MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Deferoxamine

(UBQYURCVBFRUQT-UHFFFAOYSA-N)

Structure

SMILES: NCCCCCN(C(=O)CCC(=O)NCCCCCN(C(=O)CCC(=O)NCCCCCN(C(=O)C)O)O)O
Type(s): Approved; Investigational
ATC code(s): V03AC01
Molecular Formula:: C25H48N6O8
Molecular Weight:: 560.684
Log P:: 2.4042
Hydrogen Bond Acceptor:: 14
Hydrogen Bond Donor:: 6
TPSA:: 205.84
CAS Number(s):: 70-51-9; 1950-39-6

Synonym(s)

Deferoxamine

Desferrioxamine

Deferoxamine B

Deferoxamine Mesilate

Deferoxamine Mesylate

Deferoxamine Methanesulfonate

Deferoximine

Deferrioxamine B

Desferal

10.

Desferioximine

11.

Desferrioxamine B

12.

Desferrioxamine B Mesylate

13.

Desferroxamine

14.

Mesilate, Deferoxamine

15.

Mesylate, Deferoxamine

16.

Mesylate, Desferrioxamine B

17.

Methanesulfonate, Deferoxamine

External Link(s)

MeSH	D003676
PubChem Compound	2973
BindingDB	50393308 47715
ChEBI	4356
CHEMBL	CHEMBL556
DrugBank	DB00746
DrugCentral	792
KEGG	cpd:C06940 dr:D03670
ZINC	3830635

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Pharmaceutical product complaint	FAERS: 9		US FAERS
2	Toxicity to various agents	FAERS: 8		US FAERS
3	Injection site erythema	FAERS: 5		OFFSIDES US FAERS
4	Cellulitis	FAERS: 3		OFFSIDES US FAERS
5	Chest Pain	FAERS: 3		US FAERS
6	Deafness	FAERS: 3 Canada Vigilance: 1	2861480 2923478 3362282	CTD OFFSIDES Canada Vigilance US FAERS
7	Hypersensitivity	FAERS: 3		SIDER US FAERS
8	Hypotension	FAERS: 3		SIDER US FAERS
9	Injection site pain	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
10	Retinal Degeneration	FAERS: 3	6739047	CTD OFFSIDES SIDER US FAERS
11	Wrist deformity	FAERS: 3		US FAERS
12	Blindness	FAERS: 2		SIDER US FAERS
13	Dental caries	FAERS: 2		US FAERS
14	Erythema	FAERS: 2		OFFSIDES SIDER US FAERS
15	Febrile Neutropenia	FAERS: 2		OFFSIDES US FAERS
16	Infection	FAERS: 2		SIDER US FAERS
17	Injection Site Reaction	FAERS: 2		SIDER US FAERS
18	Keratoconjunctivitis Sicca	FAERS: 2		US FAERS
19	Neutropenia	FAERS: 2		US FAERS
20	Osteopenia	FAERS: 2		US FAERS
21	Punctate keratitis	FAERS: 2		US FAERS
22	Respiratory distress	FAERS: 2		SIDER US FAERS
23	Retinal pigment epitheliopathy	FAERS: 2		OFFSIDES US FAERS
24	Sjogren's Syndrome	FAERS: 2		US FAERS
25	Splenomegaly	FAERS: 2		US FAERS
26	Tachycardia	FAERS: 2		SIDER US FAERS
27	Abdominal Abscess	FAERS: 1		US FAERS
28	Abdominal Pain	FAERS: 1		OFFSIDES SIDER US FAERS
29	Abdominal discomfort	FAERS: 1		OFFSIDES SIDER US FAERS
30	Accidental overdose	FAERS: 1		US FAERS
31	Angiogram abnormal	FAERS: 1		OFFSIDES US FAERS
32	Arterial thrombosis	FAERS: 1		US FAERS
33	Arthritis	FAERS: 1		OFFSIDES US FAERS
34	Blood creatinine increased	FAERS: 1		OFFSIDES SIDER US FAERS
35	Blood glucose increased	FAERS: 1		US FAERS
36	Blood potassium decreased	FAERS: 1		US FAERS
37	Blood sodium increased	FAERS: 1		US FAERS
38	Cardiac Arrest	FAERS: 1		US FAERS
39	Cardiac siderosis	FAERS: 1		US FAERS
40	Chromatopsia	FAERS: 1		SIDER US FAERS
41	Cyanosis	FAERS: 1		SIDER US FAERS
42	Dehydration	FAERS: 1		US FAERS
43	Deposit eye	FAERS: 1		US FAERS
44	Depressed Level of Consciousness	FAERS: 1		US FAERS
45	Depressed mood	FAERS: 1		US FAERS
46	Device malfunction	FAERS: 1		US FAERS
47	Diabetes Mellitus	FAERS: 1		US FAERS
48	Discomfort	FAERS: 1		US FAERS
49	Drug dose omission	FAERS: 1		US FAERS
50	Drug ineffective	FAERS: 1 Canada Vigilance: 6		Canada Vigilance OFFSIDES US FAERS
51	Electrocardiogram T wave peaked	FAERS: 1		US FAERS
52	Facial Pain	FAERS: 1		US FAERS
53	Facial paralysis	FAERS: 1		US FAERS
54	Feeling abnormal	FAERS: 1		OFFSIDES US FAERS
55	Gastrointestinal toxicity	FAERS: 1		OFFSIDES US FAERS
56	Granulocyte count decreased	FAERS: 1		OFFSIDES US FAERS
57	Hepatic siderosis	FAERS: 1		US FAERS
58	Hepatitis C	FAERS: 1		OFFSIDES US FAERS
59	Hepatomegaly	FAERS: 1		US FAERS
60	Hypoparathyroidism	FAERS: 1		US FAERS
61	Hypothyroidism	FAERS: 1		US FAERS
62	Incorrect drug administration rate	FAERS: 1		US FAERS
63	Infusion site burning	FAERS: 1		US FAERS
64	Infusion site infection	FAERS: 1		US FAERS
65	Infusion site pain	FAERS: 1		OFFSIDES US FAERS
66	Infusion site swelling	FAERS: 1		US FAERS
67	Injection site abscess	FAERS: 1		US FAERS
68	Injection site hypersensitivity	FAERS: 1		US FAERS
69	Injection site infection	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
70	Injection site joint warmth	FAERS: 1		US FAERS
71	Injection site mass	FAERS: 1		US FAERS
72	Injection site warmth	FAERS: 1		OFFSIDES US FAERS
73	Lethargy	FAERS: 1		US FAERS
74	Liver Abscess	FAERS: 1		US FAERS
75	Localised skin reaction	FAERS: 1		US FAERS
76	Macular dystrophy congenital	FAERS: 1		US FAERS
77	Medication Error	FAERS: 1		US FAERS
78	Meningitis	FAERS: 1		US FAERS
79	Mental status changes	FAERS: 1		OFFSIDES US FAERS
80	Metabolic acidosis	FAERS: 1		OFFSIDES US FAERS
81	Metamorphopsia	FAERS: 1		OFFSIDES US FAERS
82	Mucormycosis	FAERS: 1		OFFSIDES SIDER US FAERS
83	Myalgia	FAERS: 1		SIDER US FAERS
84	Nocardia sepsis	FAERS: 1		US FAERS
85	Optic Neuropathy	FAERS: 1		OFFSIDES US FAERS
86	Ototoxicity	FAERS: 1		OFFSIDES US FAERS
87	Overdose	FAERS: 1		US FAERS
88	PO2 increased	FAERS: 1		US FAERS
89	Pain	FAERS: 1	20721892	CTD OFFSIDES SIDER US FAERS
90	Peripheral venous disease	FAERS: 1		US FAERS
91	Pneumonia	FAERS: 1		US FAERS
92	Pneumothorax	FAERS: 1		US FAERS
93	Poisoning	FAERS: 1		US FAERS
94	Pulmonary Embolism	FAERS: 1		US FAERS
95	Pulmonary thrombosis	FAERS: 1		US FAERS
96	Rales	FAERS: 1		US FAERS
97	Retinal Detachment	FAERS: 1		US FAERS
98	Retinal pigmentation	FAERS: 1		US FAERS
99	Retinal toxicity	FAERS: 1		US FAERS
100	Sepsis	FAERS: 1		US FAERS
101	Septic Shock	FAERS: 1		OFFSIDES US FAERS
102	Sinusitis	FAERS: 1		US FAERS
103	Swelling	FAERS: 1		SIDER US FAERS
104	Syncope	FAERS: 1		US FAERS
105	Therapy non-responder	FAERS: 1		US FAERS
106	Visual acuity tests abnormal	FAERS: 1		US FAERS
107	Vomiting	FAERS: 1		SIDER US FAERS
108	Zygomycosis	FAERS: 1		SIDER US FAERS
109	Abdominal rebound tenderness			OFFSIDES
110	Acute kidney injury		View details 451459 1324513 3123518 12644925 19204016 30431687	CTD
111	Alanine Aminotransferase Increased			OFFSIDES
112	Alopecia			OFFSIDES
113	Anaphylactic shock			SIDER
114	Anaphylactoid Reaction			SIDER
115	Anemia, Diamond-Blackfan		3485251 9106087	CTD
116	Anemia, Sickle Cell		9106087 17233848 20721892	CTD
117	Anemia		3826071	CTD
118	Angioedema			SIDER
119	Angiogram retina abnormal			OFFSIDES
120	Angiomyolipoma			OFFSIDES
121	Ankle Fracture			OFFSIDES
122	Anti-erythropoietin antibody			OFFSIDES
123	Anti-erythropoietin antibody positive			OFFSIDES
124	Anuria			OFFSIDES
125	Aphasia			SIDER
126	Arthralgia			SIDER
127	Arthroscopy			OFFSIDES
128	Aspartate aminotransferase decreased			OFFSIDES
129	Aspiration Pneumonia			OFFSIDES
130	Asthma			OFFSIDES SIDER
131	Astigmatism			OFFSIDES
132	Atelectasis			OFFSIDES
133	Atrial Flutter			OFFSIDES
134	Atrial tachycardia			OFFSIDES
135	Atrioventricular Block			OFFSIDES
136	Biopsy liver abnormal			OFFSIDES
137	Blood Glucose			OFFSIDES
138	Blood amylase increased			OFFSIDES
139	Blood and lymphatic system disorders			SIDER
140	Blood count abnormal			OFFSIDES
141	Blood iron decreased	Canada Vigilance: 1		Canada Vigilance
142	Blood iron increased	Canada Vigilance: 1		Canada Vigilance
143	Blood lactate dehydrogenase decreased			OFFSIDES
144	Blood osmolarity decreased			OFFSIDES
145	Blood triglycerides increased			OFFSIDES
146	Blood urea increased			OFFSIDES
147	Blurred vision			OFFSIDES
148	Bone Diseases		3400633 3602745	CTD
149	Bone Marrow Diseases		2322425	CTD
150	Bone density decreased			OFFSIDES
151	Bone lesion			OFFSIDES
152	Bone marrow transplant rejection	Canada Vigilance: 1		Canada Vigilance
153	Bone pain			OFFSIDES SIDER
154	Bradycardia			SIDER
155	Brain Diseases, Metabolic		4095247	CTD
156	Brain Diseases		2382654 2496351 2510071	CTD
157	Bronchitis			OFFSIDES
158	Bronchoscopy			OFFSIDES
159	Bulbar palsy			OFFSIDES
160	CD4 Lymphocytes Decreased			OFFSIDES
161	CD8 lymphocytes decreased			OFFSIDES
162	Cardiac discomfort			OFFSIDES
163	Cardiomyopathies		7987999 18298856	CTD
164	Cardiovascular Diseases		2378340 8800186	CTD
165	Cataract operation			OFFSIDES
166	Cataract		2519168	CTD OFFSIDES SIDER
167	Catheter related infection			OFFSIDES
168	Catheter site infection	Canada Vigilance: 1		Canada Vigilance
169	Catheter site necrosis			OFFSIDES
170	Catheter site related reaction			OFFSIDES
171	Chemical and Drug Induced Liver Injury		1301648 22166485 27095094	CTD
172	Choking sensation			OFFSIDES
173	Chromaturia			OFFSIDES SIDER
174	Color blindness			OFFSIDES
175	Concomitant disease progression			OFFSIDES
176	Confusion		2496351	CTD
177	Congenital tricuspid valve incompetence			OFFSIDES
178	Contact Dermatitis			OFFSIDES
179	Cord blood transplant therapy			OFFSIDES
180	Corneal Opacity			SIDER
181	Cramps of lower extremities			SIDER
182	Deafness Neurosensory			OFFSIDES SIDER
183	Debridement			OFFSIDES
184	Dementia		3400633	CTD
185	Demyelination			OFFSIDES
186	Device related infection			OFFSIDES
187	Dialysis dementia			SIDER
188	Disseminated Intravascular Coagulation			OFFSIDES
189	Dizziness			SIDER
190	Drug exposure before pregnancy			OFFSIDES
191	Drug exposure during pregnancy			OFFSIDES
192	Drug toxicity			OFFSIDES
193	Drug withdrawal headache			OFFSIDES
194	Duodenal Ulcer			OFFSIDES
195	Dyschromatopsia			SIDER
196	Dysuria			SIDER
197	Ear Diseases		8800186	CTD
198	Ear and labyrinth disorders			SIDER
199	Ecthyma			OFFSIDES
200	Eczema			OFFSIDES
201	Ejection Fraction Decreased			OFFSIDES
202	Electrocardiogram ST segment abnormal			OFFSIDES
203	Encephalitis			OFFSIDES
204	Enterocutaneous Fistula			OFFSIDES
205	Eosinophilia			SIDER
206	Eosinophilic Pneumonia			OFFSIDES
207	Eosinophilic myocarditis			OFFSIDES
208	Eschar			OFFSIDES SIDER
209	Escherichia urinary tract infection			OFFSIDES
210	Eye laser surgery			OFFSIDES
211	Eyelid margin crusting			OFFSIDES
212	Fatigue	Canada Vigilance: 1		Canada Vigilance
213	Feeling Cold			OFFSIDES
214	Fever		16844102	CTD
215	Folliculitis			OFFSIDES
216	Fundoscopy abnormal			OFFSIDES
217	Fungal test positive			OFFSIDES
218	Gamma-Glutamyltransferase Increased			OFFSIDES
219	Gastroenteritis yersinia			SIDER
220	Gastrointestinal Pain			SIDER
221	Glomerulonephritis			OFFSIDES
222	Graft infection			OFFSIDES
223	Granuloma			OFFSIDES
224	Growth retardation			SIDER
225	Hallucinations		2496351	CTD
226	Headache		17233848	CTD SIDER
227	Hearing Loss, Bilateral		3365862	CTD
228	Hearing Loss, High-Frequency		3503576	CTD
229	Hearing Loss		View details 2019945 2328556 3380052 9106087 9223576	CTD
230	Heart Diseases		11401411 22166485	CTD
231	Hemiparesis			OFFSIDES
232	Hemosiderosis		6739047	CTD
233	Hepatic impairment			SIDER
234	Hepatitis A			OFFSIDES
235	High turnover osteopathy			OFFSIDES
236	Histiocytosis haematophagic			OFFSIDES
237	Hypoxia			OFFSIDES
238	Immobile			SIDER
239	Incorrect dose administered			OFFSIDES
240	Increased bronchial secretion			OFFSIDES
241	Induration			OFFSIDES SIDER
242	Infestation			SIDER
243	Inflammation		6830329	CTD
244	Influenza serology positive			OFFSIDES
245	Infusion site erythema			OFFSIDES
246	Injection site discomfort	Canada Vigilance: 1		Canada Vigilance OFFSIDES
247	Injection site inflammation			OFFSIDES
248	Injection site urticaria			OFFSIDES
249	Iron Overload		17233848 20721892	CTD OFFSIDES
250	Ischemia		14629283	CTD
251	Jejunal ulcer			OFFSIDES
252	Joint Range of Motion Decreased			OFFSIDES
253	Kidney Diseases		View details 1585386 7967359 7987999 22115772	CTD
254	Kidney Failure			OFFSIDES
255	Klebsiella sepsis			OFFSIDES
256	Leukopenia neonatal			OFFSIDES
257	Leukopenia			SIDER
258	Liver Cirrhosis		27095094	CTD
259	Liver diseases		11401411	CTD
260	Liver palpable subcostal			OFFSIDES
261	Local reaction			SIDER
262	Lung Injury			OFFSIDES
263	Lung diseases		8800186	CTD
264	Lymphocyte count decreased			OFFSIDES
265	Memory Disorders		2496351	CTD
266	Micronuclei, Chromosome-Defective		15066570	CTD
267	Motor Neuron Disease		9149744	CTD
268	Muscle necrosis			OFFSIDES
269	Muscular Atrophy		1528723	CTD
270	Musculoskeletal Pain			OFFSIDES
271	Musculoskeletal chest pain			OFFSIDES
272	Musculoskeletal discomfort			SIDER
273	Myasthenia Gravis		7628591	CTD
274	Myocardial Reperfusion Injury		1540057	CTD
275	Nasal mucosal disorder			OFFSIDES
276	Nasopharyngitis		17233848	CTD
277	Nausea			SIDER
278	Necrosis		View details 1571126 2512535 14629283 22115772	CTD
279	Nerve Degeneration		23358137	CTD
280	Neuropathy			SIDER
281	Neutrophil count decreased			OFFSIDES
282	Nodule			OFFSIDES
283	Ocular Toxicity			OFFSIDES
284	Optic Atrophy			OFFSIDES
285	Optic Neuritis			SIDER
286	Osteoporosis			OFFSIDES
287	Palliative Care			OFFSIDES
288	Periarthritis			OFFSIDES
289	Peritonitis			OFFSIDES
290	Phlebitis			OFFSIDES
291	Plasmacytoma			OFFSIDES
292	Pneumocystis jiroveci pneumonia			OFFSIDES
293	Polyneuropathy			OFFSIDES
294	Polyuria			OFFSIDES
295	Presbyopia			OFFSIDES
296	Proteinuria		2848972 8821819 8958702	CTD
297	Pruritus			SIDER
298	Psychiatric symptom			OFFSIDES
299	Pulmonary arteriopathy			OFFSIDES
300	Purulent discharge			OFFSIDES
301	Pyelonephritis			OFFSIDES SIDER
302	Renal Colic			OFFSIDES
303	Renal Insufficiency		1289188 22166485	CTD
304	Renal abscess			OFFSIDES
305	Renal tubular atrophy			OFFSIDES
306	Renal tubular disorder			SIDER
307	Renal tubular necrosis			OFFSIDES
308	Reperfusion Injury		2225430 8322925	CTD
309	Respiratory Tract Infections		17233848	CTD
310	Restrictive pulmonary disease			OFFSIDES
311	Retinal Diseases		View details 2234245 6135026 7719074 8053479 15957612 18536609	CTD
312	Retinal Vascular Disorder			OFFSIDES
313	Retinitis Pigmentosa		3587485 6739047 17998528	CTD
314	Retinogram abnormal			OFFSIDES
315	Scab			SIDER
316	Scotoma		6135026 15957612 17998528	CTD OFFSIDES SIDER
317	Secretion discharge			OFFSIDES
318	Seizures		2496351	CTD
319	Shock		1227766	CTD SIDER
320	Sinoatrial Block			OFFSIDES
321	Skin necrosis			OFFSIDES
322	Speech Disorders		2496351	CTD
323	Splenectomy			OFFSIDES
324	Sputum retention			OFFSIDES
325	Stem cell transplant			OFFSIDES
326	Stevens-Johnson Syndrome			OFFSIDES
327	Subarachnoid Hemorrhage		20736956	CTD
328	Subcutaneous Abscess			OFFSIDES
329	Synovitis		6830329	CTD
330	Tenosynovitis			OFFSIDES
331	Thalassemia		View details 2605127 3241755 3485251 3778067	CTD
332	Thrombocytopenia		4050784	CTD SIDER
333	Tinea Pedis			OFFSIDES
334	Tinea			OFFSIDES
335	Tinnitus		7329898	CTD SIDER
336	Transaminases abnormal			OFFSIDES
337	Transaminases increased			OFFSIDES SIDER
338	Transfusion Reaction			OFFSIDES
339	Unspecified visual loss			SIDER
340	Urine calcium increased			OFFSIDES
341	Urticaria			SIDER
342	Uveitis		8407215	CTD
343	Ventricular Dysfunction, Left		18298856	CTD
344	Vision Disorders		View details 1648295 2127831 2234245 2328556 2380834 2784062 2858690 3152975 3485251 3503576 3587485 3600932 4052864 6136665 6142370 7719074 9668591 18536609	CTD
345	Visual Impairment			SIDER
346	Visual disturbance			SIDER
347	Vulvovaginal mycotic infection			OFFSIDES
348	Welts			SIDER
349	Wound Infection			OFFSIDES
350	effusion			OFFSIDES
351	nervous system disorder			SIDER

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