MetaADEDB 2.0 @ LMMD
Apomorphine
(VMWNQDUVQKEIOC-CYBMUJFWSA-N)
Structure
SMILES
CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O
Type(s)
Approved; Investigational
ATC code(s)
G04BE07; N04BC07
Molecular Formula:
C17H17NO2
Molecular Weight:
267.322
Log P:
2.7878
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
2
TPSA:
43.7
CAS Number(s):
58-00-4; 41372-20-7
Synonym(s)
1.
Apomorphine
2.
Apokinon
3.
Apomorphin-Teclapharm
4.
Apomorphine Chloride
5.
Apomorphine Hydrochloride
6.
Apomorphine Hydrochloride Anhydrous
7.
Apomorphine Hydrochloride, Anhydrous
8.
Apomorphine Hydrochloride, Hemihydrate
9.
Britaject
10.
Apomorphin Teclapharm
External Link(s)
MeSHD001058
PubChem Compound6005
BindingDB29644
50001955
ChEBI48538
CHEMBLCHEMBL53
DrugBankDB00714
DrugCentral228
IUPHAR/BPS Guide to PHARMACOLOGY33
KEGGdr:D07460
Therapeutic Target DatabaseD0H6QU
ZINC9073
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 110

View details

8726538
11035390
12068841
15592807
16575035
17466338
18537952
 		CTD
OFFSIDES
SIDER
US FAERS
2SomnolenceFAERS: 78SIDER
US FAERS
3DizzinessFAERS: 7612068841
17466338
18537952		CTD
OFFSIDES
SIDER
US FAERS
4Drug ineffectiveFAERS: 63OFFSIDES
US FAERS
5HypotensionFAERS: 37

View details

6815
1724532
3304729
7711465
8577817
8851490
10626749
12068841
12531464
12946566
15592733
 		CTD
SIDER
US FAERS
6FatigueFAERS: 33SIDER
US FAERS
7VomitingFAERS: 32

View details

6815
43118
1171496
1819906
2947255
6123475
6139838
7193623
7711465
8726538
8851490
12130853
12593651
13688671
16575035
18537952
19000276
 		CTD
SIDER
US FAERS
8Feeling abnormalFAERS: 27SIDER
US FAERS
9MalaiseFAERS: 24US FAERS
10YawningFAERS: 23OFFSIDES
SIDER
US FAERS
11HeadacheFAERS: 2118537952CTD
SIDER
US FAERS
12Injection site bruisingFAERS: 17US FAERS
13Chest PainFAERS: 16SIDER
US FAERS
14SyncopeFAERS: 1612068841CTD
SIDER
US FAERS
15AstheniaFAERS: 14SIDER
US FAERS
16TremorFAERS: 147246199CTD
US FAERS
17Injection site pruritusFAERS: 13OFFSIDES
US FAERS
18FlushingFAERS: 11SIDER
US FAERS
19Injection site erythemaFAERS: 11US FAERS
20PallorFAERS: 11OFFSIDES
SIDER
US FAERS
21Pharmaceutical product complaintFAERS: 10OFFSIDES
US FAERS
22Cold sweatFAERS: 9OFFSIDES
US FAERS
23Incorrect dose administeredFAERS: 9US FAERS
24PneumoniaFAERS: 9SIDER
US FAERS
25Urinary tract infectionFAERS: 9SIDER
US FAERS
26Freezing phenomenonFAERS: 8OFFSIDES
US FAERS
27Injection site noduleFAERS: 8US FAERS
28Injection site painFAERS: 8US FAERS
29AnxietyFAERS: 7SIDER
US FAERS
30Cerebrovascular accidentFAERS: 7US FAERS
31ErythemaFAERS: 7US FAERS
32DroolingFAERS: 6US FAERS
33Injection site massFAERS: 6US FAERS
34Joint injuryFAERS: 6US FAERS
35Myocardial InfarctionFAERS: 6US FAERS
36Product dose omissionFAERS: 6US FAERS
37PruritusFAERS: 6SIDER
US FAERS
38LethargyFAERS: 5US FAERS
39PainFAERS: 5OFFSIDES
US FAERS
40Unresponsive to stimuliFAERS: 5OFFSIDES
US FAERS
41AbasiaFAERS: 4OFFSIDES
US FAERS
42Abdominal PainFAERS: 4US FAERS
43Abdominal discomfortFAERS: 4US FAERS
44AgitationFAERS: 4US FAERS
45AmnesiaFAERS: 48829135
9384221
16631214		CTD
US FAERS
46Burning sensationFAERS: 4US FAERS
47Drug effect incompleteFAERS: 4US FAERS
48Head discomfortFAERS: 4US FAERS
49HypersensitivityFAERS: 4US FAERS
50Joint swellingFAERS: 4US FAERS
51Limb discomfortFAERS: 4OFFSIDES
US FAERS
52Musculoskeletal stiffnessFAERS: 4OFFSIDES
US FAERS
53Obsessive-Compulsive DisorderFAERS: 4US FAERS
54ParanoiaFAERS: 4OFFSIDES
US FAERS
55Peripheral swellingFAERS: 4US FAERS
56UrticariaFAERS: 4US FAERS
57Adverse eventFAERS: 3US FAERS
58Back PainFAERS: 3SIDER
US FAERS
59Blood pressure fluctuationFAERS: 3US FAERS
60Chest discomfortFAERS: 3US FAERS
61DementiaFAERS: 3US FAERS
62Depressed Level of ConsciousnessFAERS: 3US FAERS
63Device use issueFAERS: 3US FAERS
64Disease ProgressionFAERS: 3US FAERS
65Drug administration errorFAERS: 3US FAERS
66Incorrect dose administered by deviceFAERS: 3US FAERS
67Injection Site ReactionFAERS: 3SIDER
US FAERS
68Memory impairmentFAERS: 3US FAERS
69MyalgiaFAERS: 3US FAERS
70NervousnessFAERS: 3US FAERS
71PalpitationsFAERS: 3US FAERS
72RestlessnessFAERS: 3US FAERS
73Retinal DetachmentFAERS: 3US FAERS
74Spontaneous penile erectionFAERS: 3US FAERS
75Suicide attemptFAERS: 3US FAERS
76Blood glucose decreasedFAERS: 2US FAERS
77Blood sodium decreasedFAERS: 2US FAERS
78Cardiac ArrestFAERS: 2US FAERS
79CellulitisFAERS: 2US FAERS
80ChillsFAERS: 2US FAERS
81CholelithiasisFAERS: 2US FAERS
82ConstipationFAERS: 2SIDER
US FAERS
83DehydrationFAERS: 2SIDER
US FAERS
84Depressed moodFAERS: 2US FAERS
85Drug dose omissionFAERS: 2US FAERS
86DystoniaFAERS: 2

View details

87799
1350058
1560859
7651452
7753372
11844244
 		CTD
OFFSIDES
US FAERS
87HyperventilationFAERS: 2US FAERS
88HypokinesiaFAERS: 2945166
2880435
19385059		CTD
US FAERS
89Incorrect drug administration durationFAERS: 2US FAERS
90InfectionFAERS: 2OFFSIDES
US FAERS
91InflammationFAERS: 2US FAERS
92InfluenzaFAERS: 2US FAERS
93Injury associated with deviceFAERS: 2US FAERS
94Intentional product use issueFAERS: 2US FAERS
95Limb injuryFAERS: 2US FAERS
96MalnutritionFAERS: 2US FAERS
97Muscle RigidityFAERS: 22998546
19385059		CTD
US FAERS
98Musculoskeletal PainFAERS: 2US FAERS
99NasopharyngitisFAERS: 2SIDER
US FAERS
100Prescribed overdoseFAERS: 2US FAERS
101Product quality issueFAERS: 2US FAERS
102Pulmonary EmbolismFAERS: 2US FAERS
103RetchingFAERS: 2US FAERS
104SepsisFAERS: 2US FAERS
105SneezingFAERS: 2US FAERS
106SwellingFAERS: 2SIDER
US FAERS
107TachycardiaFAERS: 27711465CTD
US FAERS
108ThrombosisFAERS: 211157560CTD
US FAERS
109TrismusFAERS: 2US FAERS
110Weight decreasedFAERS: 2US FAERS
111Wrong technique in product usage processFAERS: 2US FAERS
112Abdominal massFAERS: 1US FAERS
113Accidental needle stickFAERS: 1US FAERS
114Accidental overdoseFAERS: 1US FAERS
115Activities of daily living impairedFAERS: 1OFFSIDES
US FAERS
116Acute psychosisFAERS: 1US FAERS
117AkinesiaFAERS: 1US FAERS
118Altered state of consciousnessFAERS: 1US FAERS
119AmblyopiaFAERS: 1US FAERS
120Angina PectorisFAERS: 1SIDER
US FAERS
121ApathyFAERS: 1OFFSIDES
US FAERS
122AphagiaFAERS: 1US FAERS
123AphasiaFAERS: 1US FAERS
124ArthralgiaFAERS: 1SIDER
US FAERS
125AsthenopiaFAERS: 1US FAERS
126AsthmaFAERS: 1US FAERS
127AtaxiaFAERS: 1US FAERS
128Atrial FibrillationFAERS: 18866506
17632031		CTD
US FAERS
129Atypical pneumoniaFAERS: 1US FAERS
130AversionFAERS: 1US FAERS
131BelligerenceFAERS: 1US FAERS
132Bipolar DisorderFAERS: 11620150CTD
US FAERS
133Bladder dysfunctionFAERS: 1US FAERS
134BradycardiaFAERS: 1

View details

1724532
7131940
7711465
8577817
10626749
12531464
 		CTD
OFFSIDES
US FAERS
135BradyphreniaFAERS: 1US FAERS
136BronchitisFAERS: 1US FAERS
137BruxismFAERS: 1US FAERS
138CardiomegalyFAERS: 1US FAERS
139CatatoniaFAERS: 14397415
17486685		CTD
US FAERS
140Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
141ClumsinessFAERS: 1US FAERS
142Delusional disorder, unspecified typeFAERS: 1US FAERS
143DependenceFAERS: 1US FAERS
144Device breakageFAERS: 1US FAERS
145Device difficult to useFAERS: 1US FAERS
146Device malfunctionFAERS: 1US FAERS
147DiplegiaFAERS: 1US FAERS
148DiscomfortFAERS: 1US FAERS
149Disease recurrenceFAERS: 1US FAERS
150DisorientationFAERS: 1US FAERS
151Drug effect delayedFAERS: 1US FAERS
152Drug ineffective for unapproved indicationFAERS: 1US FAERS
153DysarthriaFAERS: 1US FAERS
154DysgeusiaFAERS: 1OFFSIDES
US FAERS
155DyspepsiaFAERS: 1US FAERS
156Erectile dysfunctionFAERS: 1

View details

9613749
11035390
12068841
14624921
19845547
 		CTD
US FAERS
157Erection increasedFAERS: 1US FAERS
158ExcoriationFAERS: 1US FAERS
159Failure to ThriveFAERS: 1US FAERS
160Feeling jitteryFAERS: 1US FAERS
161Flank PainFAERS: 1US FAERS
162Food cravingFAERS: 1US FAERS
163Gait inabilityFAERS: 1US FAERS
164Gastrointestinal motility disorderFAERS: 1US FAERS
165Gaze palsyFAERS: 1US FAERS
166General physical health deteriorationFAERS: 1US FAERS
167Head lag abnormalFAERS: 1US FAERS
168Head titubationFAERS: 1US FAERS
169HemiplegiaFAERS: 1US FAERS
170Hilar lymphadenopathyFAERS: 1US FAERS
171HypersomniaFAERS: 1US FAERS
172Hyporesponsive to stimuliFAERS: 1US FAERS
173Iatrogenic injuryFAERS: 1US FAERS
174ImmobileFAERS: 1OFFSIDES
US FAERS
175Impaired driving abilityFAERS: 1US FAERS
176Increased upper airway secretionFAERS: 1OFFSIDES
US FAERS
177Infective tenosynovitisFAERS: 1US FAERS
178Injection site scarFAERS: 1US FAERS
179Injection site urticariaFAERS: 1US FAERS
180Injection site vesiclesFAERS: 1US FAERS
181Injection site warmthFAERS: 1US FAERS
182Intentional dose omissionFAERS: 1US FAERS
183Intentional self-injuryFAERS: 1US FAERS
184Intestinal ObstructionFAERS: 1US FAERS
185Joint stiffnessFAERS: 1US FAERS
186Ligament ruptureFAERS: 1US FAERS
187Limbal swellingFAERS: 1US FAERS
188Lip swellingFAERS: 1US FAERS
189Loss of personal independence in daily activitiesFAERS: 1US FAERS
190Macular degenerationFAERS: 1US FAERS
191Malignant neoplasm progressionFAERS: 1US FAERS
192Mental status changesFAERS: 1US FAERS
193MonoplegiaFAERS: 1US FAERS
194Muscle strainFAERS: 1US FAERS
195Muscle tightnessFAERS: 1US FAERS
196Musculoskeletal chest painFAERS: 1US FAERS
197Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
198Neck PainFAERS: 1US FAERS
199Needle issueFAERS: 1US FAERS
200NephrolithiasisFAERS: 1US FAERS
201Night sweatsFAERS: 1US FAERS
202No adverse eventFAERS: 1US FAERS
203Nonspecific reactionFAERS: 1US FAERS
204Orthostatic hypertensionFAERS: 1US FAERS
205OsteomyelitisFAERS: 1US FAERS
206Pharyngeal swellingFAERS: 1US FAERS
207Poor quality sleepFAERS: 1US FAERS
208Prescription drug used without a prescriptionFAERS: 1US FAERS
209Procedural complicationFAERS: 1US FAERS
210Product use complaintFAERS: 1US FAERS
211Product use in unapproved indicationFAERS: 1US FAERS
212Product use issueFAERS: 1US FAERS
213Psychiatric symptomFAERS: 1US FAERS
214Pulmonary congestionFAERS: 1US FAERS
215Rash erythematousFAERS: 1US FAERS
216Restless Legs SyndromeFAERS: 1US FAERS
217Retroperitoneal fibrosisFAERS: 1US FAERS
218RhinitisFAERS: 1US FAERS
219Secretion dischargeFAERS: 1US FAERS
220Skin reactionFAERS: 1US FAERS
221Sleep TalkingFAERS: 1US FAERS
222SnoringFAERS: 1US FAERS
223Soft tissue massFAERS: 1US FAERS
224SplenomegalyFAERS: 1US FAERS
225StaringFAERS: 1US FAERS
226StrabismusFAERS: 1US FAERS
227StressFAERS: 1US FAERS
228Therapeutic product effect decreasedFAERS: 1US FAERS
229Therapeutic product ineffectiveFAERS: 1US FAERS
230Therapeutic response delayedFAERS: 1US FAERS
231Therapy cessationFAERS: 1US FAERS
232Therapy changeFAERS: 1US FAERS
233ThirstFAERS: 1US FAERS
234TinnitusFAERS: 1US FAERS
235TorticollisFAERS: 1US FAERS
236Unevaluable eventFAERS: 1US FAERS
237Urethral perforationFAERS: 1US FAERS
238VertigoFAERS: 1US FAERS
239Viral upper respiratory tract infectionFAERS: 1US FAERS
240Visual ImpairmentFAERS: 1US FAERS
241AmphetaminesOFFSIDES
242AngerOFFSIDES
243Angioedema1560859CTD
244ArthritisOFFSIDES
245Azotemia1107835CTD
246Basal Ganglia Diseases9536454CTD
247Blood electrolytes abnormalOFFSIDES
248Blurred visionOFFSIDES
249Catalepsy

View details

10058
567284
572550
1239323
1819906
1980731
3283778
4279348
6119681
6541951
7617729
8005645
15614572
15881857
27252111
 		CTD
250Cocaine-Related Disorders9095340CTD
251Confusion15592733CTD
252Consciousness Disorders6146154
6683970		CTD
253Consciousness fluctuatingOFFSIDES
254Deep Brain StimulationOFFSIDES
255Disorders of Excessive Somnolence17466338CTD
256Disruptive, Impulse Control, and Conduct Disorders6093179
8097040		CTD
257Disturbance in sexual arousalSIDER
258DrowsinessOFFSIDES
SIDER
259Drug withdrawal headacheOFFSIDES
260Dyskinesia, Drug-Induced

View details

945166
1350058
1469394
1620148
2581196
3942894
4116875
7477981
7688878
7753372
8749992
8982660
9065543
9623985
10091616
10442251
10762141
11009181
11222455
11481687
11835461
11844244
11869030
12504871
15090933
15115785
15390037
15592807
16684788
17028572
17452372
17466338
18175345
19500572
20615977
 		CTD
261EcchymosisSIDER
262EndocarditisOFFSIDES
263Essential Tremor19497322CTD
264Facial NeuralgiaOFFSIDES
265Feeding and Eating Disorders19710391CTD
266Fever139615
4048012		CTD
267GranulomaSIDER
268Hallucinations15592733CTD
269HyporeflexiaOFFSIDES
270Hypotension, Orthostatic8726538
8889285
15592807		CTD
271Inappropriate schedule of drug administrationOFFSIDES
272IncoherentOFFSIDES
273Labile blood pressureOFFSIDES
274Medical device implantationOFFSIDES
275Mental disorders43118CTD
276Migraine Disorders2357707CTD
277Movement Disorders

View details

874471
1311455
2098751
3378602
3513907
4058245
9095340
9431546
10376124
12373562
12535962
14696016
15728856
 		CTD
278Myoclonus7078834CTD
279Neurobehavioral Manifestations11106876
23604964
28918840		CTD
280Neutrophil count decreasedOFFSIDES
281Parenteral NutritionOFFSIDES
282Parkinson Disease

View details

1469397
1560859
8726538
9099466
10900399
11009181
11157560
14598073
15592733
15592807
17028572
17466338
18328768
25405535
 		CTD
283Parkinson's disease aggravatedSIDER
284Parkinsonian Disorders

View details

1591961
7616686
8098931
11222455
11481687
11869030
12504871
16960862
18175345
 		CTD
285Penile Diseases

View details

44457
1358647
1596750
1788138
2080187
2482105
2825910
2872065
3032653
3033702
7557243
7686437
7862903
7938138
8090810
8202215
8745169
10379793
10704759
11489462
11890511
11906527
12086979
12946584
15240992
16160878
17201256
19733217
 		CTD
286PericarditisOFFSIDES
287Personality Disorders

View details

145765
414271
562773
573477
573894
575199
823570
986054
988593
988609
1168209
1168580
1239777
1332017
1930612
1946713
2422669
2545300
2870724
2892791
3575346
4274176
4736631
5105461
5530582
6542627
6686821
7197363
7197574
7198057
7630427
7800667
8106091
9512081
9658383
10595424
10760371
10791295
10904137
11124399
11220492
11245410
11256236
11352540
11395183
19211974
 		CTD
288Poisoning6815CTD
289PriapismSIDER
290Psychomotor Agitation12768274
23068419		CTD
291Psychoses, Substance-Induced16960862
20404009		CTD
292Psychotic Disorders347574CTD
293Pulmonary thrombosisOFFSIDES
294Reperfusion Injury15336313CTD
295Respiratory Insufficiency6815CTD
296RhinorrheaOFFSIDES
297Schizophrenia24739405CTD
298Seizures

View details

1974713
3183711
3758188
7193623
7353724
7875556
7936204
8103921
8471829
10744342
 		CTD
299ShockSIDER
300Skeletal injuryOFFSIDES
301Skin tightnessOFFSIDES
302Sleep Initiation and Maintenance Disorders1964203CTD
303Spinal column stenosisOFFSIDES
304Status Epilepticus9413831CTD
305Stereotypic Movement Disorder

View details

1170714
1965041
2335961
2819921
2883335
3252688
3463941
6105775
6139838
6152791
6322065
6539708
6738831
6752913
7336983
7902980
8225947
8627534
8982660
8996184
9425613
9586843
9798262
12576211
12902993
15358981
16235717
18408917
19298320
20504471
 		CTD
306Substance Withdrawal Syndrome10744342CTD
307Substance-Related Disorders

View details

2900472
2947255
7138674
7824548
11325394
11812522
 		CTD
308Sudden Cardiac DeathOFFSIDES
309Taste Disorders18537952CTD
310Therapy non-responderOFFSIDES
311Urination Disorders2904571CTD
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120235

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.