MetaADEDB 2.0 @ LMMD
Miconazole
(BYBLEWFAAKGYCD-UHFFFAOYSA-N)
Structure
SMILES
Clc1ccc(c(c1)Cl)COC(c1ccc(cc1Cl)Cl)Cn1cncc1
Type(s)
Approved; Investigational; Vet_approved
ATC code(s)
A01AB09; A07AC01; D01AC02; D01AC52; G01AF04; G01AF20; J02AB01; S02AA13
Molecular Formula:
C18H14Cl4N2O
Molecular Weight:
416.129
Log P:
6.4548
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
27.05
CAS Number(s):
22916-47-8; 75319-47-0
Synonym(s)
1.
Miconazole
2.
Brentan
3.
Dactarin
4.
Miconasil Nitrate
5.
Miconazole Nitrate
6.
Monistat
7.
R-14,889
8.
Nitrate, Miconasil
9.
Nitrate, Miconazole
10.
R 14,889
11.
R14,889
External Link(s)
MeSHD008825
PubChem Compound4189
BindingDB31772
ChEBI82892
CHEMBLCHEMBL91
DrugBankDB01110
DrugCentral1800
IUPHAR/BPS Guide to PHARMACOLOGY2449
KEGGcpd:C08070
dr:D00416
dr:D00882
Therapeutic Target DatabaseD00AXJ
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 190
Canada Vigilance: 6		Canada Vigilance
OFFSIDES
US FAERS
2Vulvovaginal burning sensationFAERS: 145
Canada Vigilance: 5		Canada Vigilance
OFFSIDES
SIDER
US FAERS
3Vaginal burning sensationFAERS: 115OFFSIDES
US FAERS
4Vulvovaginal discomfortFAERS: 90
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
5Vulvovaginal pruritusFAERS: 71OFFSIDES
US FAERS
6Vulvovaginal painFAERS: 60
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
7Vulvovaginal swellingFAERS: 58
Canada Vigilance: 1		Canada Vigilance
US FAERS
8Vaginal DischargeFAERS: 45
Canada Vigilance: 1		Canada Vigilance
US FAERS
9PruritusFAERS: 35
Canada Vigilance: 6		454066CTD
SIDER
Canada Vigilance
US FAERS
10Burning sensationFAERS: 32
Canada Vigilance: 7		Canada Vigilance
US FAERS
11Vaginal painFAERS: 29US FAERS
12Abdominal PainFAERS: 28SIDER
US FAERS
13Application site painFAERS: 27
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
14PainFAERS: 27
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
15Anaphylactoid ReactionFAERS: 23US FAERS
16HypersensitivityFAERS: 21SIDER
US FAERS
17UrticariaFAERS: 20
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
18SwellingFAERS: 19US FAERS
19DysuriaFAERS: 18OFFSIDES
US FAERS
20Application site pruritusFAERS: 16US FAERS
21Genital burning sensationFAERS: 15OFFSIDES
US FAERS
22Hypoplastic Left Heart SyndromeFAERS: 12OFFSIDES
US FAERS
23Vulvovaginal erythemaFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
24NauseaFAERS: 10SIDER
US FAERS
25Application site swellingFAERS: 9US FAERS
26ErythemaFAERS: 9US FAERS
27Medication ErrorFAERS: 8US FAERS
28Product quality issueFAERS: 8US FAERS
29ChokingFAERS: 7OFFSIDES
SIDER
US FAERS
30CyanosisFAERS: 7OFFSIDES
US FAERS
31DiscomfortFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
32HeadacheFAERS: 7SIDER
US FAERS
33Vulvovaginal inflammationFAERS: 7US FAERS
34Application site erythemaFAERS: 6US FAERS
35Chemical injuryFAERS: 6US FAERS
36CryingFAERS: 6US FAERS
37Genital swellingFAERS: 6OFFSIDES
US FAERS
38Pharmaceutical product complaintFAERS: 6US FAERS
39Accidental exposure to productFAERS: 5US FAERS
40Application site burnFAERS: 5US FAERS
41Application site irritationFAERS: 5US FAERS
42Chemical burn of skinFAERS: 5US FAERS
43PregnancyFAERS: 5US FAERS
44StomatitisFAERS: 5SIDER
US FAERS
45Vaginal mucosal blisteringFAERS: 5OFFSIDES
US FAERS
46Vulvovaginal drynessFAERS: 5OFFSIDES
US FAERS
47Vulvovaginal rashFAERS: 5US FAERS
48Application site reactionFAERS: 4
Canada Vigilance: 2		Canada Vigilance
US FAERS
49DizzinessFAERS: 4US FAERS
50FatigueFAERS: 4SIDER
US FAERS
51Feeling abnormalFAERS: 4SIDER
US FAERS
52Genital painFAERS: 4OFFSIDES
US FAERS
53Incorrect route of drug administrationFAERS: 4US FAERS
54Intentional drug misuseFAERS: 4OFFSIDES
US FAERS
55No adverse eventFAERS: 4US FAERS
56Product physical issueFAERS: 4US FAERS
57Product use in unapproved indicationFAERS: 4US FAERS
58Respiratory arrestFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
59Skin irritationFAERS: 4US FAERS
60TremorFAERS: 4US FAERS
61Unevaluable eventFAERS: 4US FAERS
62Wrong technique in drug usage processFAERS: 4US FAERS
63Accidental exposureFAERS: 3US FAERS
64Activities of daily living impairedFAERS: 3US FAERS
65Anaphylactic shockFAERS: 3SIDER
US FAERS
66Application site inflammationFAERS: 3US FAERS
67AsphyxiaFAERS: 3OFFSIDES
US FAERS
68AstheniaFAERS: 3SIDER
US FAERS
69Caustic injuryFAERS: 3US FAERS
70Drug administration errorFAERS: 3US FAERS
71Drug exposure during pregnancyFAERS: 3OFFSIDES
US FAERS
72Drug prescribing errorFAERS: 3OFFSIDES
US FAERS
73Genital rashFAERS: 3OFFSIDES
US FAERS
74Incorrect dose administeredFAERS: 3US FAERS
75InfectionFAERS: 3SIDER
US FAERS
76MetrorrhagiaFAERS: 3US FAERS
77Middle insomniaFAERS: 3US FAERS
78MyocarditisFAERS: 3US FAERS
79OverdoseFAERS: 3US FAERS
80Pelvic PainFAERS: 3US FAERS
81Product contamination physicalFAERS: 3US FAERS
82Product measured potency issueFAERS: 3US FAERS
83Product physical consistency issueFAERS: 3US FAERS
84Rash erythematousFAERS: 3US FAERS
85SyncopeFAERS: 3
Canada Vigilance: 2		Canada Vigilance
US FAERS
86Urinary tract infectionFAERS: 3US FAERS
87Vulvovaginal injuryFAERS: 3US FAERS
88Vulvovaginal mycotic infectionFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
89Wrong technique in product usage processFAERS: 3US FAERS
90Abdominal discomfortFAERS: 2US FAERS
91Accidental exposure to product by childFAERS: 2US FAERS
92AcneFAERS: 2US FAERS
93Application site discomfortFAERS: 2SIDER
US FAERS
94Application site vesiclesFAERS: 2US FAERS
95Back PainFAERS: 2US FAERS
96Blood urine presentFAERS: 2OFFSIDES
US FAERS
97Device use issueFAERS: 2US FAERS
98Drug ineffective for unapproved indicationFAERS: 2US FAERS
99Drug resistanceFAERS: 2US FAERS
100DyspareuniaFAERS: 2OFFSIDES
US FAERS
101Foreign body traumaFAERS: 2US FAERS
102Genital erythemaFAERS: 2US FAERS
103HypersomniaFAERS: 2US FAERS
104Injury asphyxiationFAERS: 2OFFSIDES
US FAERS
105Intentional product misuseFAERS: 2US FAERS
106Nonspecific reactionFAERS: 2US FAERS
107Poor quality sleepFAERS: 2US FAERS
108Product substitution issueFAERS: 2US FAERS
109Therapeutic response unexpectedFAERS: 2US FAERS
110Vaginal erosionFAERS: 2US FAERS
111Vaginal exfoliationFAERS: 2OFFSIDES
US FAERS
112VomitingFAERS: 2SIDER
US FAERS
113AbasiaFAERS: 1US FAERS
114Abdominal tendernessFAERS: 1US FAERS
115Administration site irritationFAERS: 1US FAERS
116Anorectal discomfortFAERS: 1US FAERS
117AnuriaFAERS: 1US FAERS
118Application site dischargeFAERS: 1US FAERS
119Application site rashFAERS: 1US FAERS
120Atrophic vulvovaginitisFAERS: 1US FAERS
121Blood creatine phosphokinase increasedFAERS: 1US FAERS
122Breast FeedingFAERS: 1US FAERS
123Change in sustained attentionFAERS: 1US FAERS
124ChillsFAERS: 1SIDER
US FAERS
125ChromaturiaFAERS: 1OFFSIDES
US FAERS
126Concomitant disease aggravatedFAERS: 1US FAERS
127ConstipationFAERS: 1US FAERS
128Conversion disorderFAERS: 1OFFSIDES
US FAERS
129Device defectiveFAERS: 1US FAERS
130Device malfunctionFAERS: 1US FAERS
131Disease recurrenceFAERS: 1US FAERS
132Drug administered to patient of inappropriate ageFAERS: 1US FAERS
133Drug dispensing errorFAERS: 1OFFSIDES
US FAERS
134Drug dose omissionFAERS: 1US FAERS
135Drug effect incompleteFAERS: 1US FAERS
136DysgeusiaFAERS: 1SIDER
US FAERS
137Emotional disorderFAERS: 1US FAERS
138EosinophiliaFAERS: 1US FAERS
139Expired product administeredFAERS: 1US FAERS
140Exposure via partnerFAERS: 1US FAERS
141Eye RednessFAERS: 1OFFSIDES
US FAERS
142Eye painFAERS: 1US FAERS
143FlushingFAERS: 1US FAERS
144GastroduodenitisFAERS: 1US FAERS
145General symptomFAERS: 1US FAERS
146Genital tract inflammationFAERS: 1US FAERS
147HyperventilationFAERS: 1US FAERS
148HypotensionFAERS: 1US FAERS
149Impaired work abilityFAERS: 1US FAERS
150Incorrect dose administered by deviceFAERS: 1US FAERS
151Incorrect route of product administrationFAERS: 1US FAERS
152InflammationFAERS: 1US FAERS
153Injury associated with deviceFAERS: 1US FAERS
154Intentional product use issueFAERS: 1US FAERS
155Mastitis fungalFAERS: 1US FAERS
156Maternal exposure during pregnancyFAERS: 1US FAERS
157Medical observation abnormalFAERS: 1US FAERS
158Metabolic acidosisFAERS: 1US FAERS
159NasopharyngitisFAERS: 1US FAERS
160Neonatal disorderFAERS: 1US FAERS
161Nerve injuryFAERS: 1US FAERS
162NervousnessFAERS: 1US FAERS
163NeuralgiaFAERS: 1OFFSIDES
US FAERS
164OliguriaFAERS: 1US FAERS
165Oxygen consumption decreasedFAERS: 1US FAERS
166PneumoniaFAERS: 1US FAERS
167Poor quality drug administeredFAERS: 1US FAERS
168Prescription drug used without a prescriptionFAERS: 1US FAERS
169PresyncopeFAERS: 1US FAERS
170Product counterfeitFAERS: 1US FAERS
171Product formulation issueFAERS: 1US FAERS
172Product label issueFAERS: 1US FAERS
173Product solubility abnormalFAERS: 1US FAERS
174Reaction to drug excipientsFAERS: 1US FAERS
175Rectal tenesmusFAERS: 1US FAERS
176RegurgitationFAERS: 1SIDER
US FAERS
177Rubber sensitivityFAERS: 1US FAERS
178ScabFAERS: 1US FAERS
179ScreamingFAERS: 1US FAERS
180Sexual DysfunctionFAERS: 1US FAERS
181ShockFAERS: 1US FAERS
182Similar reaction on previous exposure to drugFAERS: 1US FAERS
183Skin UlcerFAERS: 1US FAERS
184Skin lesionFAERS: 1US FAERS
185Skin texture abnormalFAERS: 1US FAERS
186Stevens-Johnson SyndromeFAERS: 1OFFSIDES
SIDER
US FAERS
187StridorFAERS: 1US FAERS
188Thermal burnFAERS: 1US FAERS
189UlcerFAERS: 1US FAERS
190Upper respiratory tract congestionFAERS: 1US FAERS
191Vaginal lesionFAERS: 1US FAERS
192Vaginal mycosisFAERS: 1OFFSIDES
US FAERS
193WheezingFAERS: 1US FAERS
194jaundiceFAERS: 1US FAERS
195AgeusiaSIDER
196Anemia984785CTD
197Angioedema1737464CTD
SIDER
198AnorexiaSIDER
199Anti-SS-A antibody positiveOFFSIDES
200ApneaOFFSIDES
201Application site pustulesOFFSIDES
202Arthritis, Infectious6465189CTD
203Aspiration PneumoniaOFFSIDES
204Atrial FlutterOFFSIDES
205Atrial tachycardiaOFFSIDES
206Auricular swellingOFFSIDES
207Bilirubin conjugated increasedOFFSIDES
208Blastomycosis454066CTD
209Blood beta-D-glucan increasedOFFSIDES
210Blood creatine phosphokinase MB increasedOFFSIDES
211Blood glucose abnormalOFFSIDES
212Blood iron decreasedOFFSIDES
213Blood pH decreasedOFFSIDES
214Bronchial Diseases1737464CTD
215Bronchopulmonary DysplasiaOFFSIDES
216Burning feeling vaginaSIDER
217Candida sepsisOFFSIDES
218Candidiasis of vaginaOFFSIDES
219Candidiasis, Chronic Mucocutaneous454066CTD
220Candidiasis6465189CTD
221Capillary Leak SyndromeOFFSIDES
222Cardiovascular Diseases7436161CTD
223Chemical and Drug Induced Liver Injury6113423CTD
224Choking sensationOFFSIDES
225CholecystitisOFFSIDES
226Cholestasis of pregnancyOFFSIDES
227Chronic Obstructive Airway DiseaseOFFSIDES
228Circumstance or information capable of leading to medication errorOFFSIDES
229Clostridium difficile colitisOFFSIDES
230Coagulation test abnormalOFFSIDES
231Coccidioidomycosis984785CTD
232Coital bleedingOFFSIDES
233ColectomyOFFSIDES
234Completed SuicideOFFSIDES
235Complication of device removalOFFSIDES
236Complications of maternal exposure to therapeutic drugsOFFSIDES
237Congenital cystic kidney diseaseOFFSIDES
238Creatinine urine decreasedOFFSIDES
239CryptorchidismOFFSIDES
240Culture positiveOFFSIDES
241DermatitisSIDER
242Dermatomycoses9085333
18608918		CTD
243Device FailureOFFSIDES
244Diabetic FootOFFSIDES
245Drug Overdose3796399CTD
246Economic problemOFFSIDES
247Embryo Loss28263823CTD
248EndophthalmitisOFFSIDES
249Endoscopy abnormalOFFSIDES
250Enterovesical FistulaOFFSIDES
251Eosinophilic myocarditisOFFSIDES
252Epstein-Barr virus antibody positiveOFFSIDES
253Erectile dysfunctionOFFSIDES
254Erythema MultiformeSIDER
255Failure to ThriveOFFSIDES
256Fetal Growth Retardation28263823CTD
257Foaming at mouthOFFSIDES
258Gamma-Glutamyltransferase IncreasedSIDER
259GastroenteritisSIDER
260Gastrointestinal PainSIDER
261Heart Diseases22262564CTD
262Heart sounds abnormalOFFSIDES
263HepatitisSIDER
264HypoxiaOFFSIDES
265Immunosuppressant drug levelOFFSIDES
266Incorrect drug administration durationOFFSIDES
267InfestationSIDER
268Infusion site infectionOFFSIDES
269Instillation site painSIDER
270Intestinal PerforationOFFSIDES
271Intestinal infarctionOFFSIDES
272Left ventricle outflow tract obstructionOFFSIDES
273Lip exfoliationCanada Vigilance: 1Canada Vigilance
274Live BirthOFFSIDES
275Localised skin reactionOFFSIDES
276LymphangitisOFFSIDES
277LymphopeniaSIDER
278MalabsorptionOFFSIDES
279MalaiseSIDER
280Mammary Neoplasms, Experimental9212229CTD
281Medical device complicationOFFSIDES
282Medical device discomfortOFFSIDES
283Meningitis, Cryptococcal2730866
6113423		CTD
284Mucosal erosionOFFSIDES
285Multi-organ disorderOFFSIDES
286Mycoses7436161
12149384
22262564		CTD
287Neonatal hypotensionOFFSIDES
288Neonatal respiratory arrestOFFSIDES
289NeutropeniaSIDER
290OculogyrationOFFSIDES
291Onychomycosis9621140CTD
292Oral Cavity FistulaOFFSIDES
293Oral fungal infectionOFFSIDES
294Oral painSIDER
295Oropharyngitis fungalOFFSIDES
296OrthopneaOFFSIDES
297PCO2 increasedOFFSIDES
298Parvovirus B19 serology positiveOFFSIDES
299Phlebitis454066CTD
OFFSIDES
300Plasminogen decreasedOFFSIDES
301PolyuriaOFFSIDES
302PriapismOFFSIDES
303Product complaintCanada Vigilance: 1Canada Vigilance
304ProlactinomaOFFSIDES
305Prothrombin time ratio increasedOFFSIDES
306Pulmonary HypertensionOFFSIDES
307Pulmonary Valve StenosisOFFSIDES
308Punctate keratitisOFFSIDES
309Radiation PneumonitisOFFSIDES
310Red cell distribution width decreasedOFFSIDES
311Regurgitation of foodSIDER
312Renal failure neonatalOFFSIDES
313Respiratory Tract Diseases7436161CTD
314Right ventricle outflow tract obstructionOFFSIDES
315Seizures3796399CTD
316Sick Sinus SyndromeOFFSIDES
317Single functional kidneyOFFSIDES
318Skin ErosionOFFSIDES
319Stress at workOFFSIDES
320Suprapubic painOFFSIDES
321Systemic candidiasis7427274CTD
322Tachycardia, Ventricular7427274CTD
323Therapeutic product ineffectiveCanada Vigilance: 1Canada Vigilance
324Thrombocytosis984785CTD
325Thrombophlebitis7427274CTD
326Tooth LossOFFSIDES
327ToothacheSIDER
328Toxic Epidermal NecrolysisSIDER
329Troponin increasedOFFSIDES
330Ultrasound antenatal screenOFFSIDES
331Urine flow decreasedOFFSIDES
332VestibulitisOFFSIDES
333Vitamin K DeficiencyOFFSIDES
334VulvitisCanada Vigilance: 1Canada Vigilance
OFFSIDES
335Wound dehiscenceOFFSIDES
336Wrong drug administeredOFFSIDES
337anaphylaxis7436161CTD
338nervous system disorderSIDER
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