MetaADEDB 2.0 @ LMMD
Danazol
(POZRVZJJTULAOH-LHZXLZLDSA-N)
Structure
SMILES
C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cno3
Type(s)
Approved
ATC code(s)
G03XA01
Molecular Formula:
C22H27NO2
Molecular Weight:
337.455
Log P:
4.2210
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
46.26
CAS Number(s):
17230-88-5
Synonym(s)
1.
Danazol
2.
Azol
3.
Cyclomen
4.
Danatrol
5.
Danazant
6.
Danazol-Ratiopharm
7.
Danocrine
8.
Danol
9.
Danoval
10.
Ladogal
11.
Norciden
12.
Panacrine
13.
Danazol Ratiopharm
External Link(s)
MeSHD003613
PubChem Compound28417
BindingDB50423541
ChEBI4315
CHEMBLCHEMBL1479
DrugBankDB01406
DrugCentral779
IUPHAR/BPS Guide to PHARMACOLOGY6942
KEGGcpd:C06938
dr:D00289
Therapeutic Target DatabaseD09IPV
ZINC3881958
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AcneFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
2DysphoniaFAERS: 3SIDER
US FAERS
3PharyngitisFAERS: 3US FAERS
4Alanine Aminotransferase IncreasedFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
5Antiphospholipid SyndromeFAERS: 2OFFSIDES
US FAERS
6Blood alkaline phosphatase increasedFAERS: 2OFFSIDES
US FAERS
7Chest PainFAERS: 2OFFSIDES
US FAERS
8ChromaturiaFAERS: 2US FAERS
9DemyelinationFAERS: 2US FAERS
10Drug dispensing errorFAERS: 2OFFSIDES
US FAERS
11Incorrect dose administeredFAERS: 2US FAERS
12Medication ErrorFAERS: 2US FAERS
13Peliosis HepatisFAERS: 24038421
7847311		CTD
SIDER
US FAERS
14Pulmonary EmbolismFAERS: 2US FAERS
15jaundiceFAERS: 2
Canada Vigilance: 1		2929566
6102641
8497444		CTD
SIDER
Canada Vigilance
US FAERS
16nervous system disorderFAERS: 2US FAERS
17Abdominal PainFAERS: 1
Canada Vigilance: 4		Canada Vigilance
US FAERS
18AlopeciaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
19Altered state of consciousnessFAERS: 1OFFSIDES
US FAERS
20AmnesiaFAERS: 1OFFSIDES
US FAERS
21AphasiaFAERS: 1US FAERS
22Aspartate Aminotransferase IncreasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
23AstheniaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
24Blood creatine phosphokinase increasedFAERS: 1US FAERS
25Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
26Brain natriuretic peptide increasedFAERS: 1US FAERS
27Cerebral InfarctionFAERS: 1US FAERS
28DisabilityFAERS: 1US FAERS
29Disseminated Intravascular CoagulationFAERS: 1US FAERS
30Drug exposure during pregnancyFAERS: 1US FAERS
31DysarthriaFAERS: 1US FAERS
32Ejection Fraction DecreasedFAERS: 1OFFSIDES
US FAERS
33FatigueFAERS: 19764869CTD
SIDER
US FAERS
34Focal Nodular HyperplasiaFAERS: 116710600CTD
OFFSIDES
US FAERS
35Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
36GastrectomyFAERS: 1US FAERS
37HemiparesisFAERS: 1US FAERS
38HemiplegiaFAERS: 1US FAERS
39HepatitisFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
40HepatomegalyFAERS: 112651980
28108177		CTD
US FAERS
41HirsutismFAERS: 19764869CTD
SIDER
US FAERS
42HypoxiaFAERS: 1US FAERS
43Low density lipoprotein increasedFAERS: 1US FAERS
44MalaiseFAERS: 1US FAERS
45MastectomyFAERS: 1US FAERS
46Mood swingsFAERS: 1SIDER
US FAERS
47NervousnessFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
48Ocular icterusFAERS: 1US FAERS
49Ovarian adenomaFAERS: 1OFFSIDES
US FAERS
50Ovarian hyperfunctionFAERS: 1US FAERS
51PainFAERS: 1
Canada Vigilance: 2		9696224
9764869		CTD
Canada Vigilance
US FAERS
52PancytopeniaFAERS: 111757752CTD
US FAERS
53Personality change due to a general medical conditionFAERS: 1US FAERS
54Pharmaceutical product complaintFAERS: 1US FAERS
55PneumothoraxFAERS: 1US FAERS
56Precocious PubertyFAERS: 1US FAERS
57PregnancyFAERS: 1US FAERS
58Pulmonary FibrosisFAERS: 1US FAERS
59Pulmonary toxicityFAERS: 1US FAERS
60Respiratory FailureFAERS: 1US FAERS
61Retinal Artery OcclusionFAERS: 1US FAERS
62SepsisFAERS: 1US FAERS
63ShockFAERS: 1SIDER
US FAERS
64TremorFAERS: 1
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
65Trigeminal NeuralgiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
66Unevaluable eventFAERS: 1US FAERS
67Uterine atrophyFAERS: 1US FAERS
68VasculitisFAERS: 1US FAERS
69VomitingFAERS: 1SIDER
US FAERS
70Vulvovaginal discomfortFAERS: 1OFFSIDES
US FAERS
71Acne Vulgaris6453071
9764869		CTD
72Acute Coronary SyndromeSIDER
73Acute kidney injury14712320CTD
74Acute sinusitisOFFSIDES
75Adenoma2848945
15495253		CTD
76AneurysmOFFSIDES
77Angioedemas, Hereditary

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434701
2358093
3941465
7425772
9538488
19477491
 		CTD
78AngioedemaCanada Vigilance: 1

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6102641
9875659
10199359
16710600
 		CTD
OFFSIDES
Canada Vigilance
79AnorexiaOFFSIDES
80Anti-erythropoietin antibody positiveOFFSIDES
81Anxiety Disorders8422721CTD
82AnxietyCanada Vigilance: 1Canada Vigilance
SIDER
83ApathyCanada Vigilance: 1Canada Vigilance
84Arterial thrombosisOFFSIDES
SIDER
85ArteriosclerosisOFFSIDES
86Arthralgia6453071CTD
SIDER
87Arthritis656167CTD
88ArthropathyOFFSIDES
89Autoimmune thrombocytopeniaOFFSIDES
90Back PainSIDER
91BedriddenOFFSIDES
92Bile Duct Neoplasms9293063CTD
93Blast cells presentOFFSIDES
94Blood GlucoseOFFSIDES
95Blood blisterOFFSIDES
96Blood chloride decreasedOFFSIDES
97Blood potassium increasedOFFSIDES
98Blood sodiumOFFSIDES
99Blood urea increasedOFFSIDES
100Blurred visionOFFSIDES
101Bone marrow depressionOFFSIDES
102Brain Diseases3227518CTD
103Burning sensationCanada Vigilance: 1Canada Vigilance
104CalcinosisOFFSIDES
105Carotid Artery Thrombosis2759149CTD
106Carpal Tunnel Syndrome656167
1940991
6614076		CTD
SIDER
107CataractCanada Vigilance: 1Canada Vigilance
SIDER
108Catheter sepsisOFFSIDES
109CellulitisOFFSIDES
110Cerebral aspergillosisOFFSIDES
111Chemical and Drug Induced Liver Injury2390854
7991863
11862774		CTD
112Chest discomfortCanada Vigilance: 1Canada Vigilance
113Chest wall painOFFSIDES
114ChillsCanada Vigilance: 1Canada Vigilance
SIDER
115Cholangitis, Sclerosing2133530CTD
116Cholestasis2929566
8497444
8883334		CTD
117Chronic ulcerative colitisOFFSIDES
118Circumstance or information capable of leading to medication errorOFFSIDES
119ClaustrophobiaOFFSIDES
120ClumsinessCanada Vigilance: 1Canada Vigilance
121ConjunctivitisCanada Vigilance: 1Canada Vigilance
122ConstipationSIDER
123Cortical laminar necrosisOFFSIDES
124Cystitis3941465CTD
125Cytomegalovirus gastroenteritisOFFSIDES
126Cytomegalovirus test positiveOFFSIDES
127Depressive disorder9764869CTD
128DermatitisSIDER
129DiabetesOFFSIDES
130Disease ProgressionOFFSIDES
131DisorientationCanada Vigilance: 2Canada Vigilance
132DizzinessCanada Vigilance: 2Canada Vigilance
SIDER
133Drug ineffectiveOFFSIDES
134DuodenitisOFFSIDES
135Dyslipidemias6562983CTD
136DyspepsiaSIDER
137Edema9764869CTD
138EndometriomaOFFSIDES
139Endometriosis

View details

2616424
2741896
3750010
6102641
6453026
6453071
6562983
9248340
9696224
9764869
11757752
15221322
19148548
21261738
 		CTD
140Enteritis necroticansOFFSIDES
141EosinophiliaSIDER
142Eosinophilic myocarditisOFFSIDES
143Epigastric painSIDER
144EpilepsySIDER
145EpistaxisCanada Vigilance: 1Canada Vigilance
146Erythema MultiformeSIDER
147ErythemaCanada Vigilance: 2Canada Vigilance
OFFSIDES
148ErythrocytosisSIDER
149Feeling abnormalOFFSIDES
150Fibroadenoma of breastCanada Vigilance: 1Canada Vigilance
151FibromyalgiaOFFSIDES
152FlushingSIDER
153GastroenteritisSIDER
154General physical health deteriorationOFFSIDES
155Glycogen Storage Disease Type VOFFSIDES
156Guillain-Barre SyndromeSIDER
157Hamartoma9293063CTD
158HeadacheCanada Vigilance: 36453071
9764869		CTD
SIDER
Canada Vigilance
159Hearing Loss, Bilateral6726709CTD
160Hematuria3941465CTD
161Hemoglobinuria, Paroxysmal2133530CTD
162Hemorrhage7146883CTD
163HepatosplenomegalyOFFSIDES
164HepatotoxicityOFFSIDES
165Hereditary Angioedema Types I and II4014294
15806011
18387221		CTD
166HoarsenessSIDER
167Hypercalcemia2616424
6697011		CTD
168HyperinsulinismSIDER
169Hyperlipoproteinemias15806011CTD
170Hyperprolactinemia4087275CTD
171HypersensitivityCanada Vigilance: 2Canada Vigilance
172HypertrophySIDER
173Hypoalphalipoproteinemias15806011CTD
174Idiopathic intracranial hypertension with papilledema2913802CTD
175Impaired driving abilityOFFSIDES
176Infusion site mobility decreasedOFFSIDES
177Intestinal infarctionOFFSIDES
178Intracranial AneurysmOFFSIDES
179Jaundice, Obstructive1494534CTD
180Joint Range of Motion DecreasedOFFSIDES
181Joint sprainOFFSIDES
182Joint swellingSIDER
183LeukocytosisSIDER
184LeukopeniaSIDER
185Liver Failure, Acute11757752CTD
186Liver diseases6102641
16710600		CTD
187Lower respiratory tract infection bacterialOFFSIDES
188LymphomaOFFSIDES
189Memory impairmentCanada Vigilance: 2Canada Vigilance
190MenorrhagiaCanada Vigilance: 12374906
7146883		CTD
Canada Vigilance
191Menstruation Disturbances2358093
9764869		CTD
192MetrorrhagiaCanada Vigilance: 1Canada Vigilance
193Mitral Valve StenosisOFFSIDES
194Mood Disorders9764869CTD
195Multiple MyelomaOFFSIDES
196Muscle Cramp2358093
7344033
9764869		CTD
197Musculoskeletal discomfortSIDER
198Musculoskeletal stiffnessOFFSIDES
199MyalgiaCanada Vigilance: 2Canada Vigilance
200MyelodysplasiaOFFSIDES
201Myocardial InfarctionSIDER
202NauseaCanada Vigilance: 39764869CTD
OFFSIDES
SIDER
Canada Vigilance
203NephrolithiasisOFFSIDES
204Neutropenia2913802CTD
205NoduleSIDER
206Obsessive thoughtsOFFSIDES
207Oropharyngeal discomfortSIDER
208Oropharyngeal painSIDER
209PROTHROMBIN TIMEOFFSIDES
210Pain of skinOFFSIDES
211PalpitationsSIDER
212Pancreatitis2390854CTD
OFFSIDES
SIDER
213Papilledema2913802CTD
214Pelvic PainSIDER
215Peptic Ulcer PerforationCanada Vigilance: 1Canada Vigilance
216Peripheral arterial occlusive diseaseOFFSIDES
217Peripheral swellingCanada Vigilance: 1Canada Vigilance
218PlasmacytosisOFFSIDES
219Pleuritic painSIDER
220Primary Myelofibrosis7847311CTD
221Protein total increasedOFFSIDES
222PruritusCanada Vigilance: 52929566CTD
SIDER
Canada Vigilance
223Pseudotumor Cerebri

View details

1870243
1940991
2133530
2374906
3109637
 		CTD
224Pulmonary Emphysema9360432CTD
225QuadriparesisOFFSIDES
226Rash erythematousCanada Vigilance: 2Canada Vigilance
227Red blood cell schistocytes presentOFFSIDES
228Renal Insufficiency8497444CTD
229Respiratory fume inhalation disorderOFFSIDES
230Rhabdomyolysis14712320CTD
OFFSIDES
231SclerodermaOFFSIDES
232Sinus Thrombosis, Intracranial9248340CTD
233Sinus bradycardiaOFFSIDES
234Sjogren's SyndromeOFFSIDES
235Skin IndurationOFFSIDES
236Skin hypertrophyOFFSIDES
237Skin lesionOFFSIDES
238Sleep Initiation and Maintenance Disorders8422721CTD
239SplenectomyOFFSIDES
240Splenic Diseases7847311CTD
241Splenic peliosisSIDER
242Stevens-Johnson Syndrome25811541CTD
OFFSIDES
SIDER
243StressOFFSIDES
244Subarachnoid Hemorrhage1886315CTD
245Substance Withdrawal Syndrome1870243CTD
246SweatingSIDER
247SyncopeSIDER
248TachycardiaCanada Vigilance: 1Canada Vigilance
SIDER
249TachyphreniaOFFSIDES
250TensionSIDER
251ThrombocytopeniaCanada Vigilance: 112651980CTD
SIDER
Canada Vigilance
252Thrombosis11743571CTD
SIDER
253Urinary tract infection pseudomonalOFFSIDES
254Urinary tract infection staphylococcalOFFSIDES
255UrticariaCanada Vigilance: 1Canada Vigilance
SIDER
256VIIth nerve paralysisOFFSIDES
257Vaginal drynessSIDER
258Vasculitic rashOFFSIDES
259Ventricular FibrillationOFFSIDES
260VertigoSIDER
261Visual ImpairmentCanada Vigilance: 4Canada Vigilance
SIDER
262Visual disturbanceSIDER
263Voice Disorders6412898
10622516		CTD
264Vulvovaginal drynessSIDER
265Vulvovaginal pruritusCanada Vigilance: 1Canada Vigilance
266Weight Gain2358093
6453071
8422721		CTD
OFFSIDES
267bone marrow fibrosisOFFSIDES
268fibroma10494874CTD
269prostatitisOFFSIDES
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