MetaADEDB 2.0 @ LMMD
Diethylstilbestrol
(RGLYKWWBQGJZGM-ISLYRVAYSA-N)
Structure
SMILES
CC/C(=C(\c1ccc(cc1)O)/CC)/c1ccc(cc1)O
Type(s)
Approved; Investigational
ATC code(s)
G03CB02; G03CC05; L02AA01; L02AA04
Molecular Formula:
C18H20O2
Molecular Weight:
268.350
Log P:
4.8286
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
2
TPSA:
40.46
CAS Number(s):
56-53-1; 6898-97-1; 22610-99-7
Synonym(s)
1.
Diethylstilbestrol
2.
Stilbestrol
3.
Agostilben
4.
Apstil
5.
Diethylstilbestrol, (Z)-Isomer
6.
Diethylstilbestrol, Disodium Salt
7.
Distilbène
8.
Stilbene Estrogen
9.
Tampovagan
10.
Estrogen, Stilbene
External Link(s)
MeSHD004054
PubChem Compound448537
3054
BindingDB20625
ChEBI92795
41922
CHEMBLCHEMBL411
DrugBankDB00255
DrugCentral875
IUPHAR/BPS Guide to PHARMACOLOGY2801
KEGGcpd:C07620
dr:D00577
Therapeutic Target DatabaseD0Y2NE
ZINC1290
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Product adhesion issueFAERS: 38US FAERS
2Application site rashFAERS: 9OFFSIDES
US FAERS
3Feeling abnormalFAERS: 7OFFSIDES
US FAERS
4Wrong technique in product usage processFAERS: 7US FAERS
5Drug ineffectiveFAERS: 6US FAERS
6No adverse eventFAERS: 6US FAERS
7Product use issueFAERS: 6US FAERS
8AlopeciaFAERS: 5US FAERS
9HeadacheFAERS: 55171004
5658423
CTD
US FAERS
10Product quality issueFAERS: 5US FAERS
11Application site irritationFAERS: 4US FAERS
12CryingFAERS: 4OFFSIDES
US FAERS
13Drug dose omissionFAERS: 4US FAERS
14Night sweatsFAERS: 4US FAERS
15Pharmaceutical product complaintFAERS: 4OFFSIDES
US FAERS
16Application site pruritusFAERS: 3US FAERS
17Incorrect dose administeredFAERS: 3US FAERS
18MalaiseFAERS: 3US FAERS
19Mood swingsFAERS: 3US FAERS
20PainFAERS: 3577240CTD
US FAERS
21Pericardial effusionFAERS: 3OFFSIDES
US FAERS
22Product use in unapproved indicationFAERS: 3US FAERS
23Unevaluable eventFAERS: 3OFFSIDES
US FAERS
24Abdominal PainFAERS: 2OFFSIDES
US FAERS
25Adnexa uteri painFAERS: 2US FAERS
26Application site erythemaFAERS: 2OFFSIDES
US FAERS
27Depression suicidalFAERS: 2OFFSIDES
US FAERS
28ErythemaFAERS: 2US FAERS
29Medication ErrorFAERS: 2US FAERS
30NervousnessFAERS: 2US FAERS
31SomnolenceFAERS: 2US FAERS
32Weight decreasedFAERS: 2US FAERS
33AcneFAERS: 1US FAERS
34Adverse eventFAERS: 1OFFSIDES
US FAERS
35AnxietyFAERS: 1US FAERS
36AphasiaFAERS: 1US FAERS
37Application site burnFAERS: 1US FAERS
38Application site eczemaFAERS: 1US FAERS
39Application site massFAERS: 1US FAERS
40Application site necrosisFAERS: 1US FAERS
41Application site painFAERS: 1US FAERS
42Application site reactionFAERS: 1US FAERS
43Application site vesiclesFAERS: 1US FAERS
44ArthralgiaFAERS: 1US FAERS
45Back PainFAERS: 1US FAERS
46Breast engorgementFAERS: 1US FAERS
47BronchitisFAERS: 1US FAERS
48Device breakageFAERS: 1US FAERS
49Device use errorFAERS: 1US FAERS
50DiscomfortFAERS: 1US FAERS
51DizzinessFAERS: 15171004CTD
US FAERS
52Drug administered to patient of inappropriate ageFAERS: 1US FAERS
53Drug ineffective for unapproved indicationFAERS: 1US FAERS
54DysgeusiaFAERS: 1US FAERS
55Endometrial thickeningFAERS: 1US FAERS
56EpistaxisFAERS: 1US FAERS
57FatigueFAERS: 1US FAERS
58Feeling ColdFAERS: 1OFFSIDES
US FAERS
59Gastrointestinal PainFAERS: 1US FAERS
60HemiplegiaFAERS: 1US FAERS
61Hemiplegic migraineFAERS: 1US FAERS
62Hormone level abnormalFAERS: 1US FAERS
63Incorrect dose administered by productFAERS: 1US FAERS
64Incorrect drug administration durationFAERS: 1US FAERS
65Intentional product misuseFAERS: 1US FAERS
66LaryngitisFAERS: 1US FAERS
67MalabsorptionFAERS: 1US FAERS
68Maternal exposure before pregnancyFAERS: 1US FAERS
69Medical device discomfortFAERS: 1US FAERS
70Middle insomniaFAERS: 1US FAERS
71Musculoskeletal PainFAERS: 1US FAERS
72MyalgiaFAERS: 1US FAERS
73NauseaFAERS: 15171004
5658423
7212675
CTD
US FAERS
74Nipple painFAERS: 1US FAERS
75Peripheral swellingFAERS: 1US FAERS
76Physical product label issueFAERS: 1US FAERS
77Poor quality drug administeredFAERS: 1US FAERS
78Poor quality sleepFAERS: 1US FAERS
79Pre-existing condition improvedFAERS: 1US FAERS
80Product packaging issueFAERS: 1US FAERS
81PyelonephritisFAERS: 1US FAERS
82Renal Cell CarcinomaFAERS: 1US FAERS
83Skin irritationFAERS: 1US FAERS
84Skin reactionFAERS: 1US FAERS
85Suspected counterfeit productFAERS: 1US FAERS
86Therapeutic response unexpectedFAERS: 1US FAERS
87Uterine spasmFAERS: 1US FAERS
88Vulvovaginal drynessFAERS: 1OFFSIDES
US FAERS
89Abnormalities, Drug-Induced1171234
20002218
CTD
90Acute left ventricular failureOFFSIDES
91Adenocarcinoma, Clear Cell

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CTD
92Adenocarcinoma

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CTD
93Amyloidosis15469931CTD
94Anemia, Hemolytic2712071CTD
95Aneuploidy28087838CTD
96AngioedemaOFFSIDES
97AnhidrosisOFFSIDES
98Anorexia5171004CTD
99Anxiety Disorders6357269CTD
100Aortic Valve Stenosis830309CTD
101Benign biliary neoplasmOFFSIDES
102Blood Coagulation Disorders26712470CTD
103Blood alkaline phosphatase increasedOFFSIDES
104Blood creatinine increasedOFFSIDES
105Blood fibrinogenOFFSIDES
106Blood pH decreasedOFFSIDES
107Blood urea increasedOFFSIDES
108Blood uric acidOFFSIDES
109Brain Injuries1678068
20433902
CTD
110Brain Neoplasms17292458CTD
111Carcinoma

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CTD
112Cardiovascular Abnormalities20002218CTD
113Cardiovascular Diseases

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CTD
114Chemical and Drug Induced Liver Injury2835297
12890826
CTD
115Chest Pain10037391CTD
116Chronic left ventricular failureOFFSIDES
117Cold sweatOFFSIDES
118Conduct Disorder16307867CTD
119Contact DermatitisOFFSIDES
120Cryptorchidism7463583
12952375
16002989
CTD
121Cystadenocarcinoma6588221CTD
122Cystadenoma165277CTD
123Depressive disorder5171004
6357269
20332145
CTD
124Diarrhea5171004CTD
125Disease ProgressionOFFSIDES
126Disorders of Sex Development19729556CTD
127Disseminated Intravascular Coagulation65916CTD
128Dysmenorrhea16499031CTD
129Edema

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CTD
130Embryo Loss26712470CTD
131Endodontic procedureOFFSIDES
132Endometrial Hyperplasia16402032CTD
133Endometrial Neoplasms

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CTD
134Endometrial adenocarcinomaCanada Vigilance: 1Canada Vigilance
135Fatty Liver12890826CTD
136Female Urogenital Diseases

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CTD
137Feminization3284149
22275727
CTD
138Fetal Death65916CTD
139Genital Diseases, Male12446607CTD
140Genital Neoplasms, Female523031
7195652
16452187
CTD
141Gynecomastia1182631
11502463
CTD
142Heart failure4166904
4916019
10037391
CTD
143Hemangioendothelioma7438959CTD
144Hemangiosarcoma567256CTD
145Hemorrhage2821645CTD
146Hepatomegaly6628266
12217638
CTD
147Hypercalcemia4739237CTD
148Hyperesthesia5658423CTD
149Hyperplasia

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CTD
150Hyperprolactinemia1678068
4092719
9500197
CTD
151Hypertriglyceridemia1145147CTD
152Hypokinesia26712470CTD
153Hypospadias972792
11748570
16002989
CTD
154Infertility15036965CTD
155Ischemia10037391CTD
156Limb Deformities, Congenital14659782CTD
157Liver Cirrhosis12890826CTD
158Liver Neoplasms, Experimental

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CTD
159Liver neoplasms

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CTD
160Lung consolidationOFFSIDES
161Lupus Nephritis15166399CTD
162Lymphoma15700306CTD
163Male Urogenital Diseases16002989CTD
164Malignant neoplasm progressionOFFSIDES
165Mammary Neoplasms, Experimental3104256
6156259
CTD
166Menorrhagia5076457CTD
167Mesenteric Vascular Occlusion5106306CTD
168Metaplasia11389053CTD
169Migraine Disorders7212675CTD
170Myocardial Infarction

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CTD
171Myopia10209454CTD
172Neoplasm Metastasis17292458CTD
173Neoplasms, Experimental9695784
27259717
CTD
174Neoplasms, Glandular and Epithelial2040004CTD
175Neoplasms14781
821748
15313581
CTD
176Nervous tensionOFFSIDES
177Neurobehavioral Manifestations20433902
22223406
CTD
178Obesity22710028CTD
179Oligospermia12507655
19782717
CTD
180Parovarian Cyst165277CTD
181Peliosis Hepatis6736383CTD
182Pharyngolaryngeal PainOFFSIDES
183Pituitary Diseases3607779
14722030
CTD
184Pituitary Neoplasms

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CTD
185Porphyria Cutanea Tarda11851245CTD
186Pre-Eclampsia7823752
17601905
CTD
187Precancerous Conditions856457
7189642
CTD
188Pregnancy Complications

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CTD
189Premature Birth79882
10209454
CTD
190Prenatal Exposure Delayed Effects

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CTD
191Prenatal Injuries22733484CTD
192Product complaintCanada Vigilance: 1Canada Vigilance
193Prolactinoma

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CTD
194Prostatic Diseases15867144CTD
195Prostatic Neoplasms

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CTD
196Pulmonary EmbolismCanada Vigilance: 1946104CTD
Canada Vigilance
197Pulmonary HypertensionOFFSIDES
198Pulmonary InfarctionOFFSIDES
199Spermatocele1171234
16002989
16709447
CTD
200Substance Withdrawal Syndrome7010171CTD
201Testicular Diseases1171234
4027990
17679765
CTD
202Testicular Neoplasms

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CTD
203Thromboembolism1182631
8708714
CTD
204ThrombophlebitisCanada Vigilance: 1Canada Vigilance
205Tooth ExtractionOFFSIDES
206Transposition of Great Vessels830309CTD
207Trisomy16445652CTD
208Urethral stricture972792
15867144
CTD
209Urination Disorders972792CTD
210Urogenital Abnormalities

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CTD
211Uterine Diseases

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CTD
212Uterine Neoplasms

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CTD
213Uterine hemorrhage4073162CTD
214Vaginal Discharge5171004CTD
215Vaginal Diseases

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CTD
216Vaginal Neoplasms

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CTD
217Varicocele7463583CTD
218Vascular Diseases4073162CTD
219Venous Thrombosis

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CTD
220Vomiting7212675CTD
221Weight Gain5171004CTD
222Wrong technique in drug usage processOFFSIDES
223melanoma20204493CTD
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