MetaADEDB 2.0 @ LMMD
Fluticasone
(MGNNYOODZCAHBA-GQKYHHCASA-N)
Structure
SMILES
FCSC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F
Type(s)
Approved; Experimental
ATC code(s)
D07AC17; R01AD08; R01AD58; R03AK06; R03AK11; R03BA05
Molecular Formula:
C22H27F3O4S
Molecular Weight:
444.508
Log P:
3.4691
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
99.9
CAS Number(s):
90566-53-3
Synonym(s)
1.
Fluticasone
2.
Cutivate
3.
Flixonase
4.
Flixotide
5.
Flonase
6.
Flovent
7.
Flovent HFA
8.
Fluticasone Propionate
9.
HFA, Flovent
10.
Propionate, Fluticasone
External Link(s)
MeSHD000068298
PubChem Compound5311101
ChEBI5134
CHEMBLCHEMBL1201396
DrugBankDB13867
IUPHAR/BPS Guide to PHARMACOLOGY6699
KEGGcpd:C07815
dr:D07981
Therapeutic Target DatabaseD0LC6K
ZINC4097438
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 48
Canada Vigilance: 27		Canada Vigilance
OFFSIDES
US FAERS
2Product quality issueFAERS: 38
Canada Vigilance: 2		Canada Vigilance
US FAERS
3EpistaxisFAERS: 31OFFSIDES
SIDER
US FAERS
4HeadacheFAERS: 22
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
5Nasal discomfortFAERS: 17SIDER
US FAERS
6SinusitisFAERS: 11OFFSIDES
SIDER
US FAERS
7AnosmiaFAERS: 10US FAERS
8Accidental underdoseFAERS: 7US FAERS
9AgeusiaFAERS: 7SIDER
US FAERS
10MalaiseFAERS: 7
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
11NauseaFAERS: 7SIDER
US FAERS
12Product dose omissionFAERS: 7US FAERS
13HypersensitivityFAERS: 5SIDER
US FAERS
14Product use in unapproved indicationFAERS: 5US FAERS
15Product use issueFAERS: 5US FAERS
16RhinalgiaFAERS: 5SIDER
US FAERS
17Accidental exposure to productFAERS: 4US FAERS
18DizzinessFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
19Drug ineffective for unapproved indicationFAERS: 4US FAERS
20DysgeusiaFAERS: 4US FAERS
21Incorrect dose administeredFAERS: 4US FAERS
22Product contamination physicalFAERS: 4US FAERS
23Throat irritationFAERS: 4
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
24VomitingFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
25CataractFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
26ChillsFAERS: 3US FAERS
27Device malfunctionFAERS: 3US FAERS
28GlaucomaFAERS: 3SIDER
US FAERS
29Oropharyngeal painFAERS: 3SIDER
US FAERS
30Peripheral swellingFAERS: 3US FAERS
31PneumoniaFAERS: 3
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
32Abdominal PainFAERS: 2OFFSIDES
SIDER
US FAERS
33AsthmaFAERS: 2
Canada Vigilance: 1

View details

9700034
11101185
11379810
11555383
11559968
11596838
11991558
22607479
23548184
 		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
34Back PainFAERS: 2SIDER
US FAERS
35Burning sensationFAERS: 2US FAERS
36Chest discomfortFAERS: 2SIDER
US FAERS
37ChokingFAERS: 2US FAERS
38DisorientationFAERS: 2US FAERS
39Drug DependenceFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
40Ear congestionFAERS: 2US FAERS
41Eye irritationFAERS: 2SIDER
US FAERS
42FlatulenceFAERS: 2US FAERS
43HypogeusiaFAERS: 2SIDER
US FAERS
44Inappropriate schedule of drug administrationFAERS: 2US FAERS
45Incorrect route of drug administrationFAERS: 2US FAERS
46Macular degenerationFAERS: 2US FAERS
47Nasal pruritusFAERS: 2US FAERS
48NasopharyngitisFAERS: 2SIDER
US FAERS
49PalpitationsFAERS: 2SIDER
US FAERS
50Paranasal sinus discomfortFAERS: 2US FAERS
51Product substitution issueFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
52PruritusFAERS: 2SIDER
US FAERS
53Retinal DetachmentFAERS: 2US FAERS
54Suspected product contaminationFAERS: 2US FAERS
55VertigoFAERS: 2US FAERS
56WheezingFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
57treatment failureFAERS: 2OFFSIDES
US FAERS
58Accidental overdoseFAERS: 1US FAERS
59Administration site lacerationFAERS: 1US FAERS
60Alcohol poisoningFAERS: 1US FAERS
61AlopeciaFAERS: 1US FAERS
62Amphetamines positiveFAERS: 1US FAERS
63AphagiaFAERS: 1US FAERS
64AphoniaFAERS: 1OFFSIDES
SIDER
US FAERS
65Apparent deathFAERS: 1US FAERS
66AsphyxiaFAERS: 1US FAERS
67Atrial FibrillationFAERS: 1US FAERS
68Atypical pneumoniaFAERS: 1US FAERS
69BlindnessFAERS: 1US FAERS
70BronchitisFAERS: 1OFFSIDES
SIDER
US FAERS
71BronchomalaciaFAERS: 1US FAERS
72Bronchopulmonary AspergillosisFAERS: 1US FAERS
73BronchospasmFAERS: 1SIDER
US FAERS
74CandidiasisFAERS: 1US FAERS
75Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
76DeformityFAERS: 1US FAERS
77DependenceFAERS: 1OFFSIDES
US FAERS
78DermatitisFAERS: 1SIDER
US FAERS
79DisabilityFAERS: 1US FAERS
80DiscomfortFAERS: 1SIDER
US FAERS
81Drug dose omissionFAERS: 1US FAERS
82Drug effect incompleteFAERS: 1US FAERS
83DysphoniaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
84Expired product administeredFAERS: 1US FAERS
85Eye InfectionFAERS: 1US FAERS
86Eye painFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
87FatigueFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
88Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
89Feeling jitteryFAERS: 1US FAERS
90Glucocorticoid deficiencyFAERS: 1US FAERS
91Growth retardationFAERS: 1SIDER
US FAERS
92Impaired quality of lifeFAERS: 1US FAERS
93Inappropriate schedule of product administrationFAERS: 1US FAERS
94Incorrect dose administered by deviceFAERS: 1US FAERS
95Increased tendency to bruiseFAERS: 1US FAERS
96Increased viscosity of upper respiratory secretionFAERS: 1US FAERS
97InfectionFAERS: 1SIDER
US FAERS
98Infective exacerbation of bronchiectasisFAERS: 1US FAERS
99InfluenzaFAERS: 1SIDER
US FAERS
100Initial insomniaFAERS: 1US FAERS
101Instillation site painFAERS: 1US FAERS
102Intercepted drug dispensing errorFAERS: 1US FAERS
103LethargyFAERS: 1OFFSIDES
US FAERS
104Limb injuryFAERS: 1US FAERS
105Medication ErrorFAERS: 1US FAERS
106Migraine with AuraFAERS: 1US FAERS
107Mucosal atrophyFAERS: 1US FAERS
108Musculoskeletal stiffnessFAERS: 1SIDER
US FAERS
109MyalgiaFAERS: 1SIDER
US FAERS
110Nasal PolypsFAERS: 1US FAERS
111Nasal inflammationFAERS: 1US FAERS
112Nasal mucosal ulcerFAERS: 1US FAERS
113Oral pruritusFAERS: 1US FAERS
114Oropharyngeal discomfortFAERS: 1SIDER
US FAERS
115OverdoseFAERS: 1US FAERS
116PainFAERS: 1OFFSIDES
SIDER
US FAERS
117Pharmaceutical product complaintFAERS: 1OFFSIDES
US FAERS
118PneumothoraxFAERS: 1US FAERS
119PresyncopeFAERS: 1US FAERS
120Product dispensing errorFAERS: 1US FAERS
121Product formulation issueFAERS: 1US FAERS
122Product prescribing issueFAERS: 1US FAERS
123Productive CoughFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
124Recalled product administeredFAERS: 1US FAERS
125Respiratory distressFAERS: 1US FAERS
126RetchingFAERS: 1US FAERS
127RhinitisFAERS: 1SIDER
US FAERS
128ScabFAERS: 1SIDER
US FAERS
129Sinus headacheFAERS: 1SIDER
US FAERS
130Skin WrinklingFAERS: 1US FAERS
131SneezingFAERS: 1SIDER
US FAERS
132SomnolenceFAERS: 1US FAERS
133Steroid withdrawal syndromeFAERS: 1US FAERS
134StomatitisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
135SyncopeFAERS: 1US FAERS
136ThirstFAERS: 1US FAERS
137TracheobronchomegalyFAERS: 1US FAERS
138TracheomalaciaFAERS: 1US FAERS
139Transcription medication errorFAERS: 1US FAERS
140TremorFAERS: 1
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
141Unevaluable eventFAERS: 1US FAERS
142UrticariaFAERS: 1SIDER
US FAERS
143VasculitisFAERS: 1SIDER
US FAERS
144Vitamin D DeficiencyFAERS: 1US FAERS
145Wound InfectionFAERS: 1US FAERS
146AbasiaOFFSIDES
147Abdominal InfectionOFFSIDES
148Abdominal discomfortOFFSIDES
SIDER
149AbscessSIDER
150AcheSIDER
151Acid refluxOFFSIDES
152Actinic keratosisOFFSIDES
153Acute Coronary SyndromeOFFSIDES
154Acute myocardial infarctionOFFSIDES
155Acute otitis mediaOFFSIDES
156Acute prerenal failureOFFSIDES
157Acute sinusitisOFFSIDES
158Adverse eventOFFSIDES
159AgitationCanada Vigilance: 2Canada Vigilance
SIDER
160AgraphiaOFFSIDES
161Alcoholic IntoxicationOFFSIDES
162Allergy to chemicalsOFFSIDES
163AmputationOFFSIDES
164Anaphylactic shockSIDER
165Anaphylactoid ReactionSIDER
166Anemia9434678CTD
167AngioedemaSIDER
168Angle Closure GlaucomaOFFSIDES
169AnhedoniaOFFSIDES
170AnhidrosisOFFSIDES
171Anoxic EncephalopathyOFFSIDES
172Anticonvulsant drug level above therapeuticOFFSIDES
173AnxietyCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
174ApneaOFFSIDES
175ArteriosclerosisOFFSIDES
176ArthralgiaSIDER
177Arthropod biteOFFSIDES
178Aspartate aminotransferase abnormalOFFSIDES
179Aspiration PneumoniaOFFSIDES
180AstheniaSIDER
181AtelectasisOFFSIDES
182Atrial FlutterOFFSIDES
183Atrioventricular BlockSIDER
184Benign Prostatic HyperplasiaOFFSIDES
185BereavementOFFSIDES
186Biliary adenomaOFFSIDES
187Bladder calculus removalOFFSIDES
188BlepharoconjunctivitisSIDER
189BlepharospasmOFFSIDES
190Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
191Blood chloride decreasedOFFSIDES
192Blood cholesterolOFFSIDES
193Blood corticotrophinOFFSIDES
194Blood corticotrophin abnormalOFFSIDES
195Blood glucose increasedSIDER
196Blood testosterone decreasedOFFSIDES
197Blood triglycerides increasedOFFSIDES
198Blood urine presentOFFSIDES
199Blurred visionOFFSIDES
200Bone density decreasedOFFSIDES
201Breast fibromaOFFSIDES
202Breast tendernessOFFSIDES
203BronchiolitisOFFSIDES
204Bronchitis, Chronic17687719CTD
205BruxismOFFSIDES
206BursitisOFFSIDES
207Cardioactive drug level increasedOFFSIDES
208Catheter site cellulitisOFFSIDES
209Cell marker increasedOFFSIDES
210CellulitisOFFSIDES
211Cerebral artery occlusionOFFSIDES
212Cervicobrachial syndromeOFFSIDES
213Chest tightnessSIDER
214Chest wall painOFFSIDES
215Choking sensationOFFSIDES
216CholecystitisSIDER
217Chronic Obstructive Airway DiseaseOFFSIDES
218Chronic sinusitisOFFSIDES
219Cluster HeadacheOFFSIDES
220ColitisOFFSIDES
221Common ColdSIDER
222Common wartSIDER
223Concomitant disease progressionOFFSIDES
224Congenital tricuspid valve incompetenceOFFSIDES
225Conjunctival depositOFFSIDES
226ConjunctivitisSIDER
227Cortisol decreasedCanada Vigilance: 1Canada Vigilance
228Cutaneous hypersensitivitySIDER
229CystOFFSIDES
230DebridementOFFSIDES
231DehydrationOFFSIDES
232DemyelinationOFFSIDES
233Dental cariesSIDER
234Dental discomfortOFFSIDES
SIDER
235Depressed moodOFFSIDES
236Dermatitis acneiformSIDER
237DermatomyositisOFFSIDES
238Device FailureOFFSIDES
239Device breakageOFFSIDES
240Device leakageOFFSIDES
241DiabetesOFFSIDES
242Diabetes MellitusSIDER
243DiplopiaOFFSIDES
244Disease recurrenceOFFSIDES
245Dissociative Identity DisorderOFFSIDES
246Diverticular perforationOFFSIDES
247DiverticulitisOFFSIDES
248Drug screen positiveOFFSIDES
249Drug withdrawal headacheOFFSIDES
250Dry skinSIDER
251DysmenorrheaOFFSIDES
252DyspepsiaOFFSIDES
253Dyspeptic signs and symptomsSIDER
254DysphasiaOFFSIDES
255Dyspnoea exacerbatedOFFSIDES
256DysuriaOFFSIDES
257Ear discomfortOFFSIDES
258EcchymosisSIDER
259Economic problemOFFSIDES
260Eczema HerpeticumSIDER
261EczemaSIDER
262Ejection Fraction DecreasedOFFSIDES
263Emotional distressOFFSIDES
264ErythemaSIDER
265Escherichia urinary tract infectionOFFSIDES
266Eustachian tube disorderOFFSIDES
267Exacerbation of asthmaSIDER
268ExcoriationSIDER
269Exposure to toxic agentOFFSIDES
270Feeding problem in childOFFSIDES
271FibromyalgiaOFFSIDES
272Fine motor delayOFFSIDES
273FolliculitisSIDER
274Food AllergySIDER
275FormicationOFFSIDES
276FractureSIDER
277GamblingOFFSIDES
278GangreneOFFSIDES
279Gastric pH increasedOFFSIDES
280Gastrointestinal PainSIDER
281Gastrointestinal discomfortSIDER
282Gastrointestinal infectionSIDER
283Gaze palsyOFFSIDES
284Glasgow coma scaleOFFSIDES
285Glycosuria10489860CTD
SIDER
286GoiterOFFSIDES
287GoutOFFSIDES
288GranulocytosisOFFSIDES
289Hay feverOFFSIDES
290Head discomfortCanada Vigilance: 1Canada Vigilance
291HemicephalalgiaOFFSIDES
292Hepatitis B virus testOFFSIDES
293Hepatitis C antibody positiveOFFSIDES
294Hepatitis COFFSIDES
295HepatitisOFFSIDES
296HoarsenessSIDER
297HypercapniaOFFSIDES
298HyperkeratosisOFFSIDES
299HyperkinesiaSIDER
300HypertrichosisSIDER
301Hypoaesthesia facialOFFSIDES
302HypokinesiaOFFSIDES
303HypoxiaOFFSIDES
304HysterectomyOFFSIDES
305ImmobileOFFSIDES
306ImpetigoSIDER
307IncontinenceOFFSIDES
308Incorrect product administration durationCanada Vigilance: 1Canada Vigilance
309Increased bronchial secretionOFFSIDES
310IndurationOFFSIDES
311InfestationSIDER
312Inflammation12823118CTD
SIDER
313Influenza-like symptomsSIDER
314Injection site erythemaOFFSIDES
315Injection site noduleOFFSIDES
316Intention tremorOFFSIDES
317Intervertebral disc disorderOFFSIDES
318Intraocular inflammationOFFSIDES
319Joint Range of Motion DecreasedOFFSIDES
320Joint stiffnessOFFSIDES
321KeratitisSIDER
322Kidney FailureOFFSIDES
323LacerationSIDER
324LacrimationSIDER
325LaryngitisSIDER
326Leukocytoclastic vasculitisSIDER
327LeukodermaSIDER
328LeukopeniaSIDER
329LightheadednessSIDER
330Liver transplant rejectionOFFSIDES
331LividityOFFSIDES
332Lower respiratory tract infectionSIDER
333Lung Diseases, Obstructive11150940CTD
334LymphadenitisCanada Vigilance: 1Canada Vigilance
335Lymphocyte count decreasedOFFSIDES
336Malignant neoplasm of spinal cordOFFSIDES
337MalnutritionSIDER
338MastoiditisOFFSIDES
339MegacolonOFFSIDES
340MenopauseSIDER
341MenorrhagiaSIDER
342Mental impairmentOFFSIDES
343MiliariaSIDER
344MorpheaOFFSIDES
345Multiple drug overdoseOFFSIDES
346Multiple sclerosis relapseOFFSIDES
347Muscle RigiditySIDER
348Muscle WeaknessOFFSIDES
349Musculoskeletal PainSIDER
350Musculoskeletal chest painOFFSIDES
351Musculoskeletal discomfortOFFSIDES
SIDER
352MyopiaOFFSIDES
353Nasal burningSIDER
354Nasal sorenessSIDER
355Nephrogenic Fibrosing DermopathyOFFSIDES
356NephrolithiasisOFFSIDES
357NeuralgiaOFFSIDES
358NocturiaOFFSIDES
359Nodal osteoarthritisOFFSIDES
360Ocular icterusOFFSIDES
361Open woundOFFSIDES
362Oral candidiasisSIDER
363Oral mucosal erythemaOFFSIDES
364Oropharyngeal candidiasisSIDER
365Oropharyngeal swellingSIDER
366OrthopneaOFFSIDES
367OsteopeniaSIDER
368OsteoporosisSIDER
369Pain of skinSIDER
370PancreatitisOFFSIDES
371PeriodontitisOFFSIDES
372PharyngitisSIDER
373Pharyngolaryngeal PainOFFSIDES
SIDER
374Pilonidal CystOFFSIDES
375PlatybasiaOFFSIDES
376Post lumbar puncture syndromeOFFSIDES
377Posterior subcapsular cataractSIDER
378Postoperative wound complicationOFFSIDES
379Prescribed overdoseOFFSIDES
380Procedural site reactionOFFSIDES
381Product complaintCanada Vigilance: 1Canada Vigilance
382Product lot number issueCanada Vigilance: 1Canada Vigilance
383Prolonged mensesSIDER
384Protein allergySIDER
385Protein total increasedOFFSIDES
386PsoriasisSIDER
387Psychiatric symptomOFFSIDES
388Pulmonary Eosinophilia10850854CTD
389Pulmonary HypertensionOFFSIDES
390Pustular psoriasisSIDER
391PyelonephritisOFFSIDES
392Rash erythematousSIDER
393Rectal examination abnormalOFFSIDES
394Renal tubular necrosisOFFSIDES
395Respiratory FailureOFFSIDES
396Respiratory tract congestionOFFSIDES
397Rheumatic disorderSIDER
398RheumatismSIDER
399Rhinitis perennialSIDER
400Rhinitis, Allergic, Perennial9934406CTD
401Secretion dischargeCanada Vigilance: 1Canada Vigilance
OFFSIDES
402SepsisSIDER
403SerositisOFFSIDES
404Sinus bradycardiaOFFSIDES
405Sinus painSIDER
406Skin PapillomaSIDER
407Skin irritationSIDER
408Skin lacerationOFFSIDES
409Sleep Apnea Syndromes16625567CTD
410Spinal column stenosisOFFSIDES
411Stinging of noseSIDER
412Stress at workOFFSIDES
413StressOFFSIDES
414Supraventricular tachycardiaOFFSIDES
415Swelling of eyelidSIDER
416SwellingSIDER
417TalipesOFFSIDES
418Tension HeadacheOFFSIDES
419Therapy non-responderOFFSIDES
420Thoracic vertebral fractureOFFSIDES
421ThrombocytopeniaSIDER
422Tinea PedisOFFSIDES
423Tongue discomfortCanada Vigilance: 1Canada Vigilance
424Tooth ExtractionOFFSIDES
425ToothacheSIDER
426TracheitisOFFSIDES
427TraumaSIDER
428UlcerSIDER
429Umbilical herniaOFFSIDES
430Upper-airway cough syndromeSIDER
431Urinary tract infection fungalOFFSIDES
432Venous stasisOFFSIDES
433Ventricular FibrillationOFFSIDES
434Ventricular hypokinesiaOFFSIDES
435Visual ImpairmentSIDER
436Visual disturbanceSIDER
437Vulvovaginal mycotic infectionSIDER
438muscle injuryOFFSIDES
SIDER
439nervous system disorderSIDER
440pustuleSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.