MetaADEDB 2.0 @ LMMD
Nafcillin
(GPXLMGHLHQJAGZ-JTDSTZFVSA-N)
Structure
SMILES
CCOc1ccc2c(c1C(=O)N[C@@H]1C(=O)N3[C@@H]1SC([C@@H]3C(=O)O)(C)C)cccc2
Type(s)
Approved; Investigational
ATC code(s)
J01CF06; J01CR50
Molecular Formula:
C21H22N2O5S
Molecular Weight:
414.475
Log P:
2.8126
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
2
TPSA:
121.24
CAS Number(s):
147-52-4
Synonym(s)
1.
Nafcillin
2.
Naphthamidopenicillin
3.
Sodium Nafcillin
4.
Nafcil
5.
Nafcillin Sodium
6.
Nafcillin, Monosodium Salt, Anhydrous
7.
Nafcillin, Sodium
8.
Sodium, Nafcillin
External Link(s)
MeSHD009254
PubChem Compound8982
BindingDB50103525
ChEBI7447
CHEMBLCHEMBL1443
DrugBankDB00607
DrugCentral1869
KEGGcpd:C07250
dr:D08242
Therapeutic Target DatabaseD0A0JH
ZINC3875980
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Acute kidney injuryFAERS: 7US FAERS
2NauseaFAERS: 7SIDER
US FAERS
3NephritisFAERS: 6US FAERS
4VomitingFAERS: 6SIDER
US FAERS
5PruritusFAERS: 5
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
6jaundiceFAERS: 5US FAERS
7EosinophiliaFAERS: 4SIDER
US FAERS
8UrticariaFAERS: 4
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
9Abdominal PainFAERS: 3SIDER
US FAERS
10Blood creatinine increasedFAERS: 3OFFSIDES
US FAERS
11HypersensitivityFAERS: 3SIDER
US FAERS
12Weight decreasedFAERS: 3US FAERS
13CholestasisFAERS: 2US FAERS
14ChromaturiaFAERS: 2OFFSIDES
US FAERS
15DehydrationFAERS: 2US FAERS
16Nephritis allergicFAERS: 2US FAERS
17NeutropeniaFAERS: 27467307CTD
SIDER
US FAERS
18Peripheral swellingFAERS: 2US FAERS
19Respiratory FailureFAERS: 2US FAERS
20Serum SicknessFAERS: 2OFFSIDES
SIDER
US FAERS
21SwellingFAERS: 2SIDER
US FAERS
22White blood cell count decreasedFAERS: 2US FAERS
23Allergic hepatitisFAERS: 1US FAERS
24Ankle FractureFAERS: 1US FAERS
25ArthralgiaFAERS: 1SIDER
US FAERS
26Aspartate Aminotransferase IncreasedFAERS: 1SIDER
US FAERS
27AstheniaFAERS: 1US FAERS
28Autoimmune hepatitisFAERS: 1US FAERS
29Benign Prostatic HyperplasiaFAERS: 1OFFSIDES
US FAERS
30Bilirubin conjugated increasedFAERS: 1OFFSIDES
US FAERS
31Blood sodium increasedFAERS: 1US FAERS
32Blood urea increasedFAERS: 1US FAERS
33Blood urine presentFAERS: 1US FAERS
34Chest PainFAERS: 1OFFSIDES
US FAERS
35Clostridium test positiveFAERS: 1US FAERS
36Complication associated with deviceFAERS: 1US FAERS
37Contrast media reactionFAERS: 1US FAERS
38DisorientationFAERS: 1US FAERS
39Duodenal UlcerFAERS: 1US FAERS
40EpistaxisFAERS: 1US FAERS
41Erythema MultiformeFAERS: 1US FAERS
42ExophthalmosFAERS: 1US FAERS
43HeadacheFAERS: 1US FAERS
44Hepatic InfarctionFAERS: 1US FAERS
45Hepatorenal SyndromeFAERS: 1US FAERS
46HepatotoxicityFAERS: 1OFFSIDES
SIDER
US FAERS
47HypotensionFAERS: 1SIDER
US FAERS
48Incorrect dose administeredFAERS: 1US FAERS
49Joint swellingFAERS: 1US FAERS
50Markedly reduced dietary intakeFAERS: 1US FAERS
51Medication ErrorFAERS: 1US FAERS
52Metabolic acidosisFAERS: 1US FAERS
53MyoclonusFAERS: 1US FAERS
54Nephrogenic Systemic FibrosisFAERS: 1US FAERS
55Oropharyngeal painFAERS: 1US FAERS
56Palpable purpuraFAERS: 1US FAERS
57PalpitationsFAERS: 1US FAERS
58PetechiaeFAERS: 1US FAERS
59Product contamination physicalFAERS: 1US FAERS
60PurpuraFAERS: 1US FAERS
61Renal tubular necrosisFAERS: 1OFFSIDES
US FAERS
62Respiratory arrestFAERS: 1US FAERS
63SepsisFAERS: 1448989CTD
US FAERS
64Septic ShockFAERS: 1US FAERS
65Skin lesionFAERS: 1US FAERS
66Therapy changeFAERS: 1US FAERS
67Transaminases increasedFAERS: 1US FAERS
68Type III immune complex mediated reactionFAERS: 1US FAERS
69Urinary tract infectionFAERS: 1US FAERS
70Wrong technique in drug usage processFAERS: 1US FAERS
71Abdominal Compartment SyndromeOFFSIDES
72Abdominal discomfortSIDER
73Abscess3242521CTD
74AgitationCanada Vigilance: 1Canada Vigilance
75AgranulocytosisSIDER
76Alkalosis7431181CTD
77Anaphylactic shockSIDER
78AngioedemaSIDER
79Arthritis, Infectious7431181
7431606		CTD
80Asymptomatic bacteriuriaOFFSIDES
81Azotemia8621315CTD
82BabesiosisOFFSIDES
83Bacteremia6968176CTD
84Bacteria stool identifiedOFFSIDES
85Bacterial Infections6089633CTD
86Blood creatine increasedOFFSIDES
87Blood phosphorus increasedOFFSIDES
88Bone marrow depressionSIDER
89BronchospasmSIDER
90Chemical and Drug Induced Liver Injury1504413
6627877
8565754		CTD
91Circumstance or information capable of leading to medication errorOFFSIDES
92DermatitisSIDER
93Device related infectionOFFSIDES
94DiscomfortSIDER
95Drug Eruptions7431181
7431606		CTD
96Drug dispensing errorOFFSIDES
97DysphoniaCanada Vigilance: 1Canada Vigilance
98Endocarditis6268715CTD
99Eosinophils urine presentOFFSIDES
100ErythemaCanada Vigilance: 2Canada Vigilance
OFFSIDES
101Exanthema7467307
9161625		CTD
102ExtravasationSIDER
103Feeling abnormalSIDER
104Flank PainOFFSIDES
105Foaming at mouthOFFSIDES
106Gastrointestinal PainSIDER
107Haemophilus Infections6968176CTD
108Hematuria7431606CTD
109Hypokalemia448989
1067752
7431181		CTD
110InflammationSIDER
111Kidney Diseases6089633CTD
112LaryngospasmSIDER
113Leukopenia7467307CTD
114Local reactionSIDER
115MalaiseSIDER
116Meningitis, Bacterial3852897CTD
117Meningitis, Haemophilus6968176CTD
118Muscle enzymeOFFSIDES
119Musculoskeletal discomfortSIDER
120MyalgiaSIDER
121NecrosisSIDER
122Nephritis, Interstitial

View details

622610
7431606
8439691
17653125
20959502
 		CTD
123Nephrogenic Diabetes InsipidusOFFSIDES
124Oral pruritusOFFSIDES
125Osteomyelitis6176609
7431181		CTD
126Pain2278276CTD
SIDER
127PancytopeniaSIDER
128Paradoxical painOFFSIDES
129Pericardial effusionOFFSIDES
130Phlebitis9161625CTD
SIDER
131Postoperative Complications8621315CTD
132Protein urine presentSIDER
133Proteinuria7431606CTD
SIDER
134Pseudomonas Infections4015267CTD
135Pulmonary Valve StenosisOFFSIDES
136Rash erythematousCanada Vigilance: 2Canada Vigilance
137Reaction gastrointestinalSIDER
138Renal Insufficiency1504413
8439691		CTD
139RhinorrheaOFFSIDES
140Seizures3242521CTD
141ShockSIDER
142Signs and Symptoms, Digestive7431181CTD
143Skin necrosisSIDER
144Staphylococcal Infections

View details

448989
907335
3164989
3242521
3578331
3852897
6176609
6268715
7431181
7431606
8460924
9161625
10707400
11706922
 		CTD
145StomatitisSIDER
146ThrombophlebitisSIDER
147TinnitusOFFSIDES
148Urination Disorders448989
7431181		CTD
149Weight GainOFFSIDES
150Wrong drug administeredOFFSIDES
151pseudomembranous colitisSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120235

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.