MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

cevimeline

(WUTYZMFRCNBCHQ-PSASIEDQSA-N)

Structure

SMILES: C[C@H]1SC[C@]2(O1)CN1CCC2CC1
Molecular Formula:: C10H17NOS
Molecular Weight:: 199.313
Log P:: 1.4981
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 0
TPSA:: 37.77
CAS Number(s):: 107233-08-9

Synonym(s)

cevimeline

2-methyspiro(1,3-oxathiolane-5,3)quinuclidine

AF 102B

AF 102B, (cis-(+))-isomer

AF 102B, (trans)-isomer

AF-102B

AF102B

Evoxac

FKS 508

10.

FKS-508

11.

SNI 2011

12.

SNI-2011

13.

cevimeline hydrochloride

External Link(s)

MeSH	C059240
PubChem Compound	83898
KEGG	dr:D07667
ZINC	10163

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 3		US FAERS
2	Asthenia	FAERS: 1		SIDER US FAERS
3	Dizziness	FAERS: 1		OFFSIDES SIDER US FAERS
4	Dysphonia	FAERS: 1		OFFSIDES SIDER US FAERS
5	Economic problem	FAERS: 1		US FAERS
6	Fatigue	FAERS: 1		OFFSIDES SIDER US FAERS
7	Product quality issue	FAERS: 1		US FAERS
8	Product substitution issue	FAERS: 1		US FAERS
9	Wheezing	FAERS: 1		US FAERS
10	Abdominal Pain			OFFSIDES SIDER
11	Abdominal discomfort			OFFSIDES
12	Abdominal mass			OFFSIDES
13	Abnormal platelets			SIDER
14	Abnormal vision			OFFSIDES SIDER
15	Abscess			SIDER
16	Accidental overdose			OFFSIDES
17	Activities of daily living impaired			OFFSIDES
18	Acute Coronary Syndrome			SIDER
19	Acute bronchitis			OFFSIDES
20	Ageusia			OFFSIDES
21	Aggressive reaction			SIDER
22	Agitation			SIDER
23	Agranulocytosis			SIDER
24	Agraphia			OFFSIDES
25	Alanine Aminotransferase Increased			OFFSIDES SIDER
26	Albuminuria			SIDER
27	Allergy aggravated			SIDER
28	Alopecia			SIDER
29	Altered state of consciousness			OFFSIDES
30	Alveolitis			OFFSIDES
31	Amnesia		2302575 3244205	CTD OFFSIDES SIDER
32	Amphetamines			OFFSIDES
33	Amylase increased			SIDER
34	Angina Pectoris			SIDER
35	Angioedema			OFFSIDES
36	Anhedonia			OFFSIDES
37	Anhidrosis			OFFSIDES
38	Anorectal discomfort			SIDER
39	Anorexia			OFFSIDES SIDER
40	Anosmia			OFFSIDES
41	Anoxic Encephalopathy			OFFSIDES
42	Anxiety			OFFSIDES SIDER
43	Apathy			SIDER
44	Aphasia			SIDER
45	Appendicitis			SIDER
46	Arachnoiditis			OFFSIDES
47	Arthralgia			SIDER
48	Arthritis aggravated			SIDER
49	Arthritis			SIDER
50	Arthropathy			SIDER
51	Aspiration Pneumonia			OFFSIDES
52	Asthma			SIDER
53	Atelectasis			SIDER
54	Atrial Flutter			OFFSIDES
55	Atrioventricular Block			OFFSIDES
56	Atrophic vulvovaginitis			SIDER
57	Autoimmune thrombocytopenia			OFFSIDES
58	BREAST PAIN FEMALE			SIDER
59	Back Pain			SIDER
60	Basal cell carcinoma			SIDER
61	Bladder discomfort			SIDER
62	Bladder pain			SIDER
63	Blepharitis			SIDER
64	Blood Glucose			OFFSIDES
65	Blood alkaline phosphatase increased			SIDER
66	Blood antidiuretic hormone decreased			OFFSIDES
67	Blood cortisol increased			OFFSIDES
68	Blood electrolytes abnormal			SIDER
69	Blood pressure fluctuation			SIDER
70	Blood prolactin increased			OFFSIDES
71	Blood thyroid stimulating hormone			OFFSIDES
72	Blood triglycerides increased			SIDER
73	Blood urea increased			SIDER
74	Bone density decreased			OFFSIDES
75	Bone pain			SIDER
76	Breast cancer recurrent			OFFSIDES
77	Bronchial Hyperreactivity			SIDER
78	Bronchitis			SIDER
79	Bronchoconstriction			SIDER
80	Bronchospasm			SIDER
81	Bullous eruption			SIDER
82	Burning Mouth Syndrome			OFFSIDES
83	Bursitis			OFFSIDES SIDER
84	Cardiomegaly			SIDER
85	Carpal Tunnel Syndrome			SIDER
86	Cataract			SIDER
87	Catheter related complication			OFFSIDES
88	Cellulitis			OFFSIDES SIDER
89	Cervical myelopathy			OFFSIDES
90	Chest Pain			OFFSIDES SIDER
91	Chills			SIDER
92	Choking sensation			OFFSIDES
93	Choking			SIDER
94	Cholecystitis			SIDER
95	Cholelithiasis			SIDER
96	Chondromalacia			OFFSIDES
97	Chondroplasty			OFFSIDES
98	Chromaturia			OFFSIDES
99	Chronic Obstructive Airway Disease			OFFSIDES
100	Chronic sinusitis			OFFSIDES
101	Chronic ulcerative colitis			OFFSIDES
102	Cold sweat			SIDER
103	Common wart			SIDER
104	Conjunctivitis			SIDER
105	Constipation			SIDER
106	Contact Dermatitis			OFFSIDES
107	Corneal Opacity			SIDER
108	Cramps of lower extremities			SIDER
109	Crying			SIDER
110	Cystitis			SIDER
111	Deafness			SIDER
112	Dehydration			OFFSIDES SIDER
113	Delirium			SIDER
114	Dementia			SIDER
115	Demyelination			OFFSIDES
116	Dental caries			OFFSIDES SIDER
117	Denture wearer			OFFSIDES
118	Depressed Level of Consciousness			OFFSIDES
119	Depression aggravated			SIDER
120	Dermatitis			SIDER
121	Diabetes Mellitus			SIDER
122	Diarrhea			OFFSIDES
123	Diplopia			SIDER
124	Discomfort			SIDER
125	Diverticulitis			SIDER
126	Dry skin			SIDER
127	Duodenitis			SIDER
128	Dysgeusia			OFFSIDES SIDER
129	Dyspepsia			OFFSIDES SIDER
130	Dysthymic Disorder			OFFSIDES
131	Dysuria			OFFSIDES SIDER
132	Ear infection staphylococcal			OFFSIDES
133	Early satiety			OFFSIDES
134	Eczema			SIDER
135	Electrocardiogram abnormal			SIDER
136	Electrolyte imbalance			SIDER
137	Emotional distress			OFFSIDES
138	Endodontic procedure			OFFSIDES
139	Endometrial disorder			SIDER
140	Enlargement abdomen			SIDER
141	Enteritis			OFFSIDES
142	Enterococcal infection			OFFSIDES
143	Enterocolitis			SIDER
144	Eosinophilia			SIDER
145	Epididymitis			SIDER
146	Epilepsy			OFFSIDES
147	Epistaxis			OFFSIDES SIDER
148	Erectile dysfunction			SIDER
149	Eructation			SIDER
150	Erythema			OFFSIDES
151	Eustachian tube disorder			OFFSIDES
152	Eye Infection			OFFSIDES SIDER
153	Eye pain			OFFSIDES SIDER
154	Failure to Thrive			SIDER
155	Feeling abnormal			SIDER
156	Fibromyalgia			OFFSIDES
157	Flat affect			SIDER
158	Flatulence			OFFSIDES SIDER
159	Flushing			SIDER
160	Food Poisoning			SIDER
161	Furunculosis			SIDER
162	Gastric ulcer			SIDER
163	Gastritis			SIDER
164	Gastroenteritis			SIDER
165	Gastrointestinal Pain			SIDER
166	Gastrointestinal inflammation			OFFSIDES
167	Gastrointestinal motility disorder			OFFSIDES
168	Genital Herpes			OFFSIDES
169	Gingival Hyperplasia			OFFSIDES SIDER
170	Gingivitis			SIDER
171	Glaucoma			SIDER
172	Globulinuria			OFFSIDES
173	Glossitis			OFFSIDES SIDER
174	Glycosuria			SIDER
175	Goiter			OFFSIDES
176	Gout			SIDER
177	Headache			SIDER
178	Heat Stroke			SIDER
179	Hyperhemoglobinemia			SIDER
180	Hyperkeratosis			OFFSIDES SIDER
181	Hyperkinesia			SIDER
182	Hyperpigmentation			OFFSIDES
183	Hypersensitivity			SIDER
184	Hypertension worsened			SIDER
185	Hyperventilation			OFFSIDES
186	Hypoaesthesia facial			OFFSIDES
187	Hypokinesia			OFFSIDES
188	Hypomania			OFFSIDES
189	Hypophagia			OFFSIDES
190	Hyporeflexia			SIDER
191	Hypotension			SIDER
192	Hypothyroidism			SIDER
193	Hypoxia			OFFSIDES
194	Ileus			SIDER
195	Impaired gastric emptying			OFFSIDES
196	Incoherent			OFFSIDES
197	Incontinence			OFFSIDES
198	Incorrect dose administered			OFFSIDES
199	Infection			OFFSIDES SIDER
200	Influenza-like symptoms			SIDER
201	Intestinal Obstruction			SIDER
202	Intracranial Hypotension			OFFSIDES
203	Irritable Bowel Syndrome			SIDER
204	Joint prosthesis user			OFFSIDES
205	Joint sprain			OFFSIDES
206	Joint stiffness			OFFSIDES
207	Keratitis			SIDER
208	Keratoconjunctivitis			SIDER
209	Kidney Failure			OFFSIDES
210	Laryngitis			SIDER
211	Leukocytosis			SIDER
212	Leukopenia			SIDER
213	Leukorrhea			SIDER
214	Lichen Planus			SIDER
215	Life expectancy shortened			OFFSIDES
216	Limb operation			OFFSIDES
217	Lower respiratory tract inflammation			OFFSIDES
218	Lumbar radiculopathy			OFFSIDES
219	Lupus Erythematosus			SIDER
220	Lymphadenopathy			SIDER
221	Lymphocytosis			SIDER
222	Lymphoma			OFFSIDES
223	Malaise			SIDER
224	Malnutrition			SIDER
225	Manic psychosis			SIDER
226	Mechanical ventilation			OFFSIDES
227	Medical device removal			OFFSIDES
228	Meniscus removal			OFFSIDES
229	Menorrhagia			SIDER
230	Metrorrhagia			SIDER
231	Middle insomnia			OFFSIDES
232	Mixed Connective Tissue Disease			OFFSIDES
233	Mononeuritis			OFFSIDES
234	Mood swings			SIDER
235	Motion Sickness			SIDER
236	Multiple Sclerosis			SIDER
237	Muscle Weakness			OFFSIDES
238	Musculoskeletal Pain			OFFSIDES
239	Musculoskeletal chest pain			OFFSIDES
240	Musculoskeletal discomfort			SIDER
241	Musculoskeletal stiffness			OFFSIDES
242	Myalgia			SIDER
243	Mydriasis			SIDER
244	Myocardial Infarction			SIDER
245	Myopia			SIDER
246	Nasopharyngitis			OFFSIDES
247	Nausea			OFFSIDES SIDER
248	Nephrolithiasis			SIDER
249	Nephrosis			SIDER
250	Nephrotic Syndrome			SIDER
251	Neuralgia			OFFSIDES SIDER
252	Neuroma			OFFSIDES
253	Neuropathy			SIDER
254	Nocturia			OFFSIDES SIDER
255	Nodule			OFFSIDES
256	Oliguria			OFFSIDES SIDER
257	Onychia			SIDER
258	Onychomycosis			SIDER
259	Open reduction of fracture			OFFSIDES
260	Oral polypectomy			OFFSIDES
261	Oropharyngeal pain			OFFSIDES
262	Oropharyngeal plaque			OFFSIDES
263	Osteolysis			OFFSIDES
264	Osteomyelitis			OFFSIDES SIDER
265	Osteopenia			OFFSIDES
266	Osteoporosis			SIDER
267	Osteosclerosis			OFFSIDES
268	Otitis Media			SIDER
269	Overdose			OFFSIDES
270	Pain			OFFSIDES SIDER
271	Pallor			SIDER
272	Palpitations			SIDER
273	Parakeratosis			OFFSIDES
274	Paranoia			SIDER
275	Paranoid reaction			SIDER
276	Peptic Ulcer			SIDER
277	Pericarditis			SIDER
278	Periodontal destruction			SIDER
279	Periodontitis			OFFSIDES
280	Pharyngeal candidiasis			OFFSIDES
281	Pharyngitis			SIDER
282	Pharyngolaryngeal Pain			OFFSIDES
283	Physical disability			OFFSIDES
284	Pleurisy			SIDER
285	Pneumocystis jiroveci pneumonia			OFFSIDES
286	Pneumonia			SIDER
287	Pneumothorax			SIDER
288	Polymyositis			OFFSIDES
289	Polyuria			SIDER
290	Post lumbar puncture syndrome			OFFSIDES
291	Postoperative Hemorrhage			SIDER
292	Precordial pain			SIDER
293	Primary sequestrum			OFFSIDES
294	Procedural nausea			OFFSIDES
295	Proctocolitis			SIDER
296	Protein total increased			OFFSIDES
297	Pruritus			SIDER
298	Pulmonary Embolism			SIDER
299	Pulmonary Fibrosis			SIDER
300	Pulmonary congestion			SIDER
301	Purpura			SIDER
302	Pyelonephritis			SIDER
303	Pyuria			SIDER
304	Rash erythematous			SIDER
305	Rectal tenesmus			SIDER
306	Renal pain			SIDER
307	Respiratory Failure			OFFSIDES
308	Respiratory tract congestion			SIDER
309	Retinal Vasculitis			OFFSIDES
310	Retinal deposits			SIDER
311	Retrosternal pain			SIDER
312	Rheumatoid Arthritis			SIDER
313	Rheumatoid arthritis aggravated			SIDER
314	Rhinitis			SIDER
315	Rosacea			SIDER
316	Saliva altered			OFFSIDES
317	Salivary gland pain			SIDER
318	Scleritis			SIDER
319	Scleroderma			SIDER
320	Sepsis			SIDER
321	Sexual Dysfunction			SIDER
322	Shock			SIDER
323	Sinus headache			OFFSIDES
324	Sinus operation			OFFSIDES
325	Sinusitis			SIDER
326	Sjogren's Syndrome			OFFSIDES
327	Skin Papilloma			SIDER
328	Skin Ulcer			SIDER
329	Skin cold clammy			SIDER
330	Skin hypertrophy			SIDER
331	Soft tissue necrosis			OFFSIDES
332	Somnolence			SIDER
333	Spinal column stenosis			OFFSIDES
334	Squamous cell carcinoma			SIDER
335	Stomatitis			SIDER
336	Stridor			OFFSIDES
337	Supraventricular tachycardia			SIDER
338	Syncope			SIDER
339	Synovial Cyst			OFFSIDES
340	Synovitis			OFFSIDES SIDER
341	Tachycardia			SIDER
342	Tenosynovitis			SIDER
343	Thirst			SIDER
344	Thrombocytopenia			SIDER
345	Thrombocytopenic purpura			SIDER
346	Thrombocytosis			SIDER
347	Thrombophlebitis			SIDER
348	Tinnitus			SIDER
349	Toe operation			OFFSIDES
350	Tooth Extraction			OFFSIDES
351	Tooth Loss			OFFSIDES
352	Toothache			SIDER
353	Toxicity to various agents			SIDER
354	Trauma			SIDER
355	Tremor			SIDER
356	Ulcerative stomatitis			SIDER
357	Ulcer			OFFSIDES
358	Unresponsive to stimuli			OFFSIDES
359	Urethral Stenosis			OFFSIDES
360	Urinary Incontinence			SIDER
361	Urinary Retention			SIDER
362	Urinary tract infection			SIDER
363	Urine flow decreased			SIDER
364	Urine output increased			SIDER
365	Urticaria			SIDER
366	VIIth nerve paralysis			OFFSIDES
367	Vaginal Discharge			SIDER
368	Vascular purpura			SIDER
369	Vasculitis			SIDER
370	Vertigo			SIDER
371	Visual Impairment			SIDER
372	Vitreous Detachment			SIDER
373	Vomiting			SIDER
374	Weight decreased			SIDER
375	Xerophthalmia			SIDER
376	Yawning			SIDER
377	effusion			OFFSIDES
378	furuncle			SIDER
379	nervous system disorder			SIDER
380	treatment failure			OFFSIDES

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