MetaADEDB 2.0 @ LMMD
deflazacort
(FBHSPRKOSMHSIF-GRMWVWQJSA-N)
Structure
SMILES
CC(=O)OCC(=O)[C@@]12N=C(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)C
Type(s)
Approved; Investigational
ATC code(s)
H02AB13
Molecular Formula:
C25H31NO6
Molecular Weight:
441.517
Log P:
1.9988
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
1
TPSA:
102.26
CAS Number(s):
14484-47-0
Synonym(s)
1.
deflazacort
2.
Calcort
3.
Dezacor
4.
Zamene
External Link(s)
MeSHC021988
PubChem Compound189821
ChEBI135720
CHEMBLCHEMBL1201891
DrugBankDB11921
DrugCentral793
IUPHAR/BPS Guide to PHARMACOLOGY9477
KEGGdr:D03671
ZINC4212809
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NasopharyngitisFAERS: 109OFFSIDES
US FAERS
2InfluenzaFAERS: 89US FAERS
3VomitingFAERS: 80
Canada Vigilance: 2
Canada Vigilance
US FAERS
4AngerFAERS: 79US FAERS
5Weight decreasedFAERS: 65US FAERS
6Product dose omissionFAERS: 61US FAERS
7MalaiseFAERS: 54US FAERS
8HeadacheFAERS: 50
Canada Vigilance: 2
Canada Vigilance
US FAERS
9ErythemaFAERS: 49OFFSIDES
US FAERS
10FatigueFAERS: 48OFFSIDES
US FAERS
11AstheniaFAERS: 47OFFSIDES
US FAERS
12ConstipationFAERS: 43US FAERS
13Emotional disorderFAERS: 40US FAERS
14Mood swingsFAERS: 37US FAERS
15Abdominal discomfortFAERS: 36OFFSIDES
US FAERS
16AnxietyFAERS: 33US FAERS
17Drug dose omissionFAERS: 32US FAERS
18Back PainFAERS: 31US FAERS
19AcneFAERS: 28US FAERS
20NephrolithiasisFAERS: 27US FAERS
21NauseaFAERS: 25US FAERS
22Peripheral swellingFAERS: 25US FAERS
23PneumoniaFAERS: 24US FAERS
24Growth retardationFAERS: 22US FAERS
25CataractFAERS: 21US FAERS
26CryingFAERS: 21US FAERS
27DizzinessFAERS: 21US FAERS
28PainFAERS: 20US FAERS
29Abdominal PainFAERS: 18OFFSIDES
US FAERS
30PruritusFAERS: 18US FAERS
31HypersensitivityFAERS: 17US FAERS
32ArthralgiaFAERS: 16US FAERS
33AgitationFAERS: 15US FAERS
34DehydrationFAERS: 14US FAERS
35FlushingFAERS: 14US FAERS
36Nonspecific reactionFAERS: 14US FAERS
37SinusitisFAERS: 14US FAERS
38Chest PainFAERS: 13US FAERS
39Gait inabilityFAERS: 13US FAERS
40Inappropriate schedule of drug administrationFAERS: 13US FAERS
41Oropharyngeal painFAERS: 13US FAERS
42Personality ChangeFAERS: 13US FAERS
43UrticariaFAERS: 13US FAERS
44OsteoporosisFAERS: 12OFFSIDES
US FAERS
45BronchitisFAERS: 11US FAERS
46Drug ineffectiveFAERS: 11OFFSIDES
US FAERS
47Ankle FractureFAERS: 10US FAERS
48Dry skinFAERS: 10US FAERS
49DyspepsiaFAERS: 9US FAERS
50Product use in unapproved indicationFAERS: 9US FAERS
51Bone density decreasedFAERS: 8US FAERS
52EpistaxisFAERS: 8US FAERS
53Limb injuryFAERS: 8US FAERS
54ScreamingFAERS: 8US FAERS
55FractureFAERS: 7US FAERS
56Frustration tolerance decreasedFAERS: 7US FAERS
57Loss of personal independence in daily activitiesFAERS: 7US FAERS
58SwellingFAERS: 7US FAERS
59Complication associated with deviceFAERS: 6US FAERS
60Disease ProgressionFAERS: 6US FAERS
61EnuresisFAERS: 6US FAERS
62HungerFAERS: 6US FAERS
63HypotensionFAERS: 6US FAERS
64Joint injuryFAERS: 6US FAERS
65Middle insomniaFAERS: 6US FAERS
66AlopeciaFAERS: 5OFFSIDES
US FAERS
67ConjunctivitisFAERS: 5US FAERS
68Drug administered to patient of inappropriate ageFAERS: 5US FAERS
69HypertrichosisFAERS: 5US FAERS
70LethargyFAERS: 5US FAERS
71Muscle strainFAERS: 5US FAERS
72Product taste abnormalFAERS: 5US FAERS
73RetchingFAERS: 5US FAERS
74ThirstFAERS: 5US FAERS
75Urinary tract infectionFAERS: 5US FAERS
76VertigoFAERS: 5US FAERS
77Blood glucose decreasedFAERS: 4US FAERS
78CellulitisFAERS: 4OFFSIDES
US FAERS
79Depressed moodFAERS: 4OFFSIDES
US FAERS
80DiscomfortFAERS: 4US FAERS
81Intentional self-injuryFAERS: 4US FAERS
82Musculoskeletal stiffnessFAERS: 4US FAERS
83PalpitationsFAERS: 4US FAERS
84PharyngitisFAERS: 4US FAERS
85Pulmonary congestionFAERS: 4US FAERS
86Restless Legs SyndromeFAERS: 4US FAERS
87RestlessnessFAERS: 4US FAERS
88RhabdomyolysisFAERS: 4US FAERS
89SepsisFAERS: 4US FAERS
90Tooth ExtractionFAERS: 4US FAERS
91Urinary IncontinenceFAERS: 4US FAERS
92Visual ImpairmentFAERS: 4US FAERS
93AbscessFAERS: 3US FAERS
94Atrial FibrillationFAERS: 3US FAERS
95Back disorderFAERS: 3US FAERS
96Compression fractureFAERS: 3US FAERS
97FlatulenceFAERS: 3OFFSIDES
US FAERS
98HordeolumFAERS: 3US FAERS
99HypophagiaFAERS: 3US FAERS
100InfectionFAERS: 3US FAERS
101Limb discomfortFAERS: 3US FAERS
102Memory impairmentFAERS: 3US FAERS
103Multiple allergiesFAERS: 3US FAERS
104MyalgiaFAERS: 3US FAERS
105PetechiaeFAERS: 3US FAERS
106Post procedural infectionFAERS: 3US FAERS
107Product use complaintFAERS: 3US FAERS
108Respiratory distressFAERS: 3US FAERS
109Secretion dischargeFAERS: 3US FAERS
110Skin lacerationFAERS: 3US FAERS
111Vitamin D DeficiencyFAERS: 3US FAERS
112WheezingFAERS: 3US FAERS
113AppendicitisFAERS: 2OFFSIDES
US FAERS
114Blood cholesterol increasedFAERS: 2US FAERS
115Blood creatine phosphokinase decreasedFAERS: 2US FAERS
116Blood testosterone decreasedFAERS: 2US FAERS
117Blood triglycerides increasedFAERS: 2US FAERS
118Blood urine presentFAERS: 2US FAERS
119Bone density abnormalFAERS: 2US FAERS
120CholelithiasisFAERS: 2US FAERS
121CystitisFAERS: 2US FAERS
122DiplopiaFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
123DysgeusiaFAERS: 2US FAERS
124DysphemiaFAERS: 2US FAERS
125DysuriaFAERS: 2US FAERS
126EczemaFAERS: 2US FAERS
127Expulsion of medicationFAERS: 2US FAERS
128Extra dose administeredFAERS: 2US FAERS
129Food cravingFAERS: 2US FAERS
130GastroenteritisFAERS: 2US FAERS
131HerniaFAERS: 2US FAERS
132ImpatienceFAERS: 2US FAERS
133InflammationFAERS: 2US FAERS
134Joint swellingFAERS: 2US FAERS
135Large intestine perforationFAERS: 2US FAERS
136Lip swellingFAERS: 2US FAERS
137Lower respiratory tract infectionFAERS: 2US FAERS
138MenorrhagiaFAERS: 2US FAERS
139Musculoskeletal PainFAERS: 2OFFSIDES
US FAERS
140Musculoskeletal chest painFAERS: 2US FAERS
141Musculoskeletal discomfortFAERS: 2US FAERS
142MyocarditisFAERS: 2US FAERS
143No adverse eventFAERS: 2US FAERS
144Obsessive-Compulsive DisorderFAERS: 2US FAERS
145PallorFAERS: 2US FAERS
146Peptic UlcerFAERS: 2US FAERS
147Productive CoughFAERS: 2US FAERS
148Rash erythematousFAERS: 2US FAERS
149Rectal ProlapseFAERS: 2US FAERS
150Respiratory FailureFAERS: 2OFFSIDES
US FAERS
151Skin PapillomaFAERS: 2US FAERS
152Skin irritationFAERS: 2US FAERS
153Sleep study abnormalFAERS: 2US FAERS
154SneezingFAERS: 2US FAERS
155SomnolenceFAERS: 2US FAERS
156Spinal fusion surgeryFAERS: 2US FAERS
157StomatitisFAERS: 2US FAERS
158StressFAERS: 2US FAERS
159StubbornnessFAERS: 2US FAERS
160TachycardiaFAERS: 2US FAERS
161Tendon discomfortFAERS: 2US FAERS
162Tinea crurisFAERS: 2US FAERS
163TonsillectomyFAERS: 2US FAERS
164AbuliaFAERS: 1US FAERS
165Acute kidney injuryFAERS: 1US FAERS
166Alanine Aminotransferase IncreasedFAERS: 1US FAERS
167AmnesiaFAERS: 1US FAERS
168Anal abscessFAERS: 1US FAERS
169ApathyFAERS: 1OFFSIDES
US FAERS
170Arthropod biteFAERS: 1US FAERS
171Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
172AsthmaFAERS: 1US FAERS
173AtelectasisFAERS: 1US FAERS
174BK virus infectionFAERS: 1US FAERS
175BiopsyFAERS: 1US FAERS
176Blood creatine decreasedFAERS: 1US FAERS
177Blood creatine phosphokinase increasedFAERS: 1US FAERS
178Blood glucose increasedFAERS: 1US FAERS
179Blood iron decreasedFAERS: 1US FAERS
180Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
181Blood potassium increasedFAERS: 1US FAERS
182Blood urea abnormalFAERS: 1US FAERS
183Body surface area increasedFAERS: 1US FAERS
184Bone painFAERS: 1US FAERS
185Cardiac ArrestFAERS: 1US FAERS
186Cardiac FlutterFAERS: 1US FAERS
187Cardiac valve sclerosisFAERS: 1US FAERS
188Cataract operationFAERS: 1US FAERS
189Chest discomfortFAERS: 1US FAERS
190ChokingFAERS: 1US FAERS
191CholesteatomaFAERS: 1US FAERS
192ChromaturiaFAERS: 1US FAERS
193Clostridium difficile infectionFAERS: 1US FAERS
194Coating in mouthFAERS: 1US FAERS
195ColitisFAERS: 1US FAERS
196Corrective lens userFAERS: 1US FAERS
197Dark circles under eyesFAERS: 1US FAERS
198Device dislocationFAERS: 1OFFSIDES
US FAERS
199Device fastener issueFAERS: 1US FAERS
200Disruptive mood dysregulation disorderFAERS: 1US FAERS
201Drug administration errorFAERS: 1US FAERS
202Drug dispensing errorFAERS: 1US FAERS
203Drug effect incompleteFAERS: 1US FAERS
204Drug withdrawal syndromeFAERS: 1US FAERS
205Duodenal UlcerFAERS: 1US FAERS
206DysgraphiaFAERS: 1US FAERS
207DysphoniaFAERS: 1US FAERS
208Ejection Fraction DecreasedFAERS: 1US FAERS
209Emotional distressFAERS: 1US FAERS
210EructationFAERS: 1US FAERS
211Erythema MultiformeFAERS: 1OFFSIDES
US FAERS
212Excessive cerumen productionFAERS: 1US FAERS
213Exfoliative rashFAERS: 1US FAERS
214Eyelids pruritusFAERS: 1US FAERS
215Feeding tube userFAERS: 1US FAERS
216Feeling abnormalFAERS: 1US FAERS
217Feeling jitteryFAERS: 1US FAERS
218FolliculitisFAERS: 1US FAERS
219Food AllergyFAERS: 1US FAERS
220Food PoisoningFAERS: 1US FAERS
221FormicationFAERS: 1US FAERS
222GastritisFAERS: 1US FAERS
223Gastroenteritis norovirusFAERS: 1US FAERS
224Gastrointestinal infectionFAERS: 1US FAERS
225Gastrointestinal motility disorderFAERS: 1US FAERS
226Gastrointestinal obstructionFAERS: 1US FAERS
227GastrostomyFAERS: 1US FAERS
228Gingival RecessionFAERS: 1US FAERS
229GlossitisFAERS: 1US FAERS
230Head BangingFAERS: 1US FAERS
231HirsutismFAERS: 1US FAERS
232Histrionic Personality DisorderFAERS: 1US FAERS
233HyperphagiaFAERS: 1US FAERS
234HypersomniaFAERS: 1US FAERS
235HypokinesiaFAERS: 1US FAERS
236HypothyroidismFAERS: 1US FAERS
237IleusFAERS: 1US FAERS
238ImpetigoFAERS: 1US FAERS
239Incorrect dose administeredFAERS: 1US FAERS
240Increased bronchial secretionFAERS: 1US FAERS
241Insulin ResistanceFAERS: 1US FAERS
242Internal injuryFAERS: 1US FAERS
243Intestinal ObstructionFAERS: 1US FAERS
244Intestinal Pseudo-ObstructionFAERS: 1US FAERS
245Iron OverloadFAERS: 1US FAERS
246Joint stiffnessFAERS: 1US FAERS
247LacerationFAERS: 1US FAERS
248Limb fractureFAERS: 1US FAERS
249Lip erythemaFAERS: 1US FAERS
250Lyme DiseaseFAERS: 1US FAERS
251LymphadenopathyFAERS: 1US FAERS
252Medication ErrorFAERS: 1US FAERS
253Mental impairmentFAERS: 1US FAERS
254Molluscum ContagiosumFAERS: 1US FAERS
255Muscle FatigueFAERS: 1US FAERS
256Muscle tightnessFAERS: 1US FAERS
257Muscular DystrophyFAERS: 1US FAERS
258Myocardial fibrosisFAERS: 1US FAERS
259Night sweatsFAERS: 1US FAERS
260ObesityFAERS: 1US FAERS
261Ocular HypertensionFAERS: 1US FAERS
262Ocular discomfortFAERS: 1US FAERS
263OnychomycosisFAERS: 1US FAERS
264Optic NeuritisFAERS: 1OFFSIDES
US FAERS
265Orthodontic procedureFAERS: 1US FAERS
266OsteopeniaFAERS: 1US FAERS
267Otitis MediaFAERS: 1US FAERS
268PancreatitisFAERS: 1US FAERS
269ParanoiaFAERS: 1US FAERS
270Pectus excavatumFAERS: 1US FAERS
271Perineal cystFAERS: 1US FAERS
272Peritoneocutaneous fistulaFAERS: 1US FAERS
273PhotophobiaFAERS: 1US FAERS
274Poor peripheral circulationFAERS: 1US FAERS
275Portal shunt procedureFAERS: 1US FAERS
276Product substitution issueFAERS: 1US FAERS
277Product supply issueFAERS: 1US FAERS
278Psychiatric symptomFAERS: 1US FAERS
279PubertyFAERS: 1US FAERS
280Pulmonary EmbolismFAERS: 1US FAERS
281Pulmonary function test decreasedFAERS: 1US FAERS
282PurpuraFAERS: 1US FAERS
283Respiratory muscle weaknessFAERS: 1US FAERS
284Respiratory tract congestionFAERS: 1US FAERS
285Right ventricular failureFAERS: 1US FAERS
286Scoliosis surgeryFAERS: 1US FAERS
287Selective eating disorderFAERS: 1US FAERS
288Septic ShockFAERS: 1OFFSIDES
US FAERS
289Skin UlcerFAERS: 1US FAERS
290Skin hypertrophyFAERS: 1US FAERS
291Skin lesionFAERS: 1OFFSIDES
US FAERS
292Slow speechFAERS: 1US FAERS
293Soft tissue swellingFAERS: 1US FAERS
294Solar lentigoFAERS: 1US FAERS
295Steroid withdrawal syndromeFAERS: 1US FAERS
296Stevens-Johnson SyndromeFAERS: 1US FAERS
297StrabismusFAERS: 1US FAERS
298Sudden deathFAERS: 1US FAERS
299Suicide attemptFAERS: 1US FAERS
300Suicide threatFAERS: 1US FAERS
301SunburnFAERS: 1US FAERS
302Supraventricular tachycardiaFAERS: 1US FAERS
303SyncopeFAERS: 1US FAERS
304Testis discomfortFAERS: 1US FAERS
305Therapeutic response unexpectedFAERS: 1US FAERS
306Thermal burnFAERS: 1US FAERS
307Throat clearingFAERS: 1US FAERS
308Throat irritationFAERS: 1US FAERS
309ThrombosisFAERS: 1US FAERS
310Tooth LossFAERS: 1US FAERS
311Toxic Epidermal NecrolysisFAERS: 1US FAERS
312Unevaluable eventFAERS: 1US FAERS
313Urine output increasedFAERS: 1US FAERS
314Wheelchair userFAERS: 1US FAERS
315angiogramFAERS: 1US FAERS
316furuncleFAERS: 1OFFSIDES
US FAERS
317muscle injuryFAERS: 1US FAERS
318Acute bronchitisOFFSIDES
319Acute myocardial infarctionOFFSIDES
320Anal FistulaOFFSIDES
321AngiosclerosisOFFSIDES
322AnorexiaOFFSIDES
323AphoniaOFFSIDES
324Aphthous StomatitisOFFSIDES
325ArthritisOFFSIDES
326ArthropathyOFFSIDES
327BlepharitisOFFSIDES
328Blood GlucoseOFFSIDES
329Blood iron increasedOFFSIDES
330Blood magnesium decreasedOFFSIDES
331Blood pressure fluctuationOFFSIDES
332Bone fissureOFFSIDES
333Bone marrow depressionOFFSIDES
334Bronchial ObstructionOFFSIDES
335Bronchopulmonary diseaseOFFSIDES
336Burning sensationOFFSIDES
337CalciphylaxisOFFSIDES
338Cerebral ventricle dilatationOFFSIDES
339Cervical spine flatteningOFFSIDES
340Choking sensationOFFSIDES
341Chronic ulcerative colitisOFFSIDES
342CystOFFSIDES
343Deafness NeurosensoryOFFSIDES
344Decreased immune responsivenessOFFSIDES
345Dengue FeverOFFSIDES
346Dental abscessOFFSIDES
347Drug exposure during pregnancyOFFSIDES
348Drug withdrawal headacheOFFSIDES
349Emphysematous bullaOFFSIDES
350Enterocutaneous FistulaOFFSIDES
351Enterovesical FistulaOFFSIDES
352EpilepsyOFFSIDES
353Erythema NodosumOFFSIDES
354Flank PainOFFSIDES
355Gastroduodenitis haemorrhagicOFFSIDES
356General physical health deteriorationOFFSIDES
357GlaucomaOFFSIDES
358GlobulinuriaOFFSIDES
359Head deformityOFFSIDES
360HepatitisOFFSIDES
361HepatosplenomegalyOFFSIDES
362Histiocytosis haematophagicOFFSIDES
363ImmobileOFFSIDES
364IndurationOFFSIDES
365Infusion site mobility decreasedOFFSIDES
366Injection site cellulitisOFFSIDES
367Injection site infectionOFFSIDES
368Injection site ulcerOFFSIDES
369Injection site warmthOFFSIDES
370Intestinal resectionOFFSIDES
371MononeuritisOFFSIDES
372MonoplegiaOFFSIDES
373Muscle necrosisOFFSIDES
374Nephrotic SyndromeOFFSIDES
375Optic Disc EdemaOFFSIDES
376Oral pruritusOFFSIDES
377Oropharyngitis fungalOFFSIDES
378OsteolysisOFFSIDES
379PCO2 decreasedOFFSIDES
380PanniculitisOFFSIDES
381PericarditisOFFSIDES
382PneumothoraxOFFSIDES
383Polymerase Chain ReactionOFFSIDES
384PolymyositisOFFSIDES
385PyomyositisOFFSIDES
386Rheumatoid factor increasedOFFSIDES
387Sputum culture positiveOFFSIDES
388StrongyloidiasisOFFSIDES
389Suture related complicationOFFSIDES
390Thoracic vertebral fractureOFFSIDES
391Tubo-ovarian abscessOFFSIDES
392UlcerOFFSIDES
393Ultrasound antenatal screenOFFSIDES
394Ureteral Calculi11018608CTD
395Walking aid userOFFSIDES
396Weight Gain1794742CTD
OFFSIDES
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