MetaADEDB 2.0 @ LMMD
Astemizole
(GXDALQBWZGODGZ-UHFFFAOYSA-N)
Structure
SMILES
COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2
Type(s)
Approved; Withdrawn
ATC code(s)
R06AX11
Molecular Formula:
C28H31FN4O
Molecular Weight:
458.570
Log P:
5.3622
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
42.32
CAS Number(s):
68844-77-9
Synonym(s)
1.
Astemizole
2.
Alermizol
3.
Astemina
4.
Astemizol Alonga
5.
Astemizol Ratiopharm
6.
Astesen
7.
Emdar
8.
Esmacen
9.
Fustermizol
10.
Hismanal
11.
Histaminos
12.
Hubermizol
13.
Laridal
14.
Paralergin
15.
R-43-512
16.
Retolen
17.
Rifedot
18.
Rimbol
19.
Romadin
20.
Simprox
21.
Urdrim
22.
Alonga, Astemizol
23.
R 43 512
24.
R43512
25.
Ratiopharm, Astemizol
External Link(s)
MeSHD016589
PubChem Compound2247
BindingDB24226
ChEBI2896
CHEMBLCHEMBL296419
DrugBankDB00637
DrugCentral249
IUPHAR/BPS Guide to PHARMACOLOGY2603
KEGGcpd:C06832
dr:D00234
Therapeutic Target DatabaseD0Y2HR
ZINC601274
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Abdominal PainCanada Vigilance: 1Canada Vigilance
2Abdominal discomfortCanada Vigilance: 1Canada Vigilance
3AgitationCanada Vigilance: 1Canada Vigilance
4AlopeciaCanada Vigilance: 1Canada Vigilance
5Angioedema2883202CTD
6AstheniaCanada Vigilance: 2Canada Vigilance
7Bradycardia22744888CTD
8Cardiotoxicity26259608CTD
9Chemical and Drug Induced Liver Injury22258563CTD
10ChoreoathetosisCanada Vigilance: 1Canada Vigilance
11Cold sweatCanada Vigilance: 1Canada Vigilance
12DissociationCanada Vigilance: 1Canada Vigilance
13DizzinessCanada Vigilance: 23105558CTD
Canada Vigilance
14Drug Overdose8189766
8257958
9234661		CTD
15Eosinophilia1355641CTD
16EpistaxisCanada Vigilance: 1Canada Vigilance
17Euphoric moodCanada Vigilance: 1Canada Vigilance
18Feeling of body temperature changeCanada Vigilance: 1Canada Vigilance
19Folliculitis1671328CTD
20HeadacheCanada Vigilance: 3Canada Vigilance
21Hypersensitivity9377115CTD
22LethargyCanada Vigilance: 2Canada Vigilance
23Lichen Nitidus2563723CTD
24Limb Deformities, Congenital20144703CTD
25Long QT Syndrome

View details

8917271
9071844
11989578
12052668
16506357
17265420
18472280
20636881
24052561
 		CTD
26MalaiseCanada Vigilance: 1Canada Vigilance
27Malaria16816845CTD
28NauseaCanada Vigilance: 3Canada Vigilance
29OliguriaCanada Vigilance: 1Canada Vigilance
30Pain7541186CTD
31PancytopeniaCanada Vigilance: 1Canada Vigilance
32Parkinson Disease25405535CTD
33Pericardial effusion22744888CTD
34Personality Disorders9377115CTD
35Rhinitis, Allergic, Perennial

View details

1283658
2476015
2861220
10822083
 		CTD
36RhinitisCanada Vigilance: 1Canada Vigilance
37SinusitisCanada Vigilance: 1Canada Vigilance
38SomnolenceCanada Vigilance: 5Canada Vigilance
39Torsades de Pointes

View details

8189766
8250668
8256756
8257958
8480602
8792191
8917271
9071844
9272545
9583453
15787309
16506357
 		CTD
40Urticaria

View details

1683191
1976298
2147912
2565098
2568013
2568189
2859714
2883202
2885854
3080510
3097109
3134034
 		CTD
41Ventricular Dysfunction9234661CTD
42Ventricular Fibrillation8260280CTD
43Vertigo3105558CTD
44VomitingCanada Vigilance: 3Canada Vigilance
45melanoma16569656CTD
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