MetaADEDB 2.0 @ LMMD
Norethindrone Acetate
(IMONTRJLAWHYGT-ZCPXKWAGSA-N)
Structure
SMILES
C#C[C@@]1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12)OC(=O)C
Molecular Formula:
C22H28O3
Molecular Weight:
340.456
Log P:
4.0633
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
43.37
CAS Number(s):
51-98-9
Synonym(s)
1.
Norethindrone Acetate
2.
Aygestin
3.
Norethindrone Acetate, (17alpha)-(+-)-isomer
4.
Norethindrone Acetate, (17alpha)-isomer
5.
Norethisterone Acetate
6.
Norlutate
External Link(s)
MeSHD000077563
PubChem Compound5832
ChEBI7628
CHEMBLCHEMBL1201146
DrugCentral1963
KEGGcpd:C08152
dr:D00953
Therapeutic Target DatabaseD0T6RH
ZINC1849528
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug dose omissionFAERS: 3US FAERS
2Cerebral InfarctionFAERS: 2US FAERS
3DizzinessFAERS: 2
Canada Vigilance: 1		9408704CTD
Canada Vigilance
US FAERS
4NauseaFAERS: 2
Canada Vigilance: 1		9408704CTD
Canada Vigilance
US FAERS
5Product use in unapproved indicationFAERS: 2US FAERS
6UrticariaFAERS: 2US FAERS
7Abdominal discomfortFAERS: 1US FAERS
8AcneFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
9AlopeciaFAERS: 17420489CTD
US FAERS
10Back PainFAERS: 1US FAERS
11Cerebrovascular accidentFAERS: 1US FAERS
12Chest PainFAERS: 1US FAERS
13Chest discomfortFAERS: 1US FAERS
14ChromaturiaFAERS: 1US FAERS
15Contraindicated drug administeredFAERS: 1US FAERS
16Deep Vein ThrombosisFAERS: 1US FAERS
17Drug administered to patient of inappropriate ageFAERS: 1US FAERS
18Drug effective for unapproved indicationFAERS: 1US FAERS
19Drug ineffectiveFAERS: 1US FAERS
20Drug withdrawal syndromeFAERS: 1US FAERS
21Expired product administeredFAERS: 1US FAERS
22Exposure during breast feedingFAERS: 1US FAERS
23FatigueFAERS: 1US FAERS
24Feeling abnormalFAERS: 1US FAERS
25HeadacheFAERS: 1
Canada Vigilance: 3		9408704
18786290		CTD
Canada Vigilance
US FAERS
26HypersensitivityFAERS: 1US FAERS
27NecrosisFAERS: 1US FAERS
28Night sweatsFAERS: 1US FAERS
29PainFAERS: 111991445CTD
OFFSIDES
US FAERS
30Pulmonary EmbolismFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
31Rash erythematousFAERS: 1US FAERS
32Sudden deathFAERS: 1US FAERS
33SwellingFAERS: 1US FAERS
34ThrombosisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
35Tumour haemorrhageFAERS: 1US FAERS
36Vaginal DischargeFAERS: 1US FAERS
37Abdominal PainCanada Vigilance: 3Canada Vigilance
38Abnormal cervical smearOFFSIDES
39ActinomycosisOFFSIDES
40Activated Protein C Resistance11703344CTD
41Adenocarcinoma65687CTD
42Alanine Aminotransferase IncreasedOFFSIDES
43Allergy test positiveOFFSIDES
44Anastomotic stenosisOFFSIDES
45Anemia, Megaloblastic974714CTD
46AnhedoniaOFFSIDES
47AnhidrosisOFFSIDES
48AnorgasmiaCanada Vigilance: 1Canada Vigilance
49AnosmiaOFFSIDES
50AnxietyOFFSIDES
51Atrophic vulvovaginitisOFFSIDES
52Autoimmune thyroiditisOFFSIDES
53Back disorderOFFSIDES
54Bacterial test positiveOFFSIDES
55Biopsy site unspecified abnormalOFFSIDES
56Blood count abnormalOFFSIDES
57Blood sodiumOFFSIDES
58Blood thyroid stimulating hormone increasedOFFSIDES
59Blood urine presentCanada Vigilance: 1Canada Vigilance
60Bone density decreasedOFFSIDES
61CalciphylaxisOFFSIDES
62Carcinoma, Endometrioid6920328
10340283		CTD
63Cardiovascular Diseases1426186
6801981		CTD
64Cataract operationOFFSIDES
65CataractOFFSIDES
66Cerebral ventricle dilatationOFFSIDES
67Cervical dysplasiaCanada Vigilance: 1Canada Vigilance
68Chemotherapeutic drug level increasedOFFSIDES
69ChloasmaCanada Vigilance: 1Canada Vigilance
70ChokingOFFSIDES
71Chronic ulcerative colitisOFFSIDES
72Congenital vaginal cystOFFSIDES
73Cor pulmonaleOFFSIDES
74Coronary Occlusion12748457CTD
75Coronary artery reocclusionOFFSIDES
76CraniectomyOFFSIDES
77DebridementOFFSIDES
78DemyelinationOFFSIDES
79Dental prosthesis userOFFSIDES
80Depressive disorder10340283CTD
81DermatitisCanada Vigilance: 1Canada Vigilance
82Diabetic FootOFFSIDES
83Dilatation intrahepatic duct acquiredOFFSIDES
84DiplopiaOFFSIDES
85DrowsinessOFFSIDES
86Drug addictOFFSIDES
87DysgeusiaOFFSIDES
88DysmenorrheaOFFSIDES
89DysphemiaOFFSIDES
90Dysuria10340283CTD
91Ear congestionOFFSIDES
92Electromechanical dissociationOFFSIDES
93Endodontic procedureOFFSIDES
94Endometrial HyperplasiaOFFSIDES
95Endometrial Neoplasms65687CTD
96Endometrial cancer stage IIOFFSIDES
97EnteritisOFFSIDES
98Erythema NodosumCanada Vigilance: 1Canada Vigilance
99ErythemaCanada Vigilance: 1Canada Vigilance
100Face LiftOFFSIDES
101FlatulenceCanada Vigilance: 1Canada Vigilance
102General physical health deteriorationOFFSIDES
103Growth Disorders7420489CTD
104HepatitisOFFSIDES
105HepatomegalyCanada Vigilance: 1Canada Vigilance
106HepatotoxicityOFFSIDES
107HirsutismCanada Vigilance: 1Canada Vigilance
108Hyperhomocysteinemia18786290CTD
109HyperkeratosisOFFSIDES
110HypophagiaOFFSIDES
111Incorrect drug administration durationOFFSIDES
112InfectionOFFSIDES
113Injection site erythemaOFFSIDES
114Labile hypertensionOFFSIDES
115Lactose IntoleranceOFFSIDES
116Life expectancy shortenedOFFSIDES
117Liver neoplasms7420489CTD
118Loose toothOFFSIDES
119LymphedemaOFFSIDES
120MacrognathiaOFFSIDES
121MalaiseCanada Vigilance: 1Canada Vigilance
122Malignant tumour excisionOFFSIDES
123MastectomyOFFSIDES
124Medical device removalOFFSIDES
125Meniscus operationOFFSIDES
126Middle insomniaOFFSIDES
127Muscle necrosisOFFSIDES
128MyalgiaCanada Vigilance: 1Canada Vigilance
129Myocardial Ischemia6933346
7388443
12748457		CTD
130NeurodermatitisOFFSIDES
131Neutrophil count decreasedOFFSIDES
132NocturiaOFFSIDES
133Oral Cavity FistulaOFFSIDES
134OsteopeniaOFFSIDES
135Osteoporosis, Postmenopausal11991445CTD
136OsteoporosisOFFSIDES
137OsteoradionecrosisOFFSIDES
138Ovulation InductionOFFSIDES
139Pancreatic NeoplasmOFFSIDES
140Papilledema4714850CTD
141ParaparesisOFFSIDES
142Paresis18786290CTD
143Partner stressOFFSIDES
144Pectus excavatumOFFSIDES
145PeriodontitisOFFSIDES
146Personality ChangeOFFSIDES
147Phlebitis deepCanada Vigilance: 1Canada Vigilance
148Physical breast examination abnormalOFFSIDES
149Physical disabilityOFFSIDES
150Pierre Robin SyndromeOFFSIDES
151PneumonectomyOFFSIDES
152Post procedural cellulitisOFFSIDES
153Post procedural complicationOFFSIDES
154Post procedural infectionOFFSIDES
155Posterior capsule opacificationOFFSIDES
156Progesterone receptor assayOFFSIDES
157PruritusCanada Vigilance: 3Canada Vigilance
158Psychiatric symptomOFFSIDES
159Psychotic Disorders4179717CTD
160Pulmonary HypertensionOFFSIDES
161Pulmonary toxicityOFFSIDES
162Purulent dischargeOFFSIDES
163Radiation skin injuryOFFSIDES
164Radiotherapy to brainOFFSIDES
165Residual urineOFFSIDES
166Right atrial dilatationOFFSIDES
167Scan lymph nodesOFFSIDES
168SclerodermaOFFSIDES
169Secondary sequestrumOFFSIDES
170Seizures18786290CTD
171SeromaOFFSIDES
172Sinus Thrombosis, Intracranial18786290CTD
173Sinus operationOFFSIDES
174SinusitisOFFSIDES
175Skin IndurationOFFSIDES
176Sleep Initiation and Maintenance Disorders10340283CTD
177Soft Tissue InfectionOFFSIDES
178Soft tissue necrosisOFFSIDES
179Stevens-Johnson SyndromeOFFSIDES
180StridorOFFSIDES
181TalipesOFFSIDES
182Temperature intoleranceOFFSIDES
183Therapy non-responderOFFSIDES
184ThoracotomyOFFSIDES
185Thromboembolism6933346CTD
186ThrombophlebitisCanada Vigilance: 5Canada Vigilance
OFFSIDES
187TineaOFFSIDES
188Toe operationOFFSIDES
189Tooth ExtractionOFFSIDES
190Tooth InfectionOFFSIDES
191Tooth LossOFFSIDES
192Transaminases increasedOFFSIDES
193Ultrasound breast abnormalOFFSIDES
194Upper airway obstructionOFFSIDES
195Uterine Neoplasms7420489CTD
196Uterine hemorrhage11991445CTD
197Vaginal Diseases10340283CTD
198VasculitisCanada Vigilance: 1Canada Vigilance
199Venoocclusive diseaseOFFSIDES
200Venous ThrombosisCanada Vigilance: 2Canada Vigilance
201Ventricular FibrillationOFFSIDES
202VomitingCanada Vigilance: 29408704CTD
Canada Vigilance
203Weight Gain11991445CTD
204jaundiceCanada Vigilance: 1Canada Vigilance
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