MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Premenstrual syndrome

(UMLS:C0033046)

Definition:: A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.
UMLS ID:: C0033046
MeSH ID:: D011293

Classification:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.568.968

Synonym(s)

Premenstrual syndrome

Menstrual molimen

PMS

PMS - Premenstrual syndrome

PREMENSTRUAL SYNDROME

Premenstrual Syndrome

pms premenstrual syndrome

premenstrual syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Norgestrel	FAERS: 202 Canada Vigilance: 8		Canada Vigilance SIDER US FAERS
2	Isotretinoin	FAERS: 34		US FAERS
3	NuvaRing	FAERS: 26		SIDER US FAERS
4	etonogestrel	FAERS: 22		SIDER US FAERS
5	Ortho Evra	FAERS: 20		US FAERS
6	Medroxyprogesterone Acetate	FAERS: 18		US FAERS
7	Copper	FAERS: 15		US FAERS
8	Varenicline	FAERS: 10		US FAERS
9	beyaz	FAERS: 8		US FAERS
10	drospirenone and ethinyl estradiol combination	FAERS: 8	19363241	CTD US FAERS
11	Ethinyl Estradiol-Norgestrel Combination	FAERS: 7	4263090	CTD US FAERS
12	Estradiol	FAERS: 6 Canada Vigilance: 2		Canada Vigilance US FAERS
13	Paroxetine	FAERS: 6 Canada Vigilance: 1	12352284	CTD Canada Vigilance US FAERS
14	Duavee	FAERS: 5		US FAERS
15	teriflunomide	FAERS: 5		US FAERS
16	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 4		US FAERS
17	Atomoxetine Hydrochloride	FAERS: 4		US FAERS
18	Norethindrone	FAERS: 4		US FAERS
19	norgestimate, ethinyl estradiol drug combination	FAERS: 4		US FAERS
20	Anastrozole	FAERS: 3		US FAERS
21	Dimethyl Fumarate	FAERS: 3		US FAERS
22	Duloxetine Hydrochloride	FAERS: 3		US FAERS
23	Estrogens, Conjugated (USP)	FAERS: 3		US FAERS
24	Lamotrigine	FAERS: 3		US FAERS
25	Letrozole	FAERS: 3		US FAERS
26	Paroxetine	FAERS: 3		US FAERS
27	Pregabalin	FAERS: 3		US FAERS
28	Sertraline	FAERS: 3		US FAERS
29	Xulane	FAERS: 3		US FAERS
30	exemestane	FAERS: 3		US FAERS
31	Aripiprazole	FAERS: 2		SIDER US FAERS
32	Carbamazepine	FAERS: 2		US FAERS
33	Citalopram	FAERS: 2		US FAERS
34	Desogestrel	FAERS: 2		US FAERS
35	Levetiracetam	FAERS: 2		US FAERS
36	Nicotine	FAERS: 2		US FAERS
37	Oxcarbazepine	FAERS: 2		US FAERS
38	Thyroxine	FAERS: 2		US FAERS
39	apremilast	FAERS: 2		US FAERS
40	montelukast	FAERS: 2		US FAERS
41	palbociclib	FAERS: 2		US FAERS
42	4-Aminopyridine	FAERS: 1		US FAERS
43	4-hydroxybutyric acid	FAERS: 1		US FAERS
44	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
45	Cimetidine	FAERS: 1		US FAERS
46	Ciprofloxacin	FAERS: 1		US FAERS
47	Citalopram	FAERS: 1		US FAERS
48	Citalopram	FAERS: 1		US FAERS
49	Dasatinib	FAERS: 1		US FAERS
50	Dehydroepiandrosterone	FAERS: 1		US FAERS
51	Fingolimod Hydrochloride	FAERS: 1		US FAERS
52	Fluoxetine	FAERS: 1 Canada Vigilance: 1	8071300 12521737	CTD Canada Vigilance US FAERS
53	Gabapentin	FAERS: 1		US FAERS
54	Gildess Fe 1/20	FAERS: 1		US FAERS
55	Glatiramer Acetate	FAERS: 1		US FAERS
56	Ibandronic Acid	FAERS: 1		US FAERS
57	Ibuprofen	FAERS: 1		US FAERS
58	Leuprolide	FAERS: 1		US FAERS
59	Lisdexamfetamine Dimesylate	FAERS: 1		US FAERS
60	Megestrol	FAERS: 1		US FAERS
61	Minoxidil	FAERS: 1		US FAERS
62	Norethindrone acetate and ethinyl estradiol	FAERS: 1		US FAERS
63	Olanzapine	FAERS: 1		SIDER US FAERS
64	Qlaira	FAERS: 1		US FAERS
65	Quetiapine Fumarate	FAERS: 1		US FAERS
66	Raloxifene Hydrochloride	FAERS: 1		US FAERS
67	Restasis	FAERS: 1		US FAERS
68	Rivaroxaban	FAERS: 1		US FAERS
69	Sertraline	FAERS: 1		US FAERS
70	Tamoxifen	FAERS: 1		US FAERS
71	Telmisartan	FAERS: 1		US FAERS
72	Teriparatide	FAERS: 1		US FAERS
73	Thyroxine	FAERS: 1		US FAERS
74	Topiramate	FAERS: 1		US FAERS
75	Triamcinolone Acetonide	FAERS: 1		US FAERS
76	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
77	Viekira Pak	FAERS: 1		US FAERS
78	Zoely	FAERS: 1		US FAERS
79	dienogest	FAERS: 1		US FAERS
80	histrelin	FAERS: 1		US FAERS
81	norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination	FAERS: 1		US FAERS
82	zaleplon	FAERS: 1		US FAERS
83	Alprazolam			SIDER
84	Bupropion			SIDER
85	Capecitabine			SIDER
86	Citalopram		18344730	CTD SIDER
87	Doxycycline			SIDER
88	Dydrogesterone		3076492	CTD
89	Fluvoxamine		8698682	CTD SIDER
90	Indinavir			SIDER
91	Medroxyprogesterone			SIDER
92	Phenobarbital		8270591	CTD
93	Progesterone			SIDER
94	Vigabatrin	Canada Vigilance: 1		Canada Vigilance
95	estradiol, norethindrone drug combination	Canada Vigilance: 2		Canada Vigilance
96	ropinirole			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Amenorrhea	46.7%
2	Oligomenorrhea	46.7%
3	Dysmenorrhea	33.3%
4	Ascites	31%
5	Fibrosis	31%
6	Gliosis	31%
7	Growth Disorders	31%
8	Hemorrhage	31%
9	Hyperbilirubinemia	31%
10	Hyperplasia	31%
11	Inflammation	31%
12	Intraoperative Complications	31%
13	Ischemia	31%
14	Lithiasis	31%
15	Malacoplakia	31%
16	Metaplasia	31%
17	Nerve Degeneration	31%
18	Ochronosis	31%
19	Postoperative Complications	31%
20	Sclerosis	31%
21	Shock	31%
22	Ulcer	31%
23	Hyperammonemia	31%
24	Hyperamylasemia	31%
25	Teratogenesis	31%
26	Cardiac Death	31%
27	Hypovolemia	31%
28	Hyperuricemia	31%
29	Leukoaraiosis	31%
30	Dysbacteriosis	31%
31	Delayed Graft Function	31%
32	Cirrhosis	31%
33	Neointima	31%
34	Dysbiosis	31%
35	Menorrhagia	30.2%
36	Polydipsia	27.9%
37	Infarction	26.7%
38	Postoperative Hemorrhage	26.7%
39	Shock, Hemorrhagic	26.7%
40	Systemic Inflammatory Response Syndrome	26.7%
41	Extravasation of Diagnostic and Therapeutic Materials	22%
42	Neoplastic Processes	22%
43	Vascular Remodeling	21.1%
44	Necrosis	20.9%
45	Granulomatosis, Orofacial	20.9%
46	Pigmentation Disorders	20.9%
47	Respiratory Aspiration	20.9%
48	Acantholysis	20.5%
49	Chromosome Aberrations	20.5%
50	Dehydration	20.5%
51	Granuloma	20.5%
52	Leukocytosis	20.5%
53	Pleocytosis	20.5%
54	Acute Disease	20%
55	Acute-Phase Reaction	20%
56	Chronic disease	20%
57	Critical Illness	20%
58	Sudden death	20%
59	Fat necrosis	20%
60	Gangrene	20%
61	Graft Occlusion, Vascular	20%
62	Granuloma, Plasma Cell	20%
63	Hematoma	20%
64	Iatrogenic Disease	20%
65	Multiple Organ Failure	20%
66	Recurrence	20%
67	Retrograde Degeneration	20%
68	Retroperitoneal fibrosis	20%
69	Serositis	20%
70	Subcutaneous Emphysema	20%
71	Surgical Wound Dehiscence	20%
72	Syndrome	20%
73	Wallerian Degeneration	20%
74	Pyogenic granuloma	20%
75	Exsanguination	20%
76	Disease Progression	20%
77	Seroma	20%
78	Delayed Emergence from Anesthesia	20%
79	Infant Death	20%
80	Anastomotic Leak	20%
81	Intraoperative Awareness	20%
82	Sudden infant death syndrome	19.6%
83	Signs and Symptoms	18.5%
84	Pathological Conditions, Anatomical	18.5%
85	Incisional hernia	17.8%
86	jaundice	17.8%
87	Pain, Postoperative	16.5%
88	Chromosomal Instability	16.1%
89	Genomic Instability	16.1%
90	Failed Back Surgery Syndrome	15.8%
91	Azotemia	14.9%
92	Tissue Adhesions	14.8%
93	Postoperative Nausea and Vomiting	14.8%
94	Hematoma, Epidural, Spinal	14.8%
95	Asphyxia	14.3%
96	Granuloma, Respiratory Tract	14.3%
97	Shock, Traumatic	14.3%
98	Muscle Weakness	14.3%
99	Eye Hemorrhage	14%
100	Disease susceptibility	13.6%
101	Fetal Death	13.6%
102	Foreign-Body Reaction	13.6%
103	Gastrointestinal Hemorrhage	13.6%
104	Hemarthrosis	13.6%
105	Hemoperitoneum	13.6%
106	Hemothorax	13.6%
107	Neoplasm Invasiveness	13.6%
108	Neoplasm Metastasis	13.6%
109	Neoplasm Recurrence, Local	13.6%
110	Postpericardiotomy Syndrome	13.6%
111	Prosthesis Failure	13.6%
112	Reperfusion Injury	13.6%
113	Injection Site Reaction	13.6%
114	Retrobulbar Hemorrhage	13.6%
115	Aseptic Necrosis of Bone	13.6%
116	Peritoneal Fibrosis	13.6%
117	Carcinogenesis	13.6%
118	Neurogenic Inflammation	13.6%
119	Perinatal death	13.6%
120	Infusion site reaction	13.6%
121	Nephrogenic Fibrosing Dermopathy	13.6%
122	Corneal Endothelial Cell Loss	13.6%
123	Encapsulating Peritoneal Sclerosis	13.6%
124	Vasoplegia	13.6%
125	Suppuration	13.6%
126	Nephrogenic Systemic Fibrosis	13.6%
127	Metastasis	13.6%
128	Hemoptysis	13.6%
129	Endotoxic shock	13.5%
130	Septic Shock	13.5%
131	Toxic Shock Syndrome	13.5%
132	Sinus Arrhythmia	13.3%
133	Atrial Fibrillation	13.3%
134	Atrial Flutter	13.3%
135	Dental Pulp Necrosis	13.3%
136	Ecchymosis	13.3%
137	Granuloma, Foreign-Body	13.3%
138	Mediastinal Emphysema	13.3%
139	Petechiae	13.3%
140	Purpura	13.3%
141	Surgical Wound Infection	13.3%
142	Ventricular Fibrillation	13.3%
143	Ventricular Flutter	13.3%
144	Parasystole	13.3%
145	Paroxysmal atrial fibrillation	13.3%
146	Facies	13.3%
147	Bradycardia	13.3%
148	Embryo Loss	13.3%
149	Afferent Loop Syndrome	13.2%
150	Sex Chromosome Aberrations	13.2%
151	Short Bowel Syndrome	13.2%
152	Uterine hemorrhage	13.2%
153	No-Reflow Phenomenon	13.2%
154	Jaundice, Obstructive	13%
155	Cardiotoxicity	12.4%
156	Hematoma, Subdural, Spinal	12.2%
157	Chromosome Fragility	11.7%
158	Epistaxis	11%
159	Drowning	10.5%
160	Asthenia	10.3%
161	Body Temperature Changes	10.3%
162	Calculi	10.3%
163	Cyanosis	10.3%
164	Edema	10.3%
165	Failure to Thrive	10.3%
166	Fatigue	10.3%
167	Feminization	10.3%
168	Fetal Distress	10.3%
169	Hernia	10.3%
170	Hypertrophy	10.3%
171	Motion Sickness	10.3%
172	Nails, Malformed	10.3%
173	polyps	10.3%
174	Rupture, Spontaneous	10.3%
175	Signs and Symptoms, Digestive	10.3%
176	Signs and Symptoms, Respiratory	10.3%
177	Skin Manifestations	10.3%
178	Chills	10.3%
179	Lassitude	10.3%
180	Enterocele	10.3%
181	Atheroma	10.3%
182	Pseudophakia	10.3%
183	Urological Manifestations	10.3%
184	Stenosis	10.3%
185	Facial asymmetry	10.3%
186	Mobility Limitation	10.3%
187	Somnolence	10.3%
188	Plaque, Amyloid	10.3%
189	Plaque, Atherosclerotic	10.3%
190	Fetal Growth Retardation	10.2%
191	DNA Degradation, Necrotic	10.2%
192	Cross Infection	10.1%
193	Hyphema	10.1%
194	Retinal Neovascularization	10.1%
195	Septicemia	10.1%
196	Vitreous Hemorrhage	10.1%
197	Sepsis	10.1%
198	Aneuploidy	10.1%
199	Polyploidy	10.1%
200	Microsatellite Instability	10.1%
201	Heart Block	10%
202	Tachycardia	10%
203	Tachyarrhythmia	10%
204	Cicatrix	10%
205	Hematuria	9.9%
206	Granuloma Annulare	9.9%
207	Chromosome Breakage	9.9%
208	Abscess	9.9%
209	Empyema	9.9%
210	Femur Head Necrosis	9.9%
211	Fetal Resorption	9.9%
212	Lymphatic Metastasis	9.9%
213	Neoplasms, Unknown Primary	9.9%
214	Peptic Ulcer Hemorrhage	9.9%
215	Sudden Cardiac Death	9.9%
216	Leukemic Infiltration	9.9%
217	Choroidal Neovascularization	9.9%
218	Primary Graft Dysfunction	9.9%
219	Neoplasm Micrometastasis	9.9%
220	Brain Death	9.9%
221	Hematemesis	9.8%
222	Shock, Cardiogenic	9.8%
223	Dumping Syndrome	9.8%
224	Cicatrix, Hypertrophic	9.8%
225	Sinus Arrest, Cardiac	9.8%
226	Purpura Fulminans	9.8%
227	Metrorrhagia	9.7%
228	Sick Sinus Syndrome	9.7%
229	Trisomy	9.7%
230	Viremia	8.8%
231	Parasitemia	8.8%
232	Hematoma, Subdural	8.3%
233	Hematoma, Epidural, Cranial	8.3%
234	Giant Cell Epulis	8.2%
235	Long QT Syndrome	7.9%
236	Micronuclei, Chromosome-Defective	7.8%
237	Abdominal Pain	7.7%
238	Retinal Hemorrhage	7.7%
239	Phantom pain	7.6%
240	Phantom Limb Pain	7.6%
241	Choroid Hemorrhage	7.6%
242	Melena	7.6%
243	Postpartum Hemorrhage	7.4%
244	Gingival Hemorrhage	7.4%
245	Keloid	7.4%
246	Monosomy	7.3%
247	Tetraploidy	7.3%
248	Stillbirth	7.3%
249	Adams-Stokes Syndrome	7.3%
250	Atrioventricular Block	7.3%
251	Bundle-Branch Block	7.3%
252	Cyst	7.3%
253	Eye Manifestations	7.3%
254	Neurologic Manifestations	7.3%
255	Atrial Premature Complexes	7.3%
256	Sinoatrial Block	7.3%
257	Tachycardia, Paroxysmal	7.3%
258	Supraventricular tachycardia	7.3%
259	Tachycardia, Ventricular	7.3%
260	Tachycardia, Reciprocating	7.3%
261	Subarachnoid Hemorrhage	7.3%
262	Cerebral Hemorrhage	7.3%
263	Leukoplakia	7%
264	Cardiac Output, High	7%
265	Myocardial Stunning	7%
266	Reticulocytosis	7%
267	Low Cardiac Output Syndrome	7%
268	Airway Remodeling	7%
269	Hematoma, Subdural, Intracranial	6.8%
270	Hematoma, Subdural, Chronic	6.8%
271	Hematoma, Subdural, Acute	6.8%
272	Ventricular Remodeling	6.8%
273	Subacute Combined Degeneration	6.7%
274	Alopecia	6.7%
275	Intermittent Claudication	6.7%
276	Androgenetic Alopecia	6.7%
277	Thrombocytopenic purpura	6.7%
278	Anorexia	6.7%
279	Anoxia	6.7%
280	Constipation	6.7%
281	Diarrhea	6.7%
282	Dyspepsia	6.7%
283	Eructation	6.7%
284	Fever	6.7%
285	Flatulence	6.7%
286	Flushing	6.7%
287	Halitosis	6.7%
288	Heartburn	6.7%
289	Diaphragmatic Hernia	6.7%
290	Hiccough	6.7%
291	Hypercalciuria	6.7%
292	Hypercapnia	6.7%
293	Hyperphagia	6.7%
294	Intestinal Polyps	6.7%
295	Nausea	6.7%
296	Pallor	6.7%
297	Psychophysiologic Disorders	6.7%
298	Splenomegaly	6.7%
299	Vomiting	6.7%
300	Hypocapnia	6.7%
301	Dyschezia	6.7%
302	Hypoxia	6.7%
303	Hyperoxia	6.7%
304	Lower Urinary Tract Symptoms	6.7%
305	Hypoxemia	6.7%
306	Urinoma	6.7%
307	Eosinophilic Granuloma	6.6%
308	Purpura, Hyperglobulinemic	6.5%
309	Bacteremia	6.3%
310	Cell Transformation, Viral	6.2%
311	Fungemia	6.2%
312	Cellulitis	6%
313	Tachycardia, Atrioventricular Nodal Reentry	6%
314	Tachycardia, Ectopic Atrial	6%
315	Tachycardia, Ectopic Junctional	6%
316	Sinus Tachycardia	6%
317	Torsades de Pointes	6%
318	Accelerated Idioventricular Rhythm	6%
319	Renal Colic	6%
320	Abdomen, Acute	5.9%
321	Eye pain	5.9%
322	Romano-Ward Syndrome	5.8%
323	Muscular Atrophy	5.8%
324	Kernicterus	5.7%
325	Endotoxemia	5.5%
326	Purpura, Thrombotic Thrombocytopenic	5.4%
327	Hypergammaglobulinemia	5.2%
328	Granuloma, Laryngeal	5.1%
329	Diverticulum	5%
330	Diverticulosis	5%
331	Myocardial Reperfusion Injury	5%
332	Back Pain	4.9%
333	Bulimia	4.9%
334	Neck Pain	4.9%
335	Chest Pain	4.9%
336	Colonic Polyps	4.9%
337	Dizziness	4.9%
338	Dysuria	4.9%
339	Facial Pain	4.9%
340	Fever of Unknown Origin	4.9%
341	Flank Pain	4.9%
342	Headache	4.9%
343	Nocturia	4.9%
344	Pain, Intractable	4.9%
345	Pelvic Pain	4.9%
346	Snoring	4.9%
347	Chronic pain	4.9%
348	Lightheadedness	4.9%
349	Pain, Referred	4.9%
350	Prostatism	4.9%
351	Throbbing Headache	4.9%
352	Labor Pain	4.9%
353	Cancer Pain	4.9%
354	Nociceptive Pain	4.9%
355	Respiratory Tract Fistula	4.8%
356	Apnea	4.5%
357	Cheyne-Stokes Respiration	4.5%
358	Decerebrate State	4.5%
359	Dyspnea	4.5%
360	Cardiomegaly	4.5%
361	Hemiparesis	4.5%
362	Hepatomegaly	4.5%
363	Hyperventilation	4.5%
364	Meningism	4.5%
365	Mouth Breathing	4.5%
366	Paresis	4.5%
367	Parovarian Cyst	4.5%
368	Pruritus	4.5%
369	Seizures	4.5%
370	Sensation Disorders	4.5%
371	Sneezing	4.5%
372	Spermatocele	4.5%
373	Erythema	4.5%
374	Oral Fistula	4.5%
375	Complex partial seizures	4.5%
376	Necrolytic Migratory Erythema	4.5%
377	Tachypnea	4.5%
378	Monoparesis	4.5%
379	Cutaneous Fistula	4.5%
380	Gait Disorders, Neurologic	4.5%
381	Neuromuscular Manifestations	4.5%
382	Cardiac Hypertrophy	4.5%
383	Sarcopenia	4.5%
384	Edema, Cardiac	4.4%
385	Mental Fatigue	4.4%
386	Hirsutism	4.4%
387	Orthostatic intolerance	4.4%
388	Hypoventilation	4.4%
389	Vaginal Fistula	4.4%
390	Rectocele	4.4%
391	Body Weight Changes	4.4%
392	Autoimmune thrombocytopenia	4.1%
393	Immune thrombocytopenic purpura	4.1%
394	Philadelphia Chromosome	4.1%
395	Emaciation	4.1%
396	Low Back Pain	4.1%
397	Visceral Pain	4.1%
398	Waterhouse-Friderichsen Syndrome	3.9%
399	Sleep Wake Disorders	3.7%
400	Cachexia	3.6%
401	Candidemia	3.6%
402	Gait Ataxia	3.6%
403	Pupil Disorders	3.6%
404	Neurobehavioral Manifestations	3.6%
405	Nasal Polyps	3.4%
406	Basal Ganglia Hemorrhage	3.4%
407	Pleural Rub	3.4%
408	Rales	3.4%
409	Respiratory Sounds	3.4%
410	Rhonchi	3.4%
411	Stridor	3.4%
412	Wheezing	3.4%
413	Asterixis	3.4%
414	Ballismus	3.4%
415	Biliary Fistula	3.4%
416	Gastric Fistula	3.4%
417	Congenital diaphragmatic hernia	3.4%
418	Morning Sickness	3.4%
419	Vertigo	3.4%
420	Hoarseness	3.3%
421	Pain	3.3%
422	Livedo Reticularis	3.3%
423	Ache	3.3%
424	Meningocele	3.3%
425	Oliguria	3.3%
426	Polyuria	3.3%
427	Proteinuria	3.3%
428	Urinary Calculi	3.3%
429	Encephalocele	3.3%
430	Anosmia	3.3%
431	Ataxia	3.3%
432	Athetosis	3.3%
433	Catalepsy	3.3%
434	Dental Fistula	3.3%
435	Dystonia	3.3%
436	Hemiplegia	3.3%
437	Locked-In Syndrome	3.3%
438	Muscle Hypertonia	3.3%
439	Muscle hypotonia	3.3%
440	Myoclonus	3.3%
441	Myotonia	3.3%
442	Neuralgia	3.3%
443	Oroantral Fistula	3.3%
444	Paraplegia	3.3%
445	Pseudobulbar Palsy	3.3%
446	Quadriplegia	3.3%
447	Spasm	3.3%
448	Spastic Paraplegia	3.3%
449	Status Epilepticus	3.3%
450	Taste Disorders	3.3%
451	Tremor	3.3%
452	Monoplegia	3.3%
453	Hypokinesia	3.3%
454	Left Ventricular Hypertrophy	3.3%
455	Gastroparesis	3.3%
456	Right Ventricular Hypertrophy	3.3%
457	Paraparesis	3.3%
458	Bradykinesia	3.3%
459	Waxy flexibility	3.3%
460	Action Tremor	3.3%
461	Resting Tremor	3.3%
462	Dysosmia	3.3%
463	Quadriparesis	3.3%
464	Olfaction Disorders	3.3%
465	Myokymia	3.3%
466	Somatosensory Disorders	3.3%
467	Neuropathic pain	3.3%
468	Hyperkinesia	3.3%
469	Intention tremor	3.3%
470	Body Weight	3.3%
471	Rectal Prolapse	3.3%
472	Uterine Prolapse	3.3%
473	Vaginal Prolapse	3.3%
474	Underweight	3.2%
475	Overweight	3.2%
476	Weight Gain	3.2%
477	Putaminal Hemorrhage	3.1%
478	Akathisia	3%
479	Restlessness	3%
480	Psychomotor Agitation	3%
481	Vesicovaginal Fistula	2.9%
482	Gait Apraxia	2.8%
483	Umbilical hernia	2.8%
484	Toothache	2.8%
485	Voice Disorders	2.8%
486	Voice Disturbance	2.8%
487	Hyperemesis Gravidarum	2.7%
488	Dysgeusia	2.7%
489	Formication	2.7%
490	Gagging	2.7%
491	Hyperalgesia	2.7%
492	Hyperesthesia	2.7%
493	Hypesthesia	2.7%
494	Language Disorders	2.7%
495	Numbness	2.7%
496	Paresthesia	2.7%
497	Paraparesis, Spastic	2.7%
498	Trismus	2.7%
499	Epilepsia Partialis Continua	2.7%
500	Hypogeusia	2.7%
501	Brown-Sequard Syndrome	2.7%
502	Lockjaw	2.7%
503	Allodynia	2.7%
504	Ageusia	2.7%
505	Leukoplakia, Oral	2.6%
506	Vision Disorders	2.6%
507	Metamorphopsia	2.6%
508	Visual Impairment	2.6%
509	Bronchial Fistula	2.6%
510	Metatarsalgia	2.6%
511	Pancreatic Fistula	2.6%
512	Anisocoria	2.5%
513	Confusion	2.5%
514	Facial paralysis	2.5%
515	Intestinal Fistula	2.5%
516	Lethargy	2.5%
517	Memory Disorders	2.5%
518	Muscle Cramp	2.5%
519	Perceptual Disorders	2.5%
520	Psychomotor Disorders	2.5%
521	Tonic Pupil	2.5%
522	Anhedonia	2.5%
523	Disorientation	2.5%
524	Gastroschisis	2.5%
525	Enterocutaneous Fistula	2.5%
526	Fetal Hypoxia	2.5%
527	Facial Paresis	2.5%
528	Memory Loss	2.5%
529	Hemisensory Neglect	2.5%
530	Dysacusis	2.5%
531	Dyspnea, Paroxysmal	2.5%
532	Mastodynia	2.5%
533	Respiratory Paralysis	2.5%
534	Salivary Gland Fistula	2.5%
535	Chorea	2.5%
536	Cystocele	2.5%
537	Tetany	2.5%
538	Urinary Incontinence	2.5%
539	Breakthrough Pain	2.5%
540	Albuminuria	2.4%
541	Hemoglobinuria	2.4%
542	Agraphia	2.4%
543	Alexia	2.4%
544	Anomia	2.4%
545	Cluttering	2.4%
546	Language Development Disorders	2.4%
547	Speech Disorders	2.4%
548	Syncope	2.4%
549	Stupor	2.4%
550	Dysgraphia	2.4%
551	Dyslexia	2.4%
552	Presyncope	2.4%
553	Dyslalia	2.4%
554	Alice in Wonderland Syndrome	2.3%
555	Aphasia	2.3%
556	Articulation Disorders	2.3%
557	Echolalia	2.3%
558	Stuttering	2.3%
559	Dysphasia	2.3%
560	Jet Lag Syndrome	2.2%
561	Reflex, Abnormal	2.2%
562	Hyporeflexia	2.2%
563	Hyperreflexia	2.2%
564	Dysarthria	2.2%
565	Birth Weight	2.1%
566	Diplopia	2.1%
567	Muscle Rigidity	2.1%
568	Muscle Spasticity	2.1%
569	Scotoma	2.1%
570	Photophobia	2.1%
571	Cogwheel Rigidity	2.1%
572	Hemifacial Spasm	2.1%
573	Amaurosis	2.1%
574	Blindness	2.1%
575	Nuchal Rigidity	2.1%
576	Angina Pectoris	2.1%
577	Agnosia	2%
578	Apraxias	2%
579	Consciousness Disorders	2%
580	Hallucinations	2%
581	Hemianopsia	2%
582	Mental Retardation	2%
583	Hyperacusis	2%
584	Tinnitus	2%
585	Visual Agnosia	2%
586	Anosognosia	2%
587	Wernicke-Korsakoff Syndrome	2%
588	Depressed Level of Consciousness	2%
589	Phonophobia	2%
590	Mental deficiency	2%
591	Intellectual Disability	2%
592	Hearing Loss	2%
593	Cerebellar Ataxia	2%
594	Torticollis	2%
595	Sciatica	2%
596	Urge Incontinence	2%
597	Tardive Dyskinesia	2%
598	Catatonia	2%
599	Musculoskeletal Pain	2%
600	Ophthalmoplegia	2%
601	External Ophthalmoplegia	2%
602	Aphonia	2%
603	Arthralgia	2%
604	Sleep Deprivation	2%
605	Polyarthralgia	2%
606	Dysphonia	2%
607	Cerebrospinal Fluid Otorrhea	2%
608	Cerebrospinal Fluid Rhinorrhea	2%
609	Obesity	1.9%
610	Amaurosis Fugax	1.8%
611	Blindness, Cortical	1.8%
612	Dyscalculia	1.8%
613	Angina, Unstable	1.8%
614	Deafness	1.8%
615	Hearing Loss, Sudden	1.8%
616	Gerstmann Syndrome	1.8%
617	Hearing Loss, Bilateral	1.8%
618	Hearing Loss, High-Frequency	1.8%
619	Hearing Loss, Mixed Conductive-Sensorineural	1.8%
620	Prosopagnosia	1.8%
621	Apraxia, Ideomotor	1.8%
622	Persistent Vegetative State	1.8%
623	Charles Bonnet Syndrome	1.8%
624	Hearing Loss, Unilateral	1.8%
625	Complete Hearing Loss	1.8%
626	Alien Hand Syndrome	1.8%
627	Deaf Mutism	1.8%
628	Mutism	1.7%
629	Selective Mutism	1.7%
630	Angina Pectoris, Variant	1.7%
631	Vocal Cord Paralysis	1.7%
632	Alexia, Pure	1.7%
633	Amblyopia	1.7%
634	Amnesia	1.7%
635	Delirium	1.7%
636	Horner Syndrome	1.7%
637	Dissociative Amnesia	1.7%
638	Color blindness	1.7%
639	Global Amnesia	1.7%
640	Hydrops Fetalis	1.7%
641	Urinary Bladder Fistula	1.6%
642	Rectal Fistula	1.6%
643	Anal Fistula	1.6%
644	Fetal Weight	1.6%
645	Shoulder Pain	1.6%
646	Tinea Pedis	1.6%
647	Pediatric Obesity	1.6%
648	Retrograde amnesia	1.5%
649	Amnesia, Anterograde	1.5%
650	Dyskinesia, Drug-Induced	1.4%
651	Akathisia, Drug-Induced	1.4%
652	Alcohol Withdrawal Seizures	1.4%
653	Arteriovenous fistula	1.4%
654	Myalgia	1.4%
655	Amnesia, Transient Global	1.2%
656	Kidney Calculi	1.2%
657	Ureteral Calculi	1.2%
658	Auditory Perceptual Disorders	1.2%
659	Ophthalmoplegic Migraine	1%
660	Progressive supranuclear palsy	1%
661	Kearns-Sayre syndrome	0.7%

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