MetaADEDB 2.0 @ LMMD
Sofosbuvir
(TTZHDVOVKQGIBA-IQWMDFIBSA-N)
Structure
SMILES
CC(OC(=O)[C@@H](N[P@@](=O)(Oc1ccccc1)OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)F)n1ccc(=O)[nH]c1=O)C)C
Type(s)
Approved
ATC code(s)
J05AP08; J05AP51; J05AP55; J05AP56
Molecular Formula:
C22H29FN3O9P
Molecular Weight:
529.453
Log P:
2.0474
Hydrogen Bond Acceptor:
11
Hydrogen Bond Donor:
3
TPSA:
167.99
CAS Number(s):
1064684-44-1; 1190307-88-0
Synonym(s)
1.
Sofosbuvir
2.
2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
3.
GS-7977
4.
PSI 7977
5.
PSI-7977
6.
PSI7977
7.
Sovaldi
8.
7977, PSI
9.
GS 7977
10.
GS7977
External Link(s)
MeSHD000069474
PubChem Compound45375808
ChEBI85083
CHEMBLCHEMBL1259059
DrugBankDB08934
DrugCentral4811
IUPHAR/BPS Guide to PHARMACOLOGY7368
KEGGdr:D10366
Therapeutic Target DatabaseD0D4YZ
ZINC100074252
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1FatigueFAERS: 412
Canada Vigilance: 2
25987834CTD
SIDER
Canada Vigilance
US FAERS
2HeadacheFAERS: 31025987834CTD
SIDER
US FAERS
3NauseaFAERS: 171SIDER
US FAERS
4Drug ineffectiveFAERS: 98
Canada Vigilance: 24
Canada Vigilance
US FAERS
5Drug dose omissionFAERS: 62US FAERS
6DizzinessFAERS: 57SIDER
US FAERS
7AnxietyFAERS: 51SIDER
US FAERS
8PruritusFAERS: 49SIDER
US FAERS
9OverdoseFAERS: 42US FAERS
10Hepatitis CFAERS: 41
Canada Vigilance: 5
25850880
25937625
26052383
CTD
SIDER
Canada Vigilance
US FAERS
11VomitingFAERS: 37SIDER
US FAERS
12AstheniaFAERS: 36SIDER
US FAERS
13ArthralgiaFAERS: 33SIDER
US FAERS
14PainFAERS: 33SIDER
US FAERS
15MalaiseFAERS: 32US FAERS
16Accidental overdoseFAERS: 28US FAERS
17Acute kidney injuryFAERS: 26US FAERS
18Unevaluable eventFAERS: 26
Canada Vigilance: 1
Canada Vigilance
US FAERS
19Abdominal discomfortFAERS: 23SIDER
US FAERS
20ConstipationFAERS: 21SIDER
US FAERS
21treatment failureFAERS: 21
Canada Vigilance: 7
Canada Vigilance
US FAERS
22PneumoniaFAERS: 20
Canada Vigilance: 2
Canada Vigilance
US FAERS
23Weight decreasedFAERS: 20SIDER
US FAERS
24MyalgiaFAERS: 19SIDER
US FAERS
25Back PainFAERS: 18SIDER
US FAERS
26Dry skinFAERS: 17SIDER
US FAERS
27Memory impairmentFAERS: 16SIDER
US FAERS
28Peripheral swellingFAERS: 16US FAERS
29Chest PainFAERS: 14SIDER
US FAERS
30DyspepsiaFAERS: 13SIDER
US FAERS
31Myocardial InfarctionFAERS: 13US FAERS
32AmnesiaFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
33NasopharyngitisFAERS: 11
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
34PalpitationsFAERS: 11US FAERS
35SomnolenceFAERS: 11US FAERS
36FlatulenceFAERS: 10US FAERS
37Blood glucose increasedFAERS: 9US FAERS
38AlopeciaFAERS: 8SIDER
US FAERS
39ChillsFAERS: 8SIDER
US FAERS
40ChromaturiaFAERS: 8US FAERS
41NervousnessFAERS: 8US FAERS
42Therapy cessationFAERS: 8US FAERS
43Visual ImpairmentFAERS: 8US FAERS
44Abdominal PainFAERS: 7US FAERS
45AngerFAERS: 7US FAERS
46Cerebrovascular accidentFAERS: 7US FAERS
47Feeling abnormalFAERS: 7US FAERS
48Incorrect dose administeredFAERS: 7US FAERS
49Oropharyngeal painFAERS: 7US FAERS
50Ammonia increasedFAERS: 6US FAERS
51Chest discomfortFAERS: 6US FAERS
52DehydrationFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
53Emotional disorderFAERS: 6US FAERS
54HypersensitivityFAERS: 6US FAERS
55Mood swingsFAERS: 6US FAERS
56MyocarditisFAERS: 6US FAERS
57Product packaging quantity issueFAERS: 6US FAERS
58ThirstFAERS: 6US FAERS
59TremorFAERS: 6US FAERS
60Bone painFAERS: 5US FAERS
61BronchitisFAERS: 5US FAERS
62DysgeusiaFAERS: 5US FAERS
63Hepatitis C virus test positiveFAERS: 5US FAERS
64HungerFAERS: 5US FAERS
65InfluenzaFAERS: 5US FAERS
66Joint swellingFAERS: 5US FAERS
67Product quality issueFAERS: 5US FAERS
68SinusitisFAERS: 5US FAERS
69White blood cell count decreasedFAERS: 5US FAERS
70AgitationFAERS: 4SIDER
US FAERS
71AphagiaFAERS: 4US FAERS
72AscitesFAERS: 4US FAERS
73Depressed moodFAERS: 4US FAERS
74Diabetes MellitusFAERS: 4US FAERS
75EpistaxisFAERS: 4US FAERS
76ErythemaFAERS: 4US FAERS
77LymphomaFAERS: 4US FAERS
78Musculoskeletal PainFAERS: 4US FAERS
79PresyncopeFAERS: 4US FAERS
80PsoriasisFAERS: 4US FAERS
81SwellingFAERS: 4US FAERS
82TinnitusFAERS: 4US FAERS
83jaundiceFAERS: 4US FAERS
84Blood count abnormalFAERS: 3US FAERS
85Blood glucose abnormalFAERS: 3US FAERS
86Burning sensationFAERS: 3US FAERS
87CryingFAERS: 3US FAERS
88Depressed Level of ConsciousnessFAERS: 3US FAERS
89DysphoniaFAERS: 3US FAERS
90Feeling ColdFAERS: 3US FAERS
91Full blood count decreasedFAERS: 3US FAERS
92Hepatic EncephalopathyFAERS: 3US FAERS
93HypotensionFAERS: 3US FAERS
94InfectionFAERS: 3SIDER
US FAERS
95Intentional product misuseFAERS: 3US FAERS
96Lower respiratory tract congestionFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
97Middle insomniaFAERS: 3US FAERS
98PancreatitisFAERS: 3US FAERS
99Restless Legs SyndromeFAERS: 3US FAERS
100Rheumatoid ArthritisFAERS: 3US FAERS
101StressFAERS: 3US FAERS
102SunburnFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
103SyncopeFAERS: 3US FAERS
104Therapeutic response unexpectedFAERS: 3US FAERS
105Therapy changeFAERS: 3US FAERS
106ThrombocytopeniaFAERS: 3US FAERS
107Viral load increasedFAERS: 3US FAERS
108Wrong technique in product usage processFAERS: 3US FAERS
109Angina PectorisFAERS: 2US FAERS
110ArthropathyFAERS: 2US FAERS
111AsthmaFAERS: 2US FAERS
112Atrial FibrillationFAERS: 2US FAERS
113Bipolar DisorderFAERS: 2US FAERS
114Blood glucose fluctuationFAERS: 2US FAERS
115Blood potassium decreasedFAERS: 2US FAERS
116BradycardiaFAERS: 2US FAERS
117ChokingFAERS: 2US FAERS
118ColitisFAERS: 2US FAERS
119Extra dose administeredFAERS: 2US FAERS
120Eye irritationFAERS: 2US FAERS
121Feeling jitteryFAERS: 2US FAERS
122Food PoisoningFAERS: 2US FAERS
123GlomerulonephritisFAERS: 2US FAERS
124HerniaFAERS: 2US FAERS
125HypersomniaFAERS: 2US FAERS
126Inappropriate schedule of drug administrationFAERS: 2US FAERS
127InflammationFAERS: 2US FAERS
128Irritable Bowel SyndromeFAERS: 2US FAERS
129LethargyFAERS: 2US FAERS
130LeukopeniaFAERS: 2US FAERS
131Lipase increasedFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
132Lower respiratory tract infectionFAERS: 2US FAERS
133Mental impairmentFAERS: 2US FAERS
134Neck PainFAERS: 2US FAERS
135NephrolithiasisFAERS: 2US FAERS
136Night sweatsFAERS: 2US FAERS
137Ocular icterusFAERS: 2US FAERS
138Oral painFAERS: 2US FAERS
139Personality ChangeFAERS: 2US FAERS
140Portal Vein ThrombosisFAERS: 2US FAERS
141Pregnancy of partnerFAERS: 2US FAERS
142Product difficult to swallowFAERS: 2US FAERS
143Product label issueFAERS: 2US FAERS
144Product physical issueFAERS: 2US FAERS
145Product use issueFAERS: 2US FAERS
146Productive CoughFAERS: 2US FAERS
147Pulmonary EmbolismFAERS: 2US FAERS
148Secretion dischargeFAERS: 2US FAERS
149Skin UlcerFAERS: 2US FAERS
150Suicide attemptFAERS: 2US FAERS
151TuberculosisFAERS: 2US FAERS
152UlcerFAERS: 2US FAERS
153VertigoFAERS: 2US FAERS
154Viral test positiveFAERS: 2US FAERS
155WheezingFAERS: 2US FAERS
156Wrong drug administeredFAERS: 2US FAERS
157Wrong technique in drug usage processFAERS: 2US FAERS
158Abdominal tendernessFAERS: 1US FAERS
159Accidental exposure to productFAERS: 1US FAERS
160AcidosisFAERS: 1US FAERS
161AcneFAERS: 1US FAERS
162Acute Coronary SyndromeFAERS: 1US FAERS
163Adenocarcinoma of appendixFAERS: 1US FAERS
164AgeusiaFAERS: 1US FAERS
165Alcohol abuseFAERS: 1US FAERS
166Alcohol interactionFAERS: 1US FAERS
167Allergic respiratory symptomFAERS: 1US FAERS
168Animal biteFAERS: 1US FAERS
169Ankle FractureFAERS: 1US FAERS
170AnosmiaFAERS: 1US FAERS
171ApathyFAERS: 1US FAERS
172AppendicitisFAERS: 1US FAERS
173ArthritisFAERS: 1US FAERS
174Autoimmune hepatitisFAERS: 1US FAERS
175Back disorderFAERS: 1US FAERS
176BicytopeniaFAERS: 1US FAERS
177BlindnessFAERS: 1US FAERS
178Blood albumin abnormalFAERS: 1US FAERS
179Blood magnesium decreasedFAERS: 1US FAERS
180BradyphreniaFAERS: 1US FAERS
181CachexiaFAERS: 1US FAERS
182Cardiac FlutterFAERS: 1US FAERS
183CataractFAERS: 1US FAERS
184CellulitisFAERS: 1US FAERS
185Cerebral InfarctionFAERS: 1US FAERS
186CholelithiasisFAERS: 1US FAERS
187Clostridium difficile colitisFAERS: 1US FAERS
188Clostridium difficile infectionFAERS: 1US FAERS
189Cold sweatFAERS: 1US FAERS
190ColectomyFAERS: 1US FAERS
191Corneal InfectionFAERS: 1US FAERS
192Crystal nephropathyFAERS: 1US FAERS
193CupulolithiasisFAERS: 1US FAERS
194CystitisFAERS: 1US FAERS
195Death of relativeFAERS: 1US FAERS
196DeliriumFAERS: 1US FAERS
197DementiaFAERS: 1US FAERS
198Diabetes mellitus inadequate controlFAERS: 1US FAERS
199DiplopiaFAERS: 1US FAERS
200DisabilityFAERS: 1US FAERS
201DiscomfortFAERS: 1US FAERS
202Disease complicationFAERS: 1US FAERS
203Disseminated Intravascular CoagulationFAERS: 1US FAERS
204Drug abuseFAERS: 1US FAERS
205Drug dispensing errorFAERS: 1US FAERS
206Drug withdrawal syndromeFAERS: 1US FAERS
207DysphemiaFAERS: 1US FAERS
208DysuriaFAERS: 1US FAERS
209Economic problemFAERS: 1US FAERS
210EczemaFAERS: 1US FAERS
211Ejection Fraction DecreasedFAERS: 1US FAERS
212Embolic strokeFAERS: 1US FAERS
213EncephalitisFAERS: 1US FAERS
214EndometriosisFAERS: 1US FAERS
215Endoscopy abnormalFAERS: 1US FAERS
216Enzyme level increasedFAERS: 1US FAERS
217EructationFAERS: 1US FAERS
218Exposure via fatherFAERS: 1US FAERS
219Extranodal marginal zone B-cell lymphoma (MALT type)FAERS: 1US FAERS
220Eye InfectionFAERS: 1US FAERS
221Eye painFAERS: 1US FAERS
222FibromyalgiaFAERS: 1US FAERS
223Flank PainFAERS: 1US FAERS
224FlushingFAERS: 1US FAERS
225FormicationFAERS: 1US FAERS
226FractureFAERS: 1US FAERS
227Gastric infectionFAERS: 1US FAERS
228Gastric ulcerFAERS: 1US FAERS
229Gastrointestinal PainFAERS: 1US FAERS
230Gastrointestinal hypermotilityFAERS: 1US FAERS
231General physical health deteriorationFAERS: 1US FAERS
232Genital HerpesFAERS: 1US FAERS
233Genotype drug resistance test positiveFAERS: 1US FAERS
234Hepatic cancer metastaticFAERS: 1US FAERS
235Hepatic cancer stage IFAERS: 1US FAERS
236Hepatitis B virus test positiveFAERS: 1US FAERS
237Hepatitis C RNA increasedFAERS: 1US FAERS
238Hepatitis C RNAFAERS: 1US FAERS
239HepatitisFAERS: 1US FAERS
240HepatomegalyFAERS: 1US FAERS
241Hepatorenal SyndromeFAERS: 1US FAERS
242Hormone level abnormalFAERS: 1US FAERS
243Human T-cell lymphocytic virus type II infectionFAERS: 1US FAERS
244HyperchlorhydriaFAERS: 1US FAERS
245Hypertensive crisisFAERS: 1US FAERS
246Hypertrophic CardiomyopathyFAERS: 1US FAERS
247HypophagiaFAERS: 1US FAERS
248HypoxiaFAERS: 1US FAERS
249Impaired driving abilityFAERS: 1US FAERS
250ImpatienceFAERS: 1US FAERS
251Incorrect drug administration durationFAERS: 1US FAERS
252Incorrect product storageFAERS: 1US FAERS
253Increased upper airway secretionFAERS: 1US FAERS
254Inhibitory drug interactionFAERS: 1US FAERS
255Initial insomniaFAERS: 1US FAERS
256Injection site massFAERS: 1US FAERS
257Intestinal ObstructionFAERS: 1US FAERS
258Intra-abdominal fluid collectionFAERS: 1US FAERS
259Intracardiac massFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
260Iron deficiencyFAERS: 1US FAERS
261LaryngitisFAERS: 1US FAERS
262Limb discomfortFAERS: 1US FAERS
263Lipids abnormalFAERS: 1US FAERS
264Liver transplant rejectionFAERS: 1US FAERS
265Localised intraabdominal fluid collectionFAERS: 1US FAERS
266Lymphatic system neoplasmFAERS: 1US FAERS
267Maternal exposure during pregnancyFAERS: 1US FAERS
268Medication ErrorFAERS: 1US FAERS
269MeningiomaFAERS: 1US FAERS
270MenorrhagiaFAERS: 1US FAERS
271Mental status changesFAERS: 1US FAERS
272Metastases to adrenalsFAERS: 1US FAERS
273Multi-organ disorderFAERS: 1US FAERS
274Multiple allergiesFAERS: 1US FAERS
275Muscle FatigueFAERS: 1US FAERS
276Muscle RigidityFAERS: 1US FAERS
277Musculoskeletal chest painFAERS: 1US FAERS
278Musculoskeletal stiffnessFAERS: 1US FAERS
279Nephrotic SyndromeFAERS: 1US FAERS
280NeutropeniaFAERS: 1SIDER
US FAERS
281No adverse eventFAERS: 1US FAERS
282NocturiaFAERS: 1US FAERS
283Nonspecific reactionFAERS: 1US FAERS
284Pancreatic duct obstructionFAERS: 1US FAERS
285ParesisFAERS: 1US FAERS
286Pelvic Inflammatory DiseaseFAERS: 1US FAERS
287Performance status decreasedFAERS: 1US FAERS
288Perihepatic discomfortFAERS: 1US FAERS
289PhotodermatosisFAERS: 1US FAERS
290PhotophobiaFAERS: 1US FAERS
291Physical assaultFAERS: 1US FAERS
292PoisoningFAERS: 1US FAERS
293Polymerase chain reaction positiveFAERS: 1US FAERS
294Poor quality drug administeredFAERS: 1US FAERS
295Poor quality sleepFAERS: 1US FAERS
296Pregnancy on contraceptiveFAERS: 1US FAERS
297PregnancyFAERS: 1US FAERS
298Product contamination physicalFAERS: 1US FAERS
299Product size issueFAERS: 1US FAERS
300ProstatectomyFAERS: 1US FAERS
301Pulmonary HypertensionFAERS: 1US FAERS
302Pulmonary painFAERS: 1US FAERS
303Rash erythematousFAERS: 1US FAERS
304Renal Cell CarcinomaFAERS: 1US FAERS
305Renal massFAERS: 1US FAERS
306Renal painFAERS: 1US FAERS
307RestlessnessFAERS: 1US FAERS
308RetchingFAERS: 1US FAERS
309RosaceaFAERS: 1US FAERS
310SepsisFAERS: 1US FAERS
311Septic ShockFAERS: 1US FAERS
312Skin reactionFAERS: 1US FAERS
313Spinal cord infectionFAERS: 1US FAERS
314Squamous cell carcinoma of skinFAERS: 1US FAERS
315StomatitisFAERS: 1US FAERS
316Subcutaneous AbscessFAERS: 1US FAERS
317TachycardiaFAERS: 1US FAERS
318Therapeutic response delayedFAERS: 1US FAERS
319Therapy responderFAERS: 1US FAERS
320Throat cancerFAERS: 1US FAERS
321Throat irritationFAERS: 1US FAERS
322ThrombosisFAERS: 1US FAERS
323Tooth ExtractionFAERS: 1US FAERS
324ToothacheFAERS: 1US FAERS
325Toxicity to various agentsFAERS: 1US FAERS
326TransplantFAERS: 1US FAERS
327Transplant evaluationFAERS: 1US FAERS
328Urinary tract infectionFAERS: 1US FAERS
329UrticariaFAERS: 1US FAERS
330Uterine CancerFAERS: 1US FAERS
331Vascular ruptureFAERS: 1US FAERS
332VasculitisFAERS: 1US FAERS
333Virologic failureFAERS: 1US FAERS
334Adverse eventCanada Vigilance: 1Canada Vigilance
335Blood and lymphatic system disordersSIDER
336Completed SuicideSIDER
337DermatitisSIDER
338HCV coinfectionSIDER
339Hepatitis C, Chronic25987834
26239358
CTD
340InfestationSIDER
341Lymphocyte count decreasedSIDER
342MalnutritionSIDER
343Musculoskeletal discomfortSIDER
344PancytopeniaSIDER
345SuicideSIDER
346Therapy non-responderCanada Vigilance: 1Canada Vigilance
347nervous system disorderSIDER
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