MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Ambroxol

(JBDGDEWWOUBZPM-UHFFFAOYSA-N)

Structure

SMILES: OC1CCC(CC1)NCc1cc(Br)cc(c1N)Br
Type(s): Approved; Investigational
ATC code(s): R03CC63; R05CB06
Molecular Formula:: C13H18Br2N2O
Molecular Weight:: 378.103
Log P:: 4.1590
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 3
TPSA:: 58.28
CAS Number(s):: 15942-05-9; 18683-91-5; 23828-92-4; 36557-04-7; 107814-37-9

Synonym(s)

Ambroxol

Bromhexine Metabolite VIII

4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

AMBROPP

Abrohexal

Ambril

Ambro-Puren

Ambrobeta

Ambrofur

10.

Ambrohexal

11.

Ambrolitic

12.

Ambrolös

13.

Ambroten

14.

Ambroxin

15.

Ambroxocompren

16.

Bisolvon AM

17.

Bronchopront

18.

Bronchowern

19.

Broxol

20.

Contac Husten-Trunk

21.

Dinobroxol

22.

Duramucal

23.

Ebromin

24.

Expeflen

25.

Expit

26.

Farmabroxol

27.

Flavamed

28.

Frenopect

29.

Gelopol

30.

Larylin Husten-Löser

31.

Lasolvan

32.

Mibrox

33.

Motosol

34.

Muco-Fips

35.

Mucosolvan

36.

Mucotablin

37.

NA-872

38.

Pect Hustenlöser

39.

Pulmonal S

40.

Pädiamuc

41.

Ringelheimer Pulmonal

42.

Sekretovit

43.

Surbronc

44.

Therapin Hustenlöser

45.

stas-Hustenlöser

46.

AM, Bisolvon

47.

Ambro Puren

48.

AmbroPuren

49.

Contac Husten Trunk

50.

Contac HustenTrunk

51.

Hustenlöser, Pect

52.

Hustenlöser, Therapin

53.

Larylin Husten Löser

54.

Larylin HustenLöser

55.

Metabolite VIII, Bromhexine

56.

Muco Fips

57.

MucoFips

58.

NA 872

59.

NA872

60.

Pulmonal, Ringelheimer

61.

stas Hustenlöser

62.

stasHustenlöser

External Link(s)

MeSH	D000551
PubChem Compound	2132
BindingDB	50395322
ChEBI	135590 92994
CHEMBL	CHEMBL1477775 CHEMBL153479
DrugBank	DB06742
DrugCentral	147
IUPHAR/BPS Guide to PHARMACOLOGY	10692
KEGG	dr:D07442
Therapeutic Target Database	D03DSR
ZINC	100001905 587613 100070274

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal Abscess		OFFSIDES
2	Accidental overdose		OFFSIDES
3	Acid fast stain positive		OFFSIDES
4	Acute Lung Injury	15970105	CTD
5	Acute bronchitis		OFFSIDES
6	Acute respiratory failure		OFFSIDES
7	Alanine Aminotransferase Increased		OFFSIDES
8	Altered state of consciousness		OFFSIDES
9	Alveolitis		OFFSIDES
10	Angioplasty		OFFSIDES
11	Anorexia		OFFSIDES
12	Anosmia		OFFSIDES
13	Apnea		OFFSIDES
14	Arteriosclerosis Obliterans		OFFSIDES
15	Ascites		OFFSIDES
16	Aspiration Pneumonia		OFFSIDES
17	Asthma		OFFSIDES
18	Atrioventricular Block		OFFSIDES
19	Aura		OFFSIDES
20	Avascular necrosis		OFFSIDES
21	Bacteria sputum identified		OFFSIDES
22	Beta 2 microglobulin increased		OFFSIDES
23	Beta-N-acetyl-D-glucosaminidase increased		OFFSIDES
24	Bilirubin conjugated increased		OFFSIDES
25	Blood creatine phosphokinase increased		OFFSIDES
26	Blood glucose decreased		OFFSIDES
27	Blood immunoglobulin A decreased		OFFSIDES
28	Blood immunoglobulin G decreased		OFFSIDES
29	Blood immunoglobulin M decreased		OFFSIDES
30	Blood lactate dehydrogenase increased		OFFSIDES
31	Blood sodium abnormal		OFFSIDES
32	Blood urea abnormal		OFFSIDES
33	Body Temperature		OFFSIDES
34	Bradycardia		OFFSIDES
35	Bronchiectasis		OFFSIDES
36	Bronchoalveolar Lavage		OFFSIDES
37	Bronchopneumonia		OFFSIDES
38	Bulbar palsy		OFFSIDES
39	Candida sepsis		OFFSIDES
40	Cardiac function test abnormal		OFFSIDES
41	Carnitine decreased		OFFSIDES
42	Catheter related infection		OFFSIDES
43	Cell marker increased		OFFSIDES
44	Cerebral aspergillosis		OFFSIDES
45	Cholangiolitis		OFFSIDES
46	Chromaturia		OFFSIDES
47	Clostridium colitis		OFFSIDES
48	Complications of maternal exposure to therapeutic drugs		OFFSIDES
49	Crush syndrome		OFFSIDES
50	Cyanosis		OFFSIDES
51	Cytomegalovirus test positive		OFFSIDES
52	Depressed Level of Consciousness		OFFSIDES
53	Diffuse panbronchiolitis		OFFSIDES
54	Disseminated Intravascular Coagulation		OFFSIDES
55	Drug exposure during pregnancy		OFFSIDES
56	Dry gangrene		OFFSIDES
57	Dyslalia		OFFSIDES
58	Dysphemia		OFFSIDES
59	Dysphonia		OFFSIDES
60	Echocardiogram abnormal		OFFSIDES
61	Eczema		OFFSIDES
62	Empyema		OFFSIDES
63	Encephalitis		OFFSIDES
64	Enterocolitis		OFFSIDES
65	Eosinophil percentage increased		OFFSIDES
66	Eosinophilic Pneumonia		OFFSIDES
67	Eosinophilic cystitis		OFFSIDES
68	Epidermolysis		OFFSIDES
69	Epilepsy		OFFSIDES
70	Erythema Multiforme		OFFSIDES
71	Erythropenia		OFFSIDES
72	Food Allergy		OFFSIDES
73	Gamma-Glutamyltransferase Increased		OFFSIDES
74	Gastroenteritis norovirus		OFFSIDES
75	Gastrointestinal perforation		OFFSIDES
76	Gaze palsy		OFFSIDES
77	Glucagonoma		OFFSIDES
78	Haematotoxicity		OFFSIDES
79	Hepatic congestion		OFFSIDES
80	Hepatitis B positive		OFFSIDES
81	Hepatitis C		OFFSIDES
82	Hepatosplenomegaly		OFFSIDES
83	Hostility		OFFSIDES
84	Hydronephrosis		OFFSIDES
85	Hypercapnia		OFFSIDES
86	Hyperpigmentation		OFFSIDES
87	Hyperventilation		OFFSIDES
88	Hypoxia		OFFSIDES
89	Inappropriate affect		OFFSIDES
90	Infection		OFFSIDES
91	Influenza serology positive		OFFSIDES
92	Infusion site erythema		OFFSIDES
93	Infusion site phlebitis		OFFSIDES
94	Injection site phlebitis		OFFSIDES
95	Intentional self-injury		OFFSIDES
96	Intestinal Obstruction		OFFSIDES
97	Intraocular inflammation		OFFSIDES
98	Iron binding capacity unsaturated decreased		OFFSIDES
99	Lip erosion		OFFSIDES
100	Listeria sepsis		OFFSIDES
101	Lung Abscess		OFFSIDES
102	Lymphangiosis carcinomatosa		OFFSIDES
103	Lymphocyte count decreased		OFFSIDES
104	Lymphocyte percentage decreased		OFFSIDES
105	Lymphocyte stimulation test positive		OFFSIDES
106	Middle Lobe Syndrome		OFFSIDES
107	Monocyte percentage decreased		OFFSIDES
108	Mononeuritis		OFFSIDES
109	Monoplegia		OFFSIDES
110	Myelodysplasia		OFFSIDES
111	Myoglobin blood increased		OFFSIDES
112	Nasopharyngitis		OFFSIDES
113	Negativism		OFFSIDES
114	Optic Neuropathy		OFFSIDES
115	Peripheral occlusive disease		OFFSIDES
116	Pilonidal cyst congenital		OFFSIDES
117	Plasmacytoma		OFFSIDES
118	Pneumothorax		OFFSIDES
119	Post inflammatory pigmentation change		OFFSIDES
120	Productive Cough		OFFSIDES
121	Prothrombin level decreased		OFFSIDES
122	Psychiatric symptom		OFFSIDES
123	Pulmonary Eosinophilia		OFFSIDES
124	Pulmonary Fibrosis	17997885 21921364	CTD
125	Pyoderma Gangrenosum		OFFSIDES
126	Quadriparesis		OFFSIDES
127	Quadriplegia		OFFSIDES
128	Radiation Pneumonitis		OFFSIDES
129	Radiation skin injury		OFFSIDES
130	Renal tubular disorder		OFFSIDES
131	Respiratory Failure		OFFSIDES
132	Reticulocytosis		OFFSIDES
133	Rhabdomyolysis		OFFSIDES
134	Rhinitis		OFFSIDES
135	Sarcoidosis		OFFSIDES
136	Screaming		OFFSIDES
137	Scrotal erythema		OFFSIDES
138	Small intestine carcinoma		OFFSIDES
139	Smallpox		OFFSIDES
140	Sputum retention		OFFSIDES
141	Status Epilepticus		OFFSIDES
142	Stevens-Johnson Syndrome		OFFSIDES
143	Supraventricular tachycardia		OFFSIDES
144	Talipes		OFFSIDES
145	Testicular embryonal carcinoma		OFFSIDES
146	Therapy non-responder		OFFSIDES
147	Tolosa-Hunt Syndrome		OFFSIDES
148	Tracheal Stenosis		OFFSIDES
149	Type III immune complex mediated reaction		OFFSIDES
150	Upper respiratory tract inflammation		OFFSIDES
151	Vertebral artery occlusion		OFFSIDES
152	Vitamin K Deficiency		OFFSIDES
153	Vocal Cord Paralysis		OFFSIDES
154	prostatitis		OFFSIDES

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