MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Breakthrough Pain

(UMLS:C1135120)

Definition:: Acute pain that comes on rapidly despite the use of pain medication.
UMLS ID:: C1135120
MeSH ID:: D059390

Classification 1:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.592.612.191

Classification 2:

Name:

Psychological Phenomena
MeSH Tree Number(s):: F02.830.816.131

Classification 3:

Name:

Musculoskeletal and Neural Physiological Phenomena
MeSH Tree Number(s):: G11.561.790.444.393

Synonym(s)

Breakthrough Pain

Breakthrough pain

breakthrough pain

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Fentanyl	FAERS: 337	OFFSIDES US FAERS
2	Buprenorphine	FAERS: 116 Canada Vigilance: 2	Canada Vigilance US FAERS
3	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 32	SIDER US FAERS
4	Pregabalin	FAERS: 22	US FAERS
5	Morphine	FAERS: 17	OFFSIDES SIDER US FAERS
6	Hydrocodone	FAERS: 12	US FAERS
7	tofacitinib	FAERS: 12	US FAERS
8	Gabapentin	FAERS: 11	US FAERS
9	Duloxetine Hydrochloride	FAERS: 6	US FAERS
10	Hydrocodone	FAERS: 6	US FAERS
11	Tapentadol	FAERS: 6	US FAERS
12	Sunitinib	FAERS: 5	US FAERS
13	4-hydroxybutyric acid	FAERS: 3	US FAERS
14	Baclofen	FAERS: 3	US FAERS
15	Buprenorphine	FAERS: 3	US FAERS
16	Fentanyl	FAERS: 3	US FAERS
17	Oxycodone	FAERS: 3	US FAERS
18	Tramadol	FAERS: 3 Canada Vigilance: 1	Canada Vigilance US FAERS
19	apremilast	FAERS: 3	US FAERS
20	Hydromorphone	FAERS: 2	US FAERS
21	Lamotrigine	FAERS: 2	US FAERS
22	Octreotide	FAERS: 2	US FAERS
23	Oxymorphone	FAERS: 2	US FAERS
24	Pantoprazole	FAERS: 2	OFFSIDES US FAERS
25	ropinirole	FAERS: 2	US FAERS
26	ziconotide	FAERS: 2	US FAERS
27	Acetaminophen	FAERS: 1	OFFSIDES US FAERS
28	Alendronate	FAERS: 1	US FAERS
29	Atorvastatin	FAERS: 1	US FAERS
30	Carbamazepine	FAERS: 1	US FAERS
31	Ciprofloxacin	FAERS: 1	US FAERS
32	Clonidine	FAERS: 1	US FAERS
33	Estrogens, Conjugated (USP)	FAERS: 1	US FAERS
34	Gemfibrozil	FAERS: 1	US FAERS
35	Imatinib Mesylate	FAERS: 1	US FAERS
36	Leuprolide	FAERS: 1	US FAERS
37	Lidoderm	FAERS: 1	OFFSIDES US FAERS
38	Lorcet	FAERS: 1	US FAERS
39	Medroxyprogesterone Acetate	FAERS: 1	US FAERS
40	Meperidine	FAERS: 1	US FAERS
41	Methadone	FAERS: 1	US FAERS
42	Metoprolol	FAERS: 1	US FAERS
43	Nicotine	FAERS: 1	US FAERS
44	Nitroglycerin	FAERS: 1	US FAERS
45	Olanzapine	FAERS: 1	US FAERS
46	Omeprazole	FAERS: 1	US FAERS
47	Pramipexole	FAERS: 1	US FAERS
48	Tapentadol	FAERS: 1	US FAERS
49	Teriparatide	FAERS: 1	US FAERS
50	Ticagrelor	FAERS: 1	US FAERS
51	Valacyclovir	FAERS: 1	US FAERS
52	Verapamil	FAERS: 1	US FAERS
53	dexamethasone 21-phosphate	FAERS: 1	US FAERS
54	exemestane	FAERS: 1	US FAERS
55	norgestimate, ethinyl estradiol drug combination	FAERS: 1	US FAERS
56	palbociclib	FAERS: 1	US FAERS
57	pomalidomide	FAERS: 1	US FAERS
58	regorafenib	FAERS: 1	US FAERS
59	telotristat ethyl	FAERS: 1	US FAERS
60	Benzodiazepines		OFFSIDES
61	Bisacodyl		OFFSIDES
62	Carisoprodol		OFFSIDES
63	Cefazolin		OFFSIDES
64	Cephalexin		OFFSIDES
65	Clonazepam		OFFSIDES
66	Diphenoxylate		OFFSIDES
67	Dutasteride		OFFSIDES
68	Fluticasone		OFFSIDES
69	Hydromorphone		OFFSIDES SIDER
70	Kanamycin		OFFSIDES
71	Mebendazole		OFFSIDES
72	Meperidine		OFFSIDES
73	Methadone		OFFSIDES
74	Methocarbamol		OFFSIDES
75	Modafinil		OFFSIDES
76	Nortriptyline		OFFSIDES
77	Phenylephrine		OFFSIDES
78	Riluzole		OFFSIDES
79	Spironolactone		OFFSIDES
80	Temazepam		OFFSIDES
81	alfuzosin		OFFSIDES
82	magnesium citrate		OFFSIDES
83	tizanidine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Renal Colic	45.1%
2	Mastodynia	43.2%
3	Arthralgia	38%
4	Polyarthralgia	38%
5	Musculoskeletal Pain	37.4%
6	Shoulder Pain	28.9%
7	Abdominal Pain	25.5%
8	Back Pain	24.4%
9	Neck Pain	24.4%
10	Chest Pain	24.4%
11	Facial Pain	24.4%
12	Flank Pain	24.4%
13	Headache	24.4%
14	Pain, Intractable	24.4%
15	Pelvic Pain	24.4%
16	Chronic pain	24.4%
17	Pain, Referred	24.4%
18	Throbbing Headache	24.4%
19	Labor Pain	24.4%
20	Cancer Pain	24.4%
21	Nociceptive Pain	24.4%
22	Myalgia	23.6%
23	Pain, Postoperative	21.6%
24	Eye pain	21.5%
25	Neuralgia	19.6%
26	Neuropathic pain	19.6%
27	Abdomen, Acute	18.4%
28	Low Back Pain	18.2%
29	Visceral Pain	18.2%
30	Psychophysiologic Disorders	17.2%
31	Metatarsalgia	16.8%
32	Dysmenorrhea	16.6%
33	Failed Back Surgery Syndrome	16.6%
34	Pain	15.4%
35	Ache	15.4%
36	Toothache	14.9%
37	Gagging	14.3%
38	Phantom pain	14.2%
39	Phantom Limb Pain	14.2%
40	Decerebrate State	14%
41	Hemiparesis	14%
42	Meningism	14%
43	Paresis	14%
44	Seizures	14%
45	Sensation Disorders	14%
46	Complex partial seizures	14%
47	Monoparesis	14%
48	Gait Disorders, Neurologic	14%
49	Neuromuscular Manifestations	14%
50	Wakefulness	13.8%
51	Orthostatic intolerance	13.8%
52	Polydipsia	13.5%
53	Asthenia	12.5%
54	Body Temperature Changes	12.5%
55	Cyanosis	12.5%
56	Edema	12.5%
57	Failure to Thrive	12.5%
58	Fatigue	12.5%
59	Feminization	12.5%
60	Fetal Distress	12.5%
61	Motion Sickness	12.5%
62	Signs and Symptoms, Digestive	12.5%
63	Signs and Symptoms, Respiratory	12.5%
64	Skin Manifestations	12.5%
65	Chills	12.5%
66	Lassitude	12.5%
67	Pseudophakia	12.5%
68	Urological Manifestations	12.5%
69	Mobility Limitation	12.5%
70	Somnolence	12.5%
71	Sleep Wake Disorders	12.4%
72	Reflex, Abnormal	12.3%
73	Hyporeflexia	12.3%
74	Hyperreflexia	12.3%
75	Angina Pectoris	12.3%
76	Sleep Deprivation	12.2%
77	Sciatica	12.1%
78	Pupil Disorders	12.1%
79	Neurobehavioral Manifestations	12.1%
80	Piloerection	11.7%
81	Asterixis	11.7%
82	Ballismus	11.7%
83	Vertigo	11.6%
84	Dizziness	11.4%
85	Lightheadedness	11.4%
86	Gait Ataxia	11.4%
87	Eye Manifestations	10.4%
88	Voice Disorders	10.2%
89	Voice Disturbance	10.2%
90	Cardiac Output, High	10.1%
91	Myocardial Stunning	10.1%
92	Reticulocytosis	10.1%
93	Low Cardiac Output Syndrome	10.1%
94	Angina, Unstable	10.1%
95	Akathisia	10%
96	Restlessness	10%
97	Psychomotor Agitation	10%
98	Intermittent Claudication	9.9%
99	Muscular Atrophy	9.3%
100	Gait Apraxia	9.2%
101	Anosmia	9.2%
102	Ataxia	9.2%
103	Athetosis	9.2%
104	Catalepsy	9.2%
105	Dystonia	9.2%
106	Hemiplegia	9.2%
107	Locked-In Syndrome	9.2%
108	Muscle Hypertonia	9.2%
109	Muscle hypotonia	9.2%
110	Myoclonus	9.2%
111	Myotonia	9.2%
112	Paraplegia	9.2%
113	Pseudobulbar Palsy	9.2%
114	Quadriplegia	9.2%
115	Spasm	9.2%
116	Spastic Paraplegia	9.2%
117	Status Epilepticus	9.2%
118	Taste Disorders	9.2%
119	Tremor	9.2%
120	Monoplegia	9.2%
121	Hypokinesia	9.2%
122	Gastroparesis	9.2%
123	Paraparesis	9.2%
124	Bradykinesia	9.2%
125	Waxy flexibility	9.2%
126	Action Tremor	9.2%
127	Resting Tremor	9.2%
128	Dysosmia	9.2%
129	Quadriparesis	9.2%
130	Olfaction Disorders	9.2%
131	Myokymia	9.2%
132	Somatosensory Disorders	9.2%
133	Hyperkinesia	9.2%
134	Intention tremor	9.2%
135	Muscle Weakness	9.1%
136	Angina Pectoris, Variant	9%
137	Hoarseness	8.5%
138	Hypergammaglobulinemia	8.4%
139	Postoperative Nausea and Vomiting	8.2%
140	Vision Disorders	7.9%
141	Metamorphopsia	7.9%
142	Visual Impairment	7.9%
143	jaundice	7.9%
144	Pathological Conditions, Anatomical	7.8%
145	Anisocoria	7.7%
146	Confusion	7.7%
147	Facial paralysis	7.7%
148	Lethargy	7.7%
149	Memory Disorders	7.7%
150	Muscle Cramp	7.7%
151	Perceptual Disorders	7.7%
152	Psychomotor Disorders	7.7%
153	Tonic Pupil	7.7%
154	Anhedonia	7.7%
155	Disorientation	7.7%
156	Facial Paresis	7.7%
157	Memory Loss	7.7%
158	Hemisensory Neglect	7.7%
159	Dysacusis	7.7%
160	Respiratory Paralysis	7.7%
161	Chorea	7.6%
162	Tetany	7.6%
163	Alice in Wonderland Syndrome	7.5%
164	Anorexia	7.4%
165	Anoxia	7.4%
166	Constipation	7.4%
167	Diarrhea	7.4%
168	Dyspepsia	7.4%
169	Eructation	7.4%
170	Fever	7.4%
171	Flatulence	7.4%
172	Flushing	7.4%
173	Halitosis	7.4%
174	Heartburn	7.4%
175	Hiccough	7.4%
176	Hypercalciuria	7.4%
177	Hypercapnia	7.4%
178	Hyperphagia	7.4%
179	Nausea	7.4%
180	Pallor	7.4%
181	Vomiting	7.4%
182	Hypocapnia	7.4%
183	Dyschezia	7.4%
184	Hypoxia	7.4%
185	Hyperoxia	7.4%
186	Lower Urinary Tract Symptoms	7.4%
187	Hypoxemia	7.4%
188	Urinoma	7.4%
189	Alexia	7%
190	Dyslexia	7%
191	Eye Hemorrhage	6.8%
192	Dysgeusia	6.8%
193	Formication	6.8%
194	Hyperalgesia	6.8%
195	Hyperesthesia	6.8%
196	Hypesthesia	6.8%
197	Language Disorders	6.8%
198	Numbness	6.8%
199	Paresthesia	6.8%
200	Paraparesis, Spastic	6.8%
201	Trismus	6.8%
202	Epilepsia Partialis Continua	6.8%
203	Hypogeusia	6.8%
204	Brown-Sequard Syndrome	6.8%
205	Lockjaw	6.8%
206	Allodynia	6.8%
207	Ageusia	6.8%
208	Sarcopenia	6.7%
209	Consciousness Disorders	6.7%
210	Mental Retardation	6.7%
211	Depressed Level of Consciousness	6.7%
212	Mental deficiency	6.7%
213	Intellectual Disability	6.7%
214	Hemoptysis	6.7%
215	Catatonia	6.6%
216	Ophthalmoplegia	6.6%
217	External Ophthalmoplegia	6.6%
218	Ecchymosis	6.6%
219	Petechiae	6.6%
220	Purpura	6.6%
221	Aphonia	6.6%
222	Dysphonia	6.6%
223	Cerebrospinal Fluid Otorrhea	6.5%
224	Cerebrospinal Fluid Rhinorrhea	6.5%
225	Body Weight	6.1%
226	Apnea	6%
227	Cheyne-Stokes Respiration	6%
228	Dyspnea	6%
229	Hyperventilation	6%
230	Mouth Breathing	6%
231	Pruritus	6%
232	Sneezing	6%
233	Erythema	6%
234	Necrolytic Migratory Erythema	6%
235	Tachypnea	6%
236	Edema, Cardiac	5.9%
237	Mental Fatigue	5.9%
238	Hirsutism	5.9%
239	Hypoventilation	5.9%
240	Body Weight Changes	5.9%
241	Vocal Cord Paralysis	5.9%
242	Epistaxis	5.8%
243	Diplopia	5.8%
244	Muscle Rigidity	5.8%
245	Muscle Spasticity	5.8%
246	Scotoma	5.8%
247	Photophobia	5.8%
248	Cogwheel Rigidity	5.8%
249	Hemifacial Spasm	5.8%
250	Amaurosis	5.8%
251	Blindness	5.8%
252	Nuchal Rigidity	5.8%
253	Agnosia	5.7%
254	Apraxias	5.7%
255	Hallucinations	5.7%
256	Hemianopsia	5.7%
257	Hyperacusis	5.7%
258	Tinnitus	5.7%
259	Visual Agnosia	5.7%
260	Anosognosia	5.7%
261	Wernicke-Korsakoff Syndrome	5.7%
262	Phonophobia	5.7%
263	Hearing Loss	5.7%
264	Vascular Remodeling	5.7%
265	Cerebellar Ataxia	5.7%
266	Torticollis	5.7%
267	Tardive Dyskinesia	5.6%
268	Agraphia	5.6%
269	Anomia	5.6%
270	Cluttering	5.6%
271	Language Development Disorders	5.6%
272	Speech Disorders	5.6%
273	Syncope	5.6%
274	Stupor	5.6%
275	Dysgraphia	5.6%
276	Presyncope	5.6%
277	Dyslalia	5.6%
278	Jaundice, Obstructive	5.2%
279	Dyskinesia, Drug-Induced	5.2%
280	Alcohol Withdrawal Seizures	5.1%
281	Aphasia	5.1%
282	Articulation Disorders	5.1%
283	Echolalia	5.1%
284	Stuttering	5.1%
285	Dysphasia	5.1%
286	Pleural Rub	5%
287	Rales	5%
288	Respiratory Sounds	5%
289	Rhonchi	5%
290	Stridor	5%
291	Wheezing	5%
292	Livedo Reticularis	4.9%
293	Amblyopia	4.9%
294	Amnesia	4.9%
295	Delirium	4.9%
296	Horner Syndrome	4.9%
297	Dissociative Amnesia	4.9%
298	Color blindness	4.9%
299	Global Amnesia	4.9%
300	Oliguria	4.9%
301	Polyuria	4.9%
302	Proteinuria	4.9%
303	Bulimia	4.9%
304	Dysuria	4.9%
305	Fever of Unknown Origin	4.9%
306	Nocturia	4.9%
307	Snoring	4.9%
308	Prostatism	4.9%
309	Underweight	4.9%
310	Overweight	4.9%
311	Dysarthria	4.8%
312	Amaurosis Fugax	4.7%
313	Blindness, Cortical	4.7%
314	Dyscalculia	4.7%
315	Deafness	4.7%
316	Hearing Loss, Sudden	4.7%
317	Gerstmann Syndrome	4.7%
318	Hearing Loss, Bilateral	4.7%
319	Hearing Loss, High-Frequency	4.7%
320	Hearing Loss, Mixed Conductive-Sensorineural	4.7%
321	Prosopagnosia	4.7%
322	Apraxia, Ideomotor	4.7%
323	Persistent Vegetative State	4.7%
324	Charles Bonnet Syndrome	4.7%
325	Hearing Loss, Unilateral	4.7%
326	Complete Hearing Loss	4.7%
327	Alien Hand Syndrome	4.7%
328	Deaf Mutism	4.7%
329	Akathisia, Drug-Induced	4.4%
330	Hematemesis	4.3%
331	Purpura Fulminans	4.3%
332	Mutism	4.3%
333	Selective Mutism	4.3%
334	Ascites	4.2%
335	Calculi	4.2%
336	Fibrosis	4.2%
337	Gliosis	4.2%
338	Growth Disorders	4.2%
339	Hemorrhage	4.2%
340	Hernia	4.2%
341	Hyperbilirubinemia	4.2%
342	Hyperplasia	4.2%
343	Hypertrophy	4.2%
344	Hypomenorrhea	4.2%
345	Inflammation	4.2%
346	Intraoperative Complications	4.2%
347	Ischemia	4.2%
348	Lithiasis	4.2%
349	Malacoplakia	4.2%
350	Menstruation Disturbances	4.2%
351	Metaplasia	4.2%
352	Nails, Malformed	4.2%
353	Nerve Degeneration	4.2%
354	Ochronosis	4.2%
355	Polymenorrhea	4.2%
356	polyps	4.2%
357	Postoperative Complications	4.2%
358	Rupture, Spontaneous	4.2%
359	Sclerosis	4.2%
360	Shock	4.2%
361	Ulcer	4.2%
362	Enterocele	4.2%
363	Hyperammonemia	4.2%
364	Hyperamylasemia	4.2%
365	Teratogenesis	4.2%
366	Muscle Fatigue	4.2%
367	Atheroma	4.2%
368	Cardiac Death	4.2%
369	Hypovolemia	4.2%
370	Hyperuricemia	4.2%
371	Muscle tightness	4.2%
372	Leukoaraiosis	4.2%
373	Stenosis	4.2%
374	Facial asymmetry	4.2%
375	Dysbacteriosis	4.2%
376	Delayed Graft Function	4.2%
377	Cirrhosis	4.2%
378	Plaque, Amyloid	4.2%
379	Plaque, Atherosclerotic	4.2%
380	Neointima	4.2%
381	Dysbiosis	4.2%
382	Retrograde amnesia	4%
383	Amnesia, Anterograde	4%
384	Alexia, Pure	4%
385	Morning Sickness	4%
386	Infarction	3.9%
387	Postoperative Hemorrhage	3.9%
388	Shock, Hemorrhagic	3.9%
389	Systemic Inflammatory Response Syndrome	3.9%
390	Incisional hernia	3.9%
391	Somatosensory Evoked Potentials	3.9%
392	Weight Gain	3.9%
393	Auditory Perceptual Disorders	3.8%
394	Jet Lag Syndrome	3.7%
395	Emaciation	3.6%
396	Birth Weight	3.6%
397	Amnesia, Transient Global	3.6%
398	Cyst	3.5%
399	Extravasation of Diagnostic and Therapeutic Materials	3.5%
400	Neoplastic Processes	3.5%
401	Ophthalmoplegic Migraine	3.5%
402	Progressive supranuclear palsy	3.4%
403	Leukoplakia	3.4%
404	Necrosis	3.4%
405	Granulomatosis, Orofacial	3.4%
406	Pigmentation Disorders	3.4%
407	Respiratory Aspiration	3.4%
408	Airway Remodeling	3.4%
409	Acantholysis	3.3%
410	Chromosome Aberrations	3.3%
411	Dehydration	3.3%
412	Granuloma	3.3%
413	Leukocytosis	3.3%
414	Pleocytosis	3.3%
415	Ventricular Remodeling	3.3%
416	Thrombocytopenic purpura	3.3%
417	Fetal Hypoxia	3.3%
418	Alopecia	3.3%
419	Androgenetic Alopecia	3.3%
420	Decreased Libido	3.3%
421	Dyspnea, Paroxysmal	3.3%
422	Perceptual distortions	3.3%
423	Urinary Incontinence	3.3%
424	Purpura, Hyperglobulinemic	3.3%
425	Albuminuria	3.2%
426	Hemoglobinuria	3.2%
427	Cachexia	3%
428	Hydrops Fetalis	3%
429	Hyperemesis Gravidarum	2.9%
430	Fetal Weight	2.9%
431	Genomic Instability	2.9%
432	Chromosomal Instability	2.8%
433	Obesity	2.8%
434	Diverticulum	2.7%
435	Diverticulosis	2.7%
436	Azotemia	2.7%
437	Menorrhagia	2.7%
438	Sudden infant death syndrome	2.6%
439	Acute Disease	2.5%
440	Acute-Phase Reaction	2.5%
441	Amenorrhea	2.5%
442	Chronic disease	2.5%
443	Critical Illness	2.5%
444	Sudden death	2.5%
445	Fat necrosis	2.5%
446	Gangrene	2.5%
447	Graft Occlusion, Vascular	2.5%
448	Granuloma, Plasma Cell	2.5%
449	Hematoma	2.5%
450	Diaphragmatic Hernia	2.5%
451	Iatrogenic Disease	2.5%
452	Intestinal Polyps	2.5%
453	Multiple Organ Failure	2.5%
454	Oligomenorrhea	2.5%
455	Premenstrual syndrome	2.5%
456	Prone Position	2.5%
457	Recurrence	2.5%
458	Retrograde Degeneration	2.5%
459	Retroperitoneal fibrosis	2.5%
460	Serositis	2.5%
461	Splenomegaly	2.5%
462	Subcutaneous Emphysema	2.5%
463	Surgical Wound Dehiscence	2.5%
464	Syndrome	2.5%
465	Wallerian Degeneration	2.5%
466	Pyogenic granuloma	2.5%
467	Exsanguination	2.5%
468	Disease Progression	2.5%
469	Seroma	2.5%
470	Premenstrual Tension	2.5%
471	Delayed Emergence from Anesthesia	2.5%
472	Infant Death	2.5%
473	Anastomotic Leak	2.5%
474	Intraoperative Awareness	2.5%
475	Automatism	2.4%
476	Deja Vu	2.4%
477	Tinea Pedis	2.4%
478	Urge Incontinence	2.4%
479	Purpura, Thrombotic Thrombocytopenic	2.4%
480	Cardiotoxicity	2.4%
481	Kearns-Sayre syndrome	2.2%
482	Waterhouse-Friderichsen Syndrome	2.2%
483	Pediatric Obesity	2.1%
484	Asphyxia	2.1%
485	Granuloma, Respiratory Tract	2.1%
486	Shock, Traumatic	2.1%
487	Respiratory Tract Fistula	2.1%
488	Bone Resorption	2%
489	Disease susceptibility	2%
490	Fetal Death	2%
491	Foreign-Body Reaction	2%
492	Gastrointestinal Hemorrhage	2%
493	Cardiomegaly	2%
494	Hemarthrosis	2%
495	Hemoperitoneum	2%
496	Hemothorax	2%
497	Hepatomegaly	2%
498	Neoplasm Invasiveness	2%
499	Neoplasm Metastasis	2%
500	Neoplasm Recurrence, Local	2%
501	Parovarian Cyst	2%
502	Postpericardiotomy Syndrome	2%
503	Prosthesis Failure	2%
504	Reperfusion Injury	2%
505	Spermatocele	2%
506	Oral Fistula	2%
507	Injection Site Reaction	2%
508	Retrobulbar Hemorrhage	2%
509	Cutaneous Fistula	2%
510	Aseptic Necrosis of Bone	2%
511	Peritoneal Fibrosis	2%
512	Carcinogenesis	2%
513	Neurogenic Inflammation	2%
514	Perinatal death	2%
515	Infusion site reaction	2%
516	Cardiac Hypertrophy	2%
517	Nephrogenic Fibrosing Dermopathy	2%
518	Corneal Endothelial Cell Loss	2%
519	Encapsulating Peritoneal Sclerosis	2%
520	Vasoplegia	2%
521	Suppuration	2%
522	Nephrogenic Systemic Fibrosis	2%
523	Metastasis	2%
524	Sinus Arrhythmia	2%
525	Atrial Fibrillation	2%
526	Atrial Flutter	2%
527	Dental Pulp Necrosis	2%
528	Granuloma, Foreign-Body	2%
529	Mediastinal Emphysema	2%
530	Surgical Wound Infection	2%
531	Ventricular Fibrillation	2%
532	Ventricular Flutter	2%
533	Parasystole	2%
534	Paroxysmal atrial fibrillation	2%
535	Facies	2%
536	Bradycardia	2%
537	Embryo Loss	2%
538	Autoimmune thrombocytopenia	2%
539	Immune thrombocytopenic purpura	2%
540	Afferent Loop Syndrome	2%
541	Sex Chromosome Aberrations	2%
542	Short Bowel Syndrome	2%
543	Uterine hemorrhage	2%
544	Vaginal Fistula	2%
545	Rectocele	2%
546	No-Reflow Phenomenon	2%
547	Endotoxic shock	1.9%
548	Septic Shock	1.9%
549	Toxic Shock Syndrome	1.9%
550	Chromosome Fragility	1.9%
551	Drowning	1.7%
552	Nasal Polyps	1.7%
553	Fetal Growth Retardation	1.7%
554	DNA Degradation, Necrotic	1.7%
555	Aneuploidy	1.7%
556	Polyploidy	1.7%
557	Microsatellite Instability	1.7%
558	Heart Block	1.6%
559	Tachycardia	1.6%
560	Tachyarrhythmia	1.6%
561	Cicatrix	1.6%
562	Hematuria	1.6%
563	Meningocele	1.6%
564	Urinary Calculi	1.6%
565	Granuloma Annulare	1.6%
566	Chromosome Breakage	1.6%
567	Encephalocele	1.6%
568	Brain Death	1.6%
569	Shock, Cardiogenic	1.6%
570	Tissue Adhesions	1.6%
571	Colonic Polyps	1.6%
572	Hematoma, Epidural, Spinal	1.6%
573	Sick Sinus Syndrome	1.6%
574	Trisomy	1.6%
575	Giant Cell Epulis	1.4%
576	Hematoma, Subdural	1.4%
577	Hematoma, Epidural, Cranial	1.4%
578	Leukoplakia, Oral	1.4%
579	Long QT Syndrome	1.4%
580	Vesicovaginal Fistula	1.4%
581	Micronuclei, Chromosome-Defective	1.4%
582	Biliary Fistula	1.3%
583	Cross Infection	1.3%
584	Gastric Fistula	1.3%
585	Hyphema	1.3%
586	Retinal Neovascularization	1.3%
587	Septicemia	1.3%
588	Vitreous Hemorrhage	1.3%
589	Congenital diaphragmatic hernia	1.3%
590	Sepsis	1.3%
591	Abscess	1.3%
592	Dental Fistula	1.3%
593	Empyema	1.3%
594	Femur Head Necrosis	1.3%
595	Fetal Resorption	1.3%
596	Lymphatic Metastasis	1.3%
597	Neoplasms, Unknown Primary	1.3%
598	Oroantral Fistula	1.3%
599	Peptic Ulcer Hemorrhage	1.3%
600	Sudden Cardiac Death	1.3%
601	Left Ventricular Hypertrophy	1.3%
602	Leukemic Infiltration	1.3%
603	Right Ventricular Hypertrophy	1.3%
604	Premenstrual Dysphoric Disorder	1.3%
605	Choroidal Neovascularization	1.3%
606	Primary Graft Dysfunction	1.3%
607	Neoplasm Micrometastasis	1.3%
608	Osteolysis	1.3%
609	Dumping Syndrome	1.3%
610	Rectal Prolapse	1.3%
611	Uterine Prolapse	1.3%
612	Cicatrix, Hypertrophic	1.3%
613	Vaginal Prolapse	1.3%
614	Sinus Arrest, Cardiac	1.3%
615	Metrorrhagia	1.3%
616	Subacute Combined Degeneration	1.3%
617	Eosinophilic Granuloma	1.2%
618	Hematoma, Subdural, Spinal	1.2%
619	Bronchial Fistula	1.1%
620	Pancreatic Fistula	1.1%
621	Retinal Hemorrhage	1.1%
622	Kernicterus	1.1%
623	Choroid Hemorrhage	1.1%
624	Intestinal Fistula	1.1%
625	Melena	1.1%
626	Gastroschisis	1.1%
627	Enterocutaneous Fistula	1.1%
628	Postpartum Hemorrhage	1.1%
629	Salivary Gland Fistula	1.1%
630	Cystocele	1.1%
631	Gingival Hemorrhage	1.1%
632	Keloid	1.1%
633	Monosomy	1.1%
634	Tetraploidy	1.1%
635	Stillbirth	1.1%
636	Adams-Stokes Syndrome	1.1%
637	Atrioventricular Block	1.1%
638	Bundle-Branch Block	1.1%
639	Atrial Premature Complexes	1.1%
640	Sinoatrial Block	1.1%
641	Tachycardia, Paroxysmal	1.1%
642	Supraventricular tachycardia	1.1%
643	Tachycardia, Ventricular	1.1%
644	Tachycardia, Reciprocating	1.1%
645	Subarachnoid Hemorrhage	1.1%
646	Cerebral Hemorrhage	1.1%
647	Hematoma, Subdural, Intracranial	1.1%
648	Hematoma, Subdural, Chronic	1.1%
649	Hematoma, Subdural, Acute	1.1%
650	Viremia	1%
651	Parasitemia	1%
652	Umbilical hernia	1%
653	Cellulitis	0.9%
654	Romano-Ward Syndrome	0.9%
655	Granuloma, Laryngeal	0.8%
656	Bacteremia	0.8%
657	Myocardial Reperfusion Injury	0.8%
658	Cell Transformation, Viral	0.8%
659	Fungemia	0.8%
660	Urinary Bladder Fistula	0.8%
661	Tachycardia, Atrioventricular Nodal Reentry	0.8%
662	Tachycardia, Ectopic Atrial	0.8%
663	Tachycardia, Ectopic Junctional	0.8%
664	Sinus Tachycardia	0.8%
665	Torsades de Pointes	0.8%
666	Accelerated Idioventricular Rhythm	0.8%
667	Arteriovenous fistula	0.7%
668	Philadelphia Chromosome	0.7%
669	Rectal Fistula	0.7%
670	Anal Fistula	0.7%
671	Endotoxemia	0.7%
672	Kidney Calculi	0.6%
673	Ureteral Calculi	0.6%
674	Basal Ganglia Hemorrhage	0.5%
675	Candidemia	0.5%
676	Putaminal Hemorrhage	0.4%

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