MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Indinavir

(CBVCZFGXHXORBI-PXQQMZJSSA-N)

Structure

SMILES: O[C@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1cccnc1)C[C@H](C(=O)N[C@@H]1[C@H](O)Cc2c1cccc2)Cc1ccccc1
Type(s): Approved
ATC code(s): J05AE02
Molecular Formula:: C36H47N5O4
Molecular Weight:: 613.789
Log P:: 3.5245
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 4
TPSA:: 118.03
CAS Number(s):: 150378-17-9

Synonym(s)

Indinavir

Crixivan

Indinavir Sulfate

Indinavir, Sulfate (1:1)

L-735 524

L-735,524

MK-639

L 735 524

L 735,524

10.

L735 524

11.

L735,524

12.

MK 639

13.

MK639

14.

Sulfate, Indinavir

External Link(s)

MeSH	D019469
PubChem Compound	5362440
BindingDB	50067593 517
ChEBI	44032
CHEMBL	CHEMBL115
DrugBank	DB00224
DrugCentral	1437
KEGG	cpd:C07051
ZINC	22448696

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Nephrolithiasis	FAERS: 9 Canada Vigilance: 2	View details 9117466 9229567 9230000 9471940 9598523 9679944 9875581 10476752 10846585 10877738 11061951 11110045 11177322 11434632 11545487 11546957 11816748 12473836 12537723 15824372 16798620 17044450 17417069	CTD OFFSIDES SIDER Canada Vigilance US FAERS
2	Blood creatinine increased	FAERS: 5 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
3	Blood urea increased	FAERS: 5		OFFSIDES US FAERS
4	No adverse event	FAERS: 5		US FAERS
5	Adverse event	FAERS: 4		OFFSIDES US FAERS
6	Drug exposure during pregnancy	FAERS: 3		OFFSIDES US FAERS
7	Incorrect product storage	FAERS: 3		US FAERS
8	Pneumonia	FAERS: 3		SIDER US FAERS
9	Blood cholesterol increased	FAERS: 2		SIDER US FAERS
10	Lipodystrophy acquired	FAERS: 2		OFFSIDES US FAERS
11	Maternal exposure during pregnancy	FAERS: 2		US FAERS
12	Pancreatitis	FAERS: 2	16798620	CTD SIDER US FAERS
13	Polyneuropathy	FAERS: 2		OFFSIDES US FAERS
14	Pregnancy	FAERS: 2		US FAERS
15	Angina Pectoris	FAERS: 1		SIDER US FAERS
16	Antiphospholipid antibodies positive	FAERS: 1		OFFSIDES US FAERS
17	Blood glucose increased	FAERS: 1		SIDER US FAERS
18	Cachexia	FAERS: 1		US FAERS
19	Circumstance or information capable of leading to medication error	FAERS: 1		OFFSIDES US FAERS
20	Drug administration error	FAERS: 1		OFFSIDES US FAERS
21	Drug ineffective	FAERS: 1		OFFSIDES US FAERS
22	Ectopic Pregnancy	FAERS: 1		US FAERS
23	Head deformity	FAERS: 1		US FAERS
24	Hepatitis A	FAERS: 1		US FAERS
25	Hepatitis B	FAERS: 1		US FAERS
26	Horseshoe Kidney	FAERS: 1		OFFSIDES US FAERS
27	Hydronephrosis	FAERS: 1	10069120	CTD SIDER US FAERS
28	Joint Range of Motion Decreased	FAERS: 1		US FAERS
29	Malaise	FAERS: 1		SIDER US FAERS
30	Maternal use of illicit drugs	FAERS: 1		OFFSIDES US FAERS
31	Nephrocalcinosis	FAERS: 1	17044450	CTD US FAERS
32	Osteomyelitis	FAERS: 1		OFFSIDES US FAERS
33	Pain	FAERS: 1	9875572	CTD SIDER US FAERS
34	Pancreatic carcinoma	FAERS: 1		US FAERS
35	Physical product label issue	FAERS: 1		US FAERS
36	Product coating issue	FAERS: 1		US FAERS
37	Product packaging quantity issue	FAERS: 1		US FAERS
38	Product physical issue	FAERS: 1		US FAERS
39	Silent myocardial infarction	FAERS: 1		US FAERS
40	Ventricular hypokinesia	FAERS: 1		US FAERS
41	jaundice	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
42	prostatitis	FAERS: 1		US FAERS
43	AIDS-Associated Nephropathy		11110045 19226409	CTD
44	Abdominal Pain		9337438 12473836	CTD OFFSIDES SIDER
45	Abdominal discomfort	Canada Vigilance: 1		Canada Vigilance
46	Accidental overdose			OFFSIDES
47	Acidosis, Lactic		16798620	CTD
48	Acidosis		12473836	CTD OFFSIDES
49	Acquired Immunodeficiency Syndrome		View details 8992346 9338723 9716639 9776425 10452668 10737512 15384277 17180736	CTD SIDER
50	Acute Coronary Syndrome			SIDER
51	Acute haemolytic anaemia			SIDER
52	Acute kidney injury		View details 9328372 9631152 9649271 10421052 10452668 11110045 11126974 17180736	CTD
53	Agitation			SIDER
54	Alanine Aminotransferase Increased			OFFSIDES SIDER
55	Albuminuria		12571522	CTD
56	Alcohol consumption			OFFSIDES
57	Alopecia	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
58	Amnesia			OFFSIDES
59	Amphetamines			OFFSIDES
60	Amylase increased			SIDER
61	Anaphylactic shock			SIDER
62	Anaphylactoid Reaction			SIDER
63	Anemia, Hemolytic		View details 9452755 10533645 10614088 11364438	CTD
64	Anemia		10230309 17933262	CTD
65	Angioedema			SIDER
66	Angiolipoma			OFFSIDES
67	Anogenital dysplasia			OFFSIDES
68	Anorexia			SIDER
69	Anuria		9649271 11096305 11126974	CTD
70	Anxiety			SIDER
71	Aphthous Stomatitis			SIDER
72	Arterial fibrosis			OFFSIDES
73	Arthralgia	Canada Vigilance: 1		Canada Vigilance SIDER
74	Aseptic Meningitis			OFFSIDES
75	Aspartate Aminotransferase Increased			SIDER
76	Asthenia			SIDER
77	Ataxia			OFFSIDES
78	Atherosclerosis		19429260	CTD
79	Atrioventricular Septal Defect			OFFSIDES
80	Atypical mycobacterial lymphadenitis			OFFSIDES
81	Back Pain		9679944	CTD SIDER
82	Basal Ganglia Diseases		11978161	CTD
83	Bilirubin unconjugated increased			SIDER
84	Blepharoptosis			OFFSIDES
85	Blood Glucose			OFFSIDES
86	Blood alkaline phosphatase increased			OFFSIDES
87	Blood amylase increased			OFFSIDES
88	Blood and lymphatic system disorders			SIDER
89	Blood bilirubin unconjugated increased			SIDER
90	Blood chloride decreased			OFFSIDES
91	Blood cholesterol			OFFSIDES
92	Blood creatinine decreased			OFFSIDES
93	Blood electrolytes abnormal			OFFSIDES
94	Blood follicle stimulating hormone increased			OFFSIDES
95	Blood iron increased			OFFSIDES
96	Blood ketone body decreased			OFFSIDES
97	Blood lactate dehydrogenase increased			OFFSIDES
98	Blood potassium decreased			OFFSIDES
99	Blood triglycerides increased			OFFSIDES SIDER
100	Blood uric acid			OFFSIDES
101	Body Temperature			OFFSIDES
102	Body fat disorder			OFFSIDES
103	Body odor			SIDER
104	Bone marrow depression			OFFSIDES
105	Bronchitis			OFFSIDES
106	Bruxism			SIDER
107	Bursitis			OFFSIDES
108	CD4 Lymphocytes Decreased			OFFSIDES
109	CD8 lymphocytes decreased			OFFSIDES
110	Candida serology positive			OFFSIDES
111	Cardioactive drug level			OFFSIDES
112	Carotid artery occlusion			OFFSIDES
113	Cerebral disorder			OFFSIDES
114	Cheilitis			SIDER
115	Chemical and Drug Induced Liver Injury		View details 9518018 23956101 24014644 28437613	CTD
116	Chest Pain			SIDER
117	Chills			SIDER
118	Cholecystitis			SIDER
119	Cholelithiasis		12173151	CTD
120	Cholestasis			SIDER
121	Choroiditis			OFFSIDES
122	Chronic active hepatitis			OFFSIDES
123	Cognition Disorders		18343489	CTD
124	Complications of maternal exposure to therapeutic drugs			OFFSIDES
125	Congenital abdominal hernia			OFFSIDES
126	Congenital tracheomalacia			OFFSIDES
127	Congenital tricuspid valve incompetence			OFFSIDES
128	Constipation			SIDER
129	Coronary Artery Disease		9875590 15622323	CTD
130	Creatinine increased			SIDER
131	Creatinine renal clearance decreased			OFFSIDES
132	Creatinine urine decreased			OFFSIDES
133	Cryoglobulins present			OFFSIDES
134	Cryptorchidism			OFFSIDES
135	Crystalluria			SIDER
136	Cyst			OFFSIDES
137	Cytomegalovirus chorioretinitis			OFFSIDES
138	Demyelination			OFFSIDES
139	Dependence			OFFSIDES
140	Dermatitis			SIDER
141	Diabetes			OFFSIDES
142	Diabetes Mellitus	Canada Vigilance: 2		Canada Vigilance SIDER
143	Diabetic Nephropathy			OFFSIDES
144	Diarrhea			OFFSIDES
145	Diplopia			OFFSIDES
146	Discomfort			SIDER
147	Disease complication			OFFSIDES
148	Diverticulum			OFFSIDES
149	Dizziness			OFFSIDES SIDER
150	Drug Eruptions		11832739	CTD
151	Drug Tolerance			OFFSIDES
152	Drug resistance			OFFSIDES
153	Drug toxicity			OFFSIDES
154	Dry skin	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
155	Dysgeusia	Canada Vigilance: 3		Canada Vigilance SIDER
156	Dyspepsia	Canada Vigilance: 2		Canada Vigilance SIDER
157	Dysuria		View details 9230000 9679944 9875572 10510102 11532999 17044450	CTD SIDER
158	Ear congestion			OFFSIDES
159	Ear discomfort			OFFSIDES
160	Embolism			OFFSIDES
161	Epidural Abscess			OFFSIDES
162	Epidural lipomatosis			OFFSIDES
163	Eructation			SIDER
164	Erythema Multiforme			SIDER
165	Erythema Nodosum			OFFSIDES
166	Erythropenia			OFFSIDES
167	Eustachian tube disorder			OFFSIDES
168	Eye pain			SIDER
169	Eyelid Diseases			OFFSIDES
170	Facial wasting			OFFSIDES
171	Fat redistribution			OFFSIDES SIDER
172	Fatigue	Canada Vigilance: 1	11362124	CTD SIDER Canada Vigilance
173	Fatty Liver		9562777	CTD OFFSIDES
174	Feeling abnormal			SIDER
175	Femoral arterial stenosis			OFFSIDES
176	Fever		9337438 11362124 18176653	CTD
177	Flank Pain		View details 9471940 9679944 9868678 10072627 10197375 10374801 10510102 10737512 11144699 11362124 17044450	CTD SIDER
178	Flatulence			SIDER
179	Flushing			SIDER
180	Folliculitis			SIDER
181	Food Allergy			SIDER
182	Gamma-Glutamyltransferase Increased			OFFSIDES
183	Gastritis			SIDER
184	Gastroenteritis			SIDER
185	Gastrointestinal Diseases		15824372	CTD
186	Gastrointestinal Pain			SIDER
187	Gastrointestinal mucosal disorder			OFFSIDES
188	Gastroschisis			OFFSIDES
189	General nutrition disorder			OFFSIDES
190	Gingivitis			SIDER
191	Glucose increased			SIDER
192	HIV Infections		View details 9244966 9337438 9444746 9562777 9598523 9679944 9725303 9765778 9823864 9868678 9875572 9875581 10197375 10320127 10405912 10434319 10476752 10510102 10625032 10708286 10722466 10846585 11069541 11126974 11141242 11363243 11365268 11371700 11486172 11532999 11545487 11545549 11546957 11576910 11816748 11832739 11852297 12022250 12090886 12143277 12165618 12173151 12370513 12389881 12473835 12473836 12487385 12571522 12668574 12799577 14518700 15307035 15384277 15388451 15478531 15622323 15823768 16603854 16906281 17044450 17417069 17502722 17690876 18176653 18405026	CTD
193	HIV Seropositivity		View details 9142068 9452724 10072627 10081842 10332431 10737512 10739809 11061951 11110045 11144699 11852520 12549631 14991118 17874643 20523203	CTD
194	HIV Wasting Syndrome			OFFSIDES
195	Headache			SIDER
196	Hematuria		View details 9337438 10197375 10332431 10737512 12165618 18553024	CTD
197	Hepatitis	Canada Vigilance: 1	10452668	CTD SIDER Canada Vigilance
198	Hyperbilirubinemia		11724090 12473836	CTD
199	Hypercholesterolemia		11545549 12473836	CTD
200	Hyperglycemia		12473836	CTD
201	Hypersensitivity			SIDER
202	Hypertriglyceridemia		11545549 12473836	CTD
203	Hypogonadism			OFFSIDES
204	Hypospadias			OFFSIDES
205	Incontinence			OFFSIDES
206	Infection			OFFSIDES
207	Inflammation		11915002	CTD SIDER
208	Infusion site mobility decreased			OFFSIDES
209	Insulin Resistance			OFFSIDES SIDER
210	Intention tremor			OFFSIDES
211	Intervertebral disc disorder			OFFSIDES
212	Intestinal villi atrophy			OFFSIDES
213	Intraocular inflammation			OFFSIDES
214	Iritis	Canada Vigilance: 1		Canada Vigilance
215	Kaposi's sarcoma classical type			OFFSIDES
216	Kidney Calculi		View details 8992346 9338723 9338724 9649271 9868678 10081842 10219068 10332431 10405912 10510102 11076101 11832739 15384277 17874643	CTD
217	Kidney Diseases		View details 9216244 9244966 9875572 10722466 11365268 11532999 11576910 12165618 12370513 12571522 12668574 14518698 14518700 15307035 17690876 18048001	CTD
218	Kidney Failure, Chronic		17502722 19226409 20523203	CTD
219	Kidney Failure			OFFSIDES
220	Kidney Papillary Necrosis		11545487 18191366 18553024	CTD
221	Lactate pyruvate ratio increased			OFFSIDES
222	Left Ventricular Hypertrophy			OFFSIDES
223	Leukocytoclastic vasculitis			SIDER
224	Leukocytosis		12571522	CTD
225	Leukoencephalomyelitis			OFFSIDES
226	Leukopenia neonatal			OFFSIDES
227	Lipase			OFFSIDES
228	Lipids abnormal			OFFSIDES
229	Lipoatrophy			SIDER
230	Lipohypertrophy			OFFSIDES
231	Lipomatosis		11852297	CTD SIDER
232	Lithiasis		10093594 10374801	CTD
233	Livedo Reticularis			OFFSIDES
234	Lymph Node Tuberculosis			OFFSIDES
235	Lymphadenopathy			SIDER
236	Lymphoma			OFFSIDES
237	Macrocytosis			OFFSIDES
238	Malnutrition			SIDER
239	Medication Error	Canada Vigilance: 1		Canada Vigilance
240	Mental impairment			OFFSIDES
241	Metabolic Diseases		15622323 17690876	CTD
242	Metabolic acidosis			OFFSIDES
243	Microcytosis			OFFSIDES
244	Microscopic hematuria			SIDER
245	Mitochondrial toxicity			OFFSIDES
246	Multiple Myeloma			OFFSIDES
247	Musculoskeletal Pain			SIDER
248	Musculoskeletal discomfort			SIDER
249	Musculoskeletal stiffness			SIDER
250	Myalgia			SIDER
251	Mycobacterium Infections		21442799	CTD
252	Mycobacterium avium complex immune restoration disease			OFFSIDES
253	Myocardial Infarction	Canada Vigilance: 1		Canada Vigilance SIDER
254	Myositis			SIDER
255	Nausea	Canada Vigilance: 4	10332431	CTD OFFSIDES SIDER Canada Vigilance
256	Neointima		20621964	CTD
257	Nephritis, Interstitial		View details 9337438 9681107 10739809 11126974 11362124 11545487 11915002	CTD
258	Nephritis		9499995	CTD SIDER
259	Nervousness			SIDER
260	Neuralgia			SIDER
261	Night sweats			SIDER
262	Nocturia			SIDER
263	Nodule			OFFSIDES
264	Ophthalmoplegia			OFFSIDES
265	Optic Neuritis			OFFSIDES
266	Optic Neuropathy			OFFSIDES
267	Osteopenia			OFFSIDES
268	Osteoporosis			OFFSIDES
269	Palpitations			SIDER
270	Paraparesis			OFFSIDES
271	Parotitis	Canada Vigilance: 3		Canada Vigilance
272	Pathogen resistance			OFFSIDES
273	Performance status decreased			OFFSIDES
274	Periarthritis			OFFSIDES SIDER
275	Pharyngitis			SIDER
276	Pharyngolaryngeal Pain			OFFSIDES
277	Pneumocystis jiroveci pneumonia			OFFSIDES
278	Polyuria			OFFSIDES
279	Portal Hypertension			OFFSIDES
280	Portal Vein Thrombosis			OFFSIDES
281	Portal hypertensive gastropathy			OFFSIDES
282	Pre-Eclampsia			OFFSIDES
283	Premenstrual syndrome			SIDER
284	Productive Cough			OFFSIDES
285	Protein urine present			SIDER
286	Proteinuria	Canada Vigilance: 1	9337438	CTD SIDER Canada Vigilance
287	Pruritus			SIDER
288	Psoas Abscess			OFFSIDES
289	Psoriasis			OFFSIDES
290	Pulmonary Hypertension	Canada Vigilance: 1		Canada Vigilance OFFSIDES
291	Pulmonary Valve Stenosis			OFFSIDES
292	Pyelonephritis	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
293	Pyuria		View details 9337438 9471940 9776425 11076101 11362124 11915002	CTD OFFSIDES SIDER
294	Rales			SIDER
295	Rebound effect			OFFSIDES
296	Regurgitation of food			OFFSIDES
297	Regurgitation			SIDER
298	Renal Colic		View details 9230000 9244966 9337438 9499995 9679944 9875572 10081842 10197375 10332431 10434319 10708286 10737512 11532999 11545487 11816748 12370513 15307035 17053366 18176653	CTD OFFSIDES SIDER
299	Renal Insufficiency		View details 9520176 9767973 9776425 10072627 10099891 11076101 16906281 17044450	CTD
300	Respiratory Failure			SIDER
301	Rhabdomyolysis		10452668	CTD SIDER
302	Rhinitis			OFFSIDES
303	Rhonchi			SIDER
304	Scarlet Fever			OFFSIDES
305	Schizophrenia			OFFSIDES
306	Scotoma			OFFSIDES
307	Serum Amylase Increased			SIDER
308	Serum triglycerides increased			SIDER
309	Shock			SIDER
310	Shoulder Pain			SIDER
311	Sinusitis			SIDER
312	Sjogren's Syndrome			OFFSIDES
313	Somnolence			SIDER
314	Spondylitis			OFFSIDES
315	Stevens-Johnson Syndrome		25811541	CTD SIDER
316	Stiffness			SIDER
317	Sudden death			OFFSIDES
318	Sweating			SIDER
319	Swelling			SIDER
320	Syncope			SIDER
321	Syphilis			OFFSIDES
322	Tachycardia	Canada Vigilance: 1		Canada Vigilance
323	Taste Disorders			SIDER
324	Tendinitis			OFFSIDES
325	Tenosynovitis			OFFSIDES
326	Tension			SIDER
327	Therapy non-responder			OFFSIDES
328	Thrombocytopenia			SIDER
329	Tobacco user			OFFSIDES
330	Tolosa-Hunt Syndrome			OFFSIDES
331	Tremor			SIDER
332	Unexpected therapeutic drug effect			OFFSIDES
333	Ureteral Calculi		View details 9716639 9725303 10405912 10434319 10737512 12143277 17874643	CTD
334	Urinary Calculi		View details 9142068 9186316 9444746 9452724 9765778 9798063 10072627 10421052 10765106 11126974 12685114 17053366 17658165	CTD
335	Urinary sediment abnormal			OFFSIDES
336	Urinary tract infection	Canada Vigilance: 1		Canada Vigilance SIDER
337	Urolithiasis		View details 9338724 9767973 11852520 12549631 14991118 17874643 18405026	CTD SIDER
338	Urologic Diseases		View details 9230000 10510102 11144699 12090886	CTD
339	Urticaria			SIDER
340	Vaginal burning sensation			OFFSIDES
341	Vasculitis, Leukocytoclastic, Cutaneous		11069541	CTD
342	Vasculitis			SIDER
343	Venous Thrombosis		9365776 10625032	CTD
344	Vertigo			SIDER
345	Viremia		10877738	CTD
346	Visual disturbance			OFFSIDES
347	Vitamin A Deficiency			OFFSIDES
348	Vomiting	Canada Vigilance: 3	10332431	CTD SIDER Canada Vigilance
349	Xerophthalmia			OFFSIDES
350	nervous system disorder			SIDER

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