MetaADEDB 2.0 @ LMMD
Amifostine
(JKOQGQFVAUAYPM-UHFFFAOYSA-N)
Structure
SMILES
NCCCNCCSP(=O)(O)O
Type(s)
Approved; Investigational
ATC code(s)
V03AF05
Molecular Formula:
C5H15N2O3PS
Molecular Weight:
214.223
Log P:
0.8419
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
4
TPSA:
130.69
CAS Number(s):
20537-88-6
Synonym(s)
1.
Amifostine
2.
Ethiofos
3.
Gammaphos
4.
APAETP
5.
Amifostine Anhydrous
6.
Amifostine Disodium Salt
7.
Amifostine Monohydrate
8.
Amifostine Monohydrochloride
9.
Amifostine Trihydrate
10.
Aminopropyl Aminoethylthiophosphate
11.
Aminopropylaminoethylthiophosphate
12.
Aminopropylaminoethylthiophosphoric Acid
13.
Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate
14.
Ethiofos Anhydrous
15.
Ethyol
16.
NSC-296961
17.
S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid
18.
WR-2721
19.
YM-08310
20.
NSC 296961
21.
NSC296961
22.
WR 2721
23.
WR2721
24.
YM 08310
25.
YM08310
External Link(s)
MeSHD004999
PubChem Compound29927142
2141
ChEBI2636
CHEMBLCHEMBL1006
DrugBankDB01143
DrugCentral156
KEGGcpd:C06819
Therapeutic Target DatabaseD06CIE
ZINC21992285
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 16

View details

6321681
8976823
10688811
10955873
11335791
 		CTD
OFFSIDES
SIDER
US FAERS
2VomitingFAERS: 14

View details

2431774
6321681
8976823
10688811
10955873
10971385
11335791
11712796
15064010
17710657
 		CTD
SIDER
US FAERS
3PruritusFAERS: 13SIDER
US FAERS
4HypotensionFAERS: 11

View details

2431774
6321681
8728352
8976823
9256891
10688811
10812192
10955873
11335791
11712796
12481892
15064010
 		CTD
SIDER
US FAERS
5ChillsFAERS: 715064010CTD
SIDER
US FAERS
6DehydrationFAERS: 7OFFSIDES
US FAERS
7Pulmonary toxicityFAERS: 7US FAERS
8ThrombocytopeniaFAERS: 61333372CTD
US FAERS
9Stevens-Johnson SyndromeFAERS: 525811541CTD
OFFSIDES
SIDER
US FAERS
10ErythemaFAERS: 4OFFSIDES
US FAERS
11PainFAERS: 4US FAERS
12Rash erythematousFAERS: 4US FAERS
13DizzinessFAERS: 311335791CTD
SIDER
US FAERS
14StomatitisFAERS: 3US FAERS
15ConjunctivitisFAERS: 2US FAERS
16Erythema MultiformeFAERS: 2OFFSIDES
SIDER
US FAERS
17Feeling ColdFAERS: 2SIDER
US FAERS
18HypoxiaFAERS: 2OFFSIDES
US FAERS
19Injection Site ReactionFAERS: 2US FAERS
20Injection site erythemaFAERS: 2OFFSIDES
US FAERS
21NeutropeniaFAERS: 210812192CTD
US FAERS
22PneumoniaFAERS: 2US FAERS
23Product use issueFAERS: 2US FAERS
24Toxic Epidermal NecrolysisFAERS: 2SIDER
US FAERS
25AbasiaFAERS: 1US FAERS
26AlopeciaFAERS: 111522636CTD
US FAERS
27AstheniaFAERS: 1OFFSIDES
US FAERS
28Back PainFAERS: 116452524CTD
US FAERS
29Blood pressure immeasurableFAERS: 1OFFSIDES
US FAERS
30Bone marrow depressionFAERS: 1US FAERS
31Cerebral InfarctionFAERS: 1US FAERS
32CheilitisFAERS: 1OFFSIDES
US FAERS
33Drug ineffectiveFAERS: 1US FAERS
34DysgeusiaFAERS: 1US FAERS
35Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
36FlushingFAERS: 110955873
11335791		CTD
SIDER
US FAERS
37IndurationFAERS: 1US FAERS
38Injection site painFAERS: 1US FAERS
39LeukopeniaFAERS: 1US FAERS
40Livedo ReticularisFAERS: 1US FAERS
41MalaiseFAERS: 1SIDER
US FAERS
42Malignant neoplasm progressionFAERS: 1US FAERS
43Mastication disorderFAERS: 1OFFSIDES
US FAERS
44Mental status changesFAERS: 1US FAERS
45Morbid thoughtsFAERS: 1US FAERS
46Myocardial InfarctionFAERS: 1SIDER
US FAERS
47NeuropathyFAERS: 1US FAERS
48Nonspecific reactionFAERS: 1US FAERS
49Pathogen resistanceFAERS: 1OFFSIDES
US FAERS
50Performance status decreasedFAERS: 1US FAERS
51Product preparation issueFAERS: 1US FAERS
52Purulent dischargeFAERS: 1OFFSIDES
US FAERS
53Radiation injuryFAERS: 1US FAERS
54Radiation skin injuryFAERS: 1OFFSIDES
US FAERS
55Refusal of treatment by relativeFAERS: 1US FAERS
56Respiratory FailureFAERS: 1US FAERS
57Respiratory arrestFAERS: 1SIDER
US FAERS
58Saliva alteredFAERS: 1OFFSIDES
US FAERS
59Skin lesionFAERS: 1OFFSIDES
US FAERS
60Skin reactionFAERS: 1US FAERS
61Skin toxicityFAERS: 1US FAERS
62SwellingFAERS: 1US FAERS
63SyncopeFAERS: 1SIDER
US FAERS
64Therapeutic response unexpectedFAERS: 1US FAERS
65ThrombosisFAERS: 1US FAERS
66TremorFAERS: 1US FAERS
67Unresponsive to stimuliFAERS: 1US FAERS
68Urinary RetentionFAERS: 1US FAERS
69Urinary tract infectionFAERS: 1US FAERS
70Vital functions abnormalFAERS: 1US FAERS
71White blood cell count decreasedFAERS: 1US FAERS
72Abdominal discomfortOFFSIDES
73Acute Coronary SyndromeSIDER
74Acute Lung Injury19010997CTD
75Acute bronchitisOFFSIDES
76Acute kidney injury11977638CTD
77Adnexa uteri cystOFFSIDES
78Alcohol withdrawal syndromeOFFSIDES
79Anaphylactic shockSIDER
80Anaphylactoid ReactionSIDER
81AnorexiaOFFSIDES
82Antimicrobial susceptibility test resistantOFFSIDES
83ApathyOFFSIDES
84ArthroscopyOFFSIDES
85AtelectasisOFFSIDES
86Atrial FibrillationSIDER
87Bacterial EndocarditisOFFSIDES
88Basal cell carcinomaOFFSIDES
89Bladder cancer stage IVOFFSIDES
90Blood GlucoseOFFSIDES
91Blood chloride decreasedOFFSIDES
92Blood potassium decreasedOFFSIDES
93Blood potassiumOFFSIDES
94Blood sodiumOFFSIDES
95Body TemperatureOFFSIDES
96Bone Marrow Diseases15790438CTD
97Bone density decreasedOFFSIDES
98BradycardiaSIDER
99Bronchial ObstructionOFFSIDES
100BursitisOFFSIDES
101Calcific deposits removalOFFSIDES
102Cardiac ArrestSIDER
103Cardiac FlutterSIDER
104Cardiac enzymes increasedOFFSIDES
105Cardiomyopathies15981672
18040065		CTD
106Cataract11522636CTD
107Catheter placementOFFSIDES
108Catheter related infectionOFFSIDES
109Catheter sepsisOFFSIDES
110Catheter site infectionOFFSIDES
111Catheter site painOFFSIDES
112Central line infectionOFFSIDES
113Central venous catheter removalOFFSIDES
114Cerebral artery occlusionOFFSIDES
115Cervical dysplasiaOFFSIDES
116Chest PainOFFSIDES
SIDER
117Chest discomfortSIDER
118Chest tightnessSIDER
119Choking sensationOFFSIDES
120Cholecystitis infectiveOFFSIDES
121Chronic sinusitisOFFSIDES
122ColitisOFFSIDES
123Conjunctival depositOFFSIDES
124Corneal PerforationOFFSIDES
125Corneal UlcerOFFSIDES
126Cystitis10100560
16708234
16763356		CTD
127DebridementOFFSIDES
128DemyelinationOFFSIDES
129DermatitisSIDER
130Diarrhea10971385CTD
OFFSIDES
131DiscomfortSIDER
132Disease recurrenceOFFSIDES
133DiverticulosisOFFSIDES
134DiverticulumOFFSIDES
135Drug toxicityOFFSIDES
136Dry skinOFFSIDES
137Dyspnea9794996CTD
138Endodontic procedureOFFSIDES
139EpicondylitisOFFSIDES
140Epidermal necrosisOFFSIDES
141Escherichia infectionOFFSIDES
142Esophageal Neoplasms11335791CTD
143Esophagitis9256128
9794996		CTD
144Exanthema10688811
15064010		CTD
145Extravasation of Diagnostic and Therapeutic Materials19010997CTD
146Eye InfectionOFFSIDES
147Feeding tube complicationOFFSIDES
148Fever10688811
15064010		CTD
149Foaming at mouthOFFSIDES
150FormicationOFFSIDES
151Gastric pH decreasedOFFSIDES
152Gastrointestinal Diseases11161394CTD
153Head and Neck Neoplasms15064010CTD
154Hearing Loss18669462CTD
155Heart Diseases8783663
9726805
15075674		CTD
156Hemorrhage10100560
16708234		CTD
157Hepatic Veno-Occlusive Disease11208352
15039909		CTD
158HiccoughOFFSIDES
159Histiocytosis haematophagicOFFSIDES
160HydronephrosisOFFSIDES
161HyperpigmentationOFFSIDES
162HypersensitivitySIDER
163Hypocalcemia19813275CTD
164HypoparathyroidismSIDER
165IncoherentOFFSIDES
166Infusion site mobility decreasedOFFSIDES
167Injection site burningOFFSIDES
168Injection site dermatitisOFFSIDES
169Injection site irritationOFFSIDES
170Injection site papuleOFFSIDES
171Injection site pruritusOFFSIDES
172Injection site urticariaOFFSIDES
173Injection site vesiclesOFFSIDES
174Injection site warmthOFFSIDES
175Intention tremorOFFSIDES
176Joint injuryOFFSIDES
177Kidney Diseases

View details

10755322
10757556
10812192
11149742
11219485
 		CTD
178Kidney FailureOFFSIDES
179Laboratory test interferenceOFFSIDES
180LethargyOFFSIDES
181Leukemia, Myelomonocytic, Chronic10688811CTD
182Leukopenia neonatalOFFSIDES
183Life expectancy shortenedOFFSIDES
184Ligament ruptureOFFSIDES
185Local reactionOFFSIDES
186Lymphoma, Non-Hodgkin11335791CTD
187Mallory-Weiss SyndromeOFFSIDES
188Mass excisionOFFSIDES
189Meniscus removalOFFSIDES
190Mucosal erosionOFFSIDES
191Musculoskeletal stiffnessOFFSIDES
192Necrosis15151969CTD
193NephrolithiasisOFFSIDES
194Neurotoxicity Syndromes15330181CTD
195NocturiaOFFSIDES
196NystagmusOFFSIDES
197OliguriaOFFSIDES
198OnychalgiaOFFSIDES
199Oral fungal infectionOFFSIDES
200Oral mucosal exfoliationOFFSIDES
201OsteolysisOFFSIDES
202OsteopeniaOFFSIDES
203OsteoporosisOFFSIDES
204OsteosclerosisOFFSIDES
205OtotoxicityOFFSIDES
206Pain of skinOFFSIDES
207Palmar erythemaOFFSIDES
208Paresthesia10955873
14514973		CTD
209Pharmaceutical product complaintOFFSIDES
210Pharyngolaryngeal PainOFFSIDES
211Physical disabilityOFFSIDES
212Primary sequestrumOFFSIDES
213Procedural complicationOFFSIDES
214Pulmonary radiation injuryOFFSIDES
215Radiation associated painOFFSIDES
216Radiation mucositisOFFSIDES
217Radicular painOFFSIDES
218Recall phenomenonOFFSIDES
219Renal Insufficiency11161394CTD
220RhinitisOFFSIDES
221Salpingo-oophorectomyOFFSIDES
222Sensation of warmthSIDER
223Serum calcium decreasedSIDER
224ShockSIDER
225Skin neoplasm excisionOFFSIDES
226Sneezing

View details

2431774
6321681
10955873
11335791
 		CTD
SIDER
227SomnolenceSIDER
228SpondylolisthesisOFFSIDES
229Sputum culture positiveOFFSIDES
230Staphylococcal abscessOFFSIDES
231Stem cell transplantOFFSIDES
232Stomach Diseases17160473CTD
233Stomatocytes presentOFFSIDES
234Supraventricular tachycardiaSIDER
235SymblepharonOFFSIDES
236Synovial CystOFFSIDES
237SynovitisOFFSIDES
238Systemic Inflammatory Response Syndrome10742082CTD
239TachycardiaSIDER
240TendinitisOFFSIDES
241TenosynovitisOFFSIDES
242Testicular massOFFSIDES
243Therapy non-responderOFFSIDES
244Tinea PedisOFFSIDES
245Tooth LossOFFSIDES
246Tympanic Membrane PerforationOFFSIDES
247UlcerOFFSIDES
248UrticariaSIDER
249Uterine ProlapseOFFSIDES
250VertebroplastyOFFSIDES
251Xerostomia11335791
15064010		CTD
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