MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Systemic Inflammatory Response Syndrome

(UMLS:C0242966)

Definition:: A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
UMLS ID:: C0242966
MeSH ID:: D018746

Classification:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.470.790|C23.550.835.900

Synonym(s)

Systemic Inflammatory Response Syndrome

Abacteraemic sepsis

Culture-negative sepsis

SEPSIS SYNDROME

SIRS

SIRS - System inflammatory response syndrome

SYSTEMIC INFLAMMATORY RESPONSE SYNDROME

Sepsis syndrome

Septic syndrome

10.

Systemic inflammatory response syndrome

11.

Systemic inflammatory response syndrome, unspecified

12.

organ dysfunction syndrome sepsis

13.

sepsis syndrome

14.

septic syndrome

15.

syndrome sepsis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 20		US FAERS
2	Nitrofurantoin	FAERS: 19		US FAERS
3	Acetaminophen	FAERS: 14		US FAERS
4	Zoledronic Acid	FAERS: 13		US FAERS
5	Methotrexate	FAERS: 10		US FAERS
6	Canagliflozin	FAERS: 9		US FAERS
7	Clozapine	FAERS: 8		US FAERS
8	Mirtazapine	FAERS: 8		US FAERS
9	Bortezomib	FAERS: 7		US FAERS
10	Ibuprofen	FAERS: 7		US FAERS
11	Amoxicillin	FAERS: 6		US FAERS
12	NuvaRing	FAERS: 6		US FAERS
13	Ortho Evra	FAERS: 6		US FAERS
14	Oseltamivir	FAERS: 6		US FAERS
15	Rivaroxaban	FAERS: 6		US FAERS
16	Lenalidomide	FAERS: 5		US FAERS
17	Metformin	FAERS: 5		US FAERS
18	gemcitabine	FAERS: 5 Canada Vigilance: 5		Canada Vigilance US FAERS
19	regorafenib	FAERS: 5		US FAERS
20	Alendronate	FAERS: 4		US FAERS
21	Amiodarone	FAERS: 4		US FAERS
22	Arthrotec	FAERS: 4		US FAERS
23	Ciprofloxacin	FAERS: 4		US FAERS
24	Clofarabine	FAERS: 4		SIDER US FAERS
25	Daptomycin	FAERS: 4		US FAERS
26	Lisinopril	FAERS: 4		US FAERS
27	Norgestrel	FAERS: 4		US FAERS
28	Olanzapine	FAERS: 4		US FAERS
29	4-Aminopyridine	FAERS: 3		US FAERS
30	Bendamustine Hydrochloride	FAERS: 3		US FAERS
31	Buprenorphine	FAERS: 3		US FAERS
32	Carbamazepine	FAERS: 3		US FAERS
33	Ceftriaxone	FAERS: 3		US FAERS
34	Clopidogrel	FAERS: 3		US FAERS
35	Dabigatran	FAERS: 3		US FAERS
36	Decitabine	FAERS: 3		US FAERS
37	Diclofenac	FAERS: 3		US FAERS
38	Lamotrigine	FAERS: 3		US FAERS
39	Simvastatin	FAERS: 3		US FAERS
40	Vemurafenib	FAERS: 3		US FAERS
41	Venlafaxine Hydrochloride	FAERS: 3		US FAERS
42	gemcitabine	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
43	rofecoxib	FAERS: 3		US FAERS
44	Benicar hct	FAERS: 2		US FAERS
45	Bosentan	FAERS: 2		US FAERS
46	Cytarabine	FAERS: 2		US FAERS
47	Deferasirox	FAERS: 2		US FAERS
48	Digoxin	FAERS: 2		US FAERS
49	Erlotinib Hydrochloride	FAERS: 2		US FAERS
50	Fractals	FAERS: 2		US FAERS
51	Leflunomide	FAERS: 2		US FAERS
52	Lopinavir	FAERS: 2		US FAERS
53	Moxifloxacin	FAERS: 2		US FAERS
54	Mycophenolic Acid	FAERS: 2		US FAERS
55	Olmesartan Medoxomil	FAERS: 2		US FAERS
56	PCI 32765	FAERS: 2		US FAERS
57	Pemetrexed	FAERS: 2		US FAERS
58	Phenytoin	FAERS: 2		US FAERS
59	Prednisolone	FAERS: 2	28003376	CTD US FAERS
60	Prednisone	FAERS: 2		US FAERS
61	Propofol	FAERS: 2		US FAERS
62	Sitagliptin Phosphate	FAERS: 2		US FAERS
63	Sulfasalazine	FAERS: 2		US FAERS
64	Triamcinolone Acetonide	FAERS: 2		US FAERS
65	Vancomycin	FAERS: 2		US FAERS
66	amlodipine, perindopril drug combination	FAERS: 2		US FAERS
67	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
68	carfilzomib	FAERS: 2		US FAERS
69	dabrafenib	FAERS: 2		US FAERS
70	etonogestrel	FAERS: 2		US FAERS
71	iodixanol	FAERS: 2		US FAERS
72	reviparin	FAERS: 2		US FAERS
73	temsirolimus	FAERS: 2		US FAERS
74	4-hydroxybutyric acid	FAERS: 1		US FAERS
75	Acitretin	FAERS: 1		US FAERS
76	Allopurinol	FAERS: 1		US FAERS
77	Amiodarone	FAERS: 1		US FAERS
78	Amitriptyline	FAERS: 1		US FAERS
79	Ampicillin	FAERS: 1		US FAERS
80	Aspirin	FAERS: 1		US FAERS
81	Atomoxetine Hydrochloride	FAERS: 1		US FAERS
82	Atorvastatin	FAERS: 1		US FAERS
83	Azacitidine	FAERS: 1		SIDER US FAERS
84	Azathioprine	FAERS: 1		US FAERS
85	Baclofen	FAERS: 1		US FAERS
86	Buprenorphine	FAERS: 1		US FAERS
87	Caspofungin	FAERS: 1		US FAERS
88	Ceftriaxone	FAERS: 1		US FAERS
89	Citalopram	FAERS: 1		US FAERS
90	Clarithromycin	FAERS: 1		US FAERS
91	Cyclosporine	FAERS: 1		US FAERS
92	Deferiprone	FAERS: 1		US FAERS
93	Dimethyl Fumarate	FAERS: 1		US FAERS
94	Docetaxel	FAERS: 1		US FAERS
95	Epirubicin	FAERS: 1		US FAERS
96	Epoprostenol	FAERS: 1		US FAERS
97	Ethambutol	FAERS: 1		US FAERS
98	Exenatide	FAERS: 1		US FAERS
99	Famciclovir	FAERS: 1		US FAERS
100	Fenofibrate	FAERS: 1		US FAERS
101	Fingolimod Hydrochloride	FAERS: 1		US FAERS
102	Glatiramer Acetate	FAERS: 1		US FAERS
103	Haloperidol	FAERS: 1		US FAERS
104	Hydrocortisone	FAERS: 1	12682474	CTD US FAERS
105	Hydroxyzine	FAERS: 1		US FAERS
106	INCB018424	FAERS: 1		US FAERS
107	Insulin Glargine	FAERS: 1		US FAERS
108	Invokamet	FAERS: 1		US FAERS
109	Iopamidol	FAERS: 1		US FAERS
110	Leucovorin	FAERS: 1		US FAERS
111	Liraglutide	FAERS: 1		US FAERS
112	Meloxicam	FAERS: 1		US FAERS
113	Melphalan	FAERS: 1		US FAERS
114	Memantine	FAERS: 1		US FAERS
115	Meropenem	FAERS: 1		US FAERS
116	Methotrexate	FAERS: 1		US FAERS
117	Minocycline	FAERS: 1		US FAERS
118	Minocycline	FAERS: 1		US FAERS
119	Mycophenolic Acid	FAERS: 1		US FAERS
120	Naltrexone	FAERS: 1		US FAERS
121	Naproxen	FAERS: 1		US FAERS
122	Nortriptyline	FAERS: 1		US FAERS
123	Octreotide	FAERS: 1		US FAERS
124	Propranolol	FAERS: 1		US FAERS
125	Propranolol	FAERS: 1		US FAERS
126	Ranolazine	FAERS: 1		US FAERS
127	Rifaximin	FAERS: 1		US FAERS
128	Risperidone	FAERS: 1		US FAERS
129	Ruxolitinib phosphate	FAERS: 1		US FAERS
130	Sodium Chloride	FAERS: 1		US FAERS
131	Sorafenib	FAERS: 1		US FAERS
132	Temozolomide	FAERS: 1		US FAERS
133	Terbinafine	FAERS: 1		US FAERS
134	Ticagrelor	FAERS: 1		US FAERS
135	Topiramate	FAERS: 1		US FAERS
136	Tramadol	FAERS: 1		US FAERS
137	Triamcinolone	FAERS: 1		US FAERS
138	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
139	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
140	Vortioxetine hydrobromide	FAERS: 1		US FAERS
141	acetaminophen, codeine drug combination	FAERS: 1		US FAERS
142	ambrisentan	FAERS: 1		US FAERS
143	apremilast	FAERS: 1		US FAERS
144	cefprozil	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
145	entecavir	FAERS: 1		US FAERS
146	hylan	FAERS: 1		US FAERS
147	idelalisib	FAERS: 1		US FAERS
148	iopromide	FAERS: 1		US FAERS
149	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
150	lifitegrast	FAERS: 1		US FAERS
151	palbociclib	FAERS: 1		US FAERS
152	paricalcitol	FAERS: 1		US FAERS
153	peramivir	FAERS: 1		US FAERS
154	pomalidomide	FAERS: 1		US FAERS
155	telaprevir	FAERS: 1		US FAERS
156	tizanidine	FAERS: 1		US FAERS
157	treprostinil	FAERS: 1		US FAERS
158	valdecoxib	FAERS: 1		US FAERS
159	Amifostine		10742082	CTD
160	Dexamethasone		28003376	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Shock, Hemorrhagic	53.3%
2	Acute-Phase Reaction	44.4%
3	Multiple Organ Failure	44.4%
4	Serositis	44.4%
5	Seroma	44.4%
6	Polydipsia	41.4%
7	Ascites	40.9%
8	Fibrosis	40.9%
9	Gliosis	40.9%
10	Growth Disorders	40.9%
11	Hemorrhage	40.9%
12	Hyperbilirubinemia	40.9%
13	Hyperplasia	40.9%
14	Hypomenorrhea	40.9%
15	Intraoperative Complications	40.9%
16	Ischemia	40.9%
17	Lithiasis	40.9%
18	Malacoplakia	40.9%
19	Menstruation Disturbances	40.9%
20	Metaplasia	40.9%
21	Nerve Degeneration	40.9%
22	Ochronosis	40.9%
23	Polymenorrhea	40.9%
24	Postoperative Complications	40.9%
25	Sclerosis	40.9%
26	Ulcer	40.9%
27	Hyperammonemia	40.9%
28	Hyperamylasemia	40.9%
29	Teratogenesis	40.9%
30	Cardiac Death	40.9%
31	Hypovolemia	40.9%
32	Hyperuricemia	40.9%
33	Leukoaraiosis	40.9%
34	Dysbacteriosis	40.9%
35	Delayed Graft Function	40.9%
36	Cirrhosis	40.9%
37	Neointima	40.9%
38	Dysbiosis	40.9%
39	Infarction	40%
40	Postoperative Hemorrhage	40%
41	Shock, Traumatic	35.1%
42	Foreign-Body Reaction	33.9%
43	Neurogenic Inflammation	33.9%
44	Suppuration	33.9%
45	Vascular Remodeling	33.3%
46	Extravasation of Diagnostic and Therapeutic Materials	32.1%
47	Neoplastic Processes	32.1%
48	Necrosis	31%
49	Granulomatosis, Orofacial	31%
50	Pigmentation Disorders	31%
51	Respiratory Aspiration	31%
52	Acantholysis	30.5%
53	Chromosome Aberrations	30.5%
54	Dehydration	30.5%
55	Granuloma	30.5%
56	Leukocytosis	30.5%
57	Pleocytosis	30.5%
58	Sudden infant death syndrome	29.5%
59	Menorrhagia	27.5%
60	Chromosomal Instability	26.8%
61	Acute Disease	26.7%
62	Amenorrhea	26.7%
63	Chronic disease	26.7%
64	Critical Illness	26.7%
65	Sudden death	26.7%
66	Fat necrosis	26.7%
67	Gangrene	26.7%
68	Graft Occlusion, Vascular	26.7%
69	Granuloma, Plasma Cell	26.7%
70	Hematoma	26.7%
71	Iatrogenic Disease	26.7%
72	Oligomenorrhea	26.7%
73	Premenstrual syndrome	26.7%
74	Recurrence	26.7%
75	Retrograde Degeneration	26.7%
76	Retroperitoneal fibrosis	26.7%
77	Subcutaneous Emphysema	26.7%
78	Surgical Wound Dehiscence	26.7%
79	Syndrome	26.7%
80	Wallerian Degeneration	26.7%
81	Pyogenic granuloma	26.7%
82	Exsanguination	26.7%
83	Disease Progression	26.7%
84	Incisional hernia	26.7%
85	Premenstrual Tension	26.7%
86	Delayed Emergence from Anesthesia	26.7%
87	Infant Death	26.7%
88	Anastomotic Leak	26.7%
89	Intraoperative Awareness	26.7%
90	jaundice	26.7%
91	Shock, Cardiogenic	26.3%
92	Genomic Instability	25.4%
93	Abscess	24.8%
94	Empyema	24.8%
95	Pain, Postoperative	24.8%
96	Azotemia	23.9%
97	Dysmenorrhea	23.9%
98	Failed Back Surgery Syndrome	23.9%
99	Signs and Symptoms	23.8%
100	Pathological Conditions, Anatomical	23.8%
101	Muscle Weakness	23.7%
102	Postoperative Nausea and Vomiting	23.7%
103	Eye Hemorrhage	22.2%
104	Hemoptysis	21.6%
105	Ecchymosis	21.3%
106	Petechiae	21.3%
107	Purpura	21.3%
108	Asphyxia	21.1%
109	Granuloma, Respiratory Tract	21.1%
110	Cardiotoxicity	20.6%
111	Inflammation	20.5%
112	Shock	20.5%
113	Disease susceptibility	20.3%
114	Fetal Death	20.3%
115	Gastrointestinal Hemorrhage	20.3%
116	Hemarthrosis	20.3%
117	Hemoperitoneum	20.3%
118	Hemothorax	20.3%
119	Neoplasm Invasiveness	20.3%
120	Neoplasm Metastasis	20.3%
121	Neoplasm Recurrence, Local	20.3%
122	Postpericardiotomy Syndrome	20.3%
123	Prosthesis Failure	20.3%
124	Reperfusion Injury	20.3%
125	Injection Site Reaction	20.3%
126	Retrobulbar Hemorrhage	20.3%
127	Aseptic Necrosis of Bone	20.3%
128	Peritoneal Fibrosis	20.3%
129	Carcinogenesis	20.3%
130	Perinatal death	20.3%
131	Infusion site reaction	20.3%
132	Nephrogenic Fibrosing Dermopathy	20.3%
133	Corneal Endothelial Cell Loss	20.3%
134	Encapsulating Peritoneal Sclerosis	20.3%
135	Vasoplegia	20.3%
136	Nephrogenic Systemic Fibrosis	20.3%
137	Metastasis	20.3%
138	Sinus Arrhythmia	20%
139	Atrial Fibrillation	20%
140	Atrial Flutter	20%
141	Dental Pulp Necrosis	20%
142	Granuloma, Foreign-Body	20%
143	Mediastinal Emphysema	20%
144	Surgical Wound Infection	20%
145	Ventricular Fibrillation	20%
146	Ventricular Flutter	20%
147	Parasystole	20%
148	Paroxysmal atrial fibrillation	20%
149	Systemic Inflammatory Response Syndrome	20%
150	Facies	20%
151	Bradycardia	20%
152	Embryo Loss	20%
153	Afferent Loop Syndrome	19.8%
154	Sex Chromosome Aberrations	19.8%
155	Short Bowel Syndrome	19.8%
156	Uterine hemorrhage	19.8%
157	No-Reflow Phenomenon	19.8%
158	Tissue Adhesions	19.8%
159	Hematoma, Epidural, Spinal	19.8%
160	Jaundice, Obstructive	19.7%
161	Chromosome Fragility	19.6%
162	Epistaxis	18.2%
163	Cellulitis	16.8%
164	Sick Sinus Syndrome	16.7%
165	Trisomy	16.7%
166	Drowning	16.7%
167	Hematoma, Subdural, Spinal	16.4%
168	Fetal Growth Retardation	16.2%
169	DNA Degradation, Necrotic	16.2%
170	Aneuploidy	16.1%
171	Polyploidy	16.1%
172	Microsatellite Instability	16.1%
173	Heart Block	16%
174	Tachycardia	16%
175	Tachyarrhythmia	16%
176	Cicatrix	16%
177	Hematuria	15.9%
178	Granuloma Annulare	15.9%
179	Chromosome Breakage	15.9%
180	Brain Death	15.8%
181	Hematemesis	15.8%
182	Purpura Fulminans	15.7%
183	Cross Infection	15.1%
184	Hyphema	15.1%
185	Retinal Neovascularization	15.1%
186	Vitreous Hemorrhage	15.1%
187	Femur Head Necrosis	14.9%
188	Fetal Resorption	14.9%
189	Lymphatic Metastasis	14.9%
190	Neoplasms, Unknown Primary	14.9%
191	Peptic Ulcer Hemorrhage	14.9%
192	Sudden Cardiac Death	14.9%
193	Leukemic Infiltration	14.9%
194	Premenstrual Dysphoric Disorder	14.9%
195	Choroidal Neovascularization	14.9%
196	Primary Graft Dysfunction	14.9%
197	Neoplasm Micrometastasis	14.9%
198	Dumping Syndrome	14.8%
199	Cicatrix, Hypertrophic	14.8%
200	Sinus Arrest, Cardiac	14.8%
201	Metrorrhagia	14.7%
202	Hematoma, Subdural	14.6%
203	Hematoma, Epidural, Cranial	14.6%
204	Asthenia	13.6%
205	Body Temperature Changes	13.6%
206	Calculi	13.6%
207	Cyanosis	13.6%
208	Edema	13.6%
209	Failure to Thrive	13.6%
210	Fatigue	13.6%
211	Feminization	13.6%
212	Fetal Distress	13.6%
213	Hernia	13.6%
214	Hypertrophy	13.6%
215	Motion Sickness	13.6%
216	Nails, Malformed	13.6%
217	polyps	13.6%
218	Rupture, Spontaneous	13.6%
219	Signs and Symptoms, Digestive	13.6%
220	Signs and Symptoms, Respiratory	13.6%
221	Skin Manifestations	13.6%
222	Chills	13.6%
223	Lassitude	13.6%
224	Enterocele	13.6%
225	Atheroma	13.6%
226	Pseudophakia	13.6%
227	Urological Manifestations	13.6%
228	Stenosis	13.6%
229	Facial asymmetry	13.6%
230	Mobility Limitation	13.6%
231	Somnolence	13.6%
232	Plaque, Amyloid	13.6%
233	Plaque, Atherosclerotic	13.6%
234	Giant Cell Epulis	13.6%
235	Long QT Syndrome	13.3%
236	Micronuclei, Chromosome-Defective	13.1%
237	Phantom pain	13%
238	Phantom Limb Pain	13%
239	Retinal Hemorrhage	12.2%
240	Choroid Hemorrhage	12.1%
241	Melena	12.1%
242	Hematoma, Subdural, Intracranial	12%
243	Hematoma, Subdural, Chronic	12%
244	Hematoma, Subdural, Acute	12%
245	Postpartum Hemorrhage	11.9%
246	Gingival Hemorrhage	11.8%
247	Keloid	11.8%
248	Monosomy	11.8%
249	Tetraploidy	11.8%
250	Stillbirth	11.8%
251	Adams-Stokes Syndrome	11.8%
252	Atrioventricular Block	11.8%
253	Bundle-Branch Block	11.8%
254	Atrial Premature Complexes	11.8%
255	Sinoatrial Block	11.8%
256	Tachycardia, Paroxysmal	11.8%
257	Supraventricular tachycardia	11.8%
258	Tachycardia, Ventricular	11.8%
259	Tachycardia, Reciprocating	11.8%
260	Subarachnoid Hemorrhage	11.7%
261	Cerebral Hemorrhage	11.7%
262	Abdominal Pain	11.6%
263	Subacute Combined Degeneration	11.5%
264	Thrombocytopenic purpura	11.5%
265	Eosinophilic Granuloma	11.4%
266	Purpura, Hyperglobulinemic	11.2%
267	Endotoxic shock	10.8%
268	Septic Shock	10.8%
269	Toxic Shock Syndrome	10.8%
270	Cyst	10.7%
271	Eye Manifestations	10.7%
272	Neurologic Manifestations	10.7%
273	Leukoplakia	10.3%
274	Cardiac Output, High	10.3%
275	Myocardial Stunning	10.3%
276	Reticulocytosis	10.3%
277	Low Cardiac Output Syndrome	10.3%
278	Airway Remodeling	10.3%
279	Ventricular Remodeling	10.2%
280	Alopecia	10.1%
281	Intermittent Claudication	10.1%
282	Androgenetic Alopecia	10.1%
283	Kernicterus	10%
284	Cell Transformation, Viral	10%
285	Renal Colic	9.9%
286	Romano-Ward Syndrome	9.8%
287	Tachycardia, Atrioventricular Nodal Reentry	9.7%
288	Tachycardia, Ectopic Atrial	9.7%
289	Tachycardia, Ectopic Junctional	9.7%
290	Sinus Tachycardia	9.7%
291	Torsades de Pointes	9.7%
292	Accelerated Idioventricular Rhythm	9.7%
293	Eye pain	9.4%
294	Muscular Atrophy	9.3%
295	Purpura, Thrombotic Thrombocytopenic	9.2%
296	Abdomen, Acute	9%
297	Anorexia	8.9%
298	Anoxia	8.9%
299	Constipation	8.9%
300	Diarrhea	8.9%
301	Dyspepsia	8.9%
302	Eructation	8.9%
303	Fever	8.9%
304	Flatulence	8.9%
305	Flushing	8.9%
306	Halitosis	8.9%
307	Heartburn	8.9%
308	Diaphragmatic Hernia	8.9%
309	Hiccough	8.9%
310	Hypercalciuria	8.9%
311	Hypercapnia	8.9%
312	Hyperphagia	8.9%
313	Intestinal Polyps	8.9%
314	Nausea	8.9%
315	Pallor	8.9%
316	Psychophysiologic Disorders	8.9%
317	Splenomegaly	8.9%
318	Vomiting	8.9%
319	Hypocapnia	8.9%
320	Dyschezia	8.9%
321	Hypoxia	8.9%
322	Hyperoxia	8.9%
323	Lower Urinary Tract Symptoms	8.9%
324	Hypoxemia	8.9%
325	Urinoma	8.9%
326	Granuloma, Laryngeal	8.8%
327	Myocardial Reperfusion Injury	8.5%
328	Hypergammaglobulinemia	8.2%
329	Diverticulum	8%
330	Diverticulosis	8%
331	Septicemia	7.6%
332	Sepsis	7.6%
333	Autoimmune thrombocytopenia	7.3%
334	Immune thrombocytopenic purpura	7.3%
335	Philadelphia Chromosome	7.2%
336	Sarcopenia	7.2%
337	Waterhouse-Friderichsen Syndrome	7.1%
338	Respiratory Tract Fistula	7%
339	Apnea	6.8%
340	Cheyne-Stokes Respiration	6.8%
341	Decerebrate State	6.8%
342	Dyspnea	6.8%
343	Cardiomegaly	6.8%
344	Hemiparesis	6.8%
345	Hepatomegaly	6.8%
346	Hyperventilation	6.8%
347	Meningism	6.8%
348	Mouth Breathing	6.8%
349	Paresis	6.8%
350	Parovarian Cyst	6.8%
351	Pruritus	6.8%
352	Seizures	6.8%
353	Sensation Disorders	6.8%
354	Sneezing	6.8%
355	Spermatocele	6.8%
356	Erythema	6.8%
357	Oral Fistula	6.8%
358	Complex partial seizures	6.8%
359	Necrolytic Migratory Erythema	6.8%
360	Tachypnea	6.8%
361	Monoparesis	6.8%
362	Cutaneous Fistula	6.8%
363	Gait Disorders, Neurologic	6.8%
364	Neuromuscular Manifestations	6.8%
365	Cardiac Hypertrophy	6.8%
366	Edema, Cardiac	6.7%
367	Mental Fatigue	6.7%
368	Hirsutism	6.7%
369	Orthostatic intolerance	6.7%
370	Hypoventilation	6.7%
371	Vaginal Fistula	6.6%
372	Rectocele	6.6%
373	Back Pain	6.6%
374	Bulimia	6.6%
375	Neck Pain	6.6%
376	Chest Pain	6.6%
377	Colonic Polyps	6.6%
378	Dizziness	6.6%
379	Dysuria	6.6%
380	Facial Pain	6.6%
381	Fever of Unknown Origin	6.6%
382	Flank Pain	6.6%
383	Headache	6.6%
384	Nocturia	6.6%
385	Pain, Intractable	6.6%
386	Pelvic Pain	6.6%
387	Snoring	6.6%
388	Chronic pain	6.6%
389	Lightheadedness	6.6%
390	Pain, Referred	6.6%
391	Prostatism	6.6%
392	Throbbing Headache	6.6%
393	Labor Pain	6.6%
394	Cancer Pain	6.6%
395	Nociceptive Pain	6.6%
396	Body Weight Changes	6.6%
397	Viremia	6.5%
398	Parasitemia	6.5%
399	Basal Ganglia Hemorrhage	6%
400	Gait Ataxia	6%
401	Hoarseness	5.9%
402	Sleep Wake Disorders	5.8%
403	Body Weight	5.6%
404	Pupil Disorders	5.6%
405	Neurobehavioral Manifestations	5.6%
406	Nasal Polyps	5.5%
407	Emaciation	5.5%
408	Low Back Pain	5.5%
409	Visceral Pain	5.5%
410	Pleural Rub	5.4%
411	Rales	5.4%
412	Respiratory Sounds	5.4%
413	Rhonchi	5.4%
414	Stridor	5.4%
415	Wheezing	5.4%
416	Asterixis	5.4%
417	Ballismus	5.4%
418	Putaminal Hemorrhage	5.4%
419	Vertigo	5.4%
420	Pain	5.3%
421	Livedo Reticularis	5.3%
422	Ache	5.3%
423	Meningocele	5.3%
424	Oliguria	5.3%
425	Polyuria	5.3%
426	Proteinuria	5.3%
427	Urinary Calculi	5.3%
428	Encephalocele	5.3%
429	Underweight	5.2%
430	Overweight	5.2%
431	Akathisia	5.2%
432	Restlessness	5.2%
433	Psychomotor Agitation	5.2%
434	Vesicovaginal Fistula	5.1%
435	Biliary Fistula	5%
436	Gastric Fistula	5%
437	Congenital diaphragmatic hernia	5%
438	Morning Sickness	5%
439	Bacteremia	5%
440	Anosmia	5%
441	Ataxia	5%
442	Athetosis	5%
443	Catalepsy	5%
444	Dental Fistula	5%
445	Dystonia	5%
446	Hemiplegia	5%
447	Locked-In Syndrome	5%
448	Muscle Hypertonia	5%
449	Muscle hypotonia	5%
450	Myoclonus	5%
451	Myotonia	5%
452	Neuralgia	5%
453	Oroantral Fistula	5%
454	Paraplegia	5%
455	Pseudobulbar Palsy	5%
456	Quadriplegia	5%
457	Spasm	5%
458	Spastic Paraplegia	5%
459	Status Epilepticus	5%
460	Taste Disorders	5%
461	Tremor	5%
462	Monoplegia	5%
463	Hypokinesia	5%
464	Left Ventricular Hypertrophy	5%
465	Gastroparesis	5%
466	Right Ventricular Hypertrophy	5%
467	Paraparesis	5%
468	Bradykinesia	5%
469	Waxy flexibility	5%
470	Action Tremor	5%
471	Resting Tremor	5%
472	Dysosmia	5%
473	Quadriparesis	5%
474	Olfaction Disorders	5%
475	Myokymia	5%
476	Somatosensory Disorders	5%
477	Neuropathic pain	5%
478	Hyperkinesia	5%
479	Intention tremor	5%
480	Fungemia	5%
481	Rectal Prolapse	4.9%
482	Uterine Prolapse	4.9%
483	Vaginal Prolapse	4.9%
484	Cachexia	4.9%
485	Weight Gain	4.9%
486	Gait Apraxia	4.9%
487	Voice Disorders	4.6%
488	Voice Disturbance	4.6%
489	Gagging	4.5%
490	Leukoplakia, Oral	4.4%
491	Endotoxemia	4.4%
492	Umbilical hernia	4.2%
493	Toothache	4.2%
494	Alexia	4.2%
495	Dyslexia	4.2%
496	Vision Disorders	4.1%
497	Metamorphopsia	4.1%
498	Visual Impairment	4.1%
499	Hyperemesis Gravidarum	4.1%
500	Bronchial Fistula	4.1%
501	Dysgeusia	4.1%
502	Formication	4.1%
503	Hyperalgesia	4.1%
504	Hyperesthesia	4.1%
505	Hypesthesia	4.1%
506	Language Disorders	4.1%
507	Metatarsalgia	4.1%
508	Numbness	4.1%
509	Pancreatic Fistula	4.1%
510	Paresthesia	4.1%
511	Paraparesis, Spastic	4.1%
512	Trismus	4.1%
513	Epilepsia Partialis Continua	4.1%
514	Hypogeusia	4.1%
515	Brown-Sequard Syndrome	4.1%
516	Lockjaw	4.1%
517	Allodynia	4.1%
518	Ageusia	4.1%
519	Alice in Wonderland Syndrome	4.1%
520	Anisocoria	4%
521	Confusion	4%
522	Facial paralysis	4%
523	Intestinal Fistula	4%
524	Lethargy	4%
525	Memory Disorders	4%
526	Muscle Cramp	4%
527	Perceptual Disorders	4%
528	Psychomotor Disorders	4%
529	Tonic Pupil	4%
530	Anhedonia	4%
531	Disorientation	4%
532	Gastroschisis	4%
533	Enterocutaneous Fistula	4%
534	Fetal Hypoxia	4%
535	Facial Paresis	4%
536	Memory Loss	4%
537	Hemisensory Neglect	4%
538	Dysacusis	4%
539	Dyspnea, Paroxysmal	4%
540	Mastodynia	4%
541	Respiratory Paralysis	4%
542	Salivary Gland Fistula	4%
543	Chorea	3.9%
544	Cystocele	3.9%
545	Tetany	3.9%
546	Urinary Incontinence	3.9%
547	Breakthrough Pain	3.9%
548	Albuminuria	3.9%
549	Hemoglobinuria	3.9%
550	Jet Lag Syndrome	3.8%
551	Reflex, Abnormal	3.8%
552	Hyporeflexia	3.8%
553	Hyperreflexia	3.8%
554	Birth Weight	3.7%
555	Agraphia	3.7%
556	Anomia	3.7%
557	Cluttering	3.7%
558	Language Development Disorders	3.7%
559	Speech Disorders	3.7%
560	Syncope	3.7%
561	Stupor	3.7%
562	Dysgraphia	3.7%
563	Presyncope	3.7%
564	Dyslalia	3.7%
565	Aphasia	3.4%
566	Articulation Disorders	3.4%
567	Echolalia	3.4%
568	Stuttering	3.4%
569	Dysphasia	3.4%
570	Consciousness Disorders	3.4%
571	Mental Retardation	3.4%
572	Depressed Level of Consciousness	3.4%
573	Mental deficiency	3.4%
574	Intellectual Disability	3.4%
575	Catatonia	3.4%
576	Musculoskeletal Pain	3.4%
577	Ophthalmoplegia	3.4%
578	External Ophthalmoplegia	3.4%
579	Dysarthria	3.3%
580	Diplopia	3.3%
581	Muscle Rigidity	3.3%
582	Muscle Spasticity	3.3%
583	Scotoma	3.3%
584	Photophobia	3.3%
585	Cogwheel Rigidity	3.3%
586	Hemifacial Spasm	3.3%
587	Amaurosis	3.3%
588	Blindness	3.3%
589	Nuchal Rigidity	3.3%
590	Aphonia	3.3%
591	Arthralgia	3.3%
592	Sleep Deprivation	3.3%
593	Polyarthralgia	3.3%
594	Dysphonia	3.3%
595	Angina Pectoris	3.3%
596	Agnosia	3.3%
597	Apraxias	3.3%
598	Cerebrospinal Fluid Otorrhea	3.3%
599	Cerebrospinal Fluid Rhinorrhea	3.3%
600	Hallucinations	3.3%
601	Hemianopsia	3.3%
602	Hyperacusis	3.3%
603	Tinnitus	3.3%
604	Visual Agnosia	3.3%
605	Anosognosia	3.3%
606	Wernicke-Korsakoff Syndrome	3.3%
607	Phonophobia	3.3%
608	Hearing Loss	3.3%
609	Cerebellar Ataxia	3.3%
610	Torticollis	3.3%
611	Obesity	3.2%
612	Sciatica	3.2%
613	Urge Incontinence	3.2%
614	Tardive Dyskinesia	3.2%
615	Candidemia	3.1%
616	Hydrops Fetalis	2.9%
617	Amaurosis Fugax	2.9%
618	Blindness, Cortical	2.9%
619	Dyscalculia	2.9%
620	Angina, Unstable	2.9%
621	Deafness	2.9%
622	Hearing Loss, Sudden	2.9%
623	Gerstmann Syndrome	2.9%
624	Hearing Loss, Bilateral	2.9%
625	Hearing Loss, High-Frequency	2.9%
626	Hearing Loss, Mixed Conductive-Sensorineural	2.9%
627	Prosopagnosia	2.9%
628	Apraxia, Ideomotor	2.9%
629	Persistent Vegetative State	2.9%
630	Charles Bonnet Syndrome	2.9%
631	Hearing Loss, Unilateral	2.9%
632	Complete Hearing Loss	2.9%
633	Alien Hand Syndrome	2.9%
634	Deaf Mutism	2.9%
635	Fetal Weight	2.9%
636	Vocal Cord Paralysis	2.9%
637	Urinary Bladder Fistula	2.8%
638	Mutism	2.8%
639	Selective Mutism	2.8%
640	Tinea Pedis	2.8%
641	Amblyopia	2.8%
642	Amnesia	2.8%
643	Delirium	2.8%
644	Horner Syndrome	2.8%
645	Dissociative Amnesia	2.8%
646	Color blindness	2.8%
647	Global Amnesia	2.8%
648	Angina Pectoris, Variant	2.7%
649	Rectal Fistula	2.7%
650	Anal Fistula	2.7%
651	Shoulder Pain	2.7%
652	Pediatric Obesity	2.7%
653	Alexia, Pure	2.7%
654	Dyskinesia, Drug-Induced	2.5%
655	Alcohol Withdrawal Seizures	2.5%
656	Arteriovenous fistula	2.5%
657	Retrograde amnesia	2.4%
658	Amnesia, Anterograde	2.4%
659	Akathisia, Drug-Induced	2.4%
660	Myalgia	2.4%
661	Kidney Calculi	2.2%
662	Ureteral Calculi	2.2%
663	Amnesia, Transient Global	2.1%
664	Auditory Perceptual Disorders	2%
665	Ophthalmoplegic Migraine	1.8%
666	Progressive supranuclear palsy	1.8%
667	Kearns-Sayre syndrome	1.2%

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