MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Chromosome Breakage

(UMLS:C0376628)

Definition:: A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
UMLS ID:: C0376628
MeSH ID:: D019457

Classification 1:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.210.170

Classification 2:

Name:

Genetic Phenomena
MeSH Tree Number(s):: G05.200.210.170|G05.365.590.175.175

Synonym(s)

Chromosome Breakage

Chromosome breakage

High frequency of chromosome breaks in lymphocytes

Increased chromosomal breakage

Increased chromosomal breakage rate

Multiple chromosomal breaks

Tendency to chromosomal breakage

chromosome breakage

establishment or maintenance of heterochromatin architecture

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,2-Dimethylhydrazine	29155087	CTD
2	1-hexadecyl-3-methylimidazolium chloride	29842889	CTD
3	1-nitropyrene	28633978	CTD
4	2-Acetylaminofluorene	16332721 26364502	CTD
5	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	20583320 28160022	CTD
6	2-amino-3,4-dimethylimidazo(4,5-f)quinoline	28160022	CTD
7	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	20583320 28160022	CTD
8	2-amino-3-methyl-9H-pyrido(2,3-b)indole	28160022	CTD
9	2-amino-3-methylimidazo(4,5-f)quinoline	28160022	CTD
10	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole	28160022	CTD
11	2-amino-9H-pyrido(2,3-b)indole	28160022	CTD
12	2-chloroethyl ethyl sulfide	26383632	CTD
13	2-hydroxyestradiol	10728588	CTD
14	2-hydroxyestrone	10728588	CTD
15	2-tert-butylhydroquinone	27774770	CTD
16	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine	20583320 28160022	CTD
17	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	28160022	CTD
18	3-amino-1-methyl-5H-pyrido(4,3-b)indole	28160022	CTD
19	3-nitrofluoranthene	28633978	CTD
20	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	26231820	CTD
21	4-hydroxyestradiol	10728588	CTD
22	4-hydroxyestrone	10728588	CTD
23	5-chloro-2'-deoxycytidine	31066272	CTD
24	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	30453383	CTD
25	9,10-Dimethyl-1,2-benzanthracene	29502735	CTD
26	9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole	28160022	CTD
27	Acetylcysteine	View details 23023949 26257840 26332274 27774770 28302478 29117515 29964313	CTD
28	Acrylonitrile	26332274	CTD
29	Aflatoxin B1	18347083 28943387	CTD
30	Amantadine	20575081	CTD
31	Aphidicolin	23573231	CTD
32	Apigenin	30152906	CTD
33	Asbestos, Crocidolite	21543585	CTD
34	Ascorbic Acid	30597948	CTD
35	Azinphosmethyl	26688254	CTD
36	Benzo(a)pyrene	26809139 29502735	CTD
37	Cadmium Chloride	29502735	CTD
38	Camptothecin	30720231	CTD
39	Capsaicin	29155087	CTD
40	Carnitine	28396261	CTD
41	Catechin	20583320	CTD
42	Chloranil	27989139	CTD
43	Chlorodiphenyl (54% Chlorine)	25113976	CTD
44	Citric Acid	30019796	CTD
45	Cobalt	21968949	CTD
46	Copper Sulfate	23268349	CTD
47	Cyclophosphamide	25113976	CTD
48	Cytarabine	24675086	CTD
49	Diatomaceous Earth	28757444	CTD
50	Diethylhexyl Phthalate	29502735 30720231	CTD
51	Diethylnitrosamine	8093813 16332721	CTD
52	Doxorubicin	24902966 27181935 27634759	CTD
53	Estrone	10728588	CTD
54	Ethyl Methanesulfonate	29282847	CTD
55	Ethylnitrosourea	8093813 29502735 29733868	CTD
56	Farnesol	16332721	CTD
57	Fluorouracil	23573231	CTD
58	Glu-P-2	28160022	CTD
59	Homocysteine	31082465	CTD
60	Hydrogen Peroxide	View details 20575081 20589741 21543585 22902249 24987704 26231820 27634759 30019796	CTD
61	Hydroxyurea	23573231	CTD
62	Indomethacin	30252991	CTD
63	Isoproterenol	30152906	CTD
64	Ketoconazole	18347083	CTD
65	Magnesium Oxide	29282847	CTD
66	Metformin	29117515	CTD
67	Methyl Methanesulfonate	18347083 29502735	CTD
68	Methyl Parathion	26688254	CTD
69	Methylnitronitrosoguanidine	25172298	CTD
70	Mitomycin	24675086 29502735	CTD
71	Mustard Gas	29217481	CTD
72	Nickel	23591161	CTD
73	Phenobarbital	8093813	CTD
74	Platinum	28465190	CTD
75	Potassium Dichromate	29391238 29665407	CTD
76	Potassium Permanganate	20564513	CTD
77	Quercetin	View details 22902249 24595819 24902966 25172298	CTD
78	Resveratrol	22902249	CTD
79	Rotenone	25428620	CTD
80	Silver	23804405 29462690 29703973	CTD
81	Sodium Acetate	30019796	CTD
82	Sodium Nitrite	31476334	CTD
83	Sodium Salicylate	29117515	CTD
84	Sodium Selenite	15894690 23023949 26332274	CTD
85	Thiram	7940406	CTD
86	Topotecan	24345465	CTD
87	Triclosan	29350491	CTD
88	Vitamin E	26332274	CTD
89	Zearalenone	28477956	CTD
90	Ziram	7940406	CTD
91	alpha-Chlorohydrin	28070108	CTD
92	alpha-hydroxyglutarate	28396261	CTD
93	alternariol	27422292	CTD
94	beauvericin	26809139	CTD
95	belinostat	29733868	CTD
96	beta-phellandrene	28668705	CTD
97	bisphenol A	25933419 27299659 29192164	CTD
98	boric acid	30368975	CTD
99	butylparaben	29350491	CTD
100	cadmium sulfide	27866839	CTD
101	carvacrol	30392869	CTD
102	casticin	29098808	CTD
103	ceric oxide	24987704	CTD
104	chlorpyrifos-ethyl	26257840 29359425	CTD
105	chromic acid	27005777	CTD
106	chromium hexavalent ion	30496737	CTD
107	cyanidin 3-O-glucoside	30597948	CTD
108	cyanoginosin LR	24955368	CTD
109	dicrotophos	28302478	CTD
110	diepoxybutane	25633853 31422076	CTD
111	dimethoxon	26688254 28718371	CTD
112	diphosphoric acid	30019796	CTD
113	epothilone A	29117515	CTD
114	geraniol	16332721 26364502 29745075	CTD
115	geranyl acetate	29745075	CTD
116	glyphosate	29359425	CTD
117	goniothalamin	26522230	CTD
118	hydroquinone	7517507	CTD
119	kaempferol	24595819	CTD
120	methamidophos	23125138 26688254	CTD
121	ochratoxin A	24243707	CTD
122	olaquindox	23774262	CTD
123	pendimethalin	30459330	CTD
124	peonidin 3-glucoside	30597948	CTD
125	potassium bromate	26296324	CTD
126	propiconazole	30392869	CTD
127	protocatechualdehyde	29665407	CTD
128	quercetin 3-O-glucopyranoside	30597948	CTD
129	salubrinal	25428620	CTD
130	sanguinarine	24345465	CTD
131	satratoxin H	22863859	CTD
132	sodium arsenite	View details 24004876 27774770 28283972 29705342	CTD
133	sodium chlorate	30144278	CTD
134	sodium chromate(VI)	19839025	CTD
135	sulforafan	27774770	CTD
136	tert-Butylhydroperoxide	27509014 28633978 30597948	CTD
137	tributyltin	31401084	CTD
138	triciribine	29117515	CTD
139	usnic acid	27369375	CTD
140	vanillin	26296324	CTD
141	zearalenol	28477956	CTD
142	zirconium oxide	30273565	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Trisomy	40.2%
2	Sex Chromosome Aberrations	40.1%
3	Aneuploidy	40%
4	Polyploidy	40%
5	Chromosomal Instability	40%
6	Genomic Instability	35.8%
7	Chromosome Fragility	28.9%
8	Monosomy	28.9%
9	Tetraploidy	28.9%
10	Micronuclei, Chromosome-Defective	28.4%
11	Mosaicism	27%
12	Chimerism	27%
13	Microsatellite Instability	22.2%
14	DNA Degradation, Necrotic	19.6%
15	Philadelphia Chromosome	18.7%
16	Genetic Polymorphism	17.6%
17	Polydipsia	16.3%
18	Infarction	15.9%
19	Postoperative Hemorrhage	15.9%
20	Shock, Hemorrhagic	15.9%
21	Systemic Inflammatory Response Syndrome	15.9%
22	Ascites	15.1%
23	Fibrosis	15.1%
24	Gliosis	15.1%
25	Growth Disorders	15.1%
26	Hemorrhage	15.1%
27	Hyperbilirubinemia	15.1%
28	Hyperplasia	15.1%
29	Hypomenorrhea	15.1%
30	Inflammation	15.1%
31	Intraoperative Complications	15.1%
32	Ischemia	15.1%
33	Lithiasis	15.1%
34	Malacoplakia	15.1%
35	Menstruation Disturbances	15.1%
36	Metaplasia	15.1%
37	Nerve Degeneration	15.1%
38	Ochronosis	15.1%
39	Polymenorrhea	15.1%
40	Postoperative Complications	15.1%
41	Sclerosis	15.1%
42	Shock	15.1%
43	Ulcer	15.1%
44	Hyperammonemia	15.1%
45	Hyperamylasemia	15.1%
46	Teratogenesis	15.1%
47	Cardiac Death	15.1%
48	Hypovolemia	15.1%
49	Hyperuricemia	15.1%
50	Leukoaraiosis	15.1%
51	Dysbacteriosis	15.1%
52	Delayed Graft Function	15.1%
53	Cirrhosis	15.1%
54	Neointima	15.1%
55	Dysbiosis	15.1%
56	Vascular Remodeling	13.7%
57	Clonal Evolution	13.7%
58	Extravasation of Diagnostic and Therapeutic Materials	12.6%
59	Neoplastic Processes	12.6%
60	Necrosis	12.2%
61	Granulomatosis, Orofacial	12.2%
62	Pigmentation Disorders	12.2%
63	Respiratory Aspiration	12.2%
64	Acantholysis	12.1%
65	Dehydration	12.1%
66	Granuloma	12.1%
67	Leukocytosis	12.1%
68	Pleocytosis	12.1%
69	Sudden infant death syndrome	11.8%
70	Menorrhagia	11.4%
71	Incisional hernia	10.6%
72	jaundice	10.6%
73	Muscle Weakness	10.1%
74	Acute Disease	9.9%
75	Acute-Phase Reaction	9.9%
76	Amenorrhea	9.9%
77	Chronic disease	9.9%
78	Critical Illness	9.9%
79	Sudden death	9.9%
80	Fat necrosis	9.9%
81	Gangrene	9.9%
82	Graft Occlusion, Vascular	9.9%
83	Granuloma, Plasma Cell	9.9%
84	Hematoma	9.9%
85	Iatrogenic Disease	9.9%
86	Multiple Organ Failure	9.9%
87	Oligomenorrhea	9.9%
88	Premenstrual syndrome	9.9%
89	Recurrence	9.9%
90	Retrograde Degeneration	9.9%
91	Retroperitoneal fibrosis	9.9%
92	Serositis	9.9%
93	Subcutaneous Emphysema	9.9%
94	Surgical Wound Dehiscence	9.9%
95	Syndrome	9.9%
96	Wallerian Degeneration	9.9%
97	Pyogenic granuloma	9.9%
98	Exsanguination	9.9%
99	Azotemia	9.9%
100	Disease Progression	9.9%
101	Seroma	9.9%
102	Premenstrual Tension	9.9%
103	Delayed Emergence from Anesthesia	9.9%
104	Infant Death	9.9%
105	Anastomotic Leak	9.9%
106	Intraoperative Awareness	9.9%
107	Pain, Postoperative	9.9%
108	Postoperative Nausea and Vomiting	9.8%
109	Dysmenorrhea	9.5%
110	Failed Back Surgery Syndrome	9.5%
111	Eye Hemorrhage	9.1%
112	Endotoxic shock	9%
113	Septic Shock	9%
114	Toxic Shock Syndrome	9%
115	Hemoptysis	8.9%
116	Ecchymosis	8.8%
117	Petechiae	8.8%
118	Purpura	8.8%
119	Cardiotoxicity	8.7%
120	Signs and Symptoms	8.7%
121	Pathological Conditions, Anatomical	8.7%
122	Asphyxia	8.3%
123	Granuloma, Respiratory Tract	8.3%
124	Shock, Traumatic	8.3%
125	Disease susceptibility	8.1%
126	Fetal Death	8.1%
127	Foreign-Body Reaction	8.1%
128	Gastrointestinal Hemorrhage	8.1%
129	Hemarthrosis	8.1%
130	Hemoperitoneum	8.1%
131	Hemothorax	8.1%
132	Neoplasm Invasiveness	8.1%
133	Neoplasm Metastasis	8.1%
134	Neoplasm Recurrence, Local	8.1%
135	Postpericardiotomy Syndrome	8.1%
136	Prosthesis Failure	8.1%
137	Reperfusion Injury	8.1%
138	Injection Site Reaction	8.1%
139	Retrobulbar Hemorrhage	8.1%
140	Aseptic Necrosis of Bone	8.1%
141	Peritoneal Fibrosis	8.1%
142	Carcinogenesis	8.1%
143	Neurogenic Inflammation	8.1%
144	Perinatal death	8.1%
145	Infusion site reaction	8.1%
146	Nephrogenic Fibrosing Dermopathy	8.1%
147	Corneal Endothelial Cell Loss	8.1%
148	Encapsulating Peritoneal Sclerosis	8.1%
149	Vasoplegia	8.1%
150	Suppuration	8.1%
151	Nephrogenic Systemic Fibrosis	8.1%
152	Metastasis	8.1%
153	Sinus Arrhythmia	7.9%
154	Atrial Fibrillation	7.9%
155	Atrial Flutter	7.9%
156	Dental Pulp Necrosis	7.9%
157	Granuloma, Foreign-Body	7.9%
158	Mediastinal Emphysema	7.9%
159	Surgical Wound Infection	7.9%
160	Ventricular Fibrillation	7.9%
161	Ventricular Flutter	7.9%
162	Parasystole	7.9%
163	Paroxysmal atrial fibrillation	7.9%
164	Facies	7.9%
165	Bradycardia	7.9%
166	Embryo Loss	7.9%
167	Afferent Loop Syndrome	7.9%
168	Short Bowel Syndrome	7.9%
169	Uterine hemorrhage	7.9%
170	No-Reflow Phenomenon	7.9%
171	Jaundice, Obstructive	7.8%
172	Epistaxis	7.7%
173	Tissue Adhesions	7.4%
174	Hematoma, Epidural, Spinal	7.4%
175	Sick Sinus Syndrome	7.3%
176	Drowning	6.9%
177	Fetal Growth Retardation	6.7%
178	Heart Block	6.6%
179	Tachycardia	6.6%
180	Tachyarrhythmia	6.6%
181	Cicatrix	6.6%
182	Hematuria	6.6%
183	Granuloma Annulare	6.6%
184	Brain Death	6.6%
185	Hematemesis	6.6%
186	Shock, Cardiogenic	6.6%
187	Purpura Fulminans	6.5%
188	Hematoma, Subdural	6.5%
189	Hematoma, Epidural, Cranial	6.5%
190	Hematoma, Subdural, Spinal	6.1%
191	Cross Infection	6%
192	Hyphema	6%
193	Retinal Neovascularization	6%
194	Septicemia	6%
195	Vitreous Hemorrhage	6%
196	Sepsis	6%
197	Abscess	5.9%
198	Empyema	5.9%
199	Femur Head Necrosis	5.9%
200	Fetal Resorption	5.9%
201	Lymphatic Metastasis	5.9%
202	Neoplasms, Unknown Primary	5.9%
203	Peptic Ulcer Hemorrhage	5.9%
204	Sudden Cardiac Death	5.9%
205	Leukemic Infiltration	5.9%
206	Premenstrual Dysphoric Disorder	5.9%
207	Choroidal Neovascularization	5.9%
208	Primary Graft Dysfunction	5.9%
209	Neoplasm Micrometastasis	5.9%
210	Dumping Syndrome	5.9%
211	Cicatrix, Hypertrophic	5.9%
212	Sinus Arrest, Cardiac	5.9%
213	Metrorrhagia	5.9%
214	Enzyme Induction	5.8%
215	Giant Cell Epulis	5.8%
216	Phantom pain	5.7%
217	Phantom Limb Pain	5.7%
218	Long QT Syndrome	5.7%
219	Hematoma, Subdural, Intracranial	5.3%
220	Hematoma, Subdural, Chronic	5.3%
221	Hematoma, Subdural, Acute	5.3%
222	Viremia	5.1%
223	Parasitemia	5.1%
224	Retinal Hemorrhage	5.1%
225	Asthenia	5%
226	Body Temperature Changes	5%
227	Calculi	5%
228	Cyanosis	5%
229	Edema	5%
230	Failure to Thrive	5%
231	Fatigue	5%
232	Feminization	5%
233	Fetal Distress	5%
234	Hernia	5%
235	Hypertrophy	5%
236	Motion Sickness	5%
237	Nails, Malformed	5%
238	polyps	5%
239	Rupture, Spontaneous	5%
240	Signs and Symptoms, Digestive	5%
241	Signs and Symptoms, Respiratory	5%
242	Skin Manifestations	5%
243	Chills	5%
244	Lassitude	5%
245	Enterocele	5%
246	Atheroma	5%
247	Pseudophakia	5%
248	Urological Manifestations	5%
249	Stenosis	5%
250	Facial asymmetry	5%
251	Mobility Limitation	5%
252	Somnolence	5%
253	Plaque, Amyloid	5%
254	Plaque, Atherosclerotic	5%
255	Subacute Combined Degeneration	5%
256	Thrombocytopenic purpura	5%
257	Choroid Hemorrhage	5%
258	Melena	5%
259	Eosinophilic Granuloma	5%
260	Postpartum Hemorrhage	4.9%
261	Gingival Hemorrhage	4.9%
262	Keloid	4.9%
263	Stillbirth	4.9%
264	Purpura, Hyperglobulinemic	4.9%
265	Adams-Stokes Syndrome	4.9%
266	Atrioventricular Block	4.9%
267	Bundle-Branch Block	4.9%
268	Atrial Premature Complexes	4.9%
269	Sinoatrial Block	4.9%
270	Tachycardia, Paroxysmal	4.9%
271	Supraventricular tachycardia	4.9%
272	Tachycardia, Ventricular	4.9%
273	Tachycardia, Reciprocating	4.9%
274	Subarachnoid Hemorrhage	4.9%
275	Cerebral Hemorrhage	4.9%
276	Abdominal Pain	4.6%
277	Kernicterus	4.4%
278	Cellulitis	4.3%
279	Renal Colic	4.2%
280	Cyst	4.2%
281	Eye Manifestations	4.2%
282	Neurologic Manifestations	4.2%
283	Romano-Ward Syndrome	4.2%
284	Bacteremia	4.2%
285	Cell Transformation, Viral	4.1%
286	Fungemia	4.1%
287	Leukoplakia	4.1%
288	Cardiac Output, High	4.1%
289	Myocardial Stunning	4.1%
290	Reticulocytosis	4.1%
291	Low Cardiac Output Syndrome	4.1%
292	Airway Remodeling	4.1%
293	Purpura, Thrombotic Thrombocytopenic	4%
294	Tachycardia, Atrioventricular Nodal Reentry	4%
295	Tachycardia, Ectopic Atrial	4%
296	Tachycardia, Ectopic Junctional	4%
297	Sinus Tachycardia	4%
298	Torsades de Pointes	4%
299	Accelerated Idioventricular Rhythm	4%
300	Ventricular Remodeling	4%
301	Alopecia	4%
302	Intermittent Claudication	4%
303	Androgenetic Alopecia	4%
304	Eye pain	3.9%
305	Muscular Atrophy	3.8%
306	Granuloma, Laryngeal	3.8%
307	Myocardial Reperfusion Injury	3.7%
308	Endotoxemia	3.7%
309	Abdomen, Acute	3.6%
310	Hypergammaglobulinemia	3.4%
311	Diverticulum	3.3%
312	Diverticulosis	3.3%
313	Anorexia	3.3%
314	Anoxia	3.3%
315	Constipation	3.3%
316	Diarrhea	3.3%
317	Dyspepsia	3.3%
318	Eructation	3.3%
319	Fever	3.3%
320	Flatulence	3.3%
321	Flushing	3.3%
322	Halitosis	3.3%
323	Heartburn	3.3%
324	Diaphragmatic Hernia	3.3%
325	Hiccough	3.3%
326	Hypercalciuria	3.3%
327	Hypercapnia	3.3%
328	Hyperphagia	3.3%
329	Intestinal Polyps	3.3%
330	Nausea	3.3%
331	Pallor	3.3%
332	Psychophysiologic Disorders	3.3%
333	Splenomegaly	3.3%
334	Vomiting	3.3%
335	Hypocapnia	3.3%
336	Dyschezia	3.3%
337	Hypoxia	3.3%
338	Hyperoxia	3.3%
339	Lower Urinary Tract Symptoms	3.3%
340	Hypoxemia	3.3%
341	Urinoma	3.3%
342	Autoimmune thrombocytopenia	3.3%
343	Immune thrombocytopenic purpura	3.3%
344	Chromosome Breakage	3.3%
345	Waterhouse-Friderichsen Syndrome	3.2%
346	Sarcopenia	3%
347	Respiratory Tract Fistula	2.8%
348	Candidemia	2.7%
349	Apnea	2.7%
350	Cheyne-Stokes Respiration	2.7%
351	Chromosome Aberrations	2.7%
352	Decerebrate State	2.7%
353	Dyspnea	2.7%
354	Cardiomegaly	2.7%
355	Hemiparesis	2.7%
356	Hepatomegaly	2.7%
357	Hyperventilation	2.7%
358	Meningism	2.7%
359	Mouth Breathing	2.7%
360	Paresis	2.7%
361	Parovarian Cyst	2.7%
362	Pruritus	2.7%
363	Seizures	2.7%
364	Sensation Disorders	2.7%
365	Sneezing	2.7%
366	Spermatocele	2.7%
367	Erythema	2.7%
368	Oral Fistula	2.7%
369	Complex partial seizures	2.7%
370	Necrolytic Migratory Erythema	2.7%
371	Tachypnea	2.7%
372	Monoparesis	2.7%
373	Cutaneous Fistula	2.7%
374	Gait Disorders, Neurologic	2.7%
375	Neuromuscular Manifestations	2.7%
376	Cardiac Hypertrophy	2.7%
377	Basal Ganglia Hemorrhage	2.7%
378	Edema, Cardiac	2.6%
379	Mental Fatigue	2.6%
380	Hirsutism	2.6%
381	Orthostatic intolerance	2.6%
382	Hypoventilation	2.6%
383	Vaginal Fistula	2.6%
384	Rectocele	2.6%
385	Body Weight Changes	2.6%
386	Hoarseness	2.6%
387	Gait Ataxia	2.6%
388	Body Weight	2.5%
389	Back Pain	2.5%
390	Bulimia	2.5%
391	Neck Pain	2.5%
392	Chest Pain	2.5%
393	Colonic Polyps	2.5%
394	Dizziness	2.5%
395	Dysuria	2.5%
396	Facial Pain	2.5%
397	Fever of Unknown Origin	2.5%
398	Flank Pain	2.5%
399	Headache	2.5%
400	Nocturia	2.5%
401	Pain, Intractable	2.5%
402	Pelvic Pain	2.5%
403	Snoring	2.5%
404	Chronic pain	2.5%
405	Lightheadedness	2.5%
406	Pain, Referred	2.5%
407	Prostatism	2.5%
408	Throbbing Headache	2.5%
409	Labor Pain	2.5%
410	Cancer Pain	2.5%
411	Nociceptive Pain	2.5%
412	Putaminal Hemorrhage	2.4%
413	Sleep Wake Disorders	2.4%
414	Pupil Disorders	2.3%
415	Neurobehavioral Manifestations	2.3%
416	Nasal Polyps	2.3%
417	Akathisia	2.2%
418	Restlessness	2.2%
419	Psychomotor Agitation	2.2%
420	Pleural Rub	2.2%
421	Rales	2.2%
422	Respiratory Sounds	2.2%
423	Rhonchi	2.2%
424	Stridor	2.2%
425	Wheezing	2.2%
426	Asterixis	2.2%
427	Ballismus	2.2%
428	Vertigo	2.2%
429	Vesicovaginal Fistula	2.2%
430	Pain	2.2%
431	Livedo Reticularis	2.2%
432	Ache	2.2%
433	Meningocele	2.2%
434	Oliguria	2.2%
435	Polyuria	2.2%
436	Proteinuria	2.2%
437	Urinary Calculi	2.2%
438	Encephalocele	2.2%
439	Underweight	2.2%
440	Overweight	2.2%
441	Gait Apraxia	2.1%
442	Emaciation	2%
443	Low Back Pain	2%
444	Visceral Pain	2%
445	Biliary Fistula	2%
446	Gastric Fistula	2%
447	Congenital diaphragmatic hernia	2%
448	Morning Sickness	2%
449	Anosmia	2%
450	Ataxia	2%
451	Athetosis	2%
452	Catalepsy	2%
453	Dental Fistula	2%
454	Dystonia	2%
455	Hemiplegia	2%
456	Locked-In Syndrome	2%
457	Muscle Hypertonia	2%
458	Muscle hypotonia	2%
459	Myoclonus	2%
460	Myotonia	2%
461	Neuralgia	2%
462	Oroantral Fistula	2%
463	Paraplegia	2%
464	Pseudobulbar Palsy	2%
465	Quadriplegia	2%
466	Spasm	2%
467	Spastic Paraplegia	2%
468	Status Epilepticus	2%
469	Taste Disorders	2%
470	Tremor	2%
471	Monoplegia	2%
472	Hypokinesia	2%
473	Left Ventricular Hypertrophy	2%
474	Gastroparesis	2%
475	Right Ventricular Hypertrophy	2%
476	Paraparesis	2%
477	Bradykinesia	2%
478	Waxy flexibility	2%
479	Action Tremor	2%
480	Resting Tremor	2%
481	Dysosmia	2%
482	Quadriparesis	2%
483	Olfaction Disorders	2%
484	Myokymia	2%
485	Somatosensory Disorders	2%
486	Neuropathic pain	2%
487	Hyperkinesia	2%
488	Intention tremor	2%
489	Rectal Prolapse	2%
490	Uterine Prolapse	2%
491	Vaginal Prolapse	2%
492	Voice Disorders	2%
493	Weight Gain	2%
494	Voice Disturbance	2%
495	Gagging	1.9%
496	Leukoplakia, Oral	1.9%
497	Cachexia	1.8%
498	Alexia	1.8%
499	Dyslexia	1.8%
500	Alice in Wonderland Syndrome	1.8%
501	Vision Disorders	1.7%
502	Metamorphopsia	1.7%
503	Visual Impairment	1.7%
504	Bronchial Fistula	1.7%
505	Metatarsalgia	1.7%
506	Pancreatic Fistula	1.7%
507	Anisocoria	1.7%
508	Confusion	1.7%
509	Facial paralysis	1.7%
510	Intestinal Fistula	1.7%
511	Lethargy	1.7%
512	Memory Disorders	1.7%
513	Muscle Cramp	1.7%
514	Perceptual Disorders	1.7%
515	Psychomotor Disorders	1.7%
516	Tonic Pupil	1.7%
517	Anhedonia	1.7%
518	Disorientation	1.7%
519	Gastroschisis	1.7%
520	Enterocutaneous Fistula	1.7%
521	Fetal Hypoxia	1.7%
522	Facial Paresis	1.7%
523	Memory Loss	1.7%
524	Hemisensory Neglect	1.7%
525	Dysacusis	1.7%
526	Umbilical hernia	1.7%
527	Toothache	1.7%
528	Jet Lag Syndrome	1.7%
529	Reflex, Abnormal	1.7%
530	Hyporeflexia	1.7%
531	Hyperreflexia	1.7%
532	Dyspnea, Paroxysmal	1.6%
533	Mastodynia	1.6%
534	Respiratory Paralysis	1.6%
535	Salivary Gland Fistula	1.6%
536	Chorea	1.6%
537	Cystocele	1.6%
538	Hyperemesis Gravidarum	1.6%
539	Tetany	1.6%
540	Urinary Incontinence	1.6%
541	Breakthrough Pain	1.6%
542	Dysgeusia	1.6%
543	Formication	1.6%
544	Hyperalgesia	1.6%
545	Hyperesthesia	1.6%
546	Hypesthesia	1.6%
547	Language Disorders	1.6%
548	Numbness	1.6%
549	Paresthesia	1.6%
550	Paraparesis, Spastic	1.6%
551	Trismus	1.6%
552	Epilepsia Partialis Continua	1.6%
553	Hypogeusia	1.6%
554	Brown-Sequard Syndrome	1.6%
555	Lockjaw	1.6%
556	Allodynia	1.6%
557	Ageusia	1.6%
558	Albuminuria	1.6%
559	Hemoglobinuria	1.6%
560	Birth Weight	1.6%
561	Agraphia	1.5%
562	Anomia	1.5%
563	Cluttering	1.5%
564	Language Development Disorders	1.5%
565	Speech Disorders	1.5%
566	Syncope	1.5%
567	Stupor	1.5%
568	Dysgraphia	1.5%
569	Presyncope	1.5%
570	Dyslalia	1.5%
571	Consciousness Disorders	1.4%
572	Mental Retardation	1.4%
573	Depressed Level of Consciousness	1.4%
574	Mental deficiency	1.4%
575	Intellectual Disability	1.4%
576	Catatonia	1.4%
577	Musculoskeletal Pain	1.4%
578	Ophthalmoplegia	1.4%
579	External Ophthalmoplegia	1.4%
580	Aphonia	1.4%
581	Arthralgia	1.4%
582	Sleep Deprivation	1.4%
583	Polyarthralgia	1.4%
584	Dysphonia	1.4%
585	Cerebrospinal Fluid Otorrhea	1.4%
586	Cerebrospinal Fluid Rhinorrhea	1.4%
587	Obesity	1.4%
588	Diplopia	1.4%
589	Muscle Rigidity	1.4%
590	Muscle Spasticity	1.4%
591	Scotoma	1.4%
592	Photophobia	1.4%
593	Cogwheel Rigidity	1.4%
594	Hemifacial Spasm	1.4%
595	Amaurosis	1.4%
596	Blindness	1.4%
597	Nuchal Rigidity	1.4%
598	Aphasia	1.4%
599	Articulation Disorders	1.4%
600	Echolalia	1.4%
601	Stuttering	1.4%
602	Dysphasia	1.4%
603	Angina Pectoris	1.4%
604	Agnosia	1.4%
605	Apraxias	1.4%
606	Hallucinations	1.4%
607	Hemianopsia	1.4%
608	Hyperacusis	1.4%
609	Tinnitus	1.4%
610	Visual Agnosia	1.4%
611	Anosognosia	1.4%
612	Wernicke-Korsakoff Syndrome	1.4%
613	Phonophobia	1.4%
614	Hearing Loss	1.4%
615	Cerebellar Ataxia	1.4%
616	Torticollis	1.4%
617	Sciatica	1.4%
618	Urge Incontinence	1.4%
619	Tardive Dyskinesia	1.4%
620	Dysarthria	1.3%
621	Hydrops Fetalis	1.3%
622	Fetal Weight	1.3%
623	Vocal Cord Paralysis	1.3%
624	Urinary Bladder Fistula	1.2%
625	Amaurosis Fugax	1.2%
626	Blindness, Cortical	1.2%
627	Dyscalculia	1.2%
628	Angina, Unstable	1.2%
629	Deafness	1.2%
630	Hearing Loss, Sudden	1.2%
631	Gerstmann Syndrome	1.2%
632	Hearing Loss, Bilateral	1.2%
633	Hearing Loss, High-Frequency	1.2%
634	Tinea Pedis	1.2%
635	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
636	Prosopagnosia	1.2%
637	Apraxia, Ideomotor	1.2%
638	Persistent Vegetative State	1.2%
639	Charles Bonnet Syndrome	1.2%
640	Hearing Loss, Unilateral	1.2%
641	Complete Hearing Loss	1.2%
642	Alien Hand Syndrome	1.2%
643	Deaf Mutism	1.2%
644	Amblyopia	1.2%
645	Amnesia	1.2%
646	Delirium	1.2%
647	Horner Syndrome	1.2%
648	Dissociative Amnesia	1.2%
649	Color blindness	1.2%
650	Global Amnesia	1.2%
651	Rectal Fistula	1.2%
652	Anal Fistula	1.2%
653	Mutism	1.2%
654	Selective Mutism	1.2%
655	Shoulder Pain	1.2%
656	Pediatric Obesity	1.2%
657	Angina Pectoris, Variant	1.1%
658	Alexia, Pure	1.1%
659	Dyskinesia, Drug-Induced	1.1%
660	Alcohol Withdrawal Seizures	1.1%
661	Arteriovenous fistula	1.1%
662	Akathisia, Drug-Induced	1%
663	Retrograde amnesia	1%
664	Amnesia, Anterograde	1%
665	Myalgia	1%
666	Kidney Calculi	1%
667	Ureteral Calculi	1%
668	Amnesia, Transient Global	0.9%
669	Auditory Perceptual Disorders	0.9%
670	Ophthalmoplegic Migraine	0.8%
671	Progressive supranuclear palsy	0.8%
672	Kearns-Sayre syndrome	0.6%

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