MetaADEDB 2.0 @ LMMD
Pentoxifylline
(BYPFEZZEUUWMEJ-UHFFFAOYSA-N)
Structure
SMILES
CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C
Type(s)
Approved; Investigational
ATC code(s)
C04AD03; R03DA20
Molecular Formula:
C13H18N4O3
Molecular Weight:
278.307
Log P:
0.1930
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
0
TPSA:
78.89
CAS Number(s):
6493-05-6; 1677687
Synonym(s)
1.
Pentoxifylline
2.
Agapurin
3.
BL-191
4.
Oxpentifylline
5.
Pentoxil
6.
Torental
7.
Trental
8.
BL 191
9.
BL191
External Link(s)
MeSHD010431
PubChem Compound4740
BindingDB10850
ChEBI7986
CHEMBLCHEMBL628
DrugBankDB00806
DrugCentral2099
IUPHAR/BPS Guide to PHARMACOLOGY7095
KEGGcpd:C07424
dr:D00501
Therapeutic Target DatabaseD09QEI
ZINC1530776
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DizzinessFAERS: 11
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
2HeadacheFAERS: 812427911
16260695		CTD
SIDER
US FAERS
3VomitingFAERS: 8

View details

8275036
10688811
12427911
18787510
 		CTD
SIDER
US FAERS
4NauseaFAERS: 7

View details

3619234
8275036
10688811
14677181
16260695
18787510
 		CTD
SIDER
US FAERS
5TachycardiaFAERS: 5SIDER
US FAERS
6DyspepsiaFAERS: 4OFFSIDES
SIDER
US FAERS
7HypotensionFAERS: 48048393
10688811		CTD
SIDER
US FAERS
8Metabolic acidosisFAERS: 4US FAERS
9OliguriaFAERS: 4US FAERS
10Abdominal PainFAERS: 3
Canada Vigilance: 1		16260695CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
11Abdominal discomfortFAERS: 3SIDER
US FAERS
12AstheniaFAERS: 316260695CTD
OFFSIDES
SIDER
US FAERS
13Completed SuicideFAERS: 3US FAERS
14Drug ineffectiveFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
15OverdoseFAERS: 3OFFSIDES
US FAERS
16PetechiaeFAERS: 3US FAERS
17AgitationFAERS: 2SIDER
US FAERS
18AmnesiaFAERS: 2
Canada Vigilance: 1		11981227CTD
Canada Vigilance
US FAERS
19AnxietyFAERS: 2OFFSIDES
SIDER
US FAERS
20Atrial FibrillationFAERS: 2US FAERS
21ChromatopsiaFAERS: 2OFFSIDES
US FAERS
22ColitisFAERS: 2US FAERS
23DroolingFAERS: 2US FAERS
24Eye irritationFAERS: 2US FAERS
25FlatulenceFAERS: 2SIDER
US FAERS
26Hypertensive crisisFAERS: 2US FAERS
27PalpitationsFAERS: 2SIDER
US FAERS
28Pharmaceutical product complaintFAERS: 2OFFSIDES
US FAERS
29Respiratory distressFAERS: 2US FAERS
30ShockFAERS: 2SIDER
US FAERS
31ThrombocytopeniaFAERS: 2SIDER
US FAERS
32TinnitusFAERS: 28351028CTD
US FAERS
33Toxicity to various agentsFAERS: 2US FAERS
34Troponin T increasedFAERS: 2US FAERS
35Urinary IncontinenceFAERS: 2US FAERS
36Urinary RetentionFAERS: 2US FAERS
37Ventricular FibrillationFAERS: 2OFFSIDES
US FAERS
38VertigoFAERS: 2
Canada Vigilance: 1		2651175
16260695		CTD
Canada Vigilance
US FAERS
39Visual ImpairmentFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
40Acute kidney injuryFAERS: 1US FAERS
41Altered state of consciousnessFAERS: 1US FAERS
42Ammonia increasedFAERS: 1OFFSIDES
US FAERS
43AnorexiaFAERS: 1OFFSIDES
SIDER
US FAERS
44ArthralgiaFAERS: 1US FAERS
45Blood ethanol increasedFAERS: 1US FAERS
46Blood glucose decreasedFAERS: 1OFFSIDES
US FAERS
47Blood pressure fluctuationFAERS: 1US FAERS
48Blood triglycerides increasedFAERS: 1US FAERS
49BronchospasmFAERS: 1SIDER
US FAERS
50Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
51Chest discomfortFAERS: 1US FAERS
52Cholestatic liver injuryFAERS: 1US FAERS
53Chronic Fatigue SyndromeFAERS: 1US FAERS
54Deep Vein ThrombosisFAERS: 1US FAERS
55Diabetes MellitusFAERS: 1US FAERS
56DisorientationFAERS: 1US FAERS
57Drug exposure during pregnancyFAERS: 1US FAERS
58EpistaxisFAERS: 1SIDER
US FAERS
59EructationFAERS: 1SIDER
US FAERS
60FatigueFAERS: 1OFFSIDES
US FAERS
61FractureFAERS: 1US FAERS
62GangreneFAERS: 1OFFSIDES
US FAERS
63General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
64HepatotoxicityFAERS: 1US FAERS
65HypersensitivityFAERS: 1SIDER
US FAERS
66HypophagiaFAERS: 1US FAERS
67IncoherentFAERS: 1US FAERS
68Incorrect route of drug administrationFAERS: 1US FAERS
69Intentional misuseFAERS: 1US FAERS
70Joint stiffnessFAERS: 1OFFSIDES
US FAERS
71Joint swellingFAERS: 1US FAERS
72LethargyFAERS: 1US FAERS
73MalaiseFAERS: 1SIDER
US FAERS
74Medication residue presentFAERS: 1US FAERS
75Mental status changesFAERS: 1OFFSIDES
US FAERS
76Musculoskeletal stiffnessFAERS: 1US FAERS
77Myocardial InfarctionFAERS: 1US FAERS
78MyotoniaFAERS: 1US FAERS
79Oropharyngeal blisteringFAERS: 1OFFSIDES
US FAERS
80PainFAERS: 1OFFSIDES
US FAERS
81Product quality issueFAERS: 1US FAERS
82Product substitution issueFAERS: 1US FAERS
83PruritusFAERS: 1SIDER
US FAERS
84Pulmonary HypertensionFAERS: 1OFFSIDES
US FAERS
85Retinal DetachmentFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
86SomnolenceFAERS: 1SIDER
US FAERS
87Suicide attemptFAERS: 1US FAERS
88SyncopeFAERS: 1US FAERS
89Therapeutic response unexpectedFAERS: 1US FAERS
90Therapeutic response unexpected with drug substitutionFAERS: 1OFFSIDES
US FAERS
91Throat irritationFAERS: 1US FAERS
92ThrombosisFAERS: 13308412CTD
US FAERS
93TremorFAERS: 111981227CTD
SIDER
US FAERS
94UrticariaFAERS: 1SIDER
US FAERS
95Vascular encephalopathyFAERS: 1US FAERS
96Weight decreasedFAERS: 1US FAERS
97AbasiaOFFSIDES
98Abdominal InfectionOFFSIDES
99Abdominal adhesionsOFFSIDES
100Abdominal bloatingSIDER
101Abnormal cervical smearOFFSIDES
102Accidental deathOFFSIDES
103Accidental exposureOFFSIDES
104Acid refluxOFFSIDES
105ActinomycosisOFFSIDES
106Activities of daily living impairedOFFSIDES
107Acute bronchitisOFFSIDES
108Acute myocardial infarctionOFFSIDES
109Acute respiratory failureOFFSIDES
110AdenomaOFFSIDES
111Administration site infectionOFFSIDES
112Aggressive Periodontitis1976392CTD
113Alanine Aminotransferase IncreasedOFFSIDES
114Albuminuria17167242CTD
115Altitude Sickness3308412CTD
116AlveolitisOFFSIDES
117AnalgesiaOFFSIDES
118Anaphylactic shockSIDER
119Anaphylactoid ReactionSIDER
120Anemia, Sickle Cell3308412CTD
121AneurysmOFFSIDES
122Angina PectorisSIDER
123AngioedemaSIDER
124Angiogram abnormalOFFSIDES
125AngiolipomaOFFSIDES
126AnhedoniaOFFSIDES
127AnhidrosisOFFSIDES
128Ankle FractureOFFSIDES
129Anti-erythropoietin antibody positiveOFFSIDES
130Anticonvulsant drug level below therapeuticOFFSIDES
131Aortic AneurysmOFFSIDES
132AphagiaOFFSIDES
133Aphthous StomatitisOFFSIDES
134AppendicitisOFFSIDES
135Arterial bypass operationOFFSIDES
136Arterial insufficiencyOFFSIDES
137ArteriosclerosisOFFSIDES
138ArteritisOFFSIDES
139Arthritis, Experimental7589090CTD
140ArthritisOFFSIDES
141Arthropod biteOFFSIDES
142Aspiration PneumoniaOFFSIDES
143Asthenozoospermia3308412CTD
144AtaxiaOFFSIDES
145AtelectasisOFFSIDES
146Atherosclerosis2651175CTD
147Atrioventricular Block8926709CTD
148AutomatismOFFSIDES
149Autonomic neuropathyOFFSIDES
150Avascular necrosisOFFSIDES
151Back PainSIDER
152Bacteremia1411948CTD
153Bacterial sepsisOFFSIDES
154Basal cell carcinomaOFFSIDES
155Biopsy breast abnormalOFFSIDES
156BlepharitisOFFSIDES
157Blood 25-hydroxycholecalciferol decreasedOFFSIDES
158Blood GlucoseOFFSIDES
159Blood cholesterolOFFSIDES
160Blood creatinine decreasedOFFSIDES
161Blood creatinine increasedOFFSIDES
162Blood erythropoietin increasedOFFSIDES
163Blood fibrinogen decreasedSIDER
164Blood glucose fluctuationOFFSIDES
165Blood immunoglobulin EOFFSIDES
166Blood immunoglobulin MOFFSIDES
167Blood iron decreasedOFFSIDES
168Blood pH increasedOFFSIDES
169Blood phosphorus increasedOFFSIDES
170Blood potassium decreasedOFFSIDES
171Blood potassium increasedOFFSIDES
172Blood urea increasedOFFSIDES
173Blood uric acidOFFSIDES
174Blurred visionOFFSIDES
175Bone SarcomaOFFSIDES
176Bone density decreasedOFFSIDES
177Bone fragmentationOFFSIDES
178Bone lesionOFFSIDES
179Bone swellingOFFSIDES
180Brain Neoplasms9735411CTD
181BronchitisOFFSIDES
182Cachexia18801959CTD
183Cardiac discomfortOFFSIDES
184Cardiomyopathies14970111CTD
185Carotid bruitOFFSIDES
186Cartilage atrophyOFFSIDES
187Cataract operationOFFSIDES
188CataractOFFSIDES
189CausalgiaOFFSIDES
190CellulitisOFFSIDES
191Cerebrovascular Disorders3308412CTD
192Cerebrovascular accidentCanada Vigilance: 1Canada Vigilance
193Cervical myelopathyOFFSIDES
194Chemical and Drug Induced Liver Injury

View details

16044092
16227642
16581537
17709330
 		CTD
195Chemotherapeutic drug level increasedOFFSIDES
196Chills12427911CTD
197Choking sensationOFFSIDES
198CholangiolitisOFFSIDES
199Cholecystitis infectiveOFFSIDES
200CholecystitisOFFSIDES
SIDER
201CholestasisSIDER
202Chronic sinusitisOFFSIDES
203ClaustrophobiaOFFSIDES
204Clostridium difficile colitisOFFSIDES
205Colon adenomaOFFSIDES
206Color blindnessOFFSIDES
207Compression fractureOFFSIDES
208ConfabulationOFFSIDES
209Congenital heart diseaseOFFSIDES
210ConjunctivitisSIDER
211ConstipationSIDER
212Cramps of lower extremitiesSIDER
213Creatinine renal clearance decreasedOFFSIDES
214Creatinine renal clearance increasedOFFSIDES
215CyanosisOFFSIDES
216Cytolytic hepatitisOFFSIDES
217DeafnessOFFSIDES
218DemyelinationOFFSIDES
219Dental abscessOFFSIDES
220Dental cariesOFFSIDES
221Dental prosthesis userOFFSIDES
222DermatitisSIDER
223Device FailureOFFSIDES
224DiabetesOFFSIDES
225Diabetes mellitus inadequate controlOFFSIDES
226Diabetic FootOFFSIDES
227Diabetic NephropathyOFFSIDES
228Diabetic RetinopathyOFFSIDES
229Diarrhea3619234
12427911		CTD
230Diastolic dysfunctionOFFSIDES
231DiscomfortSIDER
232DiverticulosisOFFSIDES
233DrowsinessSIDER
234Drug level below therapeuticOFFSIDES
235Dry skinOFFSIDES
236DysgeusiaSIDER
237Ecchymosis3619234CTD
238Economic problemOFFSIDES
239Edema10773043CTD
240Ejection Fraction DecreasedOFFSIDES
241Ejection fraction abnormalOFFSIDES
242Electrocardiogram poor R-wave progressionOFFSIDES
243Embolic strokeOFFSIDES
244Emotional distressOFFSIDES
SIDER
245Endodontic procedureOFFSIDES
246Enterococcal infectionOFFSIDES
247Enterococcal sepsisOFFSIDES
248Eosinophilic myocarditisOFFSIDES
249EpididymitisOFFSIDES
250ErythemaSIDER
251EscharOFFSIDES
252Escherichia urinary tract infectionOFFSIDES
253Exanthema10688811CTD
254ExcoriationOFFSIDES
255Extremity contractureOFFSIDES
256Facial NeuralgiaOFFSIDES
257Fatty Liver16317704CTD
258Feeling abnormalSIDER
259Femoral arterial stenosisOFFSIDES
260Fever3619234
10688811
12427911		CTD
261Fibrinogen DecreasedSIDER
262Fibrosis16260695CTD
263Fistula dischargeOFFSIDES
264FlushingCanada Vigilance: 1Canada Vigilance
SIDER
265Focal glomerulosclerosisOFFSIDES
266Food cravingOFFSIDES
267FormicationOFFSIDES
268Gallop rhythm presentOFFSIDES
269GammopathyOFFSIDES
270Gastrointestinal PainSIDER
271GlaucomaOFFSIDES
272Glomerulonephritis14993492CTD
273GoiterOFFSIDES
274GranulomaOFFSIDES
275Hallucinations8315195
8351028		CTD
276HeartburnSIDER
277HemiparesisOFFSIDES
278Hepatic InfectionOFFSIDES
279HepatitisSIDER
280HiccoughOFFSIDES
281HydrocephalusOFFSIDES
282HydronephrosisOFFSIDES
283HyperkeratosisOFFSIDES
284HyperpigmentationOFFSIDES
285Hypertrophic CardiomyopathyOFFSIDES
286Hypoaesthesia facialOFFSIDES
287HypokinesiaOFFSIDES
288HypoxiaOFFSIDES
289Iliac artery stenosisOFFSIDES
290Impaired self-careOFFSIDES
291Implantable defibrillator insertionOFFSIDES
292IncontinenceOFFSIDES
293IndurationOFFSIDES
294InfectionOFFSIDES
SIDER
295InfestationSIDER
296Inflammation14970111CTD
297Influenza-like symptomsSIDER
298Infusion site mobility decreasedOFFSIDES
299Injection site discomfortOFFSIDES
300Intermittent Claudication2348231
3619234
8873633		CTD
OFFSIDES
301Intervertebral Disc DegenerationOFFSIDES
302Intervertebral disc disorderOFFSIDES
303Intestinal ObstructionOFFSIDES
304Intestinal PerforationOFFSIDES
305Intraductal papilloma of breastOFFSIDES
306Intraocular inflammationOFFSIDES
307IritisOFFSIDES
308Ischemia8005172CTD
309Job Syndrome1976392CTD
310Joint Range of Motion DecreasedOFFSIDES
311Kidney Diseases2327772
19212910
22847133		CTD
312Kidney FailureOFFSIDES
313Klebsiella sepsisOFFSIDES
314LacrimationSIDER
315LaryngitisSIDER
316Left Ventricular HypertrophyOFFSIDES
317Leg Ulcer3619234CTD
318Leishmaniasis, Cutaneous16863518CTD
319Leukemia, Myelomonocytic, Chronic10688811CTD
320LeukopeniaSIDER
321LightheadednessSIDER
322Lip swellingCanada Vigilance: 1Canada Vigilance
323Liver AbscessOFFSIDES
324Liver Cirrhosis, Experimental11788567
16703270		CTD
325Liver Cirrhosis1976392CTD
326Loose toothOFFSIDES
327Lower respiratory tract infection viralOFFSIDES
328Lumbar radiculopathyOFFSIDES
329Lupus Nephritis14677181CTD
330Lymphocyte count decreasedOFFSIDES
331Lymphoma, T-Cell, Cutaneous18851957CTD
332MacrocytosisOFFSIDES
333Macular degenerationCanada Vigilance: 1Canada Vigilance
334Medical device complicationOFFSIDES
335Metastases to reproductive organOFFSIDES
336Mixed Connective Tissue Disease12427911CTD
337Modified radical mastectomyOFFSIDES
338Movement Disorders2417922CTD
339Multiple MyelomaOFFSIDES
340Muscle SpasticityCanada Vigilance: 1Canada Vigilance
341Muscle WeaknessOFFSIDES
342Muscle fibrosisOFFSIDES
343Muscle necrosisOFFSIDES
344Muscle tightnessOFFSIDES
345Musculoskeletal discomfortSIDER
346MyalgiaSIDER
347Myasthenia GravisOFFSIDES
348MyelodysplasiaOFFSIDES
349Myocardial Ischemia14970111CTD
350Myoclonus8275036CTD
351MyosclerosisOFFSIDES
352NasopharyngitisOFFSIDES
353Neck Pain12427911CTD
354Necrosis

View details

8005172
15145246
19737289
21983523
 		CTD
355Neonatal hypotensionOFFSIDES
356Neoplasm Metastasis9735411
14720322		CTD
357Nephrogenic Fibrosing DermopathyOFFSIDES
358Nephrotic Syndrome14677181CTD
359NervousnessSIDER
360Neutropenia1976392CTD
361Occult blood positiveOFFSIDES
362Ocular icterusOFFSIDES
363Oral torusOFFSIDES
364Oropharyngeal discomfortSIDER
365Oropharyngeal painSIDER
366OrthopneaOFFSIDES
367OsteomyelitisOFFSIDES
368OsteopeniaOFFSIDES
369OsteoradionecrosisOFFSIDES
370OsteosclerosisOFFSIDES
371PallorOFFSIDES
372Pancreatic enzymes increasedOFFSIDES
373Pancreatitis10773043CTD
OFFSIDES
374Pancytopenia3619234CTD
SIDER
375Panic Disorder8296908CTD
376Parkinson Disease11234661CTD
377ParotidectomyOFFSIDES
378ParotitisOFFSIDES
379PericarditisOFFSIDES
380Peripheral Vascular Diseases1593221
3308412		CTD
381Peripheral arterial occlusive diseaseOFFSIDES
382Pharyngolaryngeal PainOFFSIDES
383Physical disabilityOFFSIDES
384PlasmacytomaOFFSIDES
385PleurisyOFFSIDES
386Polymyalgia RheumaticaOFFSIDES
387PolyneuropathyOFFSIDES
388Poor peripheral circulationOFFSIDES
389Poor quality drug administeredOFFSIDES
390Poor quality sleepOFFSIDES
391Postoperative feverOFFSIDES
392Postoperative ileusOFFSIDES
393Prescribed overdoseOFFSIDES
394PriapismOFFSIDES
395Product administration errorCanada Vigilance: 1Canada Vigilance
396Proteinuria14677181
14993492
18617301		CTD
397Prothrombin level decreasedOFFSIDES
398Pulmonary arterial pressure increasedOFFSIDES
399Pulmonary function test decreasedOFFSIDES
400Purpura3619234CTD
SIDER
401PurulenceOFFSIDES
402Purulent dischargeOFFSIDES
403QuadriparesisOFFSIDES
404Quality of life decreasedOFFSIDES
405Radial nerve palsyOFFSIDES
406RalesOFFSIDES
407Raynaud Disease12427911
14504440		CTD
408Reduced dexterityOFFSIDES
409Renal Artery StenosisOFFSIDES
410Renal aneurysmOFFSIDES
411Renal cystOFFSIDES
412Renal tubular disorderOFFSIDES
413Reperfusion Injury10673075CTD
414Respiratory FailureOFFSIDES
415Retinal Artery OcclusionOFFSIDES
416Retinal Vascular DisorderCanada Vigilance: 1Canada Vigilance
OFFSIDES
417Retinal Vein OcclusionOFFSIDES
418Retinal aneurysmOFFSIDES
419Retinal vascular occlusionOFFSIDES
420Retroperitoneal lymphadenopathyOFFSIDES
421RhonchiOFFSIDES
422Risus sardonicusOFFSIDES
423SacroiliitisOFFSIDES
424ScotomaSIDER
425Seizures11981227CTD
426Sepsis8308680
8342136		CTD
427Septic ShockOFFSIDES
428SequestrectomyOFFSIDES
429Serum SicknessOFFSIDES
430Silent myocardial infarctionOFFSIDES
431Sinus bradycardiaOFFSIDES
432Sinus headacheOFFSIDES
433SinusitisOFFSIDES
434Skin ErosionOFFSIDES
435Skin IndurationOFFSIDES
436Skin hypertrophyOFFSIDES
437Skin lesionOFFSIDES
438Skin neoplasm excisionOFFSIDES
439Skin test positiveOFFSIDES
440Skin tightnessOFFSIDES
441Spinal column stenosisOFFSIDES
442SpondylitisOFFSIDES
443Staphylococcal Infections3674202CTD
444Stevens-Johnson SyndromeOFFSIDES
445Subcutaneous noduleOFFSIDES
446Sudden onset of sleepOFFSIDES
447SweatingSIDER
448SwellingSIDER
449Synovial CystOFFSIDES
450TenosynovitisOFFSIDES
451Tension HeadacheOFFSIDES
452TensionSIDER
453ThirstSIDER
454ThyroidectomyOFFSIDES
455Tooth ErosionOFFSIDES
456Tooth ExtractionOFFSIDES
457Tooth InfectionOFFSIDES
458Tooth LossOFFSIDES
459Triple vessel bypass graftOFFSIDES
460Troponin TOFFSIDES
461Tryptase increasedOFFSIDES
462Urge IncontinenceOFFSIDES
463Vascular Diseases2327772CTD
464Vascular insufficiencyOFFSIDES
465Vascular purpuraSIDER
466Vascular stent insertionOFFSIDES
467VasculitisCanada Vigilance: 1Canada Vigilance
468Ventricular Dysfunction, Left14970111CTD
469VertebroplastyOFFSIDES
470Visual brightnessOFFSIDES
471Visual disturbanceOFFSIDES
472Vitamin B 12 DeficiencyOFFSIDES
473Wound InfectionOFFSIDES
474Wound infection staphylococcalOFFSIDES
475XanthopsiaOFFSIDES
476bad tasteSIDER
477effusionOFFSIDES
478jaundiceSIDER
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