intermittent ClaudicationOFFSIDES
263Intervertebral Disc DegenerationOFFSIDES
264Intestinal infarctionOFFSIDES
265Keratitis siccaOFFSIDES
266LacerationOFFSIDES
SIDER
267LaryngitisSIDER
268Left atrial dilatationOFFSIDES
269Leriche SyndromeOFFSIDES
270LeukoplakiaOFFSIDES
271Limb injuryOFFSIDES
272ListeriosisOFFSIDES
273Loose toothOFFSIDES
274Lower respiratory tract infection viralOFFSIDES
275Lumbar spine flatteningOFFSIDES
276Lung infection pseudomonalOFFSIDES
277Lymphocyte count decreasedOFFSIDES
278Lysosomal Storage Diseases28551711CTD
279MalaiseSIDER
280Mastication disorderOFFSIDES
281Megakaryocytes increasedOFFSIDES
282Metastatic NeoplasmOFFSIDES
283MetatarsalgiaOFFSIDES
284Middle insomniaOFFSIDES
285MoaningOFFSIDES
286MononeuritisOFFSIDES
287Multiple MyelomaOFFSIDES
288Multiple allergiesOFFSIDES
289Muscle WeaknessOFFSIDES
290Muscle flap operationOFFSIDES
291Musculoskeletal PainOFFSIDES
292Musculoskeletal discomfortOFFSIDES
SIDER
293MyomectomyOFFSIDES
294Nasal burningSIDER
295Nasal sinus drainageOFFSIDES
296NasopharyngitisSIDER
297Nervous tensionOFFSIDES
298NervousnessSIDER
299NeuralgiaOFFSIDES
300No reaction on previous exposure to drugOFFSIDES
301NocturiaOFFSIDES
302Nodule on extremityOFFSIDES
303Ocular ToxicityOFFSIDES
304Ocular icterusOFFSIDES
305Open reduction of fractureOFFSIDES
306Open woundOFFSIDES
307Opiates positiveOFFSIDES
308Oral Cavity FistulaOFFSIDES
309Oral mucosa atrophyOFFSIDES
310Oral polypectomyOFFSIDES
311Oropharyngeal blisteringOFFSIDES
312Oropharyngeal plaqueOFFSIDES
313OsteolysisOFFSIDES
314OsteomyelitisOFFSIDES
315OsteopeniaOFFSIDES
316OsteoporosisOFFSIDES
317OsteoradionecrosisOFFSIDES
318OsteosclerosisOFFSIDES
319Pacemaker complicationOFFSIDES
320PainOFFSIDES
SIDER
321PalpitationsSIDER
322PancreatitisOFFSIDES
323Paranasal sinus hypersecretionOFFSIDES
SIDER
324Perineal operationOFFSIDES
325PeriodontitisOFFSIDES
326Pharmaceutical product complaintOFFSIDES
327PharyngitisSIDER
328Pharyngolaryngeal PainOFFSIDES
SIDER
329Physical disabilityOFFSIDES
330PlasmacytosisOFFSIDES
331PneumothoraxOFFSIDES
332Polymyalgia RheumaticaOFFSIDES
333PolyuriaOFFSIDES
334Post procedural infectionOFFSIDES
335Postmenopausal bleedingOFFSIDES
336Primary sequestrumOFFSIDES
337Proctitis herpesOFFSIDES
338Product contaminationOFFSIDES
339Productive CoughOFFSIDES
340Progesterone receptor assayOFFSIDES
341Prolapse repairOFFSIDES
342ProstatectomyOFFSIDES
343Pruritus19657356CTD
SIDER
344Psychiatric symptomOFFSIDES
345Pulmonary congestionOFFSIDES
346Pulmonary vascular disorderOFFSIDES
347Purulent dischargeOFFSIDES
348QuadriparesisOFFSIDES
349Rectal polypOFFSIDES
350Refusal of treatment by relativeOFFSIDES
351Renal Artery StenosisOFFSIDES
352Renal cystOFFSIDES
353Rheumatoid ArthritisSIDER
354RhinalgiaOFFSIDES
355RhinitisOFFSIDES
SIDER
356RhinorrheaOFFSIDES
357Schizoaffective DisorderOFFSIDES
358Seizures9301134CTD
359Sinus bradycardiaOFFSIDES
360Sinus operationOFFSIDES
361SinusitisOFFSIDES
SIDER
362Skeletal injuryOFFSIDES
363Skin WrinklingOFFSIDES
364Skin lacerationSIDER
365Skin lesionOFFSIDES
366Skin neoplasm excisionOFFSIDES
367Sleep TalkingOFFSIDES
368SnoringOFFSIDES
369SomnolenceSIDER
370Spinal column stenosisOFFSIDES
371Spinal fusion surgeryOFFSIDES
372SpondylolisthesisOFFSIDES
373Stem cell transplantOFFSIDES
374StressOFFSIDES
375Subcutaneous AbscessOFFSIDES
376TachycardiaSIDER
377Taste Disorders3057041
10400480
21381763		CTD
378Taste sweetSIDER
379Temporal ArteritisOFFSIDES
380TendinitisOFFSIDES
381TensionSIDER
382Therapeutic reaction time decreasedOFFSIDES
383ThoracotomyOFFSIDES
384ThrombophlebitisOFFSIDES
385Thymus enlargementOFFSIDES
386ThyroidectomyOFFSIDES
387Tinea crurisOFFSIDES
388TinnitusOFFSIDES
389Tobacco userOFFSIDES
390Tobacco withdrawal symptomsOFFSIDES
391Tooth ExtractionOFFSIDES
392Tooth InfectionOFFSIDES
393Tooth LossOFFSIDES
394Tooth repairOFFSIDES
395ToothacheSIDER
396Type III immune complex mediated reactionOFFSIDES
397Ulcerative stomatitisSIDER
398UlcerSIDER
399Unresponsive to stimuliOFFSIDES
400Upper airway resistance syndromeOFFSIDES
401Urethral StenosisOFFSIDES
402Urinary tract infection enterococcalOFFSIDES
403Urine flow decreasedOFFSIDES
404VIIth nerve paralysisOFFSIDES
405Vaginal mycosisOFFSIDES
406Venous InsufficiencyOFFSIDES
407Visual ImpairmentSIDER
408Vitreous DetachmentOFFSIDES
409VomitingSIDER
410Vulvovaginal pruritusOFFSIDES
411Weight GainOFFSIDES
412Wound dehiscenceOFFSIDES
413Wound infection staphylococcalOFFSIDES
414XerophthalmiaSIDER
415colonoscopyOFFSIDES
416effusionOFFSIDES
417fibromaOFFSIDES
418furuncleSIDER
419kyphosisOFFSIDES
420muscle injuryOFFSIDES
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