MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Bezafibrate

(IIBYAHWJQTYFKB-UHFFFAOYSA-N)

Structure

SMILES: Clc1ccc(cc1)C(=O)NCCc1ccc(cc1)OC(C(=O)O)(C)C
Type(s): Approved; Investigational
ATC code(s): C10AB02
Molecular Formula:: C19H20ClNO4
Molecular Weight:: 361.819
Log P:: 3.9454
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 75.63
CAS Number(s):: 41859-67-0

Synonym(s)

Bezafibrate

Azufibrat

BM-15.075

Befibrat

Beza-Lande

Beza-Puren

Bezabeta

Bezacur

Bezafibrat PB

10.

Bezafisal

11.

Bezalip

12.

Bezamerck

13.

Béfizal

14.

Cedur

15.

Difaterol

16.

Eulitop

17.

Lipox

18.

Reducterol

19.

Regadrin B

20.

Sklerofibrat

21.

Solibay

22.

durabezur

23.

BM 15.075

24.

BM15.075

25.

Beza Lande

26.

Beza Puren

External Link(s)

MeSH	D001629
PubChem Compound	39042
BindingDB	28701
ChEBI	47612
CHEMBL	CHEMBL264374
DrugBank	DB01393
DrugCentral	362
IUPHAR/BPS Guide to PHARMACOLOGY	2668
KEGG	dr:D01366
Therapeutic Target Database	D00WCX
ZINC	3956919

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal Pain			SIDER
2	Acute Coronary Syndrome			SIDER
3	Acute kidney injury		View details 2280884 3374444 8808248 11764054 16316343	CTD
4	Adenoma		15447978	CTD
5	Alanine Aminotransferase Increased			OFFSIDES SIDER
6	Alopecia			SIDER
7	Alveolitis			OFFSIDES
8	Anal Fistula			OFFSIDES
9	Angioedema		17610533	CTD
10	Anorexia		17379010	CTD
11	Apathy			OFFSIDES
12	Ascites			OFFSIDES
13	Aspartate Aminotransferase Increased			SIDER
14	Asphyxia			OFFSIDES
15	Atherosclerosis		18712055	CTD
16	Autoimmune hepatitis			OFFSIDES
17	Back Pain		8017468	CTD
18	Bile duct cancer stage III			OFFSIDES
19	Blepharoptosis			OFFSIDES
20	Blepharospasm			OFFSIDES
21	Blood alkaline phosphatase increased			OFFSIDES SIDER
22	Blood amylase increased			OFFSIDES
23	Blood brain barrier defect			OFFSIDES
24	Blood count abnormal	Canada Vigilance: 3		Canada Vigilance
25	Blood creatine phosphokinase increased			OFFSIDES SIDER
26	Blood creatinine increased			OFFSIDES SIDER
27	Blood gases abnormal			OFFSIDES
28	Blood glucose fluctuation			OFFSIDES
29	Blood lactate dehydrogenase increased			OFFSIDES
30	Blood pH decreased			OFFSIDES
31	Blood pressure fluctuation			OFFSIDES
32	Blood triglycerides increased			OFFSIDES
33	Blood urea increased			OFFSIDES
34	Blood uric acid			OFFSIDES
35	Bradycardia			OFFSIDES
36	Brain Death			OFFSIDES
37	Brain Diseases, Metabolic		21816645	CTD
38	Bronchitis			SIDER
39	Cachexia		10628360 17379010	CTD
40	Cardiovascular Diseases		View details 10402106 10680050 12163127 16168052 18629356	CTD
41	Cerebral disorder			OFFSIDES
42	Chemical and Drug Induced Liver Injury		2737396 15447978 24085192	CTD
43	Cholangiolitis			OFFSIDES
44	Cholangitis, Sclerosing		16933007	CTD
45	Cholelithiasis			SIDER
46	Cholestasis		15447978	CTD SIDER
47	Chronic left ventricular failure			OFFSIDES
48	Clostridium colitis			OFFSIDES
49	Colonic Neoplasms		15892897	CTD
50	Color blindness			OFFSIDES
51	Concomitant disease aggravated			OFFSIDES
52	Constipation			SIDER
53	Coronary Artery Disease		View details 8622389 9359536 9717064 9822092 10716467 11123853 16511610	CTD
54	Coronary Stenosis		9359536	CTD
55	Coronary artery embolism			OFFSIDES
56	Creatine Phosphokinase Increased			SIDER
57	Cytolytic hepatitis			OFFSIDES
58	Cytomegalovirus antibody positive			OFFSIDES
59	Depressed Level of Consciousness			OFFSIDES
60	Dermatitis			SIDER
61	Detachment of retinal pigment epithelium			OFFSIDES
62	Diabetes Mellitus, Experimental		View details 12967931 15045684 16979161 17145126 21549692	CTD
63	Diabetes Mellitus		16168052 16472047 17190905	CTD
64	Diastolic dysfunction			OFFSIDES
65	Disseminated Intravascular Coagulation			OFFSIDES
66	Dizziness			SIDER
67	Drug Eruptions		3301301	CTD
68	Drug ineffective	Canada Vigilance: 3		Canada Vigilance
69	Drug resistance			OFFSIDES
70	Duodenal perforation			OFFSIDES
71	Dyslipidemias		View details 1323073 8622389 9515185 15045684 16168052 16259526 17610533 21411093	CTD
72	Dyspepsia			SIDER
73	Eczema			OFFSIDES SIDER
74	Electrocardiogram change			OFFSIDES
75	Epigastric distress			SIDER
76	Erectile dysfunction			SIDER
77	Erythema Multiforme			OFFSIDES SIDER
78	Erythema			SIDER
79	Escherichia urinary tract infection			OFFSIDES
80	Fatty Liver		11929713 18513333 19124612	CTD OFFSIDES
81	Fatty acid deficiency			OFFSIDES
82	Fibrosis		18513333	CTD
83	Flatulence			SIDER
84	Fluid intake restriction			OFFSIDES
85	Fungus serology test positive			OFFSIDES
86	Gamma-Glutamyltransferase Increased			OFFSIDES
87	Gastritis		8017468	CTD SIDER
88	Gastrointestinal Pain			SIDER
89	Gastrointestinal mucosal disorder			OFFSIDES
90	Glucose Metabolism Disorders		17002798 18230960 20404010	CTD
91	Glycosuria		21549692	CTD
92	Granuloma			OFFSIDES
93	HIV-Associated Lipodystrophy Syndrome		12472919	CTD
94	Headache		2563081 8017468	CTD SIDER
95	Hepatitis B positive			OFFSIDES
96	Hepatitis B surface antigen positive			OFFSIDES
97	Hepatitis C, Chronic		12586603 16792537 16933007	CTD
98	Hepatomegaly		View details 3301301 9920142 11216866 12782154 19124612 23485652	CTD
99	Histiocytosis haematophagic			OFFSIDES
100	Hypercholesterolemia		View details 2045526 2492189 2643751 3760707 8017468 10780315 11164425 11545549 14602771 21703979	CTD
101	Hyperglycemia		View details 10726910 11288046 17145126 17190905	CTD
102	Hyperinsulinism		21549692	CTD
103	Hyperlipidemia, Familial Combined		3760707	CTD
104	Hyperlipoproteinemia Type V		906593	CTD
105	Hyperlipoproteinemias		2360915 2722079	CTD
106	Hypersensitivity			SIDER
107	Hypertriglyceridemia		View details 2643751 2653325 3760707 7893284 8147947 8593127 9006809 9118820 9223394 9678787 10751747 10780315 11164425 11288046 11545549 11893366 12472919 12661920 12754275 15907413 16549462 17379010 20404010	CTD
108	Hypertrophy		19214135	CTD
109	Hypoalphalipoproteinemias		9118820	CTD
110	Hyporeflexia			OFFSIDES
111	Induration			OFFSIDES
112	Infection			SIDER
113	Inflammation		11893366 12657956 12704018	CTD
114	Influenza			SIDER
115	Insulin Resistance		View details 9032088 9156048 11288046 11893366 12754275 15045684 16168052 17002798 17190905 18230960 21324916	CTD
116	Isosporiasis			OFFSIDES
117	Kidney Diseases		11096145 21338618	CTD
118	Leukopenia neonatal			OFFSIDES
119	Liver Neoplasms, Experimental		15447978	CTD
120	Lymphangiosis carcinomatosa			OFFSIDES
121	Markedly reduced dietary intake			OFFSIDES
122	Metabolic acidosis			OFFSIDES
123	Mitochondrial Diseases		17499714	CTD
124	Muscle Weakness		1291164 2234250 2722079	CTD OFFSIDES
125	Musculoskeletal discomfort			SIDER
126	Myalgia			SIDER
127	Myocardial Infarction		8622389 9211018	CTD SIDER
128	Myoglobinuria		1291164 3374444	CTD
129	Myositis	Canada Vigilance: 1	2722079 11062950	CTD SIDER Canada Vigilance
130	Nausea			SIDER
131	Necrosis		1291164 2046439 8467827	CTD
132	Nephritis, Interstitial		11064678	CTD
133	Neuromuscular Diseases		16248366	CTD
134	Non-alcoholic Fatty Liver Disease		View details 10348023 12058881 12586603 16574099 21549692	CTD
135	Obesity		21324916	CTD
136	Osteolysis			OFFSIDES
137	Oxygen consumption decreased			OFFSIDES
138	Pain		2722079	CTD SIDER
139	Pancreatic Diseases		12657956	CTD
140	Pancytopenia			SIDER
141	Perianal abscess			OFFSIDES
142	Pericardial effusion			OFFSIDES
143	Peripheral Nervous System Diseases		7950666	CTD
144	Peritonitis			OFFSIDES
145	Pharyngitis			SIDER
146	Plaque, Atherosclerotic		9211018	CTD
147	Polycystic Ovary Syndrome		21734263	CTD
148	Portal Hypertension			OFFSIDES
149	Postrenal failure			OFFSIDES
150	Precancerous Conditions		15447978	CTD
151	Protein total abnormal			OFFSIDES
152	Pruritus			SIDER
153	Purpura			SIDER
154	QRS axis abnormal			OFFSIDES
155	Renal Insufficiency		7566588 8094133	CTD
156	Respiratory Failure			OFFSIDES
157	Retinal exudates			OFFSIDES
158	Retinal pigment epithelial tear			OFFSIDES
159	Rhabdomyolysis		View details 2280884 3301301 8808248 11764054	CTD OFFSIDES SIDER
160	Sarcoidosis			OFFSIDES
161	Septic Shock			OFFSIDES
162	Signs and Symptoms, Digestive		3301301	CTD
163	Sjogren-Larsson Syndrome		16837225	CTD
164	Snoring			OFFSIDES
165	Stent occlusion			OFFSIDES
166	Stevens-Johnson Syndrome			SIDER
167	Subcutaneous Abscess			OFFSIDES
168	Tenosynovitis			SIDER
169	Testicular Diseases		21703979	CTD
170	Thrombocytopenia			SIDER
171	Thrombophlebitis			OFFSIDES
172	Thrombosis		11461176	CTD
173	Toxic Epidermal Necrolysis			SIDER
174	Transaminases increased			SIDER
175	Urethral Stenosis			OFFSIDES
176	Urticaria			SIDER
177	Vascular purpura			SIDER
178	Wrong drug administered			OFFSIDES
179	prostatitis			OFFSIDES

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