MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Saquinavir

(QWAXKHKRTORLEM-UGJKXSETSA-N)

Structure

SMILES: NC(=O)C[C@@H](C(=O)N[C@H]([C@@H](CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)O)Cc1ccccc1)NC(=O)c1ccc2c(n1)cccc2
Type(s): Approved; Investigational
ATC code(s): J05AE01
Molecular Formula:: C38H50N6O5
Molecular Weight:: 670.841
Log P:: 4.9033
Hydrogen Bond Acceptor:: 11
Hydrogen Bond Donor:: 5
TPSA:: 166.75
CAS Number(s):: 127779-20-8

Synonym(s)

Saquinavir

Invirase

Ro 31-8959

Saquinavir Mesylate

Saquinavir Monomethanesulfonate

Saquinivir

Monomethanesulfonate, Saquinavir

Ro 31 8959

Ro 318959

External Link(s)

MeSH	D019258
PubChem Compound	441243
BindingDB	519 50213021
ChEBI	63621
CHEMBL	CHEMBL114
DrugBank	DB01232
DrugCentral	2422
IUPHAR/BPS Guide to PHARMACOLOGY	4813
KEGG	dr:D00429
Therapeutic Target Database	D0WI3T
ZINC	3914596

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Maternal exposure timing unspecified	FAERS: 4		US FAERS
2	Pharmaceutical product complaint	FAERS: 4		US FAERS
3	Pneumonia	FAERS: 4		SIDER US FAERS
4	Cerebrovascular accident	FAERS: 3		SIDER US FAERS
5	Gaze palsy	FAERS: 3		US FAERS
6	Hepatosplenomegaly	FAERS: 3		OFFSIDES SIDER US FAERS
7	Hypersomnia	FAERS: 3		US FAERS
8	Infection	FAERS: 3		SIDER US FAERS
9	Respiratory distress	FAERS: 3		US FAERS
10	Talipes	FAERS: 3		US FAERS
11	Trisomy 21	FAERS: 3		OFFSIDES US FAERS
12	Cardiotoxicity	FAERS: 2		US FAERS
13	Escherichia infection	FAERS: 2		US FAERS
14	Mental status changes	FAERS: 2		US FAERS
15	Penile Infection	FAERS: 2		US FAERS
16	Penis carcinoma	FAERS: 2		US FAERS
17	Stillbirth	FAERS: 2		US FAERS
18	Vomiting	FAERS: 2		SIDER US FAERS
19	Weight decreased	FAERS: 2		SIDER US FAERS
20	Blindness	FAERS: 1		US FAERS
21	Bone Tuberculosis	FAERS: 1		US FAERS
22	CD4 Lymphocytes Decreased	FAERS: 1		US FAERS
23	Cytolytic hepatitis	FAERS: 1		US FAERS
24	Developmental Coordination Disorder	FAERS: 1		US FAERS
25	Diabetes Insipidus	FAERS: 1		US FAERS
26	Drug exposure during pregnancy	FAERS: 1		OFFSIDES US FAERS
27	Drug resistance	FAERS: 1		OFFSIDES US FAERS
28	Epilepsy	FAERS: 1		US FAERS
29	Fracture	FAERS: 1		US FAERS
30	Headache	FAERS: 1		SIDER US FAERS
31	Lip and/or oral cavity cancer	FAERS: 1		US FAERS
32	Lipodystrophy acquired	FAERS: 1		OFFSIDES SIDER US FAERS
33	Malabsorption	FAERS: 1		OFFSIDES US FAERS
34	Nausea	FAERS: 1		SIDER US FAERS
35	Neonatal tachycardia	FAERS: 1		US FAERS
36	Neutropenia	FAERS: 1		SIDER US FAERS
37	No adverse event	FAERS: 1		US FAERS
38	Overdose	FAERS: 1		US FAERS
39	Perinatal brain damage	FAERS: 1		US FAERS
40	Pneumocystis jiroveci pneumonia	FAERS: 1		US FAERS
41	Respiratory Failure	FAERS: 1		US FAERS
42	Retching	FAERS: 1		US FAERS
43	Sepsis	FAERS: 1		US FAERS
44	Septic Shock	FAERS: 1		US FAERS
45	Suicide attempt	FAERS: 1		SIDER US FAERS
46	Throat cancer	FAERS: 1		US FAERS
47	Tuberculous abscess central nervous system	FAERS: 1		US FAERS
48	Unevaluable event	FAERS: 1		US FAERS
49	jaundice	FAERS: 1		SIDER US FAERS
50	treatment failure	FAERS: 1		OFFSIDES US FAERS
51	Abdominal Pain			OFFSIDES SIDER
52	Abdominal colic			SIDER
53	Abdominal discomfort			SIDER
54	Abscess			SIDER
55	Acidosis			OFFSIDES
56	Acne			SIDER
57	Acquired lipoatrophic diabetes			SIDER
58	Acute Coronary Syndrome			OFFSIDES
59	Acute kidney injury		9850700	CTD
60	Acute tonsillitis			SIDER
61	Agitation			SIDER
62	Alanine Aminotransferase Increased			SIDER
63	Alopecia			SIDER
64	Amaurosis Fugax			OFFSIDES
65	Amnesia			SIDER
66	Amniotic fluid volume decreased			OFFSIDES
67	Amylase increased			SIDER
68	Anal Fissure			OFFSIDES
69	Anisocoria			OFFSIDES
70	Anorectal discomfort			SIDER
71	Anorexia			SIDER
72	Anticholinergic Syndrome			OFFSIDES
73	Anxiety attack			SIDER
74	Anxiety			SIDER
75	Apathy			OFFSIDES
76	Aphthous Stomatitis			OFFSIDES SIDER
77	Appendectomy			OFFSIDES
78	Arthralgia			SIDER
79	Arthritis			SIDER
80	Ascites			SIDER
81	Aspartate Aminotransferase Increased			SIDER
82	Aspiration Pneumonia			OFFSIDES
83	Asthenia			SIDER
84	Asthma			SIDER
85	Ataxia			OFFSIDES SIDER
86	Atopic rhinitis			SIDER
87	Atrial tachycardia			OFFSIDES
88	Atrioventricular Septal Defect			OFFSIDES
89	Back Pain			SIDER
90	Bacterial sepsis			OFFSIDES
91	Bipolar I disorder			OFFSIDES
92	Blepharitis			SIDER
93	Blepharoptosis			OFFSIDES
94	Blood alkaline phosphatase increased			OFFSIDES SIDER
95	Blood amylase increased			OFFSIDES SIDER
96	Blood and lymphatic system disorders			SIDER
97	Blood cholesterol			OFFSIDES
98	Blood creatine phosphokinase increased			OFFSIDES SIDER
99	Blood creatinine increased			SIDER
100	Blood glucose decreased			SIDER
101	Blood glucose increased			SIDER
102	Blood ketone body increased			OFFSIDES
103	Blood ketone body present			OFFSIDES
104	Blood magnesium decreased			OFFSIDES
105	Blood potassium decreased			OFFSIDES
106	Blood pyruvic acid decreased			OFFSIDES
107	Blood thyroid stimulating hormone increased			SIDER
108	Blood triglycerides increased			OFFSIDES SIDER
109	Blood uric acid			OFFSIDES
110	Bone marrow depression			OFFSIDES
111	Bone pain			OFFSIDES
112	Bradycardia			OFFSIDES
113	Brain Concussion			OFFSIDES
114	Brain natriuretic peptide increased			OFFSIDES
115	Brain stem syndrome			OFFSIDES
116	Bronchitis			OFFSIDES SIDER
117	Buccal mucosa ulceration			SIDER
118	Buffalo hump			SIDER
119	C-reactive protein decreased			OFFSIDES
120	CD4 lymphocytes increased			OFFSIDES
121	Cachexia			SIDER
122	Calcinosis			OFFSIDES
123	Carotid artery occlusion			OFFSIDES
124	Cataract			OFFSIDES
125	Cellulitis			SIDER
126	Central nervous system lesion			OFFSIDES
127	Cerebral disorder			OFFSIDES
128	Cerebral ventricle dilatation			OFFSIDES
129	Cervical dysplasia			OFFSIDES
130	Cheilitis			SIDER
131	Chemical and Drug Induced Liver Injury		23956101 24014644	CTD
132	Chest Pain			SIDER
133	Chills			SIDER
134	Choking sensation			OFFSIDES
135	Cholecystitis			OFFSIDES
136	Cholelithiasis			SIDER
137	Cholestasis of pregnancy			OFFSIDES
138	Choroiditis			OFFSIDES
139	Chronic liver disease			SIDER
140	Chronic ulcerative colitis			OFFSIDES
141	Clostridium difficile colitis			OFFSIDES
142	Common wart			SIDER
143	Complex partial seizures			OFFSIDES
144	Compression fracture			OFFSIDES
145	Congenital androgen deficiency			OFFSIDES
146	Congenital diaphragmatic hernia			OFFSIDES
147	Congenital heart disease			OFFSIDES
148	Congenital hepatomegaly			OFFSIDES
149	Congenital hydronephrosis			OFFSIDES
150	Congenital neurological disorder			OFFSIDES
151	Conjunctival deposit			OFFSIDES
152	Conjunctivitis			SIDER
153	Constipation			SIDER
154	Corneal Ulcer			OFFSIDES
155	Corneal abscess			OFFSIDES
156	Coronary Artery Disease		9848377	CTD
157	Cramps of lower extremities			SIDER
158	Creatine Phosphokinase Increased			SIDER
159	Creatinine increased			SIDER
160	Cubital Tunnel Syndrome			OFFSIDES
161	Cyanosis			SIDER
162	Cyst			OFFSIDES SIDER
163	Cytomegalovirus Retinitis			SIDER
164	Cytomegalovirus chorioretinitis			SIDER
165	Deafness			SIDER
166	Dehydration			OFFSIDES SIDER
167	Demyelination			OFFSIDES
168	Dental abscess			OFFSIDES
169	Dependence			OFFSIDES
170	Dermatitis			SIDER
171	Dextrocardia			OFFSIDES
172	Diabetes			OFFSIDES
173	Diabetes Mellitus			SIDER
174	Diaphragmatic Hernia			OFFSIDES
175	Diarrhea			OFFSIDES
176	Diplopia			OFFSIDES
177	Discomfort			SIDER
178	Disease recurrence			OFFSIDES
179	Disturbance in sexual arousal			SIDER
180	Dizziness			OFFSIDES SIDER
181	Dreaming excessive			SIDER
182	Drug Overdose		10513662	CTD
183	Drug toxicity			OFFSIDES
184	Dry skin			OFFSIDES SIDER
185	Dysarthria			SIDER
186	Dyschezia			SIDER
187	Dysentery			SIDER
188	Dysgeusia			SIDER
189	Dyslipidemias		27378623	CTD
190	Dysmorphism			OFFSIDES
191	Dyspepsia			SIDER
192	Ear and labyrinth disorders			SIDER
193	Eczema			SIDER
194	Endometriosis			OFFSIDES
195	Enterocolitis AIDS			OFFSIDES
196	Enterocolitis			OFFSIDES
197	Eosinophilic Pneumonia			OFFSIDES
198	Epididymitis			SIDER
199	Epistaxis			SIDER
200	Erectile dysfunction			OFFSIDES SIDER
201	Eructation			SIDER
202	Erythema Infectiosum			OFFSIDES
203	Erythema Multiforme			SIDER
204	Erythema			SIDER
205	Escherichia sepsis			OFFSIDES
206	Euphoric mood			SIDER
207	Exfoliative rash			OFFSIDES
208	Eye Infection			OFFSIDES
209	Eye irritation			SIDER
210	Facial Neuralgia			OFFSIDES
211	Facial Pain			SIDER
212	Factor XI Deficiency			SIDER
213	Fanconi Syndrome			OFFSIDES
214	Fat redistribution			OFFSIDES SIDER
215	Fatigue			SIDER
216	Fatty Liver			OFFSIDES
217	Feeling abnormal			OFFSIDES SIDER
218	Fibrosarcoma			OFFSIDES
219	Flatulence			OFFSIDES SIDER
220	Fluid overload			OFFSIDES
221	Folliculitis			SIDER
222	Full blood count decreased			OFFSIDES
223	Furunculosis			SIDER
224	Gamma-Glutamyltransferase Increased			OFFSIDES SIDER
225	Gastric ulcer			OFFSIDES
226	Gastritis			SIDER
227	Gastrointestinal Pain			SIDER
228	Gastrointestinal inflammation			SIDER
229	Gastrointestinal toxicity			OFFSIDES
230	Gastrointestinal ulcer			SIDER
231	General physical condition			OFFSIDES
232	General physical health deterioration			OFFSIDES
233	Gingivitis			SIDER
234	Glaucoma			OFFSIDES
235	Glomerulonephritis			OFFSIDES
236	Glossitis			SIDER
237	HELLP Syndrome			OFFSIDES
238	HIV Infections		View details 9848377 10465092 10625032 11141242 11197575 11545549 14502007 15388451 16288408 17898705 20723214	CTD
239	Head deformity			OFFSIDES
240	Heartburn			SIDER
241	Hemiparesis			OFFSIDES
242	Hepatitis B			OFFSIDES
243	Hepatitis			SIDER
244	Hepatomegaly			SIDER
245	Hepatotoxicity			OFFSIDES
246	Histiocytosis haematophagic			OFFSIDES
247	Hordeolum			OFFSIDES
248	Hydronephrosis			OFFSIDES
249	Hydrothorax			OFFSIDES
250	Hyperaldosteronism			OFFSIDES
251	Hyperkeratosis			OFFSIDES
252	Hyperreflexia			SIDER
253	Hypersensitivity			SIDER
254	Hypertrophy of Breast			SIDER
255	Hypogonadotropic hypogonadism			OFFSIDES
256	Hyporeflexia			OFFSIDES SIDER
257	Hypotension			SIDER
258	Hypothyroidism			SIDER
259	Ileal ulcer			OFFSIDES
260	Impetigo			OFFSIDES
261	Infestation			SIDER
262	Inflammation			SIDER
263	Influenza			SIDER
264	Inguinal mass			OFFSIDES
265	Insulin Resistance			SIDER
266	Intention tremor			OFFSIDES
267	Intestinal Obstruction			SIDER
268	Intoxication			SIDER
269	Kaolin cephalin clotting time prolonged			OFFSIDES
270	Ketoacidosis			SIDER
271	Kidney Calculi		9764943	CTD
272	Lacrimation decreased			SIDER
273	Laryngitis			SIDER
274	Lethargy			SIDER
275	Leukopenia neonatal			OFFSIDES
276	Leukopenia			SIDER
277	Libido disorder			SIDER
278	Lightheadedness			SIDER
279	Lip erosion			OFFSIDES
280	Lipase			OFFSIDES
281	Lipoatrophy			SIDER
282	Lipodystrophy			SIDER
283	Lipohypertrophy			SIDER
284	Listeriosis			OFFSIDES
285	Live Birth			OFFSIDES
286	Low Back Pain			SIDER
287	Lymphadenopathy			SIDER
288	Lymphocyte count decreased			SIDER
289	Lymphoma			OFFSIDES
290	Macrocytosis			OFFSIDES
291	Malaise			SIDER
292	Malignant tumour excision			OFFSIDES
293	Malnutrition			SIDER
294	Mental impairment			OFFSIDES
295	Microcytosis			OFFSIDES
296	Mitochondrial toxicity			OFFSIDES
297	Molluscum Contagiosum			SIDER
298	Mononeuritis			OFFSIDES
299	Muscle Weakness			OFFSIDES
300	Muscle necrosis			OFFSIDES
301	Muscular Dystrophy			OFFSIDES
302	Musculoskeletal Deformity			OFFSIDES
303	Musculoskeletal Pain			SIDER
304	Musculoskeletal discomfort			SIDER
305	Musculoskeletal stiffness			SIDER
306	Mutagenic effect			OFFSIDES
307	Myalgia			SIDER
308	Mycosis Fungoides			OFFSIDES
309	Myopathy			SIDER
310	Myositis			SIDER
311	Necrosis		19147209	CTD
312	Nephrolithiasis			OFFSIDES SIDER
313	Neurologic Manifestations		10465092	CTD
314	Neuropathy			SIDER
315	Night sweats			SIDER
316	No adverse effect			OFFSIDES
317	Nocturia			SIDER
318	Nodular regenerative hyperplasia			OFFSIDES
319	Nodule			OFFSIDES
320	Normal delivery			OFFSIDES
321	Numbness of limbs			SIDER
322	Nystagmus			OFFSIDES
323	Oliguria			OFFSIDES
324	Ophthalmoplegia			OFFSIDES
325	Osteoporosis			OFFSIDES
326	Other bacterial diseases			SIDER
327	Pain			SIDER
328	Pancreatic Insufficiency			OFFSIDES
329	Pancreatic Pseudocyst		9848377	CTD
330	Pancreatitis		9848377	CTD SIDER
331	Pancytopenia			SIDER
332	Papillomatosis			SIDER
333	Papilloma			OFFSIDES SIDER
334	Paraparesis			OFFSIDES
335	Parasite DNA test positive			OFFSIDES
336	Paresis			SIDER
337	Pathogen resistance			OFFSIDES
338	Pelvic Pain			SIDER
339	Performance status decreased			OFFSIDES
340	Peripheral paralysis			OFFSIDES
341	Peritonsillar Abscess			SIDER
342	Pharyngitis			SIDER
343	Plagiocephaly			OFFSIDES
344	Poisoning			SIDER
345	Poliomyelitis			SIDER
346	Polyarthritis			SIDER
347	Polyhydramnios			OFFSIDES
348	Polyneuropathy			OFFSIDES
349	Poor quality sleep			OFFSIDES
350	Portal Hypertension			OFFSIDES SIDER
351	Portal Vein Thrombosis			OFFSIDES
352	Portal hypertensive gastropathy			OFFSIDES
353	Potentiating drug interaction			OFFSIDES
354	Pre-Eclampsia			OFFSIDES
355	Predisposition to disease			OFFSIDES
356	Prurigo			SIDER
357	Pruritus			SIDER
358	Psoriasis			OFFSIDES SIDER
359	Pulmonary Hypertension			OFFSIDES
360	Rales			OFFSIDES
361	Rebound effect			OFFSIDES
362	Redness of face			SIDER
363	Renal Colic			OFFSIDES SIDER
364	Retinal Vein Occlusion			OFFSIDES
365	Retinitis			OFFSIDES
366	Retrosternal pain			SIDER
367	Rhabdomyolysis			SIDER
368	Rhinitis			OFFSIDES SIDER
369	Rhonchi			OFFSIDES
370	Scab			OFFSIDES
371	Scarlet Fever			OFFSIDES
372	Shivering			SIDER
373	Shock			SIDER
374	Sick Sinus Syndrome			OFFSIDES
375	Sinusitis			SIDER
376	Skeleton dysplasia			OFFSIDES
377	Skin Papilloma			SIDER
378	Skin Ulcer			SIDER
379	Skin nodule			SIDER
380	Somnolence			SIDER
381	Splenic abscess			OFFSIDES
382	Splenomegaly			SIDER
383	Stevens-Johnson Syndrome		25811541	CTD OFFSIDES SIDER
384	Stiffness			SIDER
385	Stomach ache			SIDER
386	Stomatitis			SIDER
387	Subacute combined cord degeneration			OFFSIDES
388	Supraventricular tachycardia			OFFSIDES
389	Syncope			SIDER
390	T-lymphocyte count increased			OFFSIDES
391	Thirst			SIDER
392	Thoracic vertebral fracture			OFFSIDES
393	Thrombocytopenia			SIDER
394	Thrombophlebitis			SIDER
395	Tinnitus			SIDER
396	Tongue biting			OFFSIDES
397	Toothache			SIDER
398	Toxicity to various agents			SIDER
399	Toxoplasmosis			OFFSIDES
400	Tracheobronchitis			OFFSIDES
401	Transaminases increased			OFFSIDES SIDER
402	Trauma			SIDER
403	Tremor			SIDER
404	Ulcer			SIDER
405	Upset stomach			SIDER
406	Urinary sediment abnormal			OFFSIDES
407	Urinary tract infection			SIDER
408	Urticaria			SIDER
409	Vaginal Discharge			SIDER
410	Venous Thrombosis		10625032	CTD
411	Vertigo			SIDER
412	Viral mutation identified			OFFSIDES
413	Visual Impairment			SIDER
414	Visual disturbance			OFFSIDES SIDER
415	Visual tracking test abnormal			OFFSIDES
416	Vitamin A Deficiency			OFFSIDES
417	Vitamin B 12 Deficiency			OFFSIDES
418	White blood cell count decreased			SIDER
419	Xeroderma			SIDER
420	Xerophthalmia			SIDER
421	furuncle			SIDER
422	nervous system disorder			SIDER
423	overdose effect			SIDER

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