MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Phenprocoumon

(DQDAYGNAKTZFIW-UHFFFAOYSA-N)

Structure

SMILES: CCC(c1c(=O)oc2c(c1O)cccc2)c1ccccc1
Type(s): Approved; Investigational
ATC code(s): B01AA04
Molecular Formula:: C18H16O3
Molecular Weight:: 280.318
Log P:: 4.0405
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 1
TPSA:: 50.44
CAS Number(s):: 435-97-2; 70206-44-9

Synonym(s)

Phenprocoumon

Phenprocoumalol

Phenprocoumarol

Phenylpropylhydroxycumarinum

Falithrom

Liquamar

Marcoumar

Marcumar

Phenprogramma

External Link(s)

MeSH	D010644
PubChem Compound	54680692
BindingDB	768 50053909
ChEBI	50438
CHEMBL	CHEMBL16694 CHEMBL1465
DrugBank	DB00946
DrugCentral	2138
IUPHAR/BPS Guide to PHARMACOLOGY	6839
KEGG	dr:D05457
Therapeutic Target Database	D0QV5T

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal Abscess		OFFSIDES
2	Acne		OFFSIDES
3	Activated partial thromboplastin time abnormal		OFFSIDES
4	Acute glomerulonephritis		OFFSIDES
5	Acute prerenal failure		OFFSIDES
6	Adenocarcinoma		OFFSIDES
7	Ageusia		OFFSIDES
8	Agraphia		OFFSIDES
9	Alanine Aminotransferase Increased		OFFSIDES
10	Alcohol withdrawal syndrome		OFFSIDES
11	Alcoholic Intoxication		OFFSIDES
12	Alpha 2 globulin increased		OFFSIDES
13	Alveolitis		OFFSIDES
14	Amaurosis Fugax		OFFSIDES
15	Amphetamines		OFFSIDES
16	Anal Fissure		OFFSIDES
17	Anal erosion		OFFSIDES
18	Angiodysplasia		OFFSIDES
19	Anisocoria		OFFSIDES
20	Anisocytosis		OFFSIDES
21	Anti-erythrocyte antibody		OFFSIDES
22	Anticholinergic Syndrome		OFFSIDES
23	Anticoagulation drug level below therapeutic		OFFSIDES
24	Antiphospholipid Syndrome		OFFSIDES
25	Arteriovenous fistula		OFFSIDES
26	Ascites	20221993	CTD
27	Aspergillosis		OFFSIDES
28	Ataxia		OFFSIDES
29	Atrial Fibrillation	View details 11926860 12464809 12970822 20221993	CTD
30	Atrial hypertrophy		OFFSIDES
31	Atrial tachycardia		OFFSIDES
32	Atrial thrombosis		OFFSIDES
33	Autoimmune thrombocytopenia		OFFSIDES
34	Bacterial conjunctivitis		OFFSIDES
35	Basal cell carcinoma		OFFSIDES
36	Beta 2 microglobulin increased		OFFSIDES
37	Bile duct stent insertion		OFFSIDES
38	Biliary dilatation		OFFSIDES
39	Biopsy bone abnormal		OFFSIDES
40	Blood Coagulation Disorders	20221993	CTD
41	Blood alcohol increased		OFFSIDES
42	Blood alkaline phosphatase increased		OFFSIDES
43	Blood cholinesterase decreased		OFFSIDES
44	Blood count abnormal		OFFSIDES
45	Blood creatine phosphokinase abnormal		OFFSIDES
46	Blood creatine phosphokinase increased		OFFSIDES
47	Blood creatinine increased		OFFSIDES
48	Blood ethanol increased		OFFSIDES
49	Blood immunoglobulin G increased		OFFSIDES
50	Blood iron increased		OFFSIDES
51	Blood lactate dehydrogenase increased		OFFSIDES
52	Blood osmolarity decreased		OFFSIDES
53	Blood sodium		OFFSIDES
54	Blood urea increased		OFFSIDES
55	Blood uric acid		OFFSIDES
56	Bone marrow myelogram abnormal		OFFSIDES
57	Bone marrow plasmacyte count increased		OFFSIDES
58	Bone trimming		OFFSIDES
59	Bradycardia		OFFSIDES
60	Bronchopneumonia		OFFSIDES
61	Bulbar palsy		OFFSIDES
62	C-reactive protein abnormal		OFFSIDES
63	Calciphylaxis		OFFSIDES
64	Candida sepsis		OFFSIDES
65	Cardiac ablation		OFFSIDES
66	Cardiac valve replacement complication		OFFSIDES
67	Cardioactive drug level increased		OFFSIDES
68	Catheter site erythema		OFFSIDES
69	Cerebral Hemorrhage	20517940 20582908	CTD
70	Cerebral atrophy		OFFSIDES
71	Chemical and Drug Induced Liver Injury	View details 11444480 12970822 15246210 20221993	CTD
72	Choking sensation		OFFSIDES
73	Cholangiolitis		OFFSIDES
74	Cholestasis	7588020 16866079	CTD
75	Choroiditis		OFFSIDES
76	Chronic left ventricular failure		OFFSIDES
77	Clonus		OFFSIDES
78	Clostridium difficile colitis		OFFSIDES
79	Coagulation test abnormal		OFFSIDES
80	Colitis erosive		OFFSIDES
81	Color blindness		OFFSIDES
82	Concomitant disease progression		OFFSIDES
83	Congenital osteodystrophy		OFFSIDES
84	Cor pulmonale		OFFSIDES
85	Creatinine renal clearance decreased		OFFSIDES
86	Crush syndrome		OFFSIDES
87	Cytomegalovirus test positive		OFFSIDES
88	Dental prosthesis user		OFFSIDES
89	Diabetic Nephropathy		OFFSIDES
90	Diabetic dermopathy		OFFSIDES
91	Differential white blood cell count abnormal		OFFSIDES
92	Diverticular perforation		OFFSIDES
93	Drug Overdose	8681749	CTD
94	Dyspnoea exacerbated		OFFSIDES
95	Electrocardiogram repolarisation abnormality		OFFSIDES
96	Electrolyte depletion		OFFSIDES
97	Electrophoresis abnormal		OFFSIDES
98	Embolic stroke		OFFSIDES
99	Empyema		OFFSIDES
100	Endocarditis		OFFSIDES
101	Epidermolysis		OFFSIDES
102	Epidural lipomatosis		OFFSIDES
103	Epistaxis		OFFSIDES
104	Erosive gastritis		OFFSIDES
105	Erysipelas		OFFSIDES
106	Erythropenia		OFFSIDES
107	Escherichia sepsis		OFFSIDES
108	Escherichia urinary tract infection		OFFSIDES
109	Excoriation		OFFSIDES
110	Exsanguination	12464809	CTD
111	Extremity necrosis		OFFSIDES
112	Fat necrosis		OFFSIDES
113	Fatty Liver		OFFSIDES
114	Femoral artery occlusion		OFFSIDES
115	Fluid imbalance		OFFSIDES
116	Gamma-Glutamyltransferase Increased		OFFSIDES
117	Gangrene		OFFSIDES
118	Gastrointestinal infection		OFFSIDES
119	Gastrointestinal inflammation		OFFSIDES
120	General physical condition		OFFSIDES
121	General physical health deterioration		OFFSIDES
122	General symptom		OFFSIDES
123	Genital erosion		OFFSIDES
124	Glomerulonephritis		OFFSIDES
125	Granulocyte count decreased		OFFSIDES
126	Granulocytosis		OFFSIDES
127	Hematoma, Subdural, Spinal	1321696	CTD
128	Hematoma	10327224	CTD
129	Hemiparesis		OFFSIDES
130	Hemorrhage	16149013	CTD
131	Hepatic Encephalopathy	20221993	CTD
132	Hepatic Infarction		OFFSIDES
133	Hepatic congestion		OFFSIDES
134	Hepatic necrosis		OFFSIDES
135	Hepatitis B positive		OFFSIDES
136	Hepatitis B		OFFSIDES
137	Hepatitis	View details 1963177 7588020 7836716 10859983 11360450 11444480 12970822 15246210 16866079	CTD OFFSIDES
138	Hepatotoxicity		OFFSIDES
139	Hernia obstructive		OFFSIDES
140	Histrionic Personality Disorder		OFFSIDES
141	Hyperkeratosis		OFFSIDES
142	Hypertransaminasaemia		OFFSIDES
143	Hypertrichosis		OFFSIDES
144	Hyperventilation		OFFSIDES
145	Hypogeusia		OFFSIDES
146	Iatrogenic injury		OFFSIDES
147	Immobile		OFFSIDES
148	Immunosuppressant drug level		OFFSIDES
149	Implantable defibrillator insertion		OFFSIDES
150	Increased bronchial secretion		OFFSIDES
151	Injection site irritation		OFFSIDES
152	Intentional misuse		OFFSIDES
153	Jaundice, Obstructive	7588020	CTD
154	Kidney Failure		OFFSIDES
155	Lateral Medullary Syndrome		OFFSIDES
156	Lip erosion		OFFSIDES
157	Lipase		OFFSIDES
158	Liver Cirrhosis	1963177 20221993	CTD
159	Liver Failure, Acute	View details 10545730 11444480 12743448 15455285 16866079	CTD
160	Lividity		OFFSIDES
161	Long QT Syndrome		OFFSIDES
162	Macrocytosis		OFFSIDES
163	Malabsorption		OFFSIDES
164	Mantle cell lymphoma		OFFSIDES
165	Massive Hepatic Necrosis	10545730 15246210	CTD
166	Mechanical complication of implant		OFFSIDES
167	Mental disorder due to a general medical condition		OFFSIDES
168	Mental retardation severity unspecified		OFFSIDES
169	Microalbuminuria		OFFSIDES
170	Monoparesis		OFFSIDES
171	Morphea		OFFSIDES
172	Mucosal Infection		OFFSIDES
173	Mucosal erosion		OFFSIDES
174	Multiple drug overdose intentional		OFFSIDES
175	Muscle Weakness		OFFSIDES
176	Muscle abscess		OFFSIDES
177	Myasthenia Gravis		OFFSIDES
178	Myelitis		OFFSIDES
179	Necrosis	6884225 11284095	CTD
180	Nephrogenic Fibrosing Dermopathy		OFFSIDES
181	Neutropenic infection		OFFSIDES
182	Obstruction		OFFSIDES
183	Ocular icterus		OFFSIDES
184	Optic Atrophy		OFFSIDES
185	Optic Disc Edema		OFFSIDES
186	Optic Neuropathy		OFFSIDES
187	Oropharyngeal spasm		OFFSIDES
188	Orthopnea		OFFSIDES
189	Osteotomy		OFFSIDES
190	PROTHROMBIN TIME		OFFSIDES
191	Pacemaker generated arrhythmia		OFFSIDES
192	Pain of skin		OFFSIDES
193	Palpable purpura		OFFSIDES
194	Pancreas lipomatosis		OFFSIDES
195	Pancreatic Neoplasm		OFFSIDES
196	Pelvic venous thrombosis		OFFSIDES
197	Percutaneous Coronary Intervention		OFFSIDES
198	Performance status decreased		OFFSIDES
199	Peripheral arterial occlusive disease		OFFSIDES
200	Peritonitis		OFFSIDES
201	Phrenic nerve paralysis		OFFSIDES
202	Platelet count abnormal		OFFSIDES
203	Platelet function test abnormal		OFFSIDES
204	Pleurisy		OFFSIDES
205	Poikilocytosis		OFFSIDES
206	Polymyalgia Rheumatica		OFFSIDES
207	Polyneuropathy		OFFSIDES
208	Portal Vein Thrombosis		OFFSIDES
209	Postmenopausal bleeding		OFFSIDES
210	Potentiating drug interaction		OFFSIDES
211	Pregnancy on oral contraceptive		OFFSIDES
212	Proctitis		OFFSIDES
213	Prosthesis Implantation		OFFSIDES
214	Prothrombin level decreased		OFFSIDES
215	Prothrombin time abnormal		OFFSIDES
216	Prothrombin time ratio decreased		OFFSIDES
217	Pubic pain		OFFSIDES
218	Pulmonary Hypertension		OFFSIDES
219	Pulmonary artery thrombosis		OFFSIDES
220	Pulmonary congestion		OFFSIDES
221	Pyogenic granuloma		OFFSIDES
222	Radiation mucositis		OFFSIDES
223	Red blood cell macrocytes present		OFFSIDES
224	Red blood cell microcytes present		OFFSIDES
225	Renal tubular atrophy		OFFSIDES
226	Reticulocyte count decreased		OFFSIDES
227	Retinal Vasculitis		OFFSIDES
228	Rhabdomyolysis		OFFSIDES
229	Rheumatoid Nodule		OFFSIDES
230	Scleroderma		OFFSIDES
231	Septic arthritis staphylococcal		OFFSIDES
232	Shunt occlusion		OFFSIDES
233	Shunt thrombosis		OFFSIDES
234	Sinus bradycardia		OFFSIDES
235	Skin Diseases, Vascular	1410981 6884225	CTD
236	Skin lesion		OFFSIDES
237	Skin necrosis		OFFSIDES
238	Soft Tissue Infection		OFFSIDES
239	Soft tissue necrosis		OFFSIDES
240	Stenotrophomonas infection		OFFSIDES
241	Stent occlusion		OFFSIDES
242	Stevens-Johnson Syndrome		OFFSIDES
243	Subcutaneous Abscess		OFFSIDES
244	Sudden Cardiac Death		OFFSIDES
245	Superficial Thrombophlebitis		OFFSIDES
246	Synovial Cyst		OFFSIDES
247	Tarsal Tunnel Syndrome		OFFSIDES
248	Terminal state		OFFSIDES
249	Thrombectomy		OFFSIDES
250	Thromboembolism	8659220 12743448 18698879	CTD
251	Thrombosis	7498216	CTD
252	Tracheitis		OFFSIDES
253	Transaminases increased		OFFSIDES
254	Tri-iodothyronine free increased		OFFSIDES
255	Trifascicular block		OFFSIDES
256	Urinary tract infection pseudomonal		OFFSIDES
257	Uterine atrophy		OFFSIDES
258	Vaginal abscess		OFFSIDES
259	Vasculitis	6884225	CTD
260	Venous stenosis		OFFSIDES
261	Venous thrombosis limb		OFFSIDES
262	Ventricular Fibrillation		OFFSIDES
263	Ventricular Flutter		OFFSIDES
264	Ventricular hypokinesia		OFFSIDES
265	Vertebral Artery Stenosis		OFFSIDES
266	Vertebral artery occlusion		OFFSIDES
267	Vestibular Neuronitis		OFFSIDES
268	Vitamin K Deficiency		OFFSIDES
269	Wound closure		OFFSIDES
270	Xanthopsia		OFFSIDES
271	furuncle		OFFSIDES
272	jaundice	1963177 15455285	CTD
273	treatment failure		OFFSIDES

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