MetaADEDB 2.0 @ LMMD
bupropion hydrochloride, naltrexone hydrochoride drug combination
(KVNBDVQGENTICK-ITLPAZOVSA-N)
Structure
SMILES
O=C1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O.Clc1cccc(c1)C(=O)C(NC(C)(C)C)C
Molecular Formula:
C33H41ClN2O5
Molecular Weight:
581.142
Log P:
5.1535
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
3
TPSA:
99.1
CAS Number(s):
1201668-08-7
Synonym(s)
1.
bupropion hydrochloride, naltrexone hydrochoride drug combination
2.
Contrave
3.
Mysimba
4.
bupropion hydrochloride - natrexone hydrochloride
External Link(s)
MeSHC000591595
PubChem Compound11556075
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 360
Canada Vigilance: 9
Canada Vigilance
US FAERS
2HeadacheFAERS: 185
Canada Vigilance: 9
Canada Vigilance
US FAERS
3DizzinessFAERS: 150
Canada Vigilance: 8
Canada Vigilance
US FAERS
4VomitingFAERS: 126
Canada Vigilance: 2
Canada Vigilance
US FAERS
5Drug ineffectiveFAERS: 122
Canada Vigilance: 7
Canada Vigilance
US FAERS
6Feeling abnormalFAERS: 120
Canada Vigilance: 3
Canada Vigilance
US FAERS
7ConstipationFAERS: 87
Canada Vigilance: 5
Canada Vigilance
US FAERS
8UrticariaFAERS: 63US FAERS
9Inappropriate schedule of drug administrationFAERS: 61US FAERS
10FatigueFAERS: 59
Canada Vigilance: 3
Canada Vigilance
US FAERS
11No adverse eventFAERS: 58US FAERS
12TremorFAERS: 53
Canada Vigilance: 2
Canada Vigilance
US FAERS
13AnxietyFAERS: 52US FAERS
14MalaiseFAERS: 46
Canada Vigilance: 7
Canada Vigilance
US FAERS
15PalpitationsFAERS: 36
Canada Vigilance: 1
Canada Vigilance
US FAERS
16SomnolenceFAERS: 29
Canada Vigilance: 1
Canada Vigilance
US FAERS
17Drug prescribing errorFAERS: 28US FAERS
18Feeling jitteryFAERS: 27US FAERS
19Chest PainFAERS: 25US FAERS
20AlopeciaFAERS: 22US FAERS
21PruritusFAERS: 20
Canada Vigilance: 1
Canada Vigilance
US FAERS
22Abdominal PainFAERS: 19
Canada Vigilance: 3
Canada Vigilance
US FAERS
23Adverse eventFAERS: 18US FAERS
24Chest discomfortFAERS: 17US FAERS
25HypersensitivityFAERS: 17US FAERS
26AgitationFAERS: 16
Canada Vigilance: 1
Canada Vigilance
US FAERS
27Drug dose omissionFAERS: 16US FAERS
28TinnitusFAERS: 16
Canada Vigilance: 1
Canada Vigilance
US FAERS
29AstheniaFAERS: 15
Canada Vigilance: 3
Canada Vigilance
US FAERS
30Visual ImpairmentFAERS: 15
Canada Vigilance: 1
Canada Vigilance
US FAERS
31NervousnessFAERS: 14US FAERS
32Depressed moodFAERS: 13US FAERS
33DysarthriaFAERS: 13US FAERS
34AngerFAERS: 12US FAERS
35Eye painFAERS: 12
Canada Vigilance: 1
Canada Vigilance
US FAERS
36DyspepsiaFAERS: 11US FAERS
37Food cravingFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
38Abdominal discomfortFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
39FlushingFAERS: 10US FAERS
40HungerFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
41Impaired work abilityFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
42Lip swellingFAERS: 10US FAERS
43Back PainFAERS: 9US FAERS
44Cold sweatFAERS: 9US FAERS
45DysgeusiaFAERS: 9US FAERS
46Euphoric moodFAERS: 9US FAERS
47Mood swingsFAERS: 9US FAERS
48Product use issueFAERS: 9US FAERS
49VertigoFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
50AmnesiaFAERS: 8US FAERS
51DehydrationFAERS: 8
Canada Vigilance: 2
Canada Vigilance
US FAERS
52PainFAERS: 8US FAERS
53AngioedemaFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
54CryingFAERS: 7US FAERS
55DisorientationFAERS: 7US FAERS
56Drug titration errorFAERS: 7
Canada Vigilance: 9
Canada Vigilance
US FAERS
57Peripheral swellingFAERS: 7US FAERS
58PresyncopeFAERS: 7US FAERS
59Blood glucose increasedFAERS: 6US FAERS
60ChillsFAERS: 6US FAERS
61HypersomniaFAERS: 6US FAERS
62Memory impairmentFAERS: 6US FAERS
63Mental impairmentFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
64Motion SicknessFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
65Night sweatsFAERS: 6US FAERS
66SwellingFAERS: 6US FAERS
67SyncopeFAERS: 6
Canada Vigilance: 2
Canada Vigilance
US FAERS
68AphasiaFAERS: 5US FAERS
69ArthralgiaFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
70ChromaturiaFAERS: 5US FAERS
71Head discomfortFAERS: 5US FAERS
72Impaired driving abilityFAERS: 5US FAERS
73Incorrect dose administeredFAERS: 5US FAERS
74Joint swellingFAERS: 5US FAERS
75RestlessnessFAERS: 5US FAERS
76RetchingFAERS: 5US FAERS
77TachycardiaFAERS: 5US FAERS
78Wrong technique in product usage processFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
79Activities of daily living impairedFAERS: 4US FAERS
80Angina PectorisFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
81Breast engorgementFAERS: 4US FAERS
82Drug screen positiveFAERS: 4US FAERS
83IncoherentFAERS: 4US FAERS
84LethargyFAERS: 4US FAERS
85LymphadenopathyFAERS: 4US FAERS
86Oropharyngeal painFAERS: 4US FAERS
87Rash erythematousFAERS: 4US FAERS
88Restless Legs SyndromeFAERS: 4US FAERS
89Therapy cessationFAERS: 4
Canada Vigilance: 7
Canada Vigilance
US FAERS
90ThirstFAERS: 4US FAERS
91Angle Closure GlaucomaFAERS: 3US FAERS
92AsthenopiaFAERS: 3US FAERS
93Atrial FibrillationFAERS: 3US FAERS
94BedriddenFAERS: 3
Canada Vigilance: 2
Canada Vigilance
US FAERS
95Blood creatinine increasedFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
96Drug withdrawal syndromeFAERS: 3US FAERS
97DysuriaFAERS: 3US FAERS
98Emotional disorderFAERS: 3US FAERS
99EructationFAERS: 3US FAERS
100Extra dose administeredFAERS: 3US FAERS
101Hypertensive crisisFAERS: 3US FAERS
102Initial insomniaFAERS: 3US FAERS
103Lack of satietyFAERS: 3US FAERS
104Muscle tightnessFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
105Musculoskeletal discomfortFAERS: 3US FAERS
106MyalgiaFAERS: 3US FAERS
107NasopharyngitisFAERS: 3US FAERS
108Neck PainFAERS: 3US FAERS
109NephrolithiasisFAERS: 3US FAERS
110PancreatitisFAERS: 3US FAERS
111PhotophobiaFAERS: 3US FAERS
112Poor quality sleepFAERS: 3US FAERS
113PregnancyFAERS: 3US FAERS
114SinusitisFAERS: 3US FAERS
115StomatitisFAERS: 3US FAERS
116Therapy changeFAERS: 3US FAERS
117ToothacheFAERS: 3US FAERS
118Accidental exposure to productFAERS: 2US FAERS
119AsthmaFAERS: 2US FAERS
120Blood glucose decreasedFAERS: 2US FAERS
121Blood pressure fluctuationFAERS: 2US FAERS
122Burning sensationFAERS: 2US FAERS
123Cerebrovascular accidentFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
124Contraindicated drug administeredFAERS: 2US FAERS
125CystitisFAERS: 2US FAERS
126DysphemiaFAERS: 2US FAERS
127DysphoniaFAERS: 2US FAERS
128DystoniaFAERS: 2US FAERS
129Electrocardiogram abnormalFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
130ErythemaFAERS: 2US FAERS
131Eye irritationFAERS: 2US FAERS
132Facial paralysisFAERS: 2US FAERS
133Feeling ColdFAERS: 2US FAERS
134FlatulenceFAERS: 2US FAERS
135GastritisFAERS: 2US FAERS
136GlaucomaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
137HyperphagiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
138HypophagiaFAERS: 2US FAERS
139Incorrect drug administration durationFAERS: 2US FAERS
140InflammationFAERS: 2US FAERS
141InfluenzaFAERS: 2US FAERS
142Intentional product use issueFAERS: 2
Canada Vigilance: 3
Canada Vigilance
US FAERS
143Loss of personal independence in daily activitiesFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
144Meniscus injuryFAERS: 2US FAERS
145MenorrhagiaFAERS: 2US FAERS
146Middle insomniaFAERS: 2US FAERS
147Musculoskeletal chest painFAERS: 2US FAERS
148Nonspecific reactionFAERS: 2US FAERS
149Panic DisorderFAERS: 2US FAERS
150Serotonin SyndromeFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
151Stevens-Johnson SyndromeFAERS: 2US FAERS
152Suicide attemptFAERS: 2US FAERS
153TachyphreniaFAERS: 2US FAERS
154Tooth InfectionFAERS: 2US FAERS
155Urinary tract infectionFAERS: 2US FAERS
156AbasiaFAERS: 1US FAERS
157Accidental overdoseFAERS: 1US FAERS
158Acute kidney injuryFAERS: 1US FAERS
159Acute psychosisFAERS: 1US FAERS
160Alanine Aminotransferase IncreasedFAERS: 1US FAERS
161Allergic coughFAERS: 1US FAERS
162Allergic sinusitisFAERS: 1US FAERS
163Altered state of consciousnessFAERS: 1US FAERS
164Amphetamines positiveFAERS: 1US FAERS
165Ankle FractureFAERS: 1US FAERS
166ApathyFAERS: 1US FAERS
167ArthritisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
168AsphyxiaFAERS: 1US FAERS
169Atrioventricular BlockFAERS: 1US FAERS
170BlepharospasmFAERS: 1US FAERS
171Blood glucose abnormalFAERS: 1US FAERS
172Blood glucose fluctuationFAERS: 1US FAERS
173Blood potassium decreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
174Blood potassium increasedFAERS: 1US FAERS
175Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
176BradycardiaFAERS: 1US FAERS
177Breast cancer stage IIFAERS: 1US FAERS
178Breast discomfortFAERS: 1US FAERS
179BronchitisFAERS: 1US FAERS
180BronchospasmFAERS: 1US FAERS
181BruxismFAERS: 1US FAERS
182Cardiac ArrestFAERS: 1US FAERS
183Cardiac discomfortFAERS: 1US FAERS
184CatatoniaFAERS: 1US FAERS
185CholecystitisFAERS: 1US FAERS
186Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
187ColitisFAERS: 1US FAERS
188Contraindicated product administeredFAERS: 1US FAERS
189Dermatitis acneiformFAERS: 1US FAERS
190DermatitisFAERS: 1US FAERS
191Diabetes MellitusFAERS: 1US FAERS
192Diastolic dysfunctionFAERS: 1US FAERS
193DiscomfortFAERS: 1US FAERS
194Disease complicationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
195DiverticulitisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
196DroolingFAERS: 1US FAERS
197Drug DependenceFAERS: 1US FAERS
198Drug administered to patient of inappropriate ageFAERS: 1US FAERS
199Drug effect incompleteFAERS: 1US FAERS
200Drug ineffective for unapproved indicationFAERS: 1US FAERS
201Drug screen false positiveFAERS: 1US FAERS
202Drug-disease interactionFAERS: 1US FAERS
203DysacusisFAERS: 1US FAERS
204DysmorphismFAERS: 1US FAERS
205Ear discomfortFAERS: 1US FAERS
206EczemaFAERS: 1US FAERS
207Ejection Fraction DecreasedFAERS: 1US FAERS
208Emotional distressFAERS: 1US FAERS
209EpistaxisFAERS: 1US FAERS
210Erectile dysfunctionFAERS: 1US FAERS
211Erythema MultiformeFAERS: 1US FAERS
212Erythrodermic psoriasisFAERS: 1US FAERS
213Essential TremorFAERS: 1US FAERS
214Exposure during breast feedingFAERS: 1US FAERS
215Fat intoleranceFAERS: 1US FAERS
216Feeling of body temperature changeFAERS: 1US FAERS
217FibromyalgiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
218Food AllergyFAERS: 1US FAERS
219Food aversionFAERS: 1US FAERS
220FormicationFAERS: 1US FAERS
221Gait inabilityFAERS: 1US FAERS
222Gallbladder painFAERS: 1US FAERS
223Gastrointestinal PainFAERS: 1US FAERS
224Gastrointestinal inflammationFAERS: 1US FAERS
225GingivitisFAERS: 1US FAERS
226GoutFAERS: 1US FAERS
227Head titubationFAERS: 1US FAERS
228Heart sounds abnormalFAERS: 1US FAERS
229Histrionic Personality DisorderFAERS: 1US FAERS
230HostilityFAERS: 1US FAERS
231HyperventilationFAERS: 1US FAERS
232HypokinesiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
233HypotensionFAERS: 1US FAERS
234HysterectomyFAERS: 1US FAERS
235Impaired gastric emptyingFAERS: 1US FAERS
236ImpatienceFAERS: 1US FAERS
237Inability to afford medicationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
238Incorrect drug dosage form administeredFAERS: 1US FAERS
239Inhibitory drug interactionFAERS: 1US FAERS
240Insurance issueFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
241Intestinal ObstructionFAERS: 1US FAERS
242Invasive Ductal Breast CarcinomaFAERS: 1US FAERS
243Irritable Bowel SyndromeFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
244Joint injuryFAERS: 1US FAERS
245KeratomileusisFAERS: 1US FAERS
246LeukocytosisFAERS: 1US FAERS
247Ligament injuryFAERS: 1US FAERS
248Limb discomfortFAERS: 1US FAERS
249Limb injuryFAERS: 1US FAERS
250Macular fibrosisFAERS: 1US FAERS
251Medication residue presentFAERS: 1US FAERS
252MiliariaFAERS: 1US FAERS
253Mouth swellingFAERS: 1US FAERS
254Musculoskeletal stiffnessFAERS: 1US FAERS
255NephrectomyFAERS: 1US FAERS
256NoduleFAERS: 1US FAERS
257ObesityFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
258Oral painFAERS: 1US FAERS
259OsteomyelitisFAERS: 1US FAERS
260OverdoseFAERS: 1US FAERS
261PallorFAERS: 1US FAERS
262Pancreatic carcinomaFAERS: 1US FAERS
263Paranasal sinus hypersecretionFAERS: 1US FAERS
264ParanoiaFAERS: 1US FAERS
265Pelvic PainFAERS: 1US FAERS
266Peptic UlcerFAERS: 1US FAERS
267PetechiaeFAERS: 1US FAERS
268Physical assaultFAERS: 1US FAERS
269PiloerectionFAERS: 1US FAERS
270PneumoniaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
271Post procedural complicationFAERS: 1US FAERS
272Post procedural pulmonary embolismFAERS: 1US FAERS
273Post-traumatic neck syndromeFAERS: 1US FAERS
274Prescription drug used without a prescriptionFAERS: 1US FAERS
275Procedural complicationFAERS: 1US FAERS
276Product communication issueFAERS: 1US FAERS
277Product prescribing errorFAERS: 1US FAERS
278Product quality issueFAERS: 1US FAERS
279Product size issueFAERS: 1US FAERS
280PseudostrokeFAERS: 1US FAERS
281Psychiatric symptomFAERS: 1US FAERS
282Pustular psoriasisFAERS: 1US FAERS
283ScreamingFAERS: 1US FAERS
284Seizure like phenomenaFAERS: 1US FAERS
285Sexual DysfunctionFAERS: 1US FAERS
286ShopliftingFAERS: 1US FAERS
287Sinus headacheFAERS: 1US FAERS
288Skin reactionFAERS: 1US FAERS
289Sleep ParalysisFAERS: 1US FAERS
290Sleep-related eating disorderFAERS: 1US FAERS
291Slow speechFAERS: 1US FAERS
292StrabismusFAERS: 1US FAERS
293StressFAERS: 1US FAERS
294Supraventricular tachycardiaFAERS: 1US FAERS
295TensionFAERS: 1US FAERS
296Therapeutic product effect incompleteFAERS: 1
Canada Vigilance: 5
Canada Vigilance
US FAERS
297Therapeutic response unexpectedFAERS: 1US FAERS
298Throat irritationFAERS: 1US FAERS
299ThrombosisFAERS: 1US FAERS
300ThyroidectomyFAERS: 1US FAERS
301Tongue blisteringFAERS: 1US FAERS
302Tooth ExtractionFAERS: 1US FAERS
303Toxicity to various agentsFAERS: 1US FAERS
304Trigeminal NeuralgiaFAERS: 1US FAERS
305Unevaluable eventFAERS: 1US FAERS
306Urinary IncontinenceFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
307Urinary RetentionFAERS: 1US FAERS
308Urine amphetamine positiveFAERS: 1US FAERS
309Uterine PolypFAERS: 1US FAERS
310Violence-related symptomFAERS: 1US FAERS
311Vitreous DetachmentFAERS: 1US FAERS
312Weight decreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
313Wrong technique in drug usage processFAERS: 1US FAERS
314nervous system disorderFAERS: 1US FAERS
315Anaphylactic shockCanada Vigilance: 1Canada Vigilance
316ArthropathyCanada Vigilance: 1Canada Vigilance
317DissociationCanada Vigilance: 1Canada Vigilance
318Drug dose titration not performedCanada Vigilance: 1Canada Vigilance
319Intentional dose omissionCanada Vigilance: 1Canada Vigilance
320PoisoningCanada Vigilance: 1Canada Vigilance
321Product residue presentCanada Vigilance: 1Canada Vigilance
322Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
323Vitreous floatersCanada Vigilance: 1Canada Vigilance
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