MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Clemastine

(YNNUSGIPVFPVBX-NHCUHLMSSA-N)

Structure

SMILES: Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C
Type(s): Approved; Investigational
ATC code(s): D04AA14; R06AA04; R06AA54
Molecular Formula:: C21H26ClNO
Molecular Weight:: 343.890
Log P:: 5.0423
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 12.47
CAS Number(s):: 14976-57-9; 15686-51-8

Synonym(s)

Clemastine

Meclastine

Mecloprodin

2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine

Clemastine Fumarate

HS-592

Tavegyl

Tavist

HS 592

10.

HS592

External Link(s)

MeSH	D002974
PubChem Compound	26987
BindingDB	50253157 94606
ChEBI	3738
CHEMBL	CHEMBL1626
DrugBank	DB00283
DrugCentral	671
IUPHAR/BPS Guide to PHARMACOLOGY	6063
KEGG	cpd:C06913 dr:D03535
Therapeutic Target Database	D0C5XC
ZINC	402830

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal discomfort	FAERS: 1		US FAERS
2	Inflammation	FAERS: 1		US FAERS
3	Neuralgia	FAERS: 1		US FAERS
4	Pain	FAERS: 1		US FAERS
5	Rheumatic disorder	FAERS: 1		US FAERS
6	Rhinalgia	FAERS: 1		US FAERS
7	nervous system disorder	FAERS: 1		US FAERS
8	Abdominal Pain			OFFSIDES
9	Abnormal vision			OFFSIDES
10	Abscess soft tissue			OFFSIDES
11	Agitation			SIDER
12	Agranulocytosis			SIDER
13	Agraphia			OFFSIDES
14	Anaphylactic shock			SIDER
15	Angioedema			OFFSIDES
16	Anorectal discomfort			OFFSIDES
17	Anorexia			OFFSIDES SIDER
18	Aortic Aneurysm			OFFSIDES
19	Apnea			OFFSIDES
20	Ascites			OFFSIDES
21	Asthenia			OFFSIDES SIDER
22	Atelectasis			OFFSIDES
23	Autoimmune thrombocytopenia			OFFSIDES
24	Autoimmune thyroiditis			OFFSIDES
25	Bacterial conjunctivitis			OFFSIDES
26	Blepharospasm			OFFSIDES
27	Blood creatinine increased			OFFSIDES
28	Blood lactate dehydrogenase increased			OFFSIDES
29	Blood phosphorus increased			OFFSIDES
30	Blood sodium increased			OFFSIDES
31	Body Temperature			OFFSIDES
32	Bursitis			OFFSIDES
33	Carcinoma, Ovarian Epithelial		12442916	CTD
34	Catheter site cellulitis			OFFSIDES
35	Cerebral hypoperfusion			OFFSIDES
36	Chest discomfort			SIDER
37	Chest tightness			SIDER
38	Chills			SIDER
39	Choking sensation			OFFSIDES
40	Common Cold		6122135	CTD
41	Confabulation			OFFSIDES
42	Congenital tricuspid valve incompetence			OFFSIDES
43	Constipation			SIDER
44	Conversion disorder			SIDER
45	Cryptophthalmos			OFFSIDES
46	Cyanosis			OFFSIDES
47	Dehydration			OFFSIDES
48	Depressed Level of Consciousness			OFFSIDES
49	Diabetic Retinopathy			OFFSIDES
50	Diastolic dysfunction			OFFSIDES
51	Diplopia			SIDER
52	Disorders of Excessive Somnolence		6122135	CTD
53	Dizziness			SIDER
54	Drowsiness			SIDER
55	Drug exposure before pregnancy			OFFSIDES
56	Drug exposure during pregnancy			OFFSIDES
57	Dyspepsia			SIDER
58	Eczema			OFFSIDES
59	Emotional distress			OFFSIDES
60	Enuresis			OFFSIDES
61	Epigastric distress			SIDER
62	Epstein-Barr virus associated lymphoproliferative disorder			OFFSIDES
63	Erythema Multiforme			OFFSIDES
64	Erythema			OFFSIDES
65	Euphoric mood			SIDER
66	Fatigue			OFFSIDES SIDER
67	Febrile Neutropenia			OFFSIDES
68	Feeding disorder neonatal			OFFSIDES
69	Feeling abnormal			SIDER
70	Formication			OFFSIDES
71	Gambling			OFFSIDES
72	Gamma-Glutamyltransferase Increased			OFFSIDES
73	Gastric ulcer			OFFSIDES
74	Gastrointestinal inflammation			OFFSIDES
75	General physical health deterioration			OFFSIDES
76	Glossoptosis			OFFSIDES
77	Granulocytosis			OFFSIDES
78	Headache			SIDER
79	Hepatitis C			OFFSIDES
80	Hepatotoxicity			OFFSIDES
81	Histiocytosis haematophagic			OFFSIDES
82	Hordeolum			OFFSIDES
83	Hypertensive heart disease			OFFSIDES
84	Hypotension			SIDER
85	Hypothermia neonatal			OFFSIDES
86	Hysteria			SIDER
87	Immature respiratory system			OFFSIDES
88	Incontinence			OFFSIDES
89	Increased bronchial secretion			OFFSIDES
90	Infection			OFFSIDES
91	Injection site erythema			OFFSIDES
92	Intention tremor			OFFSIDES
93	Joint injury			OFFSIDES
94	Labyrinthitis			SIDER
95	Laryngospasm			OFFSIDES
96	Left Ventricular Hypertrophy			OFFSIDES
97	Leukopenia neonatal			OFFSIDES
98	Locked-In Syndrome			OFFSIDES
99	Lymphoma transformation			OFFSIDES
100	Lysosomal Storage Diseases		28551711	CTD
101	Mastoiditis			OFFSIDES
102	Mechanical ventilation			OFFSIDES
103	Mediastinal shift			OFFSIDES
104	Metabolic acidosis			OFFSIDES
105	Micturition frequency decreased			OFFSIDES
106	Nasal mucosal disorder			OFFSIDES
107	Nausea			SIDER
108	Neonatal aspiration			OFFSIDES
109	Nephrotic Syndrome			OFFSIDES
110	Nervousness			SIDER
111	Neuritis			SIDER
112	Pain of skin			OFFSIDES
113	Pallor			OFFSIDES
114	Palpitations			SIDER
115	Pancreatic Insufficiency			OFFSIDES
116	Panniculitis			OFFSIDES
117	Performance status decreased			OFFSIDES
118	Plasmacytoma			OFFSIDES
119	Pneumocystis jiroveci pneumonia			OFFSIDES
120	Polyneuropathy			OFFSIDES
121	Prescribed overdose			OFFSIDES
122	Prostate examination abnormal			OFFSIDES
123	Pseudomonal sepsis			OFFSIDES
124	Pulmonary Hypertension			OFFSIDES
125	Purulence			OFFSIDES
126	Pyelonephritis			OFFSIDES
127	Renal tubular disorder			OFFSIDES
128	Respiratory Failure			OFFSIDES
129	Reticulocyte count decreased			OFFSIDES
130	Reticulocytosis			OFFSIDES
131	Right Ventricular Hypertrophy			OFFSIDES
132	Sinusitis			OFFSIDES
133	Skin lesion			OFFSIDES
134	Somnolence			SIDER
135	Stevens-Johnson Syndrome		17955500	CTD OFFSIDES
136	Stridor			OFFSIDES
137	Surgical vascular shunt			OFFSIDES
138	Tachycardia			SIDER
139	Tension			SIDER
140	Thrombocytopenia			SIDER
141	Tinnitus			SIDER
142	Tracheitis			OFFSIDES
143	Transaminases increased			OFFSIDES
144	Transmission of an infectious agent via a medicinal product			OFFSIDES
145	Tremor			SIDER
146	Urinary Retention			SIDER
147	Urticaria		2569997	CTD
148	Venoocclusive disease			OFFSIDES
149	Vertebral artery thrombosis			OFFSIDES
150	Vertigo			SIDER
151	Vomiting			SIDER
152	Wheezing			SIDER
153	Wound Infection			OFFSIDES
154	anaphylaxis		16101941	CTD

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