MetaADEDB 2.0 @ LMMD
Mitomycin
(NWIBSHFKIJFRCO-WUDYKRTCSA-N)
Structure
SMILES
CO[C@@]12[C@H]3N[C@H]3CN2C2=C([C@H]1COC(=O)N)C(=O)C(=C(C2=O)C)N
Type(s)
Approved
ATC code(s)
L01DC03
Molecular Formula:
C15H18N4O5
Molecular Weight:
334.327
Log P:
0.0161
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
3
TPSA:
146.89
CAS Number(s):
50-07-7; 1404-00-8; 18451
Synonym(s)
1.
Mitomycin
2.
Mitomycin C
3.
Ametycine
4.
Mitocin-C
5.
Mitomycin-C
6.
Mutamycin
7.
NSC-26980
8.
Mitocin C
9.
MitocinC
10.
NSC 26980
11.
NSC26980
External Link(s)
MeSHD016685
PubChem Compound5746
BindingDB50428658
ChEBI27504
CHEMBLCHEMBL105
DrugBankDB00305
DrugCentral1819
IUPHAR/BPS Guide to PHARMACOLOGY7089
KEGGcpd:C06681
dr:D00208
Therapeutic Target DatabaseD0NZ1U
D0Y0GH
ZINC30726187
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Scleral thinningFAERS: 31OFFSIDES
US FAERS
2EndophthalmitisFAERS: 25OFFSIDES
US FAERS
3DysuriaFAERS: 21OFFSIDES
US FAERS
4Bladder necrosisFAERS: 19OFFSIDES
US FAERS
5Corneal epithelium defectFAERS: 19OFFSIDES
US FAERS
6CystitisFAERS: 18

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CTD
US FAERS
7BlebitisFAERS: 15US FAERS
8Conjunctival erosionFAERS: 14US FAERS
9Eosinophilic cystitisFAERS: 14OFFSIDES
US FAERS
10PainFAERS: 111454338
3129617
9759389
CTD
SIDER
US FAERS
11PruritusFAERS: 11US FAERS
12UveitisFAERS: 11US FAERS
13ExtravasationFAERS: 10SIDER
US FAERS
14IridocyclitisFAERS: 10OFFSIDES
US FAERS
15ScleromalaciaFAERS: 10OFFSIDES
US FAERS
16Conjunctival filtering bleb leakFAERS: 9US FAERS
17Burning sensationFAERS: 8OFFSIDES
SIDER
US FAERS
18Respiratory FailureFAERS: 8OFFSIDES
US FAERS
19VomitingFAERS: 8

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CTD
SIDER
US FAERS
20Accidental exposureFAERS: 7OFFSIDES
US FAERS
21Medication ErrorFAERS: 7US FAERS
22Pulmonary FibrosisFAERS: 7US FAERS
23AlopeciaFAERS: 6SIDER
US FAERS
24Corneal ScarFAERS: 6US FAERS
25Corneal erosionFAERS: 6OFFSIDES
US FAERS
26ErythemaFAERS: 62996749CTD
OFFSIDES
SIDER
US FAERS
27NeutropeniaFAERS: 615724837CTD
US FAERS
28Post procedural complicationFAERS: 6OFFSIDES
US FAERS
29UlcerFAERS: 6OFFSIDES
SIDER
US FAERS
30AstheniaFAERS: 5SIDER
US FAERS
31Limbal stem cell deficiencyFAERS: 5US FAERS
32MalaiseFAERS: 5SIDER
US FAERS
33NauseaFAERS: 5

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CTD
SIDER
US FAERS
34PancytopeniaFAERS: 5SIDER
US FAERS
35Pelvic PainFAERS: 52996749CTD
US FAERS
36PneumoniaFAERS: 5US FAERS
37Postoperative heterotopic calcificationFAERS: 5US FAERS
38Postoperative wound complicationFAERS: 5OFFSIDES
US FAERS
39ScleritisFAERS: 5US FAERS
40UrticariaFAERS: 5US FAERS
41Eye InfectionFAERS: 4OFFSIDES
US FAERS
42FatigueFAERS: 41519930CTD
SIDER
US FAERS
43FolliculitisFAERS: 4US FAERS
44HydronephrosisFAERS: 42996749CTD
US FAERS
45HypersensitivityFAERS: 4US FAERS
46InfectionFAERS: 4US FAERS
47InflammationFAERS: 4US FAERS
48KeratitisFAERS: 4US FAERS
49NecrosisFAERS: 4

View details

CTD
SIDER
US FAERS
50Product quality issueFAERS: 4US FAERS
51Accidental exposure to productFAERS: 3US FAERS
52Adverse eventFAERS: 3US FAERS
53AnuriaFAERS: 312813674CTD
US FAERS
54Choroidal DetachmentFAERS: 3US FAERS
55Conjunctival blebFAERS: 3US FAERS
56Corneal OpacityFAERS: 316805119CTD
US FAERS
57DermatitisFAERS: 3SIDER
US FAERS
58DysgeusiaFAERS: 3US FAERS
59Enterovesical FistulaFAERS: 3US FAERS
60Fat necrosisFAERS: 3OFFSIDES
US FAERS
61Incorrect route of drug administrationFAERS: 3US FAERS
62Intentional product use issueFAERS: 3US FAERS
63Large intestine perforationFAERS: 3OFFSIDES
US FAERS
64LeukocytosisFAERS: 3US FAERS
65Postoperative ileusFAERS: 3US FAERS
66SclerodermaFAERS: 3OFFSIDES
US FAERS
67Skin necrosisFAERS: 3OFFSIDES
US FAERS
68ThrombocytopeniaFAERS: 3

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CTD
SIDER
US FAERS
69Urinary RetentionFAERS: 3US FAERS
70Abdominal PainFAERS: 2US FAERS
71AbscessFAERS: 2OFFSIDES
US FAERS
72ArthralgiaFAERS: 2US FAERS
73AstigmatismFAERS: 2US FAERS
74Bladder NeoplasmFAERS: 2US FAERS
75Bladder tamponadeFAERS: 2OFFSIDES
US FAERS
76CalcinosisFAERS: 21454338
1807206
8256682
CTD
US FAERS
77CataractFAERS: 21454338CTD
US FAERS
78Catheter related infectionFAERS: 2US FAERS
79ChillsFAERS: 2US FAERS
80Corneal degenerationFAERS: 2US FAERS
81DeafnessFAERS: 2US FAERS
82DehydrationFAERS: 2US FAERS
83Diffuse alveolar damageFAERS: 2OFFSIDES
US FAERS
84DiplopiaFAERS: 2US FAERS
85Disease recurrenceFAERS: 2OFFSIDES
US FAERS
86Drug exposure during pregnancyFAERS: 2US FAERS
87EczemaFAERS: 2US FAERS
88EscharFAERS: 2US FAERS
89Eye irritationFAERS: 2US FAERS
90Eye ulcerFAERS: 2US FAERS
91FibrosisFAERS: 2
Canada Vigilance: 1
2508290
6796250
CTD
Canada Vigilance
US FAERS
92HeadacheFAERS: 2SIDER
US FAERS
93HypotensionFAERS: 2US FAERS
94KeratomalaciaFAERS: 2US FAERS
95MyalgiaFAERS: 2US FAERS
96PericarditisFAERS: 2US FAERS
97PeritonitisFAERS: 2US FAERS
98PneumonitisFAERS: 2US FAERS
99PneumothoraxFAERS: 2US FAERS
100Product contaminationFAERS: 2US FAERS
101Product use issueFAERS: 2US FAERS
102Pulmonary EmbolismFAERS: 2US FAERS
103Pulmonary arterial hypertensionFAERS: 2US FAERS
104Pulmonary toxicityFAERS: 2OFFSIDES
SIDER
US FAERS
105Respiratory distressFAERS: 2US FAERS
106Right ventricular failureFAERS: 2US FAERS
107SepsisFAERS: 2US FAERS
108SuperinfectionFAERS: 2US FAERS
109SwellingFAERS: 2US FAERS
110Toxicity to various agentsFAERS: 2US FAERS
111UrethritisFAERS: 2US FAERS
112Urinary tract infectionFAERS: 2US FAERS
113UrinomaFAERS: 2OFFSIDES
US FAERS
114Uveal prolapseFAERS: 2OFFSIDES
US FAERS
115VertigoFAERS: 2US FAERS
116Visual ImpairmentFAERS: 2US FAERS
117AbasiaFAERS: 1US FAERS
118Acute respiratory failureFAERS: 1US FAERS
119Administration site ulcerFAERS: 1US FAERS
120Alanine Aminotransferase IncreasedFAERS: 1US FAERS
121Allergic cystitisFAERS: 1US FAERS
122Ammonia increasedFAERS: 1US FAERS
123Amniotic membrane graftFAERS: 1US FAERS
124Anastomotic LeakFAERS: 1US FAERS
125AngioedemaFAERS: 1US FAERS
126AnorexiaFAERS: 1SIDER
US FAERS
127Anterior chamber inflammationFAERS: 1US FAERS
128AnxietyFAERS: 1US FAERS
129Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
130Atrial FibrillationFAERS: 1US FAERS
131Back PainFAERS: 1US FAERS
132Basal cell carcinomaFAERS: 1US FAERS
133Bile duct necrosisFAERS: 1OFFSIDES
US FAERS
134Biopsy bladder abnormalFAERS: 1US FAERS
135Bladder painFAERS: 1US FAERS
136Bladder transitional cell carcinoma recurrentFAERS: 1US FAERS
137BlindnessFAERS: 1US FAERS
138Blood urine presentFAERS: 1US FAERS
139Bone painFAERS: 1US FAERS
140BronchitisFAERS: 1OFFSIDES
US FAERS
141BronchopneumoniaFAERS: 1US FAERS
142Bronchopulmonary AspergillosisFAERS: 1US FAERS
143Cardiac TamponadeFAERS: 1US FAERS
144Cardiac perforationFAERS: 1US FAERS
145Caustic injuryFAERS: 1US FAERS
146Cerebral InfarctionFAERS: 1US FAERS
147Chemical cystitisFAERS: 1US FAERS
148Circumstance or information capable of leading to medication errorFAERS: 1OFFSIDES
US FAERS
149Conjunctival ulcerFAERS: 1US FAERS
150ConstipationFAERS: 1US FAERS
151Corneal PerforationFAERS: 11454338CTD
US FAERS
152Corneal blebFAERS: 1US FAERS
153Corneal decompensationFAERS: 1US FAERS
154Corneal hypertrophyFAERS: 1US FAERS
155DellenFAERS: 1US FAERS
156DiscomfortFAERS: 1SIDER
US FAERS
157Drug ineffectiveFAERS: 1US FAERS
158Drug toxicityFAERS: 1OFFSIDES
US FAERS
159Drug use for unknown indicationFAERS: 1US FAERS
160DysphoniaFAERS: 1US FAERS
161Enterococcus test positiveFAERS: 1US FAERS
162Escherichia infectionFAERS: 1US FAERS
163Expired drug administeredFAERS: 1US FAERS
164Exposure during breast feedingFAERS: 1US FAERS
165Exposure to toxic agentFAERS: 1OFFSIDES
US FAERS
166Exposure via direct contactFAERS: 1US FAERS
167Eye operation complicationFAERS: 1US FAERS
168Eye painFAERS: 1US FAERS
169Feeling abnormalFAERS: 1SIDER
US FAERS
170Flank PainFAERS: 1US FAERS
171FlatulenceFAERS: 1US FAERS
172FlushingFAERS: 1US FAERS
173Food aversionFAERS: 1US FAERS
174Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
175General physical health deteriorationFAERS: 1US FAERS
176Genital erythemaFAERS: 1OFFSIDES
US FAERS
177Genital rashFAERS: 1US FAERS
178Genital swellingFAERS: 1US FAERS
179Hepatic EncephalopathyFAERS: 1US FAERS
180Hepatic InfarctionFAERS: 1US FAERS
181Hepatic necrosisFAERS: 1OFFSIDES
US FAERS
182HepatotoxicityFAERS: 1US FAERS
183HypopyonFAERS: 1US FAERS
184Iatrogenic injuryFAERS: 1OFFSIDES
US FAERS
185IncoherentFAERS: 1US FAERS
186Incorrect dose administeredFAERS: 1US FAERS
187InfluenzaFAERS: 1US FAERS
188Injection Site ReactionFAERS: 1SIDER
US FAERS
189Intentional drug misuseFAERS: 1US FAERS
190Intercepted drug dispensing errorFAERS: 1US FAERS
191IridoceleFAERS: 1US FAERS
192IritisFAERS: 19759389CTD
US FAERS
193KeratopathyFAERS: 1US FAERS
194LacerationFAERS: 1US FAERS
195LaryngitisFAERS: 1US FAERS
196Localised intraabdominal fluid collectionFAERS: 1OFFSIDES
US FAERS
197Lower Urinary Tract SymptomsFAERS: 1US FAERS
198Lung consolidationFAERS: 1US FAERS
199Lymphangiosis carcinomatosaFAERS: 1OFFSIDES
US FAERS
200Malignant neoplasm progressionFAERS: 1US FAERS
201Mallory-Weiss SyndromeFAERS: 1US FAERS
202Metastatic NeoplasmFAERS: 1SIDER
US FAERS
203Moraxella test positiveFAERS: 1US FAERS
204Mucosal necrosisFAERS: 1US FAERS
205Myocardial InfarctionFAERS: 1US FAERS
206NephrolithiasisFAERS: 1US FAERS
207NeuropathyFAERS: 1US FAERS
208No adverse eventFAERS: 1US FAERS
209Occupational exposure to productFAERS: 1US FAERS
210Ocular vascular disorderFAERS: 1US FAERS
211OnychalgiaFAERS: 1US FAERS
212Oral painFAERS: 1US FAERS
213Oropharyngeal swellingFAERS: 1US FAERS
214Palmar erythemaFAERS: 1OFFSIDES
US FAERS
215ParesisFAERS: 1US FAERS
216Pelvic abscessFAERS: 1US FAERS
217Pelvic massFAERS: 1US FAERS
218Penile erythemaFAERS: 1US FAERS
219Penile exfoliationFAERS: 1US FAERS
220Penile necrosisFAERS: 1US FAERS
221Perineal erythemaFAERS: 1US FAERS
222PityriasisFAERS: 1US FAERS
223Poor quality drug administeredFAERS: 1US FAERS
224PregnancyFAERS: 1US FAERS
225PriapismFAERS: 1US FAERS
226Procedural complicationFAERS: 1OFFSIDES
US FAERS
227Procedural site reactionFAERS: 1OFFSIDES
US FAERS
228Product label issueFAERS: 1US FAERS
229Product measured potency issueFAERS: 1US FAERS
230ProteinuriaFAERS: 1US FAERS
231PseudocystFAERS: 1US FAERS
232Pseudomonas test positiveFAERS: 1US FAERS
233Pulmonary HypertensionFAERS: 1OFFSIDES
US FAERS
234PyuriaFAERS: 1US FAERS
235Residual urine volume increasedFAERS: 1US FAERS
236Retinal DegenerationFAERS: 1US FAERS
237Retinal Vascular DisorderFAERS: 1US FAERS
238SerositisFAERS: 1US FAERS
239Sexual DysfunctionFAERS: 1US FAERS
240Skin IndurationFAERS: 1US FAERS
241Staphylococcus test positiveFAERS: 1US FAERS
242StarvationFAERS: 1US FAERS
243Supraventricular tachycardiaFAERS: 1US FAERS
244Surgical failureFAERS: 1US FAERS
245Suture ruptureFAERS: 1US FAERS
246SyncopeFAERS: 1SIDER
US FAERS
247TachycardiaFAERS: 1US FAERS
248Temporal ArteritisFAERS: 1US FAERS
249Testicular necrosisFAERS: 1US FAERS
250Therapy non-responderFAERS: 1US FAERS
251TracheitisFAERS: 1US FAERS
252Treatment related secondary malignancyFAERS: 1OFFSIDES
US FAERS
253TrismusFAERS: 1US FAERS
254Unevaluable eventFAERS: 1US FAERS
255Urinary IncontinenceFAERS: 1US FAERS
256Urinary tract infection staphylococcalFAERS: 1US FAERS
257Vaginal FistulaFAERS: 1US FAERS
258Vitreous opacitiesFAERS: 1US FAERS
259VitritisFAERS: 1US FAERS
260Vulvovaginal pruritusFAERS: 1US FAERS
261Weight decreasedFAERS: 1US FAERS
262WheezingFAERS: 1US FAERS
263White blood cell count decreasedFAERS: 1US FAERS
264Wound InfectionFAERS: 1US FAERS
265Wrong drug administeredFAERS: 1US FAERS
266Wrong technique in drug usage processFAERS: 1US FAERS
267treatment failureFAERS: 1OFFSIDES
US FAERS
268Abdominal tendernessOFFSIDES
269Acute kidney injury

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CTD
270Acute myocardial infarctionOFFSIDES
271Adenocarcinoma

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CTD
272Anemia, Hemolytic

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CTD
273Anemia

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CTD
274Aneuploidy28087838CTD
275Anus Neoplasms

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CTD
276Arteritis9087350CTD
277Ataxia15793395CTD
278AutomatismOFFSIDES
279Azotemia9152802CTD
280BalanitisOFFSIDES
281Bile Duct Diseases12720104CTD
282Biliary FistulaOFFSIDES
283BilomaOFFSIDES
284Blood pressure immeasurableOFFSIDES
285Bone Marrow Diseases2982552CTD
286Bone marrow toxicitySIDER
287CD4 Lymphocytes DecreasedOFFSIDES
288Carcinoma, Transitional Cell

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CTD
289Carcinoma2934584
7491579
CTD
290CardiotoxicitySIDER
291Carotid Stenosis9087350CTD
292Chest Pain11734065CTD
293Cholecystitis6225318CTD
294Chromosome Aberrations24838295
25395496
CTD
295Chromosome Breakage24675086
29502735
CTD
296Cicatrix16113371CTD
297Colonic Neoplasms2112726
3093413
12166705
CTD
298Colorectal Neoplasms

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CTD
299Conjunctivitis9759389CTD
300Corneal Diseases20002897CTD
301Corneal edema1454338CTD
302Corneal graft rejectionOFFSIDES
303Creatinine renal clearance decreasedOFFSIDES
304Cutaneous Fistula18814818CTD
305Demyelinating Diseases2129960CTD
306Depressed Level of ConsciousnessOFFSIDES
307Diarrhea9660540
12119460
18000507
CTD
308Disease Progression9660540CTD
309DizzinessSIDER
310DrowsinessSIDER
311Dry coughSIDER
312DyscheziaOFFSIDES
313Ear Diseases15793395CTD
314Edema9152802CTD
315Eosinophilia1796854
2127988
11912421
CTD
316Erythema MultiformeOFFSIDES
317Esophageal Neoplasms1519930CTD
318Extravasation of Diagnostic and Therapeutic Materials1906166
3129617
18814818
CTD
319Fever9660540CTD
320Gastrointestinal Neoplasms6796250
8712831
18000507
CTD
321Gastrointestinal inflammationOFFSIDES
322Genomic Instability28077981CTD
323Glaucoma, Open-Angle7825687CTD
324Glaucoma1454338CTD
325Glioblastoma15655414CTD
326GlobulinuriaOFFSIDES
327HaematotoxicityOFFSIDES
328Head and Neck Neoplasms8901858
9774881
CTD
329Heart failure

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CTD
330Hematuria2996749CTD
331Hemolytic-Uremic Syndrome

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CTD
332Hemorrhage

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CTD
333Hepatic Veno-Occlusive Disease2829807CTD
334Hepatitis B positiveOFFSIDES
335HerniaOFFSIDES
336Hyperbilirubinemia1519930CTD
337Hyperkalemia9152802CTD
338Hypoaldosteronism8061399CTD
339Hypokalemia1339077CTD
340Hyponatremia1339077CTD
341IleitisOFFSIDES
342Ileus10928138CTD
343Infarction3876775CTD
344Injection site cellulitisSIDER
345Intestinal Fistula18814818CTD
346Iris Diseases1454338CTD
347Irreversible renal failureSIDER
348Joint injuryOFFSIDES
349Kidney Cortex Necrosis6796250CTD
350Kidney Diseases6010939
6105503
6412636
CTD
351Kidney Failure, Chronic

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CTD
352Leukopenia

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CTD
SIDER
353Liver AbscessOFFSIDES
354Liver neoplasms

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CTD
355Lung Neoplasms1906166CTD
356Lung diseases

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CTD
357Malignant HypertensionOFFSIDES
358Micronuclei, Chromosome-Defective

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CTD
359Multiple Organ Failure9016902CTD
360Muscle necrosisOFFSIDES
361MyelodysplasiaOFFSIDES
362MyelosuppressionSIDER
363Neoplasm Metastasis

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CTD
364Neoplasms, Experimental17878523CTD
365Neoplasms16019139CTD
366Nephrotic SyndromeOFFSIDES
367Neurotoxicity Syndromes2982552CTD
368Neutropenic colitisOFFSIDES
369Neutropenic sepsisOFFSIDES
370Neutrophil count abnormalOFFSIDES
371Ocular Hypotension

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CTD
372Oliguria6437662CTD
373Pallor9152802CTD
374PancreatectomyOFFSIDES
375Pancreatic enzymes increasedOFFSIDES
376Perirectal abscessOFFSIDES
377Pharyngolaryngeal PainOFFSIDES
378Photophobia1454338
9759389
CTD
379Postoperative Complications16113371
19829042
CTD
380Prostatic Neoplasms6340628CTD
381Pterygium9759389CTD
382Pulmonary Edema3093413
6406059
12813674
CTD
383Pulmonary InfarctionOFFSIDES
384Pulmonary radiation injuryOFFSIDES
385Pupil Disorders1454338CTD
386Purpura, Thrombotic Thrombocytopenic11604563
16388419
CTD
387PyelonephritisOFFSIDES
388Radiation PneumonitisOFFSIDES
389Radiation skin injuryOFFSIDES
390Rectal Neoplasms2112726CTD
391Recurrence9660540
9759389
CTD
392Renal Insufficiency

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CTD
393Reticulocyte count increasedOFFSIDES
394Retinal Artery Occlusion7852024CTD
395Retinal Vein Occlusion7852024CTD
396SalmonellaOFFSIDES
397Scleral Diseases1454338CTD
398Scleroderma renal crisisOFFSIDES
399ShockSIDER
400Skin Ulcer1906166CTD
401Soft Tissue InfectionOFFSIDES
402Soft Tissue InjuriesOFFSIDES
403Soft tissue inflammationOFFSIDES
404SomnolenceSIDER
405Stomach Neoplasms

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CTD
406Stomatitis12119460
18000507
CTD
SIDER
407StridorOFFSIDES
408Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
409ThrombophlebitisSIDER
410Thrombosis6810311
9087350
CTD
411Toxic anterior segment syndromeOFFSIDES
412Ureteral obstruction10071561
10368221
12566821
CTD
413Urinary Bladder Diseases1807206
2508290
24587049
CTD
414Urinary Bladder Fistula18814818CTD
415Urination Disorders7581512
8230546
CTD
416Vascular Diseases6796250
9016902
CTD
417Vascular Neoplasms3927871CTD
418Vesicovaginal Fistula18814818CTD
419Vision Disorders8336889
9076802
9859998
CTD
420Waist circumference increasedOFFSIDES
421White blood cell count abnormalOFFSIDES
422Wounds and Injuries20002897CTD
423prostatitisOFFSIDES
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