Emtricitabine, Rilpivirine, Tenofovir Drug Combination
(DQEFVRYFVZNIMK-FEDPJRJMSA-N)
Structure
- SMILES
- Nc1nc(=O)n(cc1F)[C@@H]1CS[C@@H](O1)CO.C[C@H](Cn1cnc2c1ncnc2N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.OC(=O)/C=C/C(=O)O.N#C/C=C/c1cc(C)c(c(c1)C)Nc1ccnc(n1)Nc1ccc(cc1)C#N
- Molecular Formula:
- C53H62FN14O17PS
- Molecular Weight:
- 1249.180
- Log P:
- 8.5899
- Hydrogen Bond Acceptor:
- 30
- Hydrogen Bond Donor:
- 7
- TPSA:
- 482.94
- CAS Number(s):
- 1436864-99-1
Synonym(s)
1.
Emtricitabine, Rilpivirine, Tenofovir Drug Combination
2.
Complera
3.
Emtricitabine Rilpivirine Tenofovir Drug Combination
4.
Emtricitabine-Rilpivirine-Tenofovir Drug Combination
5.
Combination, Emtricitabine-Rilpivirine-Tenofovir Drug
6.
Drug Combination, Emtricitabine-Rilpivirine-Tenofovir
External Link(s)
| MeSH | D000068678 |
| PubChem Compound | 44128157 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Anxiety | FAERS: 31 | US FAERS | |
| 2 | Pregnancy | FAERS: 31 | US FAERS | |
| 3 | Pain | FAERS: 29 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 4 | Drug ineffective | FAERS: 25 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 5 | Economic problem | FAERS: 22 | US FAERS | |
| 6 | Anhedonia | FAERS: 21 | US FAERS | |
| 7 | Emotional distress | FAERS: 21 | US FAERS | |
| 8 | Fatigue | FAERS: 20 | US FAERS | |
| 9 | Nausea | FAERS: 20 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 10 | Osteoporosis | FAERS: 19 | US FAERS | |
| 11 | Dizziness | FAERS: 16 | US FAERS | |
| 12 | Headache | FAERS: 14 | US FAERS | |
| 13 | Myalgia | FAERS: 13 | US FAERS | |
| 14 | Unevaluable event | FAERS: 10 | US FAERS | |
| 15 | Viral load increased | FAERS: 10 | US FAERS | |
| 16 | Abdominal discomfort | FAERS: 9 | US FAERS | |
| 17 | Drug dose omission | FAERS: 9 | US FAERS | |
| 18 | Genotype drug resistance test positive | FAERS: 8 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 19 | Virologic failure | FAERS: 8 | US FAERS | |
| 20 | Weight decreased | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 21 | Arthralgia | FAERS: 7 | US FAERS | |
| 22 | Bone density decreased | FAERS: 7 | US FAERS | |
| 23 | Feeling abnormal | FAERS: 7 | US FAERS | |
| 24 | Malaise | FAERS: 7 | US FAERS | |
| 25 | Alopecia | FAERS: 6 | US FAERS | |
| 26 | Pruritus | FAERS: 6 | US FAERS | |
| 27 | Rhabdomyolysis | FAERS: 6 | US FAERS | |
| 28 | Accidental overdose | FAERS: 5 | US FAERS | |
| 29 | Flatulence | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 30 | Maternal exposure during pregnancy | FAERS: 5 | US FAERS | |
| 31 | Pathogen resistance | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 32 | Tooth Loss | FAERS: 5 | US FAERS | |
| 33 | Tremor | FAERS: 5 | US FAERS | |
| 34 | treatment failure | FAERS: 5 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 35 | Acute kidney injury | FAERS: 4 | US FAERS | |
| 36 | Back Pain | FAERS: 4 | US FAERS | |
| 37 | Bone density abnormal | FAERS: 4 | US FAERS | |
| 38 | CD4 Lymphocytes Decreased | FAERS: 4 | US FAERS | |
| 39 | Diabetes Mellitus | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 40 | Drug resistance | FAERS: 4 | US FAERS | |
| 41 | Dry skin | FAERS: 4 | US FAERS | |
| 42 | Hordeolum | FAERS: 4 | US FAERS | |
| 43 | Lip swelling | FAERS: 4 | US FAERS | |
| 44 | Product quality issue | FAERS: 4 | US FAERS | |
| 45 | Therapy cessation | FAERS: 4 | US FAERS | |
| 46 | Amnesia | FAERS: 3 | US FAERS | |
| 47 | Asthenia | FAERS: 3 | US FAERS | |
| 48 | Chest Pain | FAERS: 3 | US FAERS | |
| 49 | Depressed mood | FAERS: 3 | US FAERS | |
| 50 | Fracture | FAERS: 3 | US FAERS | |
| 51 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 52 | Intentional product use issue | FAERS: 3 | US FAERS | |
| 53 | Memory impairment | FAERS: 3 | US FAERS | |
| 54 | Myocardial Infarction | FAERS: 3 | US FAERS | |
| 55 | Nasopharyngitis | FAERS: 3 | US FAERS | |
| 56 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 57 | Neutropenia | FAERS: 3 | US FAERS | |
| 58 | Osteopenia | FAERS: 3 | US FAERS | |
| 59 | Overdose | FAERS: 3 | US FAERS | |
| 60 | Product physical issue | FAERS: 3 | US FAERS | |
| 61 | Product taste abnormal | FAERS: 3 | US FAERS | |
| 62 | Psoriasis | FAERS: 3 | US FAERS | |
| 63 | Suicide attempt | FAERS: 3 | US FAERS | |
| 64 | Tinnitus | FAERS: 3 | US FAERS | |
| 65 | Vomiting | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 66 | Wrong technique in product usage process | FAERS: 3 | US FAERS | |
| 67 | Adverse event | FAERS: 2 | US FAERS | |
| 68 | Anger | FAERS: 2 | US FAERS | |
| 69 | Ankle Fracture | FAERS: 2 | US FAERS | |
| 70 | Basal cell carcinoma | FAERS: 2 | US FAERS | |
| 71 | Blood creatine increased | FAERS: 2 | US FAERS | |
| 72 | Chromaturia | FAERS: 2 | US FAERS | |
| 73 | Constipation | FAERS: 2 | US FAERS | |
| 74 | Contraindicated drug administered | FAERS: 2 | US FAERS | |
| 75 | Dependence | FAERS: 2 | US FAERS | |
| 76 | Diffuse Large B-Cell Lymphoma | FAERS: 2 | US FAERS | |
| 77 | Drug level above therapeutic | FAERS: 2 | US FAERS | |
| 78 | Dyspepsia | FAERS: 2 | US FAERS | |
| 79 | Epistaxis | FAERS: 2 | US FAERS | |
| 80 | Frostbite | FAERS: 2 | US FAERS | |
| 81 | Gastric ulcer | FAERS: 2 | US FAERS | |
| 82 | Gastrostomy | FAERS: 2 | US FAERS | |
| 83 | Hepatitis | FAERS: 2 | US FAERS | |
| 84 | Insurance issue | FAERS: 2 | US FAERS | |
| 85 | Intentional dose omission | FAERS: 2 | US FAERS | |
| 86 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 87 | Lyme Disease | FAERS: 2 | US FAERS | |
| 88 | Maternal exposure before pregnancy | FAERS: 2 | US FAERS | |
| 89 | Mental impairment | FAERS: 2 | US FAERS | |
| 90 | Middle insomnia | FAERS: 2 | US FAERS | |
| 91 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 92 | Osteomalacia | FAERS: 2 | US FAERS | |
| 93 | Palpitations | FAERS: 2 | US FAERS | |
| 94 | Peripheral swelling | FAERS: 2 | US FAERS | |
| 95 | Polyneuropathy | FAERS: 2 | US FAERS | |
| 96 | Product difficult to swallow | FAERS: 2 | US FAERS | |
| 97 | Product dispensing error | FAERS: 2 | US FAERS | |
| 98 | Product dose omission | FAERS: 2 | US FAERS | |
| 99 | Product use issue | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 100 | Regurgitation | FAERS: 2 | US FAERS | |
| 101 | Renal pain | FAERS: 2 | US FAERS | |
| 102 | Sepsis | FAERS: 2 | US FAERS | |
| 103 | Tachyarrhythmia | FAERS: 2 | US FAERS | |
| 104 | Talipes | FAERS: 2 | US FAERS | |
| 105 | Therapy change | FAERS: 2 | US FAERS | |
| 106 | Transaminases increased | FAERS: 2 | US FAERS | |
| 107 | Urinary sediment abnormal | FAERS: 2 | US FAERS | |
| 108 | Urticaria | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 109 | Vertigo | FAERS: 2 | US FAERS | |
| 110 | Abasia | FAERS: 1 | US FAERS | |
| 111 | Abdominal Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 112 | Acute Coronary Syndrome | FAERS: 1 | US FAERS | |
| 113 | Acute hepatitis C | FAERS: 1 | US FAERS | |
| 114 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 115 | Altered state of consciousness | FAERS: 1 | US FAERS | |
| 116 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 117 | Application site pruritus | FAERS: 1 | US FAERS | |
| 118 | Application site reaction | FAERS: 1 | US FAERS | |
| 119 | Arthritis | FAERS: 1 | US FAERS | |
| 120 | Arthropathy | FAERS: 1 | US FAERS | |
| 121 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 122 | Asthma | FAERS: 1 | US FAERS | |
| 123 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 124 | Blood HIV RNA increased | FAERS: 1 | US FAERS | |
| 125 | Blood cholesterol increased | FAERS: 1 | US FAERS | |
| 126 | Blood creatine phosphokinase increased | FAERS: 1 | US FAERS | |
| 127 | Blood creatinine abnormal | FAERS: 1 | US FAERS | |
| 128 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 129 | Blood glucose increased | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 130 | Blood triglycerides increased | FAERS: 1 | US FAERS | |
| 131 | Blood urea abnormal | FAERS: 1 | US FAERS | |
| 132 | Bone pain | FAERS: 1 | US FAERS | |
| 133 | Bowel movement irregularity | FAERS: 1 | US FAERS | |
| 134 | Bronchitis | FAERS: 1 | US FAERS | |
| 135 | Bursitis | FAERS: 1 | US FAERS | |
| 136 | CD4 lymphocytes increased | FAERS: 1 | US FAERS | |
| 137 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 138 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 139 | Cell Death | FAERS: 1 | US FAERS | |
| 140 | Central nervous system lesion | FAERS: 1 | US FAERS | |
| 141 | Chest discomfort | FAERS: 1 | US FAERS | |
| 142 | Chills | FAERS: 1 | US FAERS | |
| 143 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 144 | Cluster Headache | FAERS: 1 | US FAERS | |
| 145 | Cold sweat | FAERS: 1 | US FAERS | |
| 146 | Conjunctivitis | FAERS: 1 | US FAERS | |
| 147 | Creatinine renal clearance decreased | FAERS: 1 | US FAERS | |
| 148 | Deep Vein Thrombosis | FAERS: 1 | US FAERS | |
| 149 | Dehydration | FAERS: 1 | US FAERS | |
| 150 | Dengue Fever | FAERS: 1 | US FAERS | |
| 151 | Discomfort | FAERS: 1 | US FAERS | |
| 152 | Disease Progression | FAERS: 1 | US FAERS | |
| 153 | Dysuria | FAERS: 1 | US FAERS | |
| 154 | Ecchymosis | FAERS: 1 | US FAERS | |
| 155 | Emotional disorder | FAERS: 1 | US FAERS | |
| 156 | Erythema | FAERS: 1 | US FAERS | |
| 157 | Expired product administered | FAERS: 1 | US FAERS | |
| 158 | Fat redistribution | FAERS: 1 | US FAERS | |
| 159 | Feeding tube user | FAERS: 1 | US FAERS | |
| 160 | Feeling Cold | FAERS: 1 | US FAERS | |
| 161 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 162 | Flushing | FAERS: 1 | US FAERS | |
| 163 | Gallbladder pain | FAERS: 1 | US FAERS | |
| 164 | Gastrectomy | FAERS: 1 | US FAERS | |
| 165 | Gastric Bypass | FAERS: 1 | US FAERS | |
| 166 | Gastrointestinal candidiasis | FAERS: 1 | US FAERS | |
| 167 | Gastrointestinal toxicity | FAERS: 1 | US FAERS | |
| 168 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 169 | Growth retardation | FAERS: 1 | US FAERS | |
| 170 | Guillain-Barre Syndrome | FAERS: 1 | US FAERS | |
| 171 | HIV-associated neurocognitive disorder | FAERS: 1 | US FAERS | |
| 172 | Helicobacter test positive | FAERS: 1 | US FAERS | |
| 173 | Hepatitis B DNA assay positive | FAERS: 1 | US FAERS | |
| 174 | Hepatitis C virus test positive | FAERS: 1 | US FAERS | |
| 175 | Hypersomnia | FAERS: 1 | US FAERS | |
| 176 | Hypertrichosis | FAERS: 1 | US FAERS | |
| 177 | Hypotension | FAERS: 1 | US FAERS | |
| 178 | Immune Reconstitution Inflammatory Syndrome | FAERS: 1 | US FAERS | |
| 179 | Impaired work ability | FAERS: 1 | US FAERS | |
| 180 | Inability to afford medication | FAERS: 1 | US FAERS | |
| 181 | Incorrect product storage | FAERS: 1 | US FAERS | |
| 182 | Infection | FAERS: 1 | US FAERS | |
| 183 | Influenza | FAERS: 1 | US FAERS | |
| 184 | Injection related reaction | FAERS: 1 | US FAERS | |
| 185 | Intentional self-injury | FAERS: 1 | US FAERS | |
| 186 | Intercepted wrong patient selected | FAERS: 1 | US FAERS | |
| 187 | Intervertebral Disc Degeneration | FAERS: 1 | US FAERS | |
| 188 | Joint swelling | FAERS: 1 | US FAERS | |
| 189 | Laryngitis | FAERS: 1 | US FAERS | |
| 190 | Lethargy | FAERS: 1 | US FAERS | |
| 191 | Leukopenia | FAERS: 1 | US FAERS | |
| 192 | Limb discomfort | FAERS: 1 | US FAERS | |
| 193 | Lipase increased | FAERS: 1 | US FAERS | |
| 194 | Lipodystrophy acquired | FAERS: 1 | US FAERS | |
| 195 | Long QT Syndrome | FAERS: 1 | US FAERS | |
| 196 | Lymphoma | FAERS: 1 | US FAERS | |
| 197 | Mechanical ileus | FAERS: 1 | US FAERS | |
| 198 | Mechanical ventilation | FAERS: 1 | US FAERS | |
| 199 | Medication residue present | FAERS: 1 | US FAERS | |
| 200 | Menorrhagia | FAERS: 1 | US FAERS | |
| 201 | Mental status changes | FAERS: 1 | US FAERS | |
| 202 | Metrorrhagia | FAERS: 1 | US FAERS | |
| 203 | Mitochondrial cytopathy | FAERS: 1 | US FAERS | |
| 204 | Mononeuritis | FAERS: 1 | US FAERS | |
| 205 | Mood swings | FAERS: 1 | US FAERS | |
| 206 | Muscle tightness | FAERS: 1 | US FAERS | |
| 207 | Myelitis | FAERS: 1 | US FAERS | |
| 208 | Myopathy | FAERS: 1 | US FAERS | |
| 209 | Myositis | FAERS: 1 | US FAERS | |
| 210 | Nasal discomfort | FAERS: 1 | US FAERS | |
| 211 | Night sweats | FAERS: 1 | US FAERS | |
| 212 | Ocular icterus | FAERS: 1 | US FAERS | |
| 213 | Optic Neuritis | FAERS: 1 | US FAERS | |
| 214 | Oral candidiasis | FAERS: 1 | US FAERS | |
| 215 | Oral mucosal erythema | FAERS: 1 | US FAERS | |
| 216 | Oropharyngeal pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 217 | Pain of skin | FAERS: 1 | US FAERS | |
| 218 | Pancreatic Insufficiency | FAERS: 1 | US FAERS | |
| 219 | Pancreatitis | FAERS: 1 | US FAERS | |
| 220 | Pancytopenia | FAERS: 1 | US FAERS | |
| 221 | Paranoia | FAERS: 1 | US FAERS | |
| 222 | Pericarditis | FAERS: 1 | US FAERS | |
| 223 | Pneumonia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 224 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 225 | Porphyria non-acute | FAERS: 1 | US FAERS | |
| 226 | Pre-Eclampsia | FAERS: 1 | US FAERS | |
| 227 | Product packaging issue | FAERS: 1 | US FAERS | |
| 228 | Product prescribing error | FAERS: 1 | US FAERS | |
| 229 | Product size issue | FAERS: 1 | US FAERS | |
| 230 | Product storage error | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 231 | Product use complaint | FAERS: 1 | US FAERS | |
| 232 | Productive Cough | FAERS: 1 | US FAERS | |
| 233 | Proteinuria | FAERS: 1 | US FAERS | |
| 234 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 235 | Purpura | FAERS: 1 | US FAERS | |
| 236 | Quadriplegia | FAERS: 1 | US FAERS | |
| 237 | Renal Colic | FAERS: 1 | US FAERS | |
| 238 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 239 | Sacroiliitis | FAERS: 1 | US FAERS | |
| 240 | Schizophrenia | FAERS: 1 | US FAERS | |
| 241 | Septic Shock | FAERS: 1 | US FAERS | |
| 242 | Sinusitis | FAERS: 1 | US FAERS | |
| 243 | Sjogren's Syndrome | FAERS: 1 | US FAERS | |
| 244 | Skin Papilloma | FAERS: 1 | US FAERS | |
| 245 | Somnolence | FAERS: 1 | US FAERS | |
| 246 | Staring | FAERS: 1 | US FAERS | |
| 247 | Stillbirth | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 248 | Stress | FAERS: 1 | US FAERS | |
| 249 | Subcutaneous Abscess | FAERS: 1 | US FAERS | |
| 250 | Syphilis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 251 | Throat irritation | FAERS: 1 | US FAERS | |
| 252 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 253 | Tuberculosis | FAERS: 1 | US FAERS | |
| 254 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 255 | Waist circumference increased | FAERS: 1 | US FAERS | |
| 256 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 257 | Wrong technique in drug usage process | FAERS: 1 | US FAERS | |
| 258 | jaundice | FAERS: 1 | US FAERS | |
| 259 | Cellulitis | Canada Vigilance: 1 | Canada Vigilance | |
| 260 | Maternal exposure timing unspecified | Canada Vigilance: 1 | Canada Vigilance | |
| 261 | Polyuria | Canada Vigilance: 1 | Canada Vigilance | |
| 262 | Thirst | Canada Vigilance: 1 | Canada Vigilance | |
| 263 | skin abrasion | Canada Vigilance: 1 | Canada Vigilance |
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