MetaADEDB 2.0 @ LMMD
argatroban
(KXNPVXPOPUZYGB-IOVMHBDKSA-N)
Structure
SMILES
NC(=NCCC[C@@H](C(=O)N1CC[C@H](C[C@@H]1C(=O)O)C)NS(=O)(=O)c1cccc2c1NCC(C2)C)N
Type(s)
Approved; Investigational
ATC code(s)
B01AE03
Molecular Formula:
C23H36N6O5S
Molecular Weight:
508.634
Log P:
3.6511
Hydrogen Bond Acceptor:
11
Hydrogen Bond Donor:
5
TPSA:
188.59
CAS Number(s):
74863-84-6
Synonym(s)
1.
argatroban
2.
4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid
3.
Acova
4.
MCI 9038
5.
MCI-9038
6.
MD 805
7.
MD-805
8.
MD805
9.
MMTQAP
10.
MPQA
11.
Novastan
External Link(s)
MeSHC031942
PubChem Compound92722
152951
BindingDB50038001
ChEBI94385
CHEMBLCHEMBL1166
DrugBankDB00278
DrugCentral239
IUPHAR/BPS Guide to PHARMACOLOGY6385
KEGGcpd:C04931
Therapeutic Target DatabaseD07UWV
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
2Blood fibrinogen decreasedFAERS: 7US FAERS
3ThrombosisFAERS: 7

View details

CTD
SIDER
US FAERS
4VasculitisFAERS: 7US FAERS
5Disseminated Intravascular CoagulationFAERS: 612361208CTD
SIDER
US FAERS
6Medication ErrorFAERS: 6US FAERS
7OverdoseFAERS: 6OFFSIDES
US FAERS
8Activated partial thromboplastin time shortenedFAERS: 5OFFSIDES
US FAERS
9Coagulation time abnormalFAERS: 5OFFSIDES
US FAERS
10EpistaxisFAERS: 5US FAERS
11HypotensionFAERS: 5SIDER
US FAERS
12SepsisFAERS: 5SIDER
US FAERS
13Cerebral InfarctionFAERS: 4US FAERS
14Deep Vein ThrombosisFAERS: 4US FAERS
15Fibrin D dimer increasedFAERS: 4US FAERS
16Incorrect drug administration rateFAERS: 4OFFSIDES
US FAERS
17ThrombocytopeniaFAERS: 4

View details

CTD
US FAERS
18Accidental overdoseFAERS: 3OFFSIDES
US FAERS
19Aspartate Aminotransferase IncreasedFAERS: 3US FAERS
20DeafnessFAERS: 3US FAERS
21MyopathyFAERS: 3US FAERS
22PneumoniaFAERS: 3SIDER
US FAERS
23Procedural complicationFAERS: 3US FAERS
24Pulmonary EmbolismFAERS: 324733133CTD
SIDER
US FAERS
25Respiratory FailureFAERS: 3OFFSIDES
SIDER
US FAERS
26RhabdomyolysisFAERS: 3US FAERS
27Ventricular failureFAERS: 3US FAERS
28Wrong technique in drug usage processFAERS: 3US FAERS
29Accidental exposure to productFAERS: 2US FAERS
30Acute prerenal failureFAERS: 2US FAERS
31AneurysmFAERS: 2US FAERS
32Blood creatinine increasedFAERS: 2US FAERS
33Cardiac ArrestFAERS: 2SIDER
US FAERS
34EmbolismFAERS: 2OFFSIDES
US FAERS
35Heparin-induced thrombocytopeniaFAERS: 2OFFSIDES
US FAERS
36HepatotoxicityFAERS: 2US FAERS
37Hypocoagulable stateFAERS: 2US FAERS
38Post procedural complicationFAERS: 2US FAERS
39Splenic InfarctionFAERS: 2US FAERS
40Thrombosis in deviceFAERS: 2OFFSIDES
US FAERS
41Transaminases increasedFAERS: 2US FAERS
42Venous thrombosis limbFAERS: 2US FAERS
43Visual ImpairmentFAERS: 2US FAERS
44Activated partial thromboplastin time abnormalFAERS: 1OFFSIDES
US FAERS
45AgranulocytosisFAERS: 1US FAERS
46Alanine Aminotransferase IncreasedFAERS: 1OFFSIDES
US FAERS
47Anaphylactic shockFAERS: 1US FAERS
48Anticoagulation drug level below therapeuticFAERS: 1US FAERS
49Antiphospholipid SyndromeFAERS: 1US FAERS
50ArthralgiaFAERS: 1US FAERS
51AscitesFAERS: 1US FAERS
52AstheniaFAERS: 1US FAERS
53AtelectasisFAERS: 1US FAERS
54Atrial FibrillationFAERS: 1SIDER
US FAERS
55Back PainFAERS: 1SIDER
US FAERS
56Blood albumin decreasedFAERS: 1US FAERS
57Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
US FAERS
58Blood creatine phosphokinase increasedFAERS: 1US FAERS
59Blood potassium increasedFAERS: 1US FAERS
60Blood pressure immeasurableFAERS: 1US FAERS
61Blood urea increasedFAERS: 1US FAERS
62Blood urine presentFAERS: 1US FAERS
63BradycardiaFAERS: 1SIDER
US FAERS
64Cardiac TamponadeFAERS: 1US FAERS
65Catheter related infectionFAERS: 1US FAERS
66Cerebrovascular accidentFAERS: 1SIDER
US FAERS
67Cerebrovascular stenosisFAERS: 1US FAERS
68Chest discomfortFAERS: 1US FAERS
69Coagulation factor V level decreasedFAERS: 1US FAERS
70Coagulation factor increasedFAERS: 1US FAERS
71Complication of device removalFAERS: 1US FAERS
72DementiaFAERS: 1US FAERS
73Depressed Level of ConsciousnessFAERS: 1US FAERS
74Dermatitis HerpetiformisFAERS: 1US FAERS
75Device FailureFAERS: 1OFFSIDES
US FAERS
76Device malfunctionFAERS: 1US FAERS
77Device related thrombosisFAERS: 1US FAERS
78Disease ProgressionFAERS: 1US FAERS
79Drug administration errorFAERS: 1OFFSIDES
US FAERS
80Drug exposure during pregnancyFAERS: 1US FAERS
81Drug resistanceFAERS: 1OFFSIDES
US FAERS
82DysarthriaFAERS: 1US FAERS
83Electrocardiogram ST segment abnormalFAERS: 1US FAERS
84Electromechanical dissociationFAERS: 1US FAERS
85Enzyme abnormalityFAERS: 1OFFSIDES
US FAERS
86EosinophiliaFAERS: 1US FAERS
87ErythemaFAERS: 1US FAERS
88ExtravasationFAERS: 1US FAERS
89FatigueFAERS: 1US FAERS
90Fluid overloadFAERS: 1OFFSIDES
US FAERS
91Gastrointestinal mucosal disorderFAERS: 1OFFSIDES
US FAERS
92Gaze palsyFAERS: 1US FAERS
93HemicephalalgiaFAERS: 1US FAERS
94Hepatitis BFAERS: 1US FAERS
95HepatomegalyFAERS: 1US FAERS
96Histiocytosis haematophagicFAERS: 1US FAERS
97Infusion Site ExtravasationFAERS: 1US FAERS
98Infusion site reactionFAERS: 1OFFSIDES
US FAERS
99Injection Site ReactionFAERS: 1US FAERS
100Injection site vasculitisFAERS: 1US FAERS
101Intentional drug misuseFAERS: 1US FAERS
102Low birth weight babyFAERS: 1US FAERS
103Maternal exposure timing unspecifiedFAERS: 1US FAERS
104Medical device complicationFAERS: 1US FAERS
105Mental status changesFAERS: 1US FAERS
106Occupational exposure to productFAERS: 1US FAERS
107Pharmaceutical product complaintFAERS: 1US FAERS
108Prescribed overdoseFAERS: 1US FAERS
109Respiratory DepressionFAERS: 1US FAERS
110Respiratory distressFAERS: 1US FAERS
111Septic ShockFAERS: 1US FAERS
112Stress ulcerFAERS: 1US FAERS
113StuporFAERS: 1US FAERS
114Sudden deathFAERS: 1US FAERS
115SwellingFAERS: 1US FAERS
116Systemic mycosisFAERS: 1US FAERS
117TachycardiaFAERS: 1SIDER
US FAERS
118Therapeutic product ineffectiveFAERS: 1US FAERS
119Therapy partial responderFAERS: 1US FAERS
120ThrombocytosisFAERS: 1US FAERS
121TremorFAERS: 1US FAERS
122UrticariaFAERS: 1US FAERS
123Venous ThrombosisFAERS: 112221676
19519692
24733133
CTD
US FAERS
124Ventricular hypokinesiaFAERS: 1US FAERS
125Weight decreasedFAERS: 1US FAERS
126WheezingFAERS: 1US FAERS
127treatment failureFAERS: 1US FAERS
128Abdominal PainSIDER
129Acute Coronary SyndromeSIDER
130Acute psychosisOFFSIDES
131Alanine aminotransferase abnormalOFFSIDES
132AmnesiaOFFSIDES
133Angina PectorisSIDER
134AnisocoriaOFFSIDES
135Aortic Valve StenosisSIDER
136Aphthous StomatitisOFFSIDES
137Arterial Occlusive Diseases11269422CTD
138Arterial thrombosisSIDER
139Aspiration PneumoniaOFFSIDES
140Atrial FlutterOFFSIDES
141Axillary vein thrombosisOFFSIDES
142Blood Coagulation Disorders11294800
15560992
CTD
143Blood fibrinogenOFFSIDES
144Blood lactate dehydrogenase increasedOFFSIDES
145Bone lesionOFFSIDES
146BronchitisOFFSIDES
147BronchopneumoniaOFFSIDES
148Bullous eruptionSIDER
149Catheter sepsisOFFSIDES
150CellulitisOFFSIDES
151Cerebral ArteriosclerosisOFFSIDES
152Cerebral Hemorrhage16908730CTD
153Cerebral artery stenosisOFFSIDES
154Cervical dysplasiaOFFSIDES
155Chest PainSIDER
156Chronic sinusitisOFFSIDES
157Circumstance or information capable of leading to medication errorOFFSIDES
158Congenital pyelocaliectasisOFFSIDES
159ConstipationSIDER
160CyanosisOFFSIDES
161DebridementOFFSIDES
162DermatitisSIDER
163DizzinessSIDER
164DyspepsiaSIDER
165Echocardiogram abnormalOFFSIDES
166Ejection Fraction DecreasedOFFSIDES
167Embolism and Thrombosis16084352CTD
168EndocarditisOFFSIDES
169Failure to ThriveOFFSIDES
170Feeling abnormalSIDER
171Gamma-Glutamyltransferase IncreasedOFFSIDES
172Gangrene12221676CTD
OFFSIDES
SIDER
173Gastric BypassOFFSIDES
174Gastrointestinal Hemorrhage19057393CTD
175Gastrointestinal PainSIDER
176HeadacheSIDER
177Hemorrhage16313480
19338378
19698012
CTD
178HypersensitivitySIDER
179HypokinesiaOFFSIDES
180HypoxiaOFFSIDES
181ImpetigoOFFSIDES
182InfectionSIDER
183Klebsiella sepsisOFFSIDES
184Labile blood pressureOFFSIDES
185Lung infection pseudomonalOFFSIDES
186Major bleedSIDER
187Minor bleedSIDER
188Muscle necrosisOFFSIDES
189Musculoskeletal PainOFFSIDES
190Myocardial InfarctionSIDER
191NauseaSIDER
192Neutrophil count decreasedOFFSIDES
193OsteomyelitisOFFSIDES
194PainSIDER
195ParanoiaOFFSIDES
196Pelvic venous thrombosisOFFSIDES
197Pericardial effusionOFFSIDES
198Peripheral gangreneSIDER
199PneumothoraxOFFSIDES
200Postoperative Complications19364306CTD
201Postoperative Hemorrhage20003049CTD
202Product use issueCanada Vigilance: 1Canada Vigilance
203Prothrombin time abnormalOFFSIDES
204Pulmonary HypertensionOFFSIDES
205PyelonephritisOFFSIDES
206Respiratory InsufficiencySIDER
207SequestrectomyOFFSIDES
208Serratia sepsisOFFSIDES
209Suprapubic painOFFSIDES
210ThoracotomyOFFSIDES
211Thrombophilia15335186CTD
212ThrombophlebitisSIDER
213Tooth ExtractionOFFSIDES
214Unresponsive to stimuliOFFSIDES
215Urinary tract infectionSIDER
216Vasodilation procedureSIDER
217VasodilationSIDER
218Venous occlusionOFFSIDES
219Venous stenosisOFFSIDES
220Vitamin K DeficiencyOFFSIDES
221VomitingSIDER
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