MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

rizatriptan

(ULFRLSNUDGIQQP-UHFFFAOYSA-N)

Structure

SMILES: CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
Type(s): Approved
ATC code(s): N02CC04
Molecular Formula:: C15H19N5
Molecular Weight:: 269.345
Log P:: 1.9118
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 49.74
CAS Number(s):: 144034-80-0

Synonym(s)

rizatriptan

L 705,126

L 705126

L-705,126

L-705126

MK 0462

MK 462

MK-0462

MK-462

10.

Maxalt

11.

N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indole-3-yl)ethylamine

12.

rizatriptan benzoate

External Link(s)

MeSH	C093622
PubChem Compound	5078
BindingDB	50033437
ChEBI	48273
CHEMBL	CHEMBL905
DrugBank	DB00953
DrugCentral	2393
IUPHAR/BPS Guide to PHARMACOLOGY	51
KEGG	dr:D00675 dr:D08485
Therapeutic Target Database	D0S9MU
ZINC	5895

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 26 Canada Vigilance: 13		Canada Vigilance OFFSIDES US FAERS
2	Product substitution issue	FAERS: 17 Canada Vigilance: 7		Canada Vigilance US FAERS
3	Nausea	FAERS: 15 Canada Vigilance: 3	11385269 12464714	CTD OFFSIDES SIDER Canada Vigilance US FAERS
4	Chest Pain	FAERS: 7 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
5	Depressed Level of Consciousness	FAERS: 5		OFFSIDES US FAERS
6	Palpitations	FAERS: 5 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
7	Product quality issue	FAERS: 5		US FAERS
8	Chest discomfort	FAERS: 4		US FAERS
9	Dizziness	FAERS: 4 Canada Vigilance: 2	12464714 14687019	CTD OFFSIDES SIDER Canada Vigilance US FAERS
10	Vomiting	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
11	Agitation	FAERS: 3		SIDER US FAERS
12	Anxiety	FAERS: 3 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
13	Eczema	FAERS: 3		US FAERS
14	Fatigue	FAERS: 3		OFFSIDES SIDER US FAERS
15	Feeling Cold	FAERS: 3		SIDER US FAERS
16	Product physical issue	FAERS: 3		US FAERS
17	Product taste abnormal	FAERS: 3		US FAERS
18	Psoriasis	FAERS: 3		US FAERS
19	Abdominal Pain	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
20	Angina Pectoris	FAERS: 2		SIDER US FAERS
21	Cerebral Infarction	FAERS: 2		US FAERS
22	Chills	FAERS: 2		SIDER US FAERS
23	Hepatitis	FAERS: 2		US FAERS
24	Musculoskeletal stiffness	FAERS: 2		OFFSIDES SIDER US FAERS
25	Pain	FAERS: 2 Canada Vigilance: 1	15836966	CTD OFFSIDES SIDER Canada Vigilance US FAERS
26	Asthenia	FAERS: 1		OFFSIDES SIDER US FAERS
27	Cholestasis	FAERS: 1		US FAERS
28	Drug effect delayed	FAERS: 1		US FAERS
29	Drug effect incomplete	FAERS: 1		US FAERS
30	Dysgeusia	FAERS: 1		SIDER US FAERS
31	Dyspepsia	FAERS: 1		SIDER US FAERS
32	Dysphonia	FAERS: 1		SIDER US FAERS
33	Emergency Care	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
34	Facial Pain	FAERS: 1		US FAERS
35	Feeling abnormal	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
36	Feeling of body temperature change	FAERS: 1		US FAERS
37	Gastrointestinal mucosal disorder	FAERS: 1		US FAERS
38	Headache	FAERS: 1 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
39	Hepatotoxicity	FAERS: 1		US FAERS
40	Hypokinesia	FAERS: 1		US FAERS
41	Impaired work ability	FAERS: 1		US FAERS
42	Mental impairment	FAERS: 1		OFFSIDES US FAERS
43	Migraine with Aura	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
44	Muscle Fatigue	FAERS: 1		US FAERS
45	Overdose	FAERS: 1		US FAERS
46	Peripheral swelling	FAERS: 1		US FAERS
47	Product blister packaging issue	FAERS: 1		US FAERS
48	Product container issue	FAERS: 1		US FAERS
49	Product expiration date issue	FAERS: 1		US FAERS
50	Product measured potency issue	FAERS: 1		US FAERS
51	Product packaging issue	FAERS: 1		US FAERS
52	Product solubility abnormal	FAERS: 1		US FAERS
53	Restlessness	FAERS: 1		US FAERS
54	Retrograde amnesia	FAERS: 1		US FAERS
55	Sneezing	FAERS: 1		SIDER US FAERS
56	Somnolence	FAERS: 1		SIDER US FAERS
57	Supraventricular tachycardia	FAERS: 1		OFFSIDES US FAERS
58	Throat irritation	FAERS: 1		US FAERS
59	Thrombosis	FAERS: 1		US FAERS
60	Toxicity to various agents	FAERS: 1		US FAERS
61	treatment failure	FAERS: 1		US FAERS
62	Abdominal adhesions			OFFSIDES
63	Abdominal discomfort			OFFSIDES SIDER
64	Abdominal tenderness			OFFSIDES
65	Abuse			OFFSIDES
66	Accidental overdose			OFFSIDES
67	Acid reflux			OFFSIDES
68	Actinomycosis			OFFSIDES
69	Acute Coronary Syndrome			OFFSIDES SIDER
70	Acute myocardial infarction			OFFSIDES
71	Acute prerenal failure			OFFSIDES
72	Acute respiratory failure			OFFSIDES
73	Adenocarcinoma			OFFSIDES
74	Adnexa uteri mass			OFFSIDES
75	Adverse event			OFFSIDES
76	Agraphia			OFFSIDES
77	Akinesia			SIDER
78	Alcohol withdrawal syndrome			OFFSIDES
79	Altered bowel function			OFFSIDES
80	Amnesia			OFFSIDES
81	Amphetamines			OFFSIDES
82	Anaphylactic shock			SIDER
83	Anaphylactoid Reaction			SIDER
84	Anger			OFFSIDES
85	Angioedema			SIDER
86	Anhidrosis			OFFSIDES
87	Anorexia			SIDER
88	Anoxic Encephalopathy			OFFSIDES
89	Anticholinergic Syndrome			OFFSIDES
90	Antidepressant drug level increased			OFFSIDES
91	Appendicitis			OFFSIDES
92	Arthralgia			SIDER
93	Arthritis			OFFSIDES
94	Arthropathy			OFFSIDES
95	Arthroscopy			OFFSIDES
96	Asthma	Canada Vigilance: 1		Canada Vigilance OFFSIDES
97	Ataxia			SIDER
98	Aura			OFFSIDES
99	Autoimmune inner ear disease			OFFSIDES
100	Back disorder			OFFSIDES
101	Bacterial sepsis			OFFSIDES
102	Belligerence			OFFSIDES
103	Bipolar I disorder			OFFSIDES
104	Bladder prolapse			OFFSIDES
105	Blepharoptosis			OFFSIDES
106	Blepharospasm			OFFSIDES
107	Blood Glucose			OFFSIDES
108	Blood albumin decreased			OFFSIDES
109	Blood alkaline phosphatase increased			OFFSIDES
110	Blood cholesterol			OFFSIDES
111	Blood creatine decreased			OFFSIDES
112	Blood homocysteine decreased			OFFSIDES
113	Blood pH decreased			OFFSIDES
114	Blood potassium decreased			OFFSIDES
115	Blood potassium			OFFSIDES
116	Blood prolactin increased			OFFSIDES
117	Blood testosterone increased			OFFSIDES
118	Blurred vision			OFFSIDES
119	Bone density decreased			OFFSIDES
120	Bradycardia		9489607	CTD SIDER
121	Bradykinesia			SIDER
122	Breast Cyst			OFFSIDES
123	Breech Presentation			OFFSIDES
124	Bronchitis			OFFSIDES
125	Brucellosis			OFFSIDES
126	Bulbar palsy			OFFSIDES
127	Bursitis			OFFSIDES
128	Calcific deposits removal			OFFSIDES
129	Cardioactive drug level			OFFSIDES
130	Catheter bacteraemia			OFFSIDES
131	Central nervous system lesion			OFFSIDES
132	Cerebral artery occlusion			OFFSIDES
133	Cerebral cyst			OFFSIDES
134	Cerebral vasoconstriction			OFFSIDES
135	Cerebrospinal fistula			OFFSIDES
136	Cerebrovascular accident			SIDER
137	Cervical dysplasia			OFFSIDES
138	Cervicobrachial syndrome			OFFSIDES
139	Cholecystitis			OFFSIDES
140	Chronic left ventricular failure			OFFSIDES
141	Chronic sinusitis			OFFSIDES
142	Circumstance or information capable of leading to medication error			OFFSIDES
143	Colectomy			OFFSIDES
144	Colitis			OFFSIDES
145	Colonic Stenosis			OFFSIDES
146	Completed Suicide			OFFSIDES
147	Confabulation			OFFSIDES
148	Congenital tricuspid valve incompetence			OFFSIDES
149	Constipation			SIDER
150	Cranioplasty			OFFSIDES
151	Cystitis	Canada Vigilance: 1		Canada Vigilance
152	Cyst			OFFSIDES
153	Deafness			OFFSIDES SIDER
154	Debridement			OFFSIDES
155	Dehydration			SIDER
156	Dehydroepiandrosterone increased			OFFSIDES
157	Demyelination			OFFSIDES
158	Dental abscess			OFFSIDES
159	Dental caries			OFFSIDES
160	Dermatitis			SIDER
161	Device dislocation			OFFSIDES
162	Diabetes			OFFSIDES
163	Diarrhea			OFFSIDES
164	Diplopia			OFFSIDES
165	Disability	Canada Vigilance: 1		Canada Vigilance
166	Disorientation			SIDER
167	Diverticulosis			OFFSIDES
168	Drowsiness			OFFSIDES
169	Drug abuser			OFFSIDES
170	Drug addict			OFFSIDES
171	Drug exposure during pregnancy			OFFSIDES
172	Drug screen positive			OFFSIDES
173	Drug withdrawal headache			OFFSIDES
174	Duodenal Ulcer			OFFSIDES
175	Duodenitis			OFFSIDES
176	Dysarthria			SIDER
177	Dyschezia			OFFSIDES
178	Dyspareunia			OFFSIDES
179	Dysphemia			OFFSIDES
180	Dyspnoea exacerbated			OFFSIDES
181	Dysthymic Disorder			OFFSIDES
182	Dystonia			OFFSIDES
183	Dysuria			OFFSIDES SIDER
184	Ear and labyrinth disorders			SIDER
185	Electrocardiogram QRS complex			OFFSIDES
186	Electrocardiogram ST segment abnormal			OFFSIDES
187	Emotional distress			OFFSIDES
188	Encephalitis			OFFSIDES
189	Endodontic procedure			OFFSIDES
190	Endometrial hypertrophy			OFFSIDES
191	Epicondylitis			OFFSIDES
192	Epistaxis			SIDER
193	Eructation			SIDER
194	Erythema			SIDER
195	Eschar			OFFSIDES
196	Euphoric mood			OFFSIDES SIDER
197	Eye Burns			SIDER
198	Eye inflammation			OFFSIDES
199	Eye irritation			SIDER
200	Eye pain			SIDER
201	Facial Neuralgia			OFFSIDES
202	Factor VIII inhibition			OFFSIDES
203	Failure of implant			OFFSIDES
204	Fatty Liver			OFFSIDES
205	Feeding disorder neonatal			OFFSIDES
206	Fibromyalgia			OFFSIDES
207	Flank Pain			OFFSIDES
208	Flatulence			SIDER
209	Fluid overload			OFFSIDES
210	Flushing			SIDER
211	Folliculitis			OFFSIDES
212	Food Allergy			OFFSIDES
213	Formication			OFFSIDES
214	Galactorrhea			OFFSIDES
215	Gambling			OFFSIDES
216	Gastric Bypass			OFFSIDES
217	Gastritis			SIDER
218	Gastroenteritis			OFFSIDES
219	Gastrointestinal inflammation			OFFSIDES
220	Gaze palsy			OFFSIDES
221	General symptom			OFFSIDES
222	Genital Herpes			OFFSIDES
223	Genital rash			OFFSIDES
224	Gestational Diabetes			OFFSIDES
225	Gingival blister			OFFSIDES
226	Global Amnesia			OFFSIDES
227	Hay fever			OFFSIDES
228	Heart-lung transplant rejection			OFFSIDES
229	Hemiparesis			OFFSIDES
230	Hoarseness			SIDER
231	Hostility			OFFSIDES
232	Hydronephrosis			OFFSIDES
233	Hyperacusis		11385269 12464714	CTD SIDER
234	Hyperalgesia		18663655	CTD
235	Hyperkinesia			SIDER
236	Hypersensitivity			SIDER
237	Hypersomnia			SIDER
238	Hyporeflexia			SIDER
239	Hypospadias			OFFSIDES
240	Hypotension		9489607	CTD
241	Infarction		16615676	CTD
242	Infusion site mobility decreased			OFFSIDES
243	Initial insomnia			OFFSIDES
244	Injection site urticaria			OFFSIDES
245	Injection site warmth			OFFSIDES
246	Intention tremor			OFFSIDES
247	Intentional drug misuse			OFFSIDES
248	Intervertebral Disc Degeneration			OFFSIDES
249	Intestinal Perforation			OFFSIDES
250	Intracranial Hypotension			OFFSIDES
251	Joint Instability			OFFSIDES
252	Joint Range of Motion Decreased			OFFSIDES
253	Joint sprain			OFFSIDES
254	Joint stiffness			OFFSIDES
255	Kidney Diseases		16615676	CTD
256	Lacrimation			SIDER
257	Laparotomy			OFFSIDES
258	Lethargy			OFFSIDES
259	Leukopenia neonatal			OFFSIDES
260	Lichen Planus			OFFSIDES
261	Life expectancy shortened			OFFSIDES
262	Ligament rupture			OFFSIDES
263	Limb injury			OFFSIDES
264	Lipoma of breast			OFFSIDES
265	Low turnover osteopathy			OFFSIDES
266	Lower respiratory tract infection	Canada Vigilance: 1		Canada Vigilance
267	Lumbar radiculopathy			OFFSIDES
268	Lymphedema			OFFSIDES
269	Malaise	Canada Vigilance: 1		Canada Vigilance
270	Mass excision			OFFSIDES
271	Mechanical urticaria			OFFSIDES
272	Medication overuse headache			SIDER
273	Memory impairment			SIDER
274	Meniscus removal			OFFSIDES
275	Mental status changes			OFFSIDES
276	Metatarsalgia			OFFSIDES
277	Microalbuminuria			OFFSIDES
278	Migraine Disorders		View details 10709161 11284463 11385269 11576197 12464714 16615676 17112920	CTD
279	Multiple Sclerosis			OFFSIDES
280	Multiple drug overdose			OFFSIDES
281	Multiple sclerosis relapse			OFFSIDES
282	Muscle Weakness			OFFSIDES
283	Muscle strain			OFFSIDES
284	Muscle tightness			OFFSIDES
285	Musculoskeletal Pain			SIDER
286	Musculoskeletal discomfort			OFFSIDES SIDER
287	Myalgia			SIDER
288	Myocardial Infarction			SIDER
289	Nasopharyngitis			SIDER
290	Nervousness			SIDER
291	Neuralgia			OFFSIDES
292	No adverse effect			OFFSIDES
293	Non-cardiac chest pain			OFFSIDES
294	Onychalgia			OFFSIDES
295	Optic Atrophy			OFFSIDES
296	Optic Disc Edema			OFFSIDES
297	Oropharyngeal plaque			OFFSIDES
298	Osteolysis			OFFSIDES
299	Osteoma			OFFSIDES
300	Osteosclerosis			OFFSIDES
301	Otosclerosis			OFFSIDES
302	PCO2 increased			OFFSIDES
303	Pallor			OFFSIDES
304	Panic Disorder			OFFSIDES
305	Paranoia			OFFSIDES
306	Parotitis			OFFSIDES
307	Pelvic mass			OFFSIDES
308	Pharmaceutical product complaint			OFFSIDES
309	Pharmaceutical product counterfeit			OFFSIDES
310	Pharyngitis			SIDER
311	Photophobia		11385269 12464714	CTD SIDER
312	Physical disability			OFFSIDES
313	Polysubstance abuse			OFFSIDES
314	Polyuria			SIDER
315	Post procedural complication			OFFSIDES
316	Post-traumatic pain			OFFSIDES
317	Postoperative abscess			OFFSIDES
318	Pregnancy on oral contraceptive			OFFSIDES
319	Prescribed overdose			OFFSIDES
320	Presyncope			SIDER
321	Primary sequestrum			OFFSIDES
322	Procedural complication			OFFSIDES
323	Protein S decreased			OFFSIDES
324	Pruritus			SIDER
325	Pterygium			OFFSIDES
326	Pulmonary congestion			OFFSIDES
327	Pulmonary thrombosis			OFFSIDES
328	Purulent discharge			OFFSIDES
329	Pyuria			OFFSIDES
330	Radicular pain			OFFSIDES
331	Rectal Prolapse			OFFSIDES
332	Rectocele			OFFSIDES
333	Regurgitation			SIDER
334	Respiratory tract congestion			OFFSIDES
335	Retinal vascular occlusion			OFFSIDES
336	Retrocollis			OFFSIDES
337	Rhinitis			OFFSIDES
338	Rhonchi			OFFSIDES
339	Risus sardonicus			OFFSIDES
340	Salpingo-oophorectomy			OFFSIDES
341	Schizoaffective Disorder			OFFSIDES
342	Scotoma			OFFSIDES
343	Screaming			OFFSIDES
344	Serotonin Syndrome			SIDER
345	Serum Sickness			OFFSIDES
346	Shock			SIDER
347	Shoulder Pain			OFFSIDES
348	Sinusitis	Canada Vigilance: 1		Canada Vigilance OFFSIDES
349	Spondylolisthesis			OFFSIDES
350	Staring			OFFSIDES
351	Stenotrophomonas infection			OFFSIDES
352	Stevens-Johnson Syndrome		25811541	CTD
353	Stiffness			SIDER
354	Stomatocytes present			OFFSIDES
355	Sweating			SIDER
356	Swelling			SIDER
357	Syncope			SIDER
358	Synovial Cyst			OFFSIDES
359	Synovitis			OFFSIDES
360	Tachycardia			SIDER
361	Temperature intolerance			SIDER
362	Tendinitis			OFFSIDES
363	Tenosynovitis			OFFSIDES
364	Tension Headache			OFFSIDES
365	Tension			SIDER
366	Therapeutic product effect incomplete	Canada Vigilance: 1		Canada Vigilance
367	Therapeutic response unexpected			OFFSIDES
368	Thirst			SIDER
369	Thrombosis in device			OFFSIDES
370	Thyroiditis			OFFSIDES
371	Tinnitus			SIDER
372	Tooth Extraction			OFFSIDES
373	Toxic Epidermal Necrolysis			SIDER
374	Tremor			SIDER
375	Trisomy 21			OFFSIDES
376	Troponin increased			OFFSIDES
377	Ulcer			OFFSIDES
378	Unevaluable event			OFFSIDES
379	Urine output increased			SIDER
380	Urticaria			SIDER
381	Vasospasm			OFFSIDES SIDER
382	Ventricular Fibrillation			OFFSIDES SIDER
383	Vertigo			SIDER
384	Viral upper respiratory tract infection			OFFSIDES
385	Visual disturbance			OFFSIDES
386	Vitamin A Deficiency			OFFSIDES
387	Vulvovaginal pruritus			OFFSIDES
388	Weight Gain			OFFSIDES
389	Wheezing			SIDER
390	Wound Debridement			OFFSIDES
391	Yawning			SIDER
392	apprehension			SIDER
393	nervous system disorder			SIDER

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