MetaADEDB 2.0 @ LMMD
Tolbutamide
(JLRGJRBPOGGCBT-UHFFFAOYSA-N)
Structure
SMILES
CCCCNC(=O)NS(=O)(=O)c1ccc(cc1)C
Type(s)
Approved; Investigational
ATC code(s)
A10BB03; V04CA01
Molecular Formula:
C12H18N2O3S
Molecular Weight:
270.348
Log P:
3.6456
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
83.65
CAS Number(s):
64-77-7
Synonym(s)
1.
Tolbutamide
2.
Apo-Tolbutamide
3.
Artosin
4.
Diabetol
5.
Diaval
6.
Dolipol
7.
Orabet
8.
Orinase
9.
Rastinon
10.
Tolbutamid R.A.N.
External Link(s)
MeSHD014044
PubChem Compound5505
BindingDB50027886
ChEBI27999
CHEMBLCHEMBL782
DrugBankDB01124
DrugCentral2696
IUPHAR/BPS Guide to PHARMACOLOGY6848
KEGGcpd:C07148
dr:D00380
Therapeutic Target DatabaseD06OIV
ZINC1530703
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1FatigueFAERS: 2US FAERS
2Granuloma AnnulareFAERS: 2US FAERS
3AstheniaFAERS: 1US FAERS
4DizzinessFAERS: 1OFFSIDES
US FAERS
5Drug ineffectiveFAERS: 1US FAERS
6ErythemaFAERS: 1SIDER
US FAERS
7IndurationFAERS: 1US FAERS
8NauseaFAERS: 1SIDER
US FAERS
9PapuleFAERS: 1US FAERS
10Product quality issueFAERS: 1US FAERS
11Product substitution issueFAERS: 1US FAERS
12Acid refluxOFFSIDES
13AcidosisOFFSIDES
14Activities of daily living impairedOFFSIDES
15AgranulocytosisSIDER
16Alcohol IntoleranceSIDER
17Alcohol abuseOFFSIDES
18Alcohol poisoningOFFSIDES
19AlopeciaCanada Vigilance: 1Canada Vigilance
20Anemia, Hemolytic838166CTD
21AnuriaOFFSIDES
22ArthritisOFFSIDES
23AscitesOFFSIDES
24AsthenopiaOFFSIDES
25Blood alcohol increasedOFFSIDES
26Blood glucose decreasedOFFSIDES
27Blood potassium decreasedOFFSIDES
28Bone marrow depressionOFFSIDES
29Brain Diseases, Metabolic879949CTD
30Brain natriuretic peptide increasedOFFSIDES
31BronchopneumoniaOFFSIDES
32Cardiac TamponadeOFFSIDES
33Cardiovascular Diseases51292CTD
34Catheter sepsisOFFSIDES
35Cerebral artery occlusionOFFSIDES
36Chemical and Drug Induced Liver Injury24085192CTD
37Chemotherapeutic drug level increasedOFFSIDES
38Choking sensationOFFSIDES
39CyanopsiaOFFSIDES
40DehydrationOFFSIDES
41Depressed Level of ConsciousnessOFFSIDES
42Diabetes mellitus inadequate controlOFFSIDES
43Disulfiram like reactionSIDER
44DrowsinessOFFSIDES
45Drug prescribing errorOFFSIDES
46DyspepsiaSIDER
47EczemaOFFSIDES
48Electromechanical dissociationOFFSIDES
49Epigastric fullnessSIDER
50EpistaxisOFFSIDES
51Erectile dysfunctionCanada Vigilance: 2Canada Vigilance
52Extremity necrosisOFFSIDES
53Eyelid Function DisorderOFFSIDES
54Fatty LiverOFFSIDES
55Gamma-Glutamyltransferase IncreasedOFFSIDES
56Gastric ulcerOFFSIDES
57General physical health deteriorationOFFSIDES
58HeadacheSIDER
59HeartburnSIDER
60HepatitisOFFSIDES
61Hepatomegaly28108177CTD
62HepatotoxicityOFFSIDES
63Hyperalgesia15010267CTD
64Hyperglycemia18164698CTD
65HyperventilationOFFSIDES
66Hypoglycemia879949
10052646
16087376		CTD
67Kidney FailureOFFSIDES
68LethargyOFFSIDES
69LeukopeniaSIDER
70Limb discomfortOFFSIDES
71Metabolic acidosisOFFSIDES
72Muscle FatigueOFFSIDES
73Nephrosis473209CTD
74Nephrotic Syndrome6071127CTD
75NocturiaOFFSIDES
76OrthopneaOFFSIDES
77PancytopeniaSIDER
78Polymyalgia RheumaticaOFFSIDES
79Porphyria Cutanea TardaSIDER
80Porphyria non-acuteSIDER
81PruritusSIDER
82Pupillary light reflex tests abnormalOFFSIDES
83PyelonephritisOFFSIDES
84Reaction gastrointestinalSIDER
85Sjogren's SyndromeOFFSIDES
86StressOFFSIDES
87Sudden Cardiac DeathOFFSIDES
88SyncopeCanada Vigilance: 2Canada Vigilance
89TendinitisOFFSIDES
90ThrombocytopeniaSIDER
91ThrombophlebitisCanada Vigilance: 1Canada Vigilance
92UrticariaCanada Vigilance: 1Canada Vigilance
SIDER
93Vascular Diseases9777324CTD
94effusionOFFSIDES
95jaundiceCanada Vigilance: 1Canada Vigilance
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