MetaADEDB 2.0 @ LMMD
Olopatadine Hydrochloride
(JBIMVDZLSHOPLA-LSCVHKIXSA-N)
Structure
SMILES
CN(CC/C=C/1\c2cc(ccc2OCc2c1cccc2)CC(=O)O)C
Type(s)
Approved
ATC code(s)
R01AC08; S01GX09
Molecular Formula:
C21H23NO3
Molecular Weight:
337.412
Log P:
3.5895
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
49.77
CAS Number(s):
113806-05-6; 140462-76-6
Synonym(s)
1.
Olopatadine Hydrochloride
2.
11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid
3.
KW 4679
4.
KW-4679
5.
KW-4943A
6.
Olopatadine
7.
Patanol
8.
4679, KW
9.
Hydrochloride, Olopatadine
10.
KW 4943A
11.
KW4943A
External Link(s)
MeSHD000069605
PubChem Compound25271818
5281071
BindingDB50002096
ChEBI94593
CHEMBLCHEMBL1189432
DrugBankDB00768
DrugCentral1986
IUPHAR/BPS Guide to PHARMACOLOGY7249
KEGGcpd:C07789
dr:D08293
Therapeutic Target DatabaseD05GPO
ZINC1850
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 203
Canada Vigilance: 7		Canada Vigilance
OFFSIDES
US FAERS
2Eye irritationFAERS: 12
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
3HypersensitivityFAERS: 5SIDER
US FAERS
4Eye painFAERS: 4
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
SIDER
US FAERS
5Incorrect dose administeredFAERS: 3US FAERS
6CataractFAERS: 2US FAERS
7Product dropper issueFAERS: 2US FAERS
8Product substitution issueFAERS: 2US FAERS
9Visual ImpairmentFAERS: 2SIDER
US FAERS
10treatment failureFAERS: 2US FAERS
11Abdominal discomfortFAERS: 1OFFSIDES
US FAERS
12Accidental exposure to productFAERS: 1US FAERS
13Acoustic NeuromaFAERS: 1OFFSIDES
US FAERS
14Adverse eventFAERS: 1US FAERS
15Alopecia AreataFAERS: 1US FAERS
16Anaphylactoid ReactionFAERS: 1US FAERS
17AnosmiaFAERS: 1OFFSIDES
SIDER
US FAERS
18ChillsFAERS: 1US FAERS
19Concomitant disease aggravatedFAERS: 1US FAERS
20ConjunctivitisFAERS: 1SIDER
US FAERS
21Contraindicated product administeredFAERS: 1US FAERS
22Drug dispensing errorFAERS: 1US FAERS
23Drug prescribing errorFAERS: 1US FAERS
24DysgeusiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
25EpistaxisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
26ErythemaFAERS: 1OFFSIDES
SIDER
US FAERS
27Eye InfectionFAERS: 1OFFSIDES
US FAERS
28Eye allergyFAERS: 1US FAERS
29Eye inflammationFAERS: 1US FAERS
30Facial PainFAERS: 1US FAERS
31Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
32Foreign body sensation in eyesFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
33General physical health deteriorationFAERS: 1US FAERS
34HeadacheFAERS: 1SIDER
US FAERS
35MalaiseFAERS: 1SIDER
US FAERS
36Maternal exposure during pregnancyFAERS: 1US FAERS
37Multiple allergiesFAERS: 1OFFSIDES
US FAERS
38MydriasisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
39NasopharyngitisFAERS: 1OFFSIDES
SIDER
US FAERS
40NauseaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
41PoisoningFAERS: 1US FAERS
42Product label issueFAERS: 1US FAERS
43Product packaging issueFAERS: 1US FAERS
44Product use complaintFAERS: 1US FAERS
45Secretion dischargeFAERS: 1US FAERS
46SneezingFAERS: 1US FAERS
47Stevens-Johnson SyndromeFAERS: 1OFFSIDES
US FAERS
48Throat irritationFAERS: 1SIDER
US FAERS
49VomitingFAERS: 1SIDER
US FAERS
50AbasiaOFFSIDES
51Abdominal InfectionOFFSIDES
52Abdominal PainSIDER
53Abdominal adhesionsOFFSIDES
54Abnormal visionOFFSIDES
55AbuseOFFSIDES
56Acute respiratory failureOFFSIDES
57Alanine Aminotransferase IncreasedOFFSIDES
58Allergy test positiveOFFSIDES
59Allergy to animalOFFSIDES
60AlopeciaOFFSIDES
61Altered state of consciousnessOFFSIDES
62Amalgam tattooOFFSIDES
63Anal FistulaOFFSIDES
64AngioedemaOFFSIDES
65Animal scratchCanada Vigilance: 1Canada Vigilance
66Ankle FractureOFFSIDES
67AnorexiaOFFSIDES
68Aortic bruitOFFSIDES
69ApathyOFFSIDES
70AstheniaOFFSIDES
SIDER
71AsthmaOFFSIDES
72AtelectasisOFFSIDES
73Autoimmune hepatitisOFFSIDES
74Back PainSIDER
75Bacterial rhinitisOFFSIDES
76BedriddenOFFSIDES
77Bilirubin conjugated increasedOFFSIDES
78BlepharitisOFFSIDES
79BlepharospasmSIDER
80Blood GlucoseOFFSIDES
81Blood amylase increasedOFFSIDES
82Blood beta-D-glucan increasedOFFSIDES
83Blood creatine phosphokinase increasedOFFSIDES
84Blood creatinine increasedOFFSIDES
85Blood glucose fluctuationOFFSIDES
86Blood immunoglobulin G increasedOFFSIDES
87Blood immunoglobulin MOFFSIDES
88Blood osmolarity decreasedOFFSIDES
89Blood potassium increasedOFFSIDES
90Blood pressure fluctuationOFFSIDES
91Blood prolactin increasedOFFSIDES
92Blood sodium increasedOFFSIDES
93Blood urea increasedOFFSIDES
94Blood uric acidOFFSIDES
95BruxismOFFSIDES
96BursitisOFFSIDES
97Candidiasis of vaginaOFFSIDES
98Catheter sepsisOFFSIDES
99Caustic injuryOFFSIDES
100CellulitisOFFSIDES
101Cerebral ThrombosisOFFSIDES
102Cerebral atrophyOFFSIDES
103Choking sensationOFFSIDES
104CholangiolitisOFFSIDES
105ChondromalaciaOFFSIDES
106ChromaturiaOFFSIDES
107Congenital heart valve disorderOFFSIDES
108Congenital mitochondrial cytopathyOFFSIDES
109Congenital tracheomalaciaOFFSIDES
110Congenital tricuspid valve incompetenceOFFSIDES
111Conjunctival depositOFFSIDES
112ContractureOFFSIDES
113Corneal InfectionOFFSIDES
114Corneal PerforationOFFSIDES
115Corneal ScarOFFSIDES
116Corneal UlcerOFFSIDES
117Corneal calcificationSIDER
118Corneal epithelium defectSIDER
119Corneal epithelium disorderSIDER
120Corneal erosionOFFSIDES
SIDER
121Cubital Tunnel SyndromeOFFSIDES
122CyanosisOFFSIDES
123CystOFFSIDES
124Cytomegalovirus chorioretinitisOFFSIDES
125Cytoreductive SurgeryOFFSIDES
126DependenceOFFSIDES
127Depressed Level of ConsciousnessOFFSIDES
128DermatitisSIDER
129DermatomyositisOFFSIDES
130Dermoid CystOFFSIDES
131DiscomfortSIDER
132Disseminated Intravascular CoagulationOFFSIDES
133DiverticulumOFFSIDES
134DizzinessCanada Vigilance: 1Canada Vigilance
SIDER
135DrowsinessOFFSIDES
136Drug exposure during pregnancyOFFSIDES
137Dry skinSIDER
138Duodenal UlcerOFFSIDES
139Dyspnoea exacerbatedOFFSIDES
140DysuriaOFFSIDES
141EczemaOFFSIDES
142EndophthalmitisOFFSIDES
SIDER
143Eosinophilic PneumoniaOFFSIDES
144Erythema MultiformeOFFSIDES
145Esophageal PerforationOFFSIDES
146Exposure to allergenOFFSIDES
147Eye laser surgeryOFFSIDES
148Eyelid DiseasesOFFSIDES
149Eyelid irritationCanada Vigilance: 1Canada Vigilance
150Eyelid margin crustingSIDER
151Failure to ThriveOFFSIDES
152FatigueOFFSIDES
SIDER
153Femoral pulseOFFSIDES
154Flank PainOFFSIDES
155Gamma-Glutamyltransferase IncreasedOFFSIDES
156GammopathyOFFSIDES
157Gastrointestinal PainSIDER
158GlaucomaOFFSIDES
159GlomerulonephritisOFFSIDES
160Granulocyte count decreasedOFFSIDES
161Growth of eyelashesOFFSIDES
162Heat illnessOFFSIDES
163Hepatitis AOFFSIDES
164HepatitisOFFSIDES
165HiccoughOFFSIDES
166High density lipoprotein increasedOFFSIDES
167HostilityOFFSIDES
168House dust allergyOFFSIDES
169Human herpes virus 6 serology positiveOFFSIDES
170HydronephrosisOFFSIDES
171Immunology test abnormalOFFSIDES
172Impaired driving abilityOFFSIDES
173Implant site indurationOFFSIDES
174InfectionSIDER
175Infectious MononucleosisOFFSIDES
176InfestationSIDER
177InfluenzaSIDER
178Instillation site painOFFSIDES
179Intentional drug misuseOFFSIDES
180Intestinal ObstructionOFFSIDES
181KeratitisSIDER
182LaparotomyOFFSIDES
183Life expectancy shortenedOFFSIDES
184LipaseOFFSIDES
185Lower respiratory tract infection viralOFFSIDES
186Lymphocyte count decreasedOFFSIDES
187Lymphocyte stimulation test positiveOFFSIDES
188MediastinitisOFFSIDES
189Metabolic acidosisOFFSIDES
190Metastases to abdominal cavityOFFSIDES
191Multiple MyelomaOFFSIDES
192Multiple sclerosis relapseOFFSIDES
193Muscle WeaknessOFFSIDES
194Muscle necrosisOFFSIDES
195Musculoskeletal PainOFFSIDES
196Musculoskeletal stiffnessOFFSIDES
197Nasal discomfortOFFSIDES
SIDER
198Nephrotic SyndromeOFFSIDES
199Nerve Root CompressionOFFSIDES
200NeurodermatitisOFFSIDES
201Neutrophil count decreasedOFFSIDES
202NoduleOFFSIDES
203Non-cardiac chest painCanada Vigilance: 1Canada Vigilance
OFFSIDES
204Ocular discomfortSIDER
205Ocular icterusOFFSIDES
206Ocular vascular disorderOFFSIDES
207OliguriaOFFSIDES
208Oppositional Defiant DisorderOFFSIDES
209Oral mucosal erythemaOFFSIDES
210Oropharyngeal painSIDER
211OrthopneaOFFSIDES
212PainSIDER
213Panic DisorderOFFSIDES
214PanniculitisOFFSIDES
215PeriodontitisOFFSIDES
216Peripheral embolismOFFSIDES
217Peritoneal DialysisOFFSIDES
218PeritonitisOFFSIDES
219PeritonsillitisOFFSIDES
220Personality ChangeOFFSIDES
221PharyngitisSIDER
222Pharyngolaryngeal PainSIDER
223PhotophobiaSIDER
224Pneumocystis jiroveci pneumoniaOFFSIDES
225PneumothoraxCanada Vigilance: 1Canada Vigilance
OFFSIDES
226PolyhydramniosOFFSIDES
227Poor quality sleepOFFSIDES
228Productive CoughOFFSIDES
229Prothrombin level decreasedOFFSIDES
230PruritusSIDER
231Pulmonary congestionOFFSIDES
232Punctate keratitisSIDER
233PurulenceOFFSIDES
234Quality of life decreasedOFFSIDES
235Renal cystOFFSIDES
236Renal tubular disorderOFFSIDES
237Retinal Vein OcclusionOFFSIDES
238RhabdomyolysisOFFSIDES
239RhinitisSIDER
240RhinorrheaOFFSIDES
241SclerodermaOFFSIDES
242Secondary hypertensionOFFSIDES
243Septic ShockOFFSIDES
244Shoulder PainOFFSIDES
245Sinus headacheOFFSIDES
246SinusitisSIDER
247Skeletal injuryOFFSIDES
248Skin ErosionOFFSIDES
249Skin lesionOFFSIDES
250Sleep TalkingOFFSIDES
251Soft tissue atrophyOFFSIDES
252SomnolenceSIDER
253Spinal column stenosisOFFSIDES
254Splenic InfarctionOFFSIDES
255Sputum culture positiveOFFSIDES
256Stasis dermatitisOFFSIDES
257Supraventricular tachycardiaOFFSIDES
258Suture ruptureOFFSIDES
259Systemic mycosisOFFSIDES
260TendinitisOFFSIDES
261Therapy non-responderOFFSIDES
262ThirstSIDER
263Tinea crurisOFFSIDES
264Troponin I increasedOFFSIDES
265UlcerSIDER
266Unevaluable eventOFFSIDES
267Upper-airway cough syndromeSIDER
268Urinary tract infectionSIDER
269Visual disturbanceOFFSIDES
SIDER
270Vital dye staining cornea presentSIDER
271Vitamin A DeficiencyOFFSIDES
272Weight GainOFFSIDES
273Wheelchair userOFFSIDES
274Wound InfectionOFFSIDES
275muscle injuryOFFSIDES
276nervous system disorderSIDER
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