MetaADEDB 2.0 @ LMMD
Nalbuphine
(NETZHAKZCGBWSS-CEDHKZHLSA-N)
Structure
SMILES
O[C@H]1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CCC2)ccc1O)O
Type(s)
Approved
ATC code(s)
N02AF02
Molecular Formula:
C21H27NO4
Molecular Weight:
357.443
Log P:
1.6452
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
73.16
CAS Number(s):
20594-83-6
Synonym(s)
1.
Nalbuphine
2.
EN-2234A
3.
Nalbuphine Hydrochloride
4.
Nalbuphine Serb
5.
Nubain
6.
EN 2234A
7.
EN2234A
External Link(s)
MeSHD009266
PubChem Compound5311304
BindingDB50105085
ChEBI7454
CHEMBLCHEMBL895
DrugBankDB00844
DrugCentral1874
IUPHAR/BPS Guide to PHARMACOLOGY1663
KEGGcpd:C07251
dr:D08246
Therapeutic Target DatabaseD01KQA
ZINC3812989
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Muscle RigidityFAERS: 2US FAERS
2PainFAERS: 2

View details

CTD
OFFSIDES
US FAERS
3SomnolenceFAERS: 2SIDER
US FAERS
4AphoniaFAERS: 1US FAERS
5BradycardiaFAERS: 11977044CTD
SIDER
US FAERS
6Chest PainFAERS: 1OFFSIDES
US FAERS
7Chest discomfortFAERS: 1US FAERS
8CholesteatomaFAERS: 1US FAERS
9DeafnessFAERS: 1US FAERS
10Depressed Level of ConsciousnessFAERS: 1US FAERS
11Drug DependenceFAERS: 1US FAERS
12Drug abuserFAERS: 1OFFSIDES
US FAERS
13DysphoniaFAERS: 1US FAERS
14DystoniaFAERS: 1US FAERS
15ErythemaFAERS: 1OFFSIDES
SIDER
US FAERS
16Feeling ColdFAERS: 1US FAERS
17FlushingFAERS: 1SIDER
US FAERS
18HypotensionFAERS: 1SIDER
US FAERS
19Incorrect dose administeredFAERS: 1US FAERS
20Infantile apnoeic attackFAERS: 1US FAERS
21SwellingFAERS: 1SIDER
US FAERS
22TachycardiaFAERS: 17993521CTD
SIDER
US FAERS
23TremorFAERS: 1SIDER
US FAERS
24Ventricular FibrillationFAERS: 1US FAERS
25Abdominal PainSIDER
26Abdominal discomfortOFFSIDES
27Abnormal visionOFFSIDES
28AbscessOFFSIDES
29Accidental overdoseOFFSIDES
30AcidosisOFFSIDES
31Acute otitis mediaOFFSIDES
32AgitationSIDER
33AlopeciaOFFSIDES
34Anemia, Sickle Cell1373356CTD
35AneurysmOFFSIDES
36AngioedemaOFFSIDES
37Anoxic EncephalopathyOFFSIDES
38AnuriaOFFSIDES
39AnxietyOFFSIDES
SIDER
40AphakiaOFFSIDES
41Aphthous StomatitisOFFSIDES
42ApneaOFFSIDES
43Application site erythemaOFFSIDES
44Application site hypersensitivityOFFSIDES
45ArteriosclerosisOFFSIDES
46AspergillosisOFFSIDES
47AsphyxiaOFFSIDES
48AstheniaOFFSIDES
SIDER
49AsthmaSIDER
50Atrial tachycardiaOFFSIDES
51Autoimmune thyroiditisOFFSIDES
52Autologous bone marrow transplantation therapyOFFSIDES
53Bipolar II disorderOFFSIDES
54Bladder neck obstructionOFFSIDES
55BlepharoptosisOFFSIDES
56Blood albumin decreasedOFFSIDES
57Blood alkaline phosphatase increasedOFFSIDES
58Blood count abnormalOFFSIDES
59Blood creatine increasedOFFSIDES
60Blood creatinine increasedOFFSIDES
61Blood fibrinogen increasedOFFSIDES
62Blood gases abnormalOFFSIDES
63Blood homocysteineOFFSIDES
64Blood magnesium decreasedOFFSIDES
65Blood methanol increasedOFFSIDES
66Blood potassium increasedOFFSIDES
67Blood sodiumOFFSIDES
68Blood urea increasedOFFSIDES
69Blood uric acidOFFSIDES
70Bone fragmentationOFFSIDES
71Bone lesionOFFSIDES
72Brief psychotic disorder, with postpartum onsetOFFSIDES
73BronchospasmSIDER
74Cardiac ArrestSIDER
75Cataract operationOFFSIDES
76Cerebral PalsyOFFSIDES
77Cerebral ThrombosisOFFSIDES
78Choking sensationOFFSIDES
79Cholestasis6537876CTD
80ChorioamnionitisOFFSIDES
81Chronic sinusitisOFFSIDES
82Circumstance or information capable of leading to medication errorOFFSIDES
83Cocaine-Related Disorders17391744CTD
84Cold sweatOFFSIDES
85Complications of maternal exposure to therapeutic drugsOFFSIDES
86ConfabulationOFFSIDES
87Congenital nystagmusOFFSIDES
88Congenital tricuspid valve incompetenceOFFSIDES
89ContractureOFFSIDES
90Creatinine renal clearance decreasedOFFSIDES
91CyanosisOFFSIDES
92CystOFFSIDES
93Cytolytic hepatitisOFFSIDES
94DebridementOFFSIDES
95DehydrationOFFSIDES
96DemyelinationOFFSIDES
97Dental abscessOFFSIDES
98DependenceOFFSIDES
99Depressed moodOFFSIDES
100DermatitisSIDER
101Device breakageOFFSIDES
102Device related infectionOFFSIDES
103DiplopiaOFFSIDES
104Disabled relativeOFFSIDES
105DiverticulitisOFFSIDES
106DiverticulosisOFFSIDES
107DiverticulumOFFSIDES
108DizzinessSIDER
109DrowsinessOFFSIDES
110Drug addictOFFSIDES
111Drug exposure during pregnancyOFFSIDES
112Drug exposure via breast milkOFFSIDES
113Drug withdrawal headacheOFFSIDES
114DysgeusiaSIDER
115DyspepsiaSIDER
116Dysthymic DisorderOFFSIDES
117EczemaOFFSIDES
118Endodontic procedureOFFSIDES
119EpistaxisOFFSIDES
120Euphoric moodSIDER
121Eye painOFFSIDES
122FatigueOFFSIDES
123Fatty LiverOFFSIDES
124Febrile bone marrow aplasiaOFFSIDES
125Feeling abnormalSIDER
126FibromyalgiaOFFSIDES
127Fluid overloadOFFSIDES
128FormicationOFFSIDES
129Gastrointestinal PainSIDER
130Glasgow coma scaleOFFSIDES
131GoiterOFFSIDES
132GranulocytosisOFFSIDES
133HeadacheSIDER
134HemiparesisOFFSIDES
135HepatotoxicityOFFSIDES
136HostilityOFFSIDES
SIDER
137HydronephrosisOFFSIDES
138Hyperalgesia17225166CTD
139HyperlipasaemiaOFFSIDES
140HypersensitivitySIDER
141HypoxiaOFFSIDES
142Impaired gastric emptyingOFFSIDES
143IncontinenceOFFSIDES
144Injection Site ReactionSIDER
145Injection site irritationOFFSIDES
146Intention tremorOFFSIDES
147Intervertebral Disc DegenerationOFFSIDES
148Intracranial AneurysmOFFSIDES
149IridoceleOFFSIDES
150Kaolin cephalin clotting time prolongedOFFSIDES
151Labor Pain1765317
8706774
CTD
152Left atrial dilatationOFFSIDES
153LethargyOFFSIDES
154Ligament ruptureOFFSIDES
155Mental RetardationOFFSIDES
156Mental disorders2961290CTD
157Metabolic acidosisOFFSIDES
158Morphine Dependence16517095CTD
159Muscle tightnessOFFSIDES
160Musculoskeletal PainOFFSIDES
161Musculoskeletal chest painOFFSIDES
162Musculoskeletal discomfortOFFSIDES
163NasopharyngitisOFFSIDES
164Nausea1416128
11524329
CTD
OFFSIDES
SIDER
165Neonatal respiratory arrestOFFSIDES
166Nervous tensionOFFSIDES
167NervousnessSIDER
168NumbnessSIDER
169ObstructionOFFSIDES
170Ocular discomfortOFFSIDES
171Oral polypectomyOFFSIDES
172OsteomyelitisOFFSIDES
173OsteosclerosisOFFSIDES
174OverdoseOFFSIDES
175PCO2 increasedOFFSIDES
176Pain, Postoperative

View details

CTD
177PallorOFFSIDES
178PancreatitisOFFSIDES
179PhlebitisOFFSIDES
180PhonophobiaOFFSIDES
181Placental InsufficiencyOFFSIDES
182PleurisyOFFSIDES
183PneumothoraxOFFSIDES
184Polysubstance abuseOFFSIDES
185Post procedural complicationOFFSIDES
186Postoperative Nausea and Vomiting9926184CTD
187Pruritus1416128CTD
SIDER
188Pulmonary HypertensionOFFSIDES
189Pulmonary congestionOFFSIDES
190RednessSIDER
191Renal tubular disorderOFFSIDES
192Respiratory Insufficiency3938174CTD
193Respiratory arrestSIDER
194Respiratory distressSIDER
195Retroperitoneal lymphadenopathyOFFSIDES
196Right Ventricular HypertrophyOFFSIDES
197Right atrial dilatationOFFSIDES
198ShockSIDER
199Sinoatrial BlockOFFSIDES
200SinusitisOFFSIDES
201Skeletal injuryOFFSIDES
202Spasm1731556CTD
203Sphincter of Oddi Dysfunction1731556CTD
204Spinal column stenosisOFFSIDES
205SpondylolisthesisOFFSIDES
206Stem cell transplantOFFSIDES
207Stevens-Johnson SyndromeOFFSIDES
208StridorOFFSIDES
SIDER
209Substance Withdrawal Syndrome15810761CTD
210Sudden deathOFFSIDES
211Superficial ThrombophlebitisOFFSIDES
212SyncopeSIDER
213Synovial CystOFFSIDES
214TendinitisOFFSIDES
215TensionSIDER
216TinnitusOFFSIDES
217Tongue bitingOFFSIDES
218ToxoplasmosisOFFSIDES
219Unequal Limb LengthOFFSIDES
220Ureteral stent insertionOFFSIDES
221UrticariaSIDER
222VertigoSIDER
223Vocal Cord ParalysisOFFSIDES
224Vomiting1416128
11524329
17391744
CTD
SIDER
225WheezingSIDER
226White blood cell count abnormalOFFSIDES
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