MetaADEDB 2.0 @ LMMD
Maraviroc
(GSNHKUDZZFZSJB-HLMSNRGBSA-N)
Structure
SMILES
O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C
Type(s)
Approved; Investigational
ATC code(s)
J05AX09
Molecular Formula:
C29H41F2N5O
Molecular Weight:
513.666
Log P:
6.2797
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
63.05
CAS Number(s):
376348-65-1; 674782-29-7
Synonym(s)
1.
Maraviroc
2.
4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
3.
Selzentry
4.
UK-427,857
5.
UK-427857
6.
UK 427,857
7.
UK 427857
8.
UK427,857
9.
UK427857
External Link(s)
MeSHD000077592
PubChem Compound3002977
BindingDB50334986
ChEBI63608
CHEMBLCHEMBL1201187
CHEMBL256907
CHEMBL584744
DrugBankDB04835
DrugCentral1635
IUPHAR/BPS Guide to PHARMACOLOGY803
806
Therapeutic Target DatabaseD0NR6S
D0T8DO
ZINC100003902
101160855
3817234
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug resistanceFAERS: 10US FAERS
2Virologic failureFAERS: 10US FAERS
3Viral mutation identifiedFAERS: 8US FAERS
4Myocardial InfarctionFAERS: 7SIDER
US FAERS
5AsthmaFAERS: 4US FAERS
6BradycardiaFAERS: 4OFFSIDES
US FAERS
7Drug administration errorFAERS: 4US FAERS
8Gastrointestinal obstructionFAERS: 4OFFSIDES
US FAERS
9No adverse eventFAERS: 4US FAERS
10Acute myocardial infarctionFAERS: 3OFFSIDES
US FAERS
11DemyelinationFAERS: 3US FAERS
12Drug dose omissionFAERS: 3US FAERS
13FatigueFAERS: 3SIDER
US FAERS
14MalaiseFAERS: 3US FAERS
15MyalgiaFAERS: 3SIDER
US FAERS
16Pancreatic carcinoma recurrentFAERS: 3US FAERS
17treatment failureFAERS: 3US FAERS
18Anogenital dysplasiaFAERS: 2OFFSIDES
US FAERS
19AppendicitisFAERS: 2OFFSIDES
US FAERS
20BronchitisFAERS: 2SIDER
US FAERS
21Cardiac ArrestFAERS: 2US FAERS
22Chest PainFAERS: 2OFFSIDES
US FAERS
23ConstipationFAERS: 2SIDER
US FAERS
24Deep Vein ThrombosisFAERS: 2US FAERS
25DizzinessFAERS: 2SIDER
US FAERS
26Drug dispensing errorFAERS: 2US FAERS
27DyspepsiaFAERS: 2US FAERS
28General physical health deteriorationFAERS: 2US FAERS
29Hepatitis CFAERS: 2US FAERS
30MastoiditisFAERS: 2OFFSIDES
US FAERS
31NauseaFAERS: 2OFFSIDES
SIDER
US FAERS
32PancytopeniaFAERS: 2SIDER
US FAERS
33PneumoniaFAERS: 2SIDER
US FAERS
34Product use issueFAERS: 2US FAERS
35Productive CoughFAERS: 2US FAERS
36Subcutaneous AbscessFAERS: 2US FAERS
37Therapeutic response unexpectedFAERS: 2US FAERS
38TuberculosisFAERS: 2US FAERS
39Urinary tract infectionFAERS: 2US FAERS
40West Nile viral infectionFAERS: 2US FAERS
41Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
42Abdominal discomfortFAERS: 1US FAERS
43Abdominal massFAERS: 1US FAERS
44Abdominal sepsisFAERS: 1US FAERS
45Acquired Immunodeficiency SyndromeFAERS: 1SIDER
US FAERS
46Adverse eventFAERS: 1US FAERS
47Anal squamous cell carcinomaFAERS: 1US FAERS
48Angina PectorisFAERS: 1SIDER
US FAERS
49Aortic RuptureFAERS: 1US FAERS
50ArthralgiaFAERS: 1US FAERS
51AstheniaFAERS: 1SIDER
US FAERS
52AtopyFAERS: 1US FAERS
53Atrial FibrillationFAERS: 1US FAERS
54Blood HIV RNA increasedFAERS: 1US FAERS
55Blood creatine increasedFAERS: 1US FAERS
56Blood creatine phosphokinase increasedFAERS: 1OFFSIDES
SIDER
US FAERS
57Cell DeathFAERS: 1US FAERS
58Cerebrovascular accidentFAERS: 1SIDER
US FAERS
59CholestasisFAERS: 1US FAERS
60Congenital skin dimplesFAERS: 1US FAERS
61CryingFAERS: 1US FAERS
62Diabetes MellitusFAERS: 1SIDER
US FAERS
63Disease ProgressionFAERS: 1US FAERS
64Disease complicationFAERS: 1US FAERS
65Drug ineffectiveFAERS: 1US FAERS
66DysarthriaFAERS: 1US FAERS
67DysgraphiaFAERS: 1US FAERS
68Electrocardiogram abnormalFAERS: 1US FAERS
69End stage AIDSFAERS: 1US FAERS
70FlatulenceFAERS: 1OFFSIDES
SIDER
US FAERS
71GastritisFAERS: 1US FAERS
72GastroenteritisFAERS: 1US FAERS
73GiardiasisFAERS: 1US FAERS
74HIV tropism identifiedFAERS: 1US FAERS
75HypersensitivityFAERS: 1SIDER
US FAERS
76HypertransaminasaemiaFAERS: 1OFFSIDES
SIDER
US FAERS
77HypoxiaFAERS: 1OFFSIDES
US FAERS
78IleusFAERS: 1US FAERS
79Immune reconstitution syndromeFAERS: 1US FAERS
80Impaired driving abilityFAERS: 1US FAERS
81Inappropriate schedule of drug administrationFAERS: 1US FAERS
82Incorrect dose administeredFAERS: 1US FAERS
83InfluenzaFAERS: 1SIDER
US FAERS
84Joint swellingFAERS: 1US FAERS
85Lymphangiosis carcinomatosaFAERS: 1US FAERS
86LymphomaFAERS: 1OFFSIDES
SIDER
US FAERS
87MalnutritionFAERS: 1SIDER
US FAERS
88MyopathyFAERS: 1US FAERS
89Neutropenic sepsisFAERS: 1US FAERS
90Neutrophil count decreasedFAERS: 1US FAERS
91Night sweatsFAERS: 1US FAERS
92Pathogen resistanceFAERS: 1US FAERS
93Penis carcinomaFAERS: 1OFFSIDES
US FAERS
94Product dose omissionFAERS: 1US FAERS
95Product supply issueFAERS: 1US FAERS
96Product use complaintFAERS: 1US FAERS
97Product use in unapproved indicationFAERS: 1US FAERS
98Psoas AbscessFAERS: 1US FAERS
99Pulmonary malformationFAERS: 1US FAERS
100Secretion dischargeFAERS: 1US FAERS
101Septic ShockFAERS: 1OFFSIDES
SIDER
US FAERS
102SomnolenceFAERS: 1US FAERS
103Squamous cell carcinomaFAERS: 1SIDER
US FAERS
104SwellingFAERS: 1US FAERS
105Urinary RetentionFAERS: 1US FAERS
106Vascular occlusionFAERS: 1US FAERS
107VertigoFAERS: 1US FAERS
108VomitingFAERS: 1SIDER
US FAERS
109White blood cell count decreasedFAERS: 1US FAERS
110Wrong technique in product usage processFAERS: 1US FAERS
111jaundiceFAERS: 1SIDER
US FAERS
112AIDS Dementia ComplexOFFSIDES
113Abdominal bloatingSIDER
114AcneSIDER
115Acute Coronary SyndromeOFFSIDES
SIDER
116Acute bronchitisSIDER
117Acute sinusitisOFFSIDES
SIDER
118AdenocarcinomaOFFSIDES
119AgranulocytosisSIDER
120Alanine Aminotransferase IncreasedSIDER
121AlopeciaSIDER
122Altered state of consciousnessSIDER
123AmblyopiaOFFSIDES
124AmnesiaSIDER
125Anaemias NECSIDER
126Anal cancer stage IIOFFSIDES
127AnorexiaSIDER
128AnxietySIDER
129Apocrine and eccrine gland disordersSIDER
130Aspartate Aminotransferase IncreasedSIDER
131Bacterial infections NECSIDER
132Basal cell carcinomaOFFSIDES
SIDER
133Benign neoplasm of skinSIDER
134Bile duct neoplasms malignantSIDER
135Bladder NeoplasmOFFSIDES
136Bladder and urethral symptomsSIDER
137Blood GlucoseOFFSIDES
138Blood alkaline phosphatase increasedSIDER
139Blood and lymphatic system disordersSIDER
140Blood blisterOFFSIDES
141Blurred visionOFFSIDES
142Bone marrow depressionSIDER
143Bowen's DiseaseSIDER
144BronchopneumoniaSIDER
145BronchospasmSIDER
146CataractSIDER
147Central line infectionOFFSIDES
148Cerebellar AtaxiaOFFSIDES
149CholangiocarcinomaSIDER
150Chronic sinusitisSIDER
151Clostridium difficile colitisSIDER
152ColitisSIDER
153ConjunctivitisSIDER
154Coronary Artery DiseaseSIDER
155Creatine Phosphokinase IncreasedSIDER
156CystOFFSIDES
SIDER
157Cytolytic hepatitisOFFSIDES
158DeafnessSIDER
159DementiaSIDER
160Depressive disorderSIDER
161DermatitisSIDER
162Diffuse Large B-Cell LymphomaSIDER
163DiscomfortSIDER
164DistentionSIDER
165Dysthymic DisorderSIDER
166DystoniaOFFSIDES
167Ear and labyrinth disordersSIDER
168Ear disorders NECSIDER
169EczemaSIDER
170EmbolismOFFSIDES
171EndocarditisSIDER
172Endocrine neoplasms malignant and unspecifiedSIDER
173Enterococcal infectionOFFSIDES
174EosinophiliaSIDER
175EpilepsySIDER
176EpistaxisOFFSIDES
177ErysipelasOFFSIDES
178Erythema MultiformeSIDER
179ErythemaSIDER
180Esophageal StenosisOFFSIDES
181Eye InfectionSIDER
182Facial paralysisSIDER
183FolliculitisSIDER
184Gamma-Glutamyltransferase IncreasedSIDER
185Gastrointestinal PainSIDER
186Gastrointestinal signs and symptoms NECSIDER
187GlaucomaSIDER
188GlobulinuriaOFFSIDES
189HIV Infections21128663CTD
190HeadacheSIDER
191Heat ExhaustionSIDER
192Heat StrokeSIDER
193Hepatic cancer metastaticSIDER
194HepatotoxicitySIDER
195Herpes NOSSIDER
196IleitisOFFSIDES
197InfectionSIDER
198InfestationSIDER
199InflammationSIDER
200Intestinal PerforationOFFSIDES
201Joint related signs and symptomsSIDER
202Large intestine perforationOFFSIDES
203LaryngitisSIDER
204LegionellaOFFSIDES
205LeukopeniaSIDER
206Lipodystrophy acquiredSIDER
207LipodystrophySIDER
208LipomaSIDER
209Lobar PneumoniaSIDER
210LymphadenopathySIDER
211LymphangitisOFFSIDES
212Malignant tumour excisionOFFSIDES
213Mantle cell lymphomaOFFSIDES
214Memory LossSIDER
215MeningiomaOFFSIDES
216MeningitisSIDER
217Metabolic acidosisOFFSIDES
218Mucoepidermoid CarcinomaOFFSIDES
219MucormycosisSIDER
220Multiple MyelomaOFFSIDES
221Musculoskeletal discomfortSIDER
222MyelodysplasiaOFFSIDES
223MyositisSIDER
224Nasopharyngeal carcinomaSIDER
225NasopharyngitisSIDER
226Neisseria infectionSIDER
227NeuritisSIDER
228Neuropathic ulcerOFFSIDES
229NeutropeniaSIDER
230OliguriaSIDER
231Optic NeuritisOFFSIDES
232OsteomyelitisOFFSIDES
233Otitis MediaSIDER
234PainSIDER
235PancreatitisOFFSIDES
SIDER
236ParasomniaSIDER
237Peripheral embolismSIDER
238PharyngitisSIDER
239PolyneuropathySIDER
240PolyuriaSIDER
241Porphyria non-acuteOFFSIDES
242Portal Vein ThrombosisSIDER
243Post lumbar puncture syndromeOFFSIDES
244Proctitis herpesSIDER
245Protein urine presentSIDER
246ProteinuriaSIDER
247PruritusSIDER
248Pseudomyxoma PeritoneiOFFSIDES
249PsoriasisOFFSIDES
250PurpuraSIDER
251Radiation skin injuryOFFSIDES
252Respiratory FailureSIDER
253Respiratory distressSIDER
254Respiratory tract infection viralSIDER
255Retained products of conceptionOFFSIDES
256RhabdomyolysisSIDER
257RhinitisSIDER
258ScotomaSIDER
259ShockSIDER
260SinobronchitisSIDER
261SinusitisSIDER
262Skin neoplasm excisionOFFSIDES
263Splenic neoplasm malignancy unspecifiedOFFSIDES
264Squamous cell carcinoma of skinSIDER
265Stevens-Johnson Syndrome25811541CTD
OFFSIDES
SIDER
266StomatitisSIDER
267SyncopeSIDER
268Testicular massOFFSIDES
269TetanySIDER
270Toxic Epidermal NecrolysisSIDER
271TracheobronchitisSIDER
272Transaminases increasedSIDER
273TremorSIDER
274UlcerSIDER
275Urinary Tract PainOFFSIDES
276Urinary abnormalitiesSIDER
277Urinary tract signs and symptomsSIDER
278Urine output increasedSIDER
279VIIth nerve paralysisSIDER
280Vaginal lesionOFFSIDES
281Vascular purpuraSIDER
282VasculitisSIDER
283Venous ThrombosisSIDER
284Viral infections NECSIDER
285Vulvovaginal mycotic infectionOFFSIDES
286ZygomycosisSIDER
287nervous system disorderSIDER
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