Tolvaptan
(GYHCTFXIZSNGJT-UHFFFAOYSA-N)
Structure
- SMILES
- Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C
- Molecular Formula:
- C26H25ClN2O3
- Molecular Weight:
- 448.941
- Log P:
- 5.8211
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 2
- TPSA:
- 69.64
- CAS Number(s):
- 150683-30-0
Synonym(s)
1.
Tolvaptan
2.
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
3.
OPC 41061
4.
OPC-41061
5.
Samsca
6.
OPC41061
External Link(s)
| MeSH | D000077602 |
| PubChem Compound | 216237 |
| BindingDB | 35723 50094071 |
| ChEBI | 32246 |
| CHEMBL | CHEMBL344159 |
| DrugCentral | 4110 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 2226 |
| Therapeutic Target Database | D03KZM |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Incorrect drug administration duration | FAERS: 165 | US FAERS | |
| 2 | Inappropriate schedule of drug administration | FAERS: 144 | US FAERS | |
| 3 | Blood sodium decreased | FAERS: 100 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 4 | Wrong technique in product usage process | FAERS: 85 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 5 | Product use issue | FAERS: 80 | US FAERS | |
| 6 | No adverse event | FAERS: 76 | US FAERS | |
| 7 | Thirst | FAERS: 64 Canada Vigilance: 11 | Canada Vigilance SIDER US FAERS | |
| 8 | Blood sodium increased | FAERS: 61 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 9 | Drug dose omission | FAERS: 45 | US FAERS | |
| 10 | Inappropriate schedule of product administration | FAERS: 44 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 11 | Incorrect dose administered | FAERS: 43 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 12 | Dehydration | FAERS: 42 Canada Vigilance: 8 | Canada Vigilance SIDER US FAERS | |
| 13 | Therapy cessation | FAERS: 41 Canada Vigilance: 13 | Canada Vigilance US FAERS | |
| 14 | Product use in unapproved indication | FAERS: 40 | US FAERS | |
| 15 | Blood creatinine increased | FAERS: 39 Canada Vigilance: 9 | Canada Vigilance SIDER US FAERS | |
| 16 | Polyuria | FAERS: 39 Canada Vigilance: 10 | Canada Vigilance SIDER US FAERS | |
| 17 | Hepatotoxicity | FAERS: 35 | US FAERS | |
| 18 | Drug ineffective | FAERS: 34 Canada Vigilance: 15 | Canada Vigilance US FAERS | |
| 19 | Incorrect product administration duration | FAERS: 34 | US FAERS | |
| 20 | Malaise | FAERS: 34 Canada Vigilance: 5 | Canada Vigilance SIDER US FAERS | |
| 21 | Polydipsia | FAERS: 29 Canada Vigilance: 18 | Canada Vigilance SIDER US FAERS | |
| 22 | Product dose omission | FAERS: 28 Canada Vigilance: 11 | Canada Vigilance US FAERS | |
| 23 | Dizziness | FAERS: 27 Canada Vigilance: 6 | Canada Vigilance SIDER US FAERS | |
| 24 | Osmotic demyelination syndrome | FAERS: 27 | SIDER US FAERS | |
| 25 | Headache | FAERS: 24 Canada Vigilance: 10 | Canada Vigilance SIDER US FAERS | |
| 26 | Nausea | FAERS: 24 Canada Vigilance: 4 | Canada Vigilance SIDER US FAERS | |
| 27 | Pneumonia | FAERS: 24 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 28 | Inability to afford medication | FAERS: 23 | US FAERS | |
| 29 | Wrong technique in drug usage process | FAERS: 23 | US FAERS | |
| 30 | Adverse event | FAERS: 22 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 31 | Hepatic Encephalopathy | FAERS: 22 | US FAERS | |
| 32 | Nocturia | FAERS: 20 Canada Vigilance: 14 | Canada Vigilance US FAERS | |
| 33 | Alanine Aminotransferase Increased | FAERS: 19 Canada Vigilance: 8 | Canada Vigilance SIDER US FAERS | |
| 34 | Drug prescribing error | FAERS: 18 | US FAERS | |
| 35 | Fatigue | FAERS: 18 Canada Vigilance: 9 | Canada Vigilance US FAERS | |
| 36 | Aspartate Aminotransferase Increased | FAERS: 17 Canada Vigilance: 7 | Canada Vigilance SIDER US FAERS | |
| 37 | Blood urea increased | FAERS: 16 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 38 | Depressed mood | FAERS: 16 | US FAERS | |
| 39 | Intentional product use issue | FAERS: 15 | US FAERS | |
| 40 | Pain | FAERS: 15 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 41 | Altered state of consciousness | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 42 | Asthenia | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 43 | Disease Progression | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 44 | Prescribed underdose | FAERS: 14 | US FAERS | |
| 45 | Vomiting | FAERS: 13 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 46 | Hospice Care | FAERS: 12 | US FAERS | |
| 47 | Hypotension | FAERS: 12 | US FAERS | |
| 48 | Urine output increased | FAERS: 11 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 49 | Weight decreased | FAERS: 11 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 50 | Blood glucose increased | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 51 | Feeling abnormal | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 52 | Malignant neoplasm progression | FAERS: 10 | US FAERS | |
| 53 | Medication Error | FAERS: 10 | US FAERS | |
| 54 | General physical health deterioration | FAERS: 9 | US FAERS | |
| 55 | Sepsis | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 56 | Abdominal Pain | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 57 | Abdominal discomfort | FAERS: 8 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 58 | Acute kidney injury | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Blood alkaline phosphatase increased | FAERS: 8 | US FAERS | |
| 60 | Constipation | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 61 | Insurance issue | FAERS: 8 | US FAERS | |
| 62 | Mental status changes | FAERS: 8 | US FAERS | |
| 63 | Renal pain | FAERS: 8 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 64 | Respiratory Failure | FAERS: 8 | SIDER US FAERS | |
| 65 | Unresponsive to stimuli | FAERS: 8 | US FAERS | |
| 66 | Back Pain | FAERS: 7 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 67 | Blood potassium decreased | FAERS: 7 | US FAERS | |
| 68 | Infection | FAERS: 7 | US FAERS | |
| 69 | Myocardial Infarction | FAERS: 7 | US FAERS | |
| 70 | Pancytopenia | FAERS: 7 | US FAERS | |
| 71 | Septic Shock | FAERS: 7 | US FAERS | |
| 72 | Shock | FAERS: 7 | SIDER US FAERS | |
| 73 | Urinary tract infection | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 74 | Dysgeusia | FAERS: 6 | SIDER US FAERS | |
| 75 | Gamma-Glutamyltransferase Increased | FAERS: 6 | US FAERS | |
| 76 | Influenza | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 77 | Laboratory test interference | FAERS: 6 | US FAERS | |
| 78 | Peripheral swelling | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 79 | Somnolence | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 80 | Transaminases increased | FAERS: 6 | US FAERS | |
| 81 | Alopecia | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 82 | Anxiety | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 83 | Atrial Fibrillation | FAERS: 5 | US FAERS | |
| 84 | Bronchitis | FAERS: 5 | US FAERS | |
| 85 | Delirium | FAERS: 5 | US FAERS | |
| 86 | Depressed Level of Consciousness | FAERS: 5 | US FAERS | |
| 87 | Discomfort | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 88 | Drug titration error | FAERS: 5 | US FAERS | |
| 89 | Dysarthria | FAERS: 5 | US FAERS | |
| 90 | Intestinal Obstruction | FAERS: 5 | US FAERS | |
| 91 | Nasopharyngitis | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 92 | Product prescribing error | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 93 | Syncope | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 94 | Tremor | FAERS: 5 | US FAERS | |
| 95 | Arthralgia | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 96 | Ascites | FAERS: 4 | US FAERS | |
| 97 | Blood glucose decreased | FAERS: 4 | US FAERS | |
| 98 | Blood sodium abnormal | FAERS: 4 | US FAERS | |
| 99 | Blood urine present | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 100 | Cardiac Arrest | FAERS: 4 | US FAERS | |
| 101 | Cerebral disorder | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 102 | Cerebrovascular accident | FAERS: 4 | SIDER US FAERS | |
| 103 | Dementia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 104 | Epilepsy | FAERS: 4 | US FAERS | |
| 105 | Fracture | FAERS: 4 | US FAERS | |
| 106 | Hepatitis | FAERS: 4 | US FAERS | |
| 107 | Hypersensitivity | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 108 | Hypophagia | FAERS: 4 | US FAERS | |
| 109 | Incorrect drug administration rate | FAERS: 4 | US FAERS | |
| 110 | Lethargy | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 111 | Lung cyst | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 112 | Lymphocyte count decreased | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 113 | Memory impairment | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 114 | Palpitations | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 115 | Product prescribing issue | FAERS: 4 | US FAERS | |
| 116 | Urinary Retention | FAERS: 4 | US FAERS | |
| 117 | Urticaria | FAERS: 4 | US FAERS | |
| 118 | Visual Impairment | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 119 | Alanine aminotransferase decreased | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 120 | Aphasia | FAERS: 3 | US FAERS | |
| 121 | Ataxia | FAERS: 3 | US FAERS | |
| 122 | Blood creatine phosphokinase increased | FAERS: 3 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 123 | Cataract | FAERS: 3 | US FAERS | |
| 124 | Cellulitis | FAERS: 3 | US FAERS | |
| 125 | Cerebral Infarction | FAERS: 3 | US FAERS | |
| 126 | Chest Pain | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 127 | Cholecystitis | FAERS: 3 | US FAERS | |
| 128 | Completed Suicide | FAERS: 3 | US FAERS | |
| 129 | Contraindicated product administered | FAERS: 3 | US FAERS | |
| 130 | Demyelination | FAERS: 3 | US FAERS | |
| 131 | Disorientation | FAERS: 3 | US FAERS | |
| 132 | Drug administered to patient of inappropriate age | FAERS: 3 | US FAERS | |
| 133 | Drug monitoring procedure incorrectly performed | FAERS: 3 | US FAERS | |
| 134 | Drug resistance | FAERS: 3 | US FAERS | |
| 135 | Dry skin | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 136 | Gastroenteritis | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 137 | Incorrect drug dosage form administered | FAERS: 3 | US FAERS | |
| 138 | Intracranial Aneurysm | FAERS: 3 | US FAERS | |
| 139 | Joint swelling | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 140 | Leukopenia | FAERS: 3 | US FAERS | |
| 141 | Metastatic bronchial carcinoma | FAERS: 3 | US FAERS | |
| 142 | Nephrogenic Diabetes Insipidus | FAERS: 3 | US FAERS | |
| 143 | Neutropenia | FAERS: 3 | US FAERS | |
| 144 | Overdose | FAERS: 3 | US FAERS | |
| 145 | Peripheral embolism | FAERS: 3 | US FAERS | |
| 146 | Product administration error | FAERS: 3 | US FAERS | |
| 147 | Pruritus | FAERS: 3 | SIDER US FAERS | |
| 148 | Pulmonary Embolism | FAERS: 3 | SIDER US FAERS | |
| 149 | Sudden death | FAERS: 3 | US FAERS | |
| 150 | Therapy regimen changed | FAERS: 3 | US FAERS | |
| 151 | Thrombosis | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 152 | Toxic Epidermal Necrolysis | FAERS: 3 | US FAERS | |
| 153 | Unevaluable event | FAERS: 3 | US FAERS | |
| 154 | Upper respiratory tract inflammation | FAERS: 3 | US FAERS | |
| 155 | Urinary Incontinence | FAERS: 3 | US FAERS | |
| 156 | Urine albumin/creatinine ratio increased | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 157 | Vertigo | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 158 | jaundice | FAERS: 3 | US FAERS | |
| 159 | Agranulocytosis | FAERS: 2 | US FAERS | |
| 160 | Alanine aminotransferase abnormal | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 161 | Alcohol withdrawal syndrome | FAERS: 2 | US FAERS | |
| 162 | Ammonia increased | FAERS: 2 | US FAERS | |
| 163 | Amnesia | FAERS: 2 | US FAERS | |
| 164 | Amylase increased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 165 | Aortic Valve Stenosis | FAERS: 2 | US FAERS | |
| 166 | Arthropathy | FAERS: 2 | US FAERS | |
| 167 | Aspartate aminotransferase abnormal | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 168 | Aspartate aminotransferase decreased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 169 | Asthma | FAERS: 2 | US FAERS | |
| 170 | Bladder pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 171 | Blood alkaline phosphatase decreased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 172 | Blood chloride increased | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 173 | Blood potassium increased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 174 | Blood pressure fluctuation | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 175 | Chemotherapy | FAERS: 2 | US FAERS | |
| 176 | Chromaturia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 177 | Circumstance or information capable of leading to medication error | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 178 | Compression fracture | FAERS: 2 | US FAERS | |
| 179 | Diabetes Insipidus | FAERS: 2 | US FAERS | |
| 180 | Diplopia | FAERS: 2 | US FAERS | |
| 181 | Disease complication | FAERS: 2 | US FAERS | |
| 182 | Drug dispensing error | FAERS: 2 | US FAERS | |
| 183 | Drug monitoring procedure not performed | FAERS: 2 | US FAERS | |
| 184 | Dyspepsia | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 185 | Dysphemia | FAERS: 2 | US FAERS | |
| 186 | Dysuria | FAERS: 2 | US FAERS | |
| 187 | Eczema | FAERS: 2 | US FAERS | |
| 188 | Encephalitis | FAERS: 2 | US FAERS | |
| 189 | Epiploic appendagitis | FAERS: 2 | US FAERS | |
| 190 | Erythema | FAERS: 2 | US FAERS | |
| 191 | Extra dose administered | FAERS: 2 | US FAERS | |
| 192 | Failure to Thrive | FAERS: 2 | US FAERS | |
| 193 | Fluid intake restriction | FAERS: 2 | US FAERS | |
| 194 | Glaucoma | FAERS: 2 | US FAERS | |
| 195 | Gout | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 196 | Head discomfort | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 197 | Hepatic congestion | FAERS: 2 | US FAERS | |
| 198 | Hepatorenal Syndrome | FAERS: 2 | US FAERS | |
| 199 | Impaired driving ability | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 200 | Incorrect route of drug administration | FAERS: 2 | US FAERS | |
| 201 | Infected cyst | FAERS: 2 | US FAERS | |
| 202 | Inflammation | FAERS: 2 | US FAERS | |
| 203 | Initial insomnia | FAERS: 2 | US FAERS | |
| 204 | Intestinal Perforation | FAERS: 2 | US FAERS | |
| 205 | Lipase increased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 206 | Lymphoma | FAERS: 2 | US FAERS | |
| 207 | Maternal exposure during pregnancy | FAERS: 2 | US FAERS | |
| 208 | Metastatic Neoplasm | FAERS: 2 | US FAERS | |
| 209 | Neologism | FAERS: 2 | US FAERS | |
| 210 | Nystagmus | FAERS: 2 | US FAERS | |
| 211 | PCO2 increased | FAERS: 2 | US FAERS | |
| 212 | Pancreatitis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 213 | Paternal exposure during pregnancy | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 214 | Peritonitis | FAERS: 2 | US FAERS | |
| 215 | Pneumonitis | FAERS: 2 | US FAERS | |
| 216 | Polyneuropathy | FAERS: 2 | US FAERS | |
| 217 | Posturing | FAERS: 2 | US FAERS | |
| 218 | Prescribed overdose | FAERS: 2 | US FAERS | |
| 219 | Product quality issue | FAERS: 2 | US FAERS | |
| 220 | Pyelonephritis | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 221 | Respiratory arrest | FAERS: 2 | US FAERS | |
| 222 | Stevens-Johnson Syndrome | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 223 | Swelling | FAERS: 2 | US FAERS | |
| 224 | Therapeutic response unexpected | FAERS: 2 | US FAERS | |
| 225 | Transplant | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 226 | Ventricular Fibrillation | FAERS: 2 | SIDER US FAERS | |
| 227 | Wheezing | FAERS: 2 | US FAERS | |
| 228 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 229 | intensive care | FAERS: 2 | US FAERS | |
| 230 | Accidental drug intake by child | FAERS: 1 | US FAERS | |
| 231 | Accidental exposure to product by child | FAERS: 1 | US FAERS | |
| 232 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 233 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 234 | Agitation | FAERS: 1 | US FAERS | |
| 235 | Alveolitis | FAERS: 1 | US FAERS | |
| 236 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 237 | Angioedema | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 238 | Anti-neutrophil cytoplasmic antibody positive vasculitis | FAERS: 1 | US FAERS | |
| 239 | Anuria | FAERS: 1 | US FAERS | |
| 240 | Aphonia | FAERS: 1 | US FAERS | |
| 241 | Apparent death | FAERS: 1 | US FAERS | |
| 242 | Atrial Flutter | FAERS: 1 | US FAERS | |
| 243 | Atrial thrombosis | FAERS: 1 | US FAERS | |
| 244 | Atrioventricular Block | FAERS: 1 | US FAERS | |
| 245 | Bipolar Disorder | FAERS: 1 | US FAERS | |
| 246 | Blindness | FAERS: 1 | US FAERS | |
| 247 | Blood albumin decreased | FAERS: 1 | US FAERS | |
| 248 | Blood blister | FAERS: 1 | US FAERS | |
| 249 | Blood chloride decreased | FAERS: 1 | US FAERS | |
| 250 | Blood cholinesterase increased | FAERS: 1 | US FAERS | |
| 251 | Blood creatine increased | FAERS: 1 | US FAERS | |
| 252 | Blood creatine phosphokinase MB increased | FAERS: 1 | US FAERS | |
| 253 | Blood creatinine abnormal | FAERS: 1 | US FAERS | |
| 254 | Blood creatinine decreased | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 255 | Blood electrolytes abnormal | FAERS: 1 | US FAERS | |
| 256 | Blood iron increased | FAERS: 1 | US FAERS | |
| 257 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 258 | Blood osmolarity decreased | FAERS: 1 | US FAERS | |
| 259 | Blood potassium abnormal | FAERS: 1 | US FAERS | |
| 260 | Blood urea nitrogen/creatinine ratio decreased | FAERS: 1 | US FAERS | |
| 261 | Blood uric acid decreased | FAERS: 1 | US FAERS | |
| 262 | Bone density decreased | FAERS: 1 | US FAERS | |
| 263 | Bradycardia | FAERS: 1 | US FAERS | |
| 264 | Brain stem syndrome | FAERS: 1 | US FAERS | |
| 265 | Bronchopulmonary Aspergillosis | FAERS: 1 | US FAERS | |
| 266 | Burning sensation | FAERS: 1 | US FAERS | |
| 267 | CD4 lymphocytes increased | FAERS: 1 | US FAERS | |
| 268 | Cancer Pain | FAERS: 1 | US FAERS | |
| 269 | Carbon dioxide increased | FAERS: 1 | US FAERS | |
| 270 | Cardiovascular insufficiency | FAERS: 1 | US FAERS | |
| 271 | Cataract operation | FAERS: 1 | US FAERS | |
| 272 | Catheter site infection | FAERS: 1 | US FAERS | |
| 273 | Chest discomfort | FAERS: 1 | US FAERS | |
| 274 | Chills | FAERS: 1 | US FAERS | |
| 275 | Clostridium difficile infection | FAERS: 1 | US FAERS | |
| 276 | Colitis | FAERS: 1 | US FAERS | |
| 277 | Colon adenoma | FAERS: 1 | US FAERS | |
| 278 | Coma scale abnormal | FAERS: 1 | US FAERS | |
| 279 | Creatinine renal clearance decreased | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 280 | Critical Illness | FAERS: 1 | US FAERS | |
| 281 | Crying | FAERS: 1 | US FAERS | |
| 282 | Dental Restoration Failure | FAERS: 1 | US FAERS | |
| 283 | Device related infection | FAERS: 1 | US FAERS | |
| 284 | Device used for unapproved schedule | FAERS: 1 | US FAERS | |
| 285 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 286 | Disease recurrence | FAERS: 1 | US FAERS | |
| 287 | Disseminated Intravascular Coagulation | FAERS: 1 | SIDER US FAERS | |
| 288 | Drowning | FAERS: 1 | US FAERS | |
| 289 | Drug Dependence | FAERS: 1 | US FAERS | |
| 290 | Drug administration error | FAERS: 1 | US FAERS | |
| 291 | Drug dose titration not performed | FAERS: 1 | US FAERS | |
| 292 | Drug effect variable | FAERS: 1 | US FAERS | |
| 293 | Drug ineffective for unapproved indication | FAERS: 1 | US FAERS | |
| 294 | Dysphonia | FAERS: 1 | US FAERS | |
| 295 | Dystonia | FAERS: 1 | US FAERS | |
| 296 | Economic problem | FAERS: 1 | US FAERS | |
| 297 | Electrolyte imbalance | FAERS: 1 | US FAERS | |
| 298 | Embolic stroke | FAERS: 1 | US FAERS | |
| 299 | Emergency Care | FAERS: 1 | US FAERS | |
| 300 | Endocarditis | FAERS: 1 | US FAERS | |
| 301 | Eosinophilia | FAERS: 1 | US FAERS | |
| 302 | Eosinophilic Pneumonia | FAERS: 1 | US FAERS | |
| 303 | Epistaxis | FAERS: 1 | US FAERS | |
| 304 | Essential Tremor | FAERS: 1 | US FAERS | |
| 305 | Executive dysfunction | FAERS: 1 | US FAERS | |
| 306 | Flank Pain | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 307 | Fungal test positive | FAERS: 1 | US FAERS | |
| 308 | Gastrointestinal perforation | FAERS: 1 | US FAERS | |
| 309 | Gastrostomy | FAERS: 1 | US FAERS | |
| 310 | Gingivitis | FAERS: 1 | US FAERS | |
| 311 | Glioblastoma Multiforme | FAERS: 1 | US FAERS | |
| 312 | Growing pains | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 313 | Hepatitis C | FAERS: 1 | US FAERS | |
| 314 | Hernia | FAERS: 1 | US FAERS | |
| 315 | Hydrocephalus | FAERS: 1 | US FAERS | |
| 316 | Hydronephrosis | FAERS: 1 | US FAERS | |
| 317 | Hypokinesia | FAERS: 1 | US FAERS | |
| 318 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 319 | Iatrogenic injury | FAERS: 1 | US FAERS | |
| 320 | Ileus | FAERS: 1 | US FAERS | |
| 321 | Immobile | FAERS: 1 | US FAERS | |
| 322 | Immune thrombocytopenic purpura | FAERS: 1 | US FAERS | |
| 323 | Impaired work ability | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 324 | Incontinence | FAERS: 1 | US FAERS | |
| 325 | Incorrect product storage | FAERS: 1 | US FAERS | |
| 326 | Incorrect route of product administration | FAERS: 1 | US FAERS | |
| 327 | Incorrect storage of drug | FAERS: 1 | US FAERS | |
| 328 | Infectious Mononucleosis | FAERS: 1 | US FAERS | |
| 329 | Intercepted product monitoring error | FAERS: 1 | US FAERS | |
| 330 | Invasive Ductal Breast Carcinoma | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 331 | Labile blood pressure | FAERS: 1 | US FAERS | |
| 332 | Limb discomfort | FAERS: 1 | US FAERS | |
| 333 | Lip swelling | FAERS: 1 | US FAERS | |
| 334 | Living in residential institution | FAERS: 1 | US FAERS | |
| 335 | Loss of personal independence in daily activities | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 336 | Lymphangiosis carcinomatosa | FAERS: 1 | US FAERS | |
| 337 | Macular fibrosis | FAERS: 1 | US FAERS | |
| 338 | Meningitis | FAERS: 1 | US FAERS | |
| 339 | Mental impairment | FAERS: 1 | US FAERS | |
| 340 | Metabolic acidosis | FAERS: 1 | US FAERS | |
| 341 | Mitral Valve Stenosis | FAERS: 1 | US FAERS | |
| 342 | Mood swings | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 343 | Muscle tightness | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 344 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 345 | Musculoskeletal discomfort | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 346 | Myoclonus | FAERS: 1 | US FAERS | |
| 347 | Neck Pain | FAERS: 1 | US FAERS | |
| 348 | Nervousness | FAERS: 1 | US FAERS | |
| 349 | Neuralgia | FAERS: 1 | US FAERS | |
| 350 | Oropharyngeal cancer stage unspecified | FAERS: 1 | US FAERS | |
| 351 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 352 | Overweight | FAERS: 1 | US FAERS | |
| 353 | Pancreatic carcinoma | FAERS: 1 | US FAERS | |
| 354 | Pelvic venous thrombosis | FAERS: 1 | US FAERS | |
| 355 | Perirectal abscess | FAERS: 1 | US FAERS | |
| 356 | Portal Vein Thrombosis | FAERS: 1 | US FAERS | |
| 357 | Post procedural complication | FAERS: 1 | US FAERS | |
| 358 | Pre-existing condition improved | FAERS: 1 | US FAERS | |
| 359 | Prescription drug used without a prescription | FAERS: 1 | US FAERS | |
| 360 | Product administered to patient of inappropriate age | FAERS: 1 | US FAERS | |
| 361 | Product availability issue | FAERS: 1 | US FAERS | |
| 362 | Product dispensing error | FAERS: 1 | US FAERS | |
| 363 | Product physical issue | FAERS: 1 | US FAERS | |
| 364 | Product supply issue | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 365 | Protein total decreased | FAERS: 1 | US FAERS | |
| 366 | Proteinuria | FAERS: 1 | 19452240 | CTD US FAERS |
| 367 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 368 | Pulmonary arterial hypertension | FAERS: 1 | US FAERS | |
| 369 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 370 | Purpura | FAERS: 1 | US FAERS | |
| 371 | Rales | FAERS: 1 | US FAERS | |
| 372 | Rash erythematous | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 373 | Regurgitation | FAERS: 1 | US FAERS | |
| 374 | Rehabilitation therapy | FAERS: 1 | US FAERS | |
| 375 | Renal Cell Carcinoma | FAERS: 1 | US FAERS | |
| 376 | Renal cyst | FAERS: 1 | US FAERS | |
| 377 | Renal tubular necrosis | FAERS: 1 | US FAERS | |
| 378 | Retinal Detachment | FAERS: 1 | US FAERS | |
| 379 | Rhabdomyolysis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 380 | Ruptured cerebral aneurysm | FAERS: 1 | US FAERS | |
| 381 | Sciatica | FAERS: 1 | US FAERS | |
| 382 | Seizure like phenomena | FAERS: 1 | US FAERS | |
| 383 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 384 | Spondylolisthesis | FAERS: 1 | US FAERS | |
| 385 | Tachycardia | FAERS: 1 | US FAERS | |
| 386 | Terminal state | FAERS: 1 | US FAERS | |
| 387 | Therapy change | FAERS: 1 | US FAERS | |
| 388 | Tinnitus | FAERS: 1 | US FAERS | |
| 389 | Transaminases abnormal | FAERS: 1 | US FAERS | |
| 390 | Urinary tract obstruction | FAERS: 1 | US FAERS | |
| 391 | Viral upper respiratory tract infection | FAERS: 1 | US FAERS | |
| 392 | Vital functions abnormal | FAERS: 1 | US FAERS | |
| 393 | Vocal Cord Paralysis | FAERS: 1 | US FAERS | |
| 394 | Wrong schedule | FAERS: 1 | US FAERS | |
| 395 | Anaphylactic shock | SIDER | ||
| 396 | Ankle Fracture | Canada Vigilance: 1 | Canada Vigilance | |
| 397 | Anorexia | SIDER | ||
| 398 | Benign Neoplasm | Canada Vigilance: 1 | Canada Vigilance | |
| 399 | Bladder prolapse | Canada Vigilance: 1 | Canada Vigilance | |
| 400 | Blood and lymphatic system disorders | SIDER | ||
| 401 | Blood bilirubin abnormal | Canada Vigilance: 1 | Canada Vigilance | |
| 402 | Blood cholesterol increased | Canada Vigilance: 1 | Canada Vigilance | |
| 403 | Blood triglycerides increased | Canada Vigilance: 1 | Canada Vigilance | |
| 404 | Chemical and Drug Induced Liver Injury | CTD | ||
| 405 | Cyst | Canada Vigilance: 1 | Canada Vigilance | |
| 406 | Deep Vein Thrombosis | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 407 | Diabetic Ketoacidosis | SIDER | ||
| 408 | Ecchymosis | SIDER | ||
| 409 | Edema, Cardiac | 18179782 | CTD | |
| 410 | Escherichia infection | Canada Vigilance: 1 | Canada Vigilance | |
| 411 | Heart failure | 16181825 | CTD | |
| 412 | Hepatic cyst infection | Canada Vigilance: 1 | Canada Vigilance | |
| 413 | Hepatomegaly | Canada Vigilance: 1 | Canada Vigilance | |
| 414 | Hyponatraemic | SIDER | ||
| 415 | Hyponatremia | 26660633 | CTD | |
| 416 | Hysterectomy | Canada Vigilance: 1 | Canada Vigilance | |
| 417 | Incision site complication | Canada Vigilance: 1 | Canada Vigilance | |
| 418 | Incision site pain | Canada Vigilance: 1 | Canada Vigilance | |
| 419 | Incision site swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 420 | Ligament injury | Canada Vigilance: 1 | Canada Vigilance | |
| 421 | Liver Abscess | Canada Vigilance: 2 | Canada Vigilance | |
| 422 | Malnutrition | SIDER | ||
| 423 | Microalbuminuria | Canada Vigilance: 1 | Canada Vigilance | |
| 424 | Musculoskeletal stiffness | Canada Vigilance: 1 | Canada Vigilance | |
| 425 | Myalgia | Canada Vigilance: 1 | Canada Vigilance | |
| 426 | Nephrolithiasis | Canada Vigilance: 1 | Canada Vigilance | |
| 427 | Non-high-density lipoprotein cholesterol increased | Canada Vigilance: 1 | Canada Vigilance | |
| 428 | Polycystic Kidney, Autosomal Dominant | 26507107 | CTD | |
| 429 | Prurigo | SIDER | ||
| 430 | Specific gravity body fluid decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 431 | Specific gravity urine decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 432 | Therapeutic product effect incomplete | Canada Vigilance: 2 | Canada Vigilance | |
| 433 | Umbilical hernia | Canada Vigilance: 1 | Canada Vigilance | |
| 434 | nervous system disorder | SIDER |
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