MetaADEDB 2.0 @ LMMD
Pilocarpine
(QCHFTSOMWOSFHM-WPRPVWTQSA-N)
Structure
SMILES
CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C
Type(s)
Approved; Investigational
ATC code(s)
N07AX01; S01EB01; S01EB51
Molecular Formula:
C11H16N2O2
Molecular Weight:
208.257
Log P:
1.1618
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
44.12
CAS Number(s):
92-13-7
Synonym(s)
1.
Pilocarpine
2.
Isopilocarpine
3.
Isoptocarpine
4.
Ocusert
5.
Pilocarpine Hydrochloride
6.
Pilocarpine Mononitrate, (3S-cis)-Isomer
7.
Pilocarpine Nitrate
8.
Pilocarpine, Monohydrochloride, (3S-cis)-Isomer
9.
Salagen
10.
Hydrochloride, Pilocarpine
11.
Nitrate, Pilocarpine
External Link(s)
MeSHD010862
PubChem Compound5910
BindingDB50008072
ChEBI8207
CHEMBLCHEMBL550
DrugBankDB01085
DrugCentral2166
IUPHAR/BPS Guide to PHARMACOLOGY305
KEGGcpd:C07474
dr:D00525
Therapeutic Target DatabaseD06HLY
ZINC75008
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 26
Canada Vigilance: 2
Canada Vigilance
US FAERS
2DizzinessFAERS: 7
Canada Vigilance: 1
8906047
17241436
CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
3DehydrationFAERS: 5OFFSIDES
US FAERS
4NauseaFAERS: 58906047CTD
OFFSIDES
SIDER
US FAERS
5Angle Closure GlaucomaFAERS: 4OFFSIDES
US FAERS
6Eye painFAERS: 4SIDER
US FAERS
7SyncopeFAERS: 4SIDER
US FAERS
8VertigoFAERS: 4US FAERS
9AstheniaFAERS: 3SIDER
US FAERS
10FlushingFAERS: 3SIDER
US FAERS
11HeadacheFAERS: 38906047CTD
SIDER
US FAERS
12Lens dislocationFAERS: 3US FAERS
13PalpitationsFAERS: 3SIDER
US FAERS
14Urinary RetentionFAERS: 3US FAERS
15Vocal Cord ParalysisFAERS: 3US FAERS
16Abdominal PainFAERS: 2OFFSIDES
SIDER
US FAERS
17Atrial FibrillationFAERS: 2US FAERS
18Burning sensationFAERS: 2US FAERS
19ChillsFAERS: 2SIDER
US FAERS
20CholestasisFAERS: 2US FAERS
21FatigueFAERS: 23769383CTD
OFFSIDES
US FAERS
22Feeling abnormalFAERS: 2SIDER
US FAERS
23MalaiseFAERS: 2US FAERS
24Pharmaceutical product complaintFAERS: 2US FAERS
25PneumoniaFAERS: 2SIDER
US FAERS
26TachycardiaFAERS: 2SIDER
US FAERS
27Tooth LossFAERS: 2OFFSIDES
US FAERS
28VomitingFAERS: 2SIDER
US FAERS
29jaundiceFAERS: 2US FAERS
30Allergy test positiveFAERS: 1US FAERS
31AnorexiaFAERS: 1SIDER
US FAERS
32Autoimmune hepatitisFAERS: 1US FAERS
33Blood chromogranin A increasedFAERS: 1US FAERS
34Blood creatinine increasedFAERS: 1US FAERS
35Blood pressure fluctuationFAERS: 1US FAERS
36Blood urea increasedFAERS: 1US FAERS
37BronchospasmFAERS: 1SIDER
US FAERS
38Cataract operationFAERS: 1OFFSIDES
US FAERS
39Cold sweatFAERS: 1OFFSIDES
US FAERS
40DiscomfortFAERS: 1SIDER
US FAERS
41DroolingFAERS: 1US FAERS
42DysphoniaFAERS: 1OFFSIDES
US FAERS
43HypersomniaFAERS: 1US FAERS
44HypotensionFAERS: 16615679CTD
SIDER
US FAERS
45LethargyFAERS: 13769383CTD
OFFSIDES
US FAERS
46Nasal PolypsFAERS: 1US FAERS
47Night sweatsFAERS: 1US FAERS
48Ocular discomfortFAERS: 1US FAERS
49Paranasal sinus discomfortFAERS: 1US FAERS
50Post procedural complicationFAERS: 1US FAERS
51PresyncopeFAERS: 1SIDER
US FAERS
52Product packaging confusionFAERS: 1US FAERS
53Product substitution issueFAERS: 1US FAERS
54PruritusFAERS: 1SIDER
US FAERS
55Respiratory distressFAERS: 1US FAERS
56Restless Legs SyndromeFAERS: 1US FAERS
57Retinal DetachmentFAERS: 1SIDER
US FAERS
58ScotomaFAERS: 1OFFSIDES
US FAERS
59Sinus TachycardiaFAERS: 1US FAERS
60SinusitisFAERS: 1OFFSIDES
SIDER
US FAERS
61SwellingFAERS: 1US FAERS
62Therapy cessationFAERS: 1US FAERS
63TremorFAERS: 1

View details

CTD
SIDER
US FAERS
64Unevaluable eventFAERS: 1OFFSIDES
US FAERS
65Visual ImpairmentFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
66Vitreous DetachmentFAERS: 1OFFSIDES
US FAERS
67WheezingFAERS: 1US FAERS
68Abdominal discomfortCanada Vigilance: 1Canada Vigilance
OFFSIDES
69Abnormal plateletsSIDER
70Abnormal visionSIDER
71Accidental overdoseOFFSIDES
72Acid refluxOFFSIDES
73Acidosis3769383CTD
74Activities of daily living impairedOFFSIDES
75Acute Coronary SyndromeSIDER
76Acute prerenal failureOFFSIDES
77Acute respiratory failureOFFSIDES
78AdenocarcinomaOFFSIDES
79Adverse eventOFFSIDES
80AgeusiaOFFSIDES
SIDER
81AgitationSIDER
82AlopeciaSIDER
83Altered bowel functionOFFSIDES
84AmblyopiaSIDER
85Angina PectorisSIDER
86AnhedoniaOFFSIDES
87Ankle FractureOFFSIDES
88AnxietyOFFSIDES
SIDER
89ApathyOFFSIDES
90AphasiaSIDER
91AppendectomyOFFSIDES
92AppendicitisOFFSIDES
93Application site irritationOFFSIDES
94ArthralgiaSIDER
95ArthritisSIDER
96AsthmaOFFSIDES
97Atrioventricular Block3785930
3827437
CTD
SIDER
98Auditory Perceptual Disorders16596970CTD
99Back PainCanada Vigilance: 1Canada Vigilance
SIDER
100Basal Ganglia Diseases1756784
8410052
CTD
101Blepharospasm7698938
9090610
CTD
SIDER
102Blood GlucoseOFFSIDES
103Blood cholesterolOFFSIDES
104Blood creatine phosphokinase increasedOFFSIDES
105Blood sodiumOFFSIDES
106Blood triglycerides increasedOFFSIDES
107Blurred visionOFFSIDES
108Body odorSIDER
109Bone erosionOFFSIDES
110Bone fragmentationOFFSIDES
111Bone painOFFSIDES
112Bradycardia4094621
6615679
12812833
CTD
SIDER
113Brain Damage, Chronic17113938CTD
114Brain Edema20886625CTD
115Brain Injuries

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CTD
116Brain Ischemia17971868CTD
117Brain natriuretic peptide increasedOFFSIDES
118BronchiectasisOFFSIDES
119BronchitisOFFSIDES
SIDER
120BronchoconstrictionSIDER
121BronchopneumoniaOFFSIDES
122BunionOFFSIDES
123BursitisOFFSIDES
124CSF shunt removalOFFSIDES
125Cardiomegaly17872965CTD
126Carotid artery occlusionOFFSIDES
127Catalepsy

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CTD
128CataractSIDER
129CellulitisOFFSIDES
130Central venous catheter removalOFFSIDES
131Cerebral Infarction8410052CTD
132Cerebral atrophyOFFSIDES
133Chest PainOFFSIDES
SIDER
134Choking sensationOFFSIDES
135CholelithiasisSIDER
136Chronic ulcerative colitisOFFSIDES
137CirrhosisOFFSIDES
138Cocaine-Related Disorders19996296CTD
139Cognition Disorders

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CTD
140ColitisSIDER
141Compression fractureOFFSIDES
142Confusion3769383CTD
143Congenital tricuspid valve incompetenceOFFSIDES
144Conjunctival Diseases7698938
9090610
CTD
145ConjunctivitisSIDER
146ConstipationSIDER
147Cramps of lower extremitiesSIDER
148Creatinine renal clearance decreasedOFFSIDES
149Cyst aspirationOFFSIDES
150CystSIDER
151DeafnessOFFSIDES
SIDER
152DebridementOFFSIDES
153Delirium15765828CTD
154Dementia8196113CTD
155Demyelinating Diseases15193289CTD
156DemyelinationOFFSIDES
157Dental abscessOFFSIDES
158Dental cariesOFFSIDES
159Denture wearerOFFSIDES
160DermatitisSIDER
161Device FailureOFFSIDES
162DiarrheaOFFSIDES
163DiverticulosisOFFSIDES
164DiverticulumOFFSIDES
165Dry skinSIDER
166DysgeusiaSIDER
167DyspepsiaOFFSIDES
SIDER
168DysuriaOFFSIDES
SIDER
169EczemaSIDER
170Endodontic procedureOFFSIDES
171EndophthalmitisOFFSIDES
172EnteritisOFFSIDES
173Enterococcal infectionOFFSIDES
174Epidermal necrosisOFFSIDES
175Epilepsies, Partial2287490
12467714
CTD
176Epilepsy, Temporal Lobe

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CTD
177Epilepsy

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CTD
178EpistaxisSIDER
179EructationSIDER
180Erythema NodosumSIDER
181Escherichia infectionOFFSIDES
182Exfoliation Syndrome3321877CTD
183Eye BurnsCanada Vigilance: 1Canada Vigilance
184Eye irritationSIDER
185Eye laser surgeryOFFSIDES
186Facial NeuralgiaOFFSIDES
187Fever980220CTD
188FlatulenceSIDER
189Gamma-Glutamyltransferase IncreasedOFFSIDES
190GastritisSIDER
191GastroduodenitisOFFSIDES
192GastroenteritisOFFSIDES
SIDER
193Gastrointestinal PainSIDER
194General physical health deteriorationOFFSIDES
195GingivitisSIDER
196Glaucoma, Open-Angle

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CTD
197Glaucoma

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CTD
OFFSIDES
198Gliosis

View details

CTD
199GlossitisSIDER
200GranulocytosisOFFSIDES
201GranulomaOFFSIDES
202Hallucinations15765828CTD
203HepatitisSIDER
204Hospice CareOFFSIDES
205Hyperemia7698938
9090610
CTD
206HyperkinesiaSIDER
207HypersensitivityCanada Vigilance: 1Canada Vigilance
SIDER
208HysterectomyOFFSIDES
209Implantable defibrillator insertionOFFSIDES
210Incisional herniaOFFSIDES
211Increased bronchial secretionSIDER
212InfectionSIDER
213Inflammation19320047
20384764
21087489
CTD
214InfluenzaSIDER
215Intestinal hypomotilityOFFSIDES
216Intraocular inflammationOFFSIDES
217Joint injuryOFFSIDES
218Joint sprainOFFSIDES
219Joint stiffnessOFFSIDES
220KeratitisSIDER
221Kidney FailureOFFSIDES
222Lacrimal structural disorderSIDER
223LacrimationSIDER
224LaryngitisSIDER
225LaryngospasmSIDER
226Left atrial dilatationOFFSIDES
227Leukopenia neonatalOFFSIDES
228LeukopeniaSIDER
229Limb injuryOFFSIDES
230Lip exfoliationOFFSIDES
231LymphadenopathySIDER
232LymphedemaOFFSIDES
233MalocclusionOFFSIDES
234Mastication disorderOFFSIDES
235MastitisSIDER
236Memory Disorders

View details

CTD
237MenorrhagiaSIDER
238Mental disorders8570370CTD
239Metastatic NeoplasmOFFSIDES
240MetatarsalgiaOFFSIDES
241MetrorrhagiaSIDER
242Mitochondrial Diseases20206232CTD
243MononeuritisOFFSIDES
244Mood swingsSIDER
245Movement Disorders12076843CTD
246Multiple SclerosisOFFSIDES
247Multiple allergiesOFFSIDES
248Muscle strainOFFSIDES
249Musculoskeletal PainOFFSIDES
250Musculoskeletal discomfortSIDER
251Musculoskeletal stiffnessSIDER
252MyalgiaCanada Vigilance: 1Canada Vigilance
SIDER
253Mydriasis8780295CTD
254Myocardial InfarctionSIDER
255Myoclonus1324090
6498517
CTD
256MyopiaOFFSIDES
257Neck PainSIDER
258Neck stiffnessSIDER
259Necrosis10999512CTD
260Nerve BlockOFFSIDES
261Nerve Degeneration

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CTD
262NervousnessSIDER
263Neurobehavioral Manifestations1329122
8445981
19068237
CTD
264Neurotoxicity Syndromes19220411CTD
265Nuchal RigiditySIDER
266Ocular Hypertension3321877
8489450
18721251
CTD
OFFSIDES
267Ocular Hypotension

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CTD
268OliguriaOFFSIDES
269Oral fungal infectionOFFSIDES
270Osteitis DeformansOFFSIDES
271OsteolysisOFFSIDES
272OsteomyelitisOFFSIDES
273OsteopeniaOFFSIDES
274OsteoporosisOFFSIDES
275OveractivitySIDER
276Oxygen supplementationOFFSIDES
277Pain6794090
18721251
CTD
OFFSIDES
SIDER
278PancreatitisSIDER
279PeriodontitisOFFSIDES
280Personality Disorders573894CTD
281Pharyngeal candidiasisOFFSIDES
282PharyngitisSIDER
283Pneumocystis jiroveci pneumoniaOFFSIDES
284Poor dental conditionOFFSIDES
285Postoperative wound complicationOFFSIDES
286Product taste abnormalCanada Vigilance: 1Canada Vigilance
287Productive CoughOFFSIDES
288Psychoses, Substance-Induced15765828CTD
289Pulmonary HypertensionOFFSIDES
290PyelonephritisOFFSIDES
291PyuriaSIDER
292Radicular painOFFSIDES
293Reflux gastritisOFFSIDES
294Respiratory FailureOFFSIDES
295Respiratory tract congestionOFFSIDES
296Rheumatoid NoduleOFFSIDES
297RhinitisSIDER
298SalpingitisSIDER
299ScabOFFSIDES
300SclerodermaOFFSIDES
301Sclerosis20618415CTD
302Seizures

View details

1329122
1359921
1365435
1377589
1451735
1511526
1539084
1660160
1829682
1847879
1924492
1933276
1974713
1977176
1982269
2006466
2101094
2139189
2287486
2287490
2533336
2570598
2839355
2853076
3008043
3016600
3033555
3047315
3075270
3123975
3183711
3191389
3202947
3333612
3412639
3437996
3440212
3550795
3607518
3708328
3774222
3801895
3801899
3936592
4000409
6301005
6498517
6639740
7472461
7583243
7617694
7737389
7750514
7894264
7906888
7906944
7922540
7936204
7970173
7984056
8013446
8028781
8095893
8098511
8101446
8212011
8225947
8327537
8410199
8445981
8480078
8511714
8570092
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8749039
8822702
8859908
8873209
8880893
8985701
9015327
9030893
9061777
9073163
9121607
9222532
9249254
9347520
9399999
9630518
9662735
9700800
9726649
9875530
10414434
10436046
10443546
10487179
10506506
10514033
10575257
10828528
10862938
10904147
10974326
11050301
11205735
11311893
11392617
11440806
11457585
11701206
11853098
11860278
11900778
11955713
11976067
11981227
12062587
12080343
12091480
12350385
12423383
12460246
12481039
12539201
12657704
12687707
12713643
12890777
12934390
12954810
12967596
14559291
14580952
14620880
14656328
14683557
14751217
14754538
15120741
15129835
15140183
15193289
15245787
15248868
15256179
15382258
15451009
15501307
15555639
15781040
15894059
15910761
15946324
15973680
16023587
16079484
16115668
16146434
16150574
16342370
16343452
16504477
16611826
16771832
16797850
16806953
16848785
16876986
16981869
17008043
17011125
17011127
17095192
17205390
17360923
17376708
17437408
17442304
17460611
17499921
17503488
17507170
17561820
17592530
17611032
17686039
17828434
17978042
18005069
18032674
18083005
18096215
18216225
18226170
18242586
18333967
18439803
18469539
18534255
18572151
18585369
18587450
18688660
18711127
18760902
18786819
18804098
18815271
18836479
18988310
19099125
19125849
19320047
19321966
19368863
19407080
19429016
19488739
19493016
19500573
19559095
19616071
19660546
19669875
19694724
19695311
19715735
19732799
19754464
19798568
19800361
19800952
19862562
19932735
19941057
19941068
20015615
20026167
20034476
20064661
20134357
20227110
20237771
20347349
20362662
20382223
20384728
20433896
20446108
20470870
20483668
20584200
20592767
20602035
20660766
20682341
20716907
20730314
20888349
20888801
21049302
21084616
21204826
21239233
21256120
21269288
21307269
21625766
22348894
24911645
25490531
26456888
CTD
303ShockSIDER
304Shunt infectionOFFSIDES
305Sialorrhea12812833CTD
306Sjogren's Syndrome11490519CTD
OFFSIDES
307Skin UlcerSIDER
308SomnolenceSIDER
309Spinal column stenosisOFFSIDES
310SpondylolisthesisOFFSIDES
311Status Epilepticus

View details

1324090
1331919
1651249
1756784
1815138
1933279
1969357
2101094
2553470
2594148
2824229
3015661
3016600
3191389
3333612
3396644
3440212
3582562
3612132
3936592
3948956
6498517
6639740
7529610
7713058
7737389
7851985
7854063
7925839
7970173
7984056
8013446
8410052
8474571
8480078
8511714
8526461
8635431
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9413831
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9766394
10027775
10200201
10222443
10341251
10344793
10366005
10430476
10487179
10490925
10575257
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10711813
10771339
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10996502
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11461966
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11488952
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11829323
11880191
11952764
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12068345
12076839
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12121303
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12200221
12350385
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12387456
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12539201
12595191
12646302
12657704
12681001
12694930
12697140
12757899
12821374
12823472
12837569
12851778
12890517
12890777
12894279
12914250
12934390
13679415
14510819
14559291
14580952
14620880
14625039
14656328
14678764
14683557
14692902
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14711901
14746897
15003282
15058486
15120741
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15219774
15245787
15246118
15256181
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15456836
15488322
15582835
15752349
15781040
15820339
15857427
15862514
15862629
15876489
15910761
15932595
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15973680
15987249
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16023587
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16079484
16084511
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16137708
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16342370
16343452
16344154
16391389
16400415
16481111
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16504477
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16650619
16679645
16696126
16759449
16793029
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16806953
16819974
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17011125
17042797
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17113938
17166730
17181556
17194568
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17284294
17360923
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17383094
17430409
17442304
17446080
17499921
17512118
17533168
17561820
17611032
17634364
17651415
17709190
17919468
17971868
18032674
18058944
18065154
18083005
18083839
18094240
18096215
18216225
18242586
18289512
18445534
18455351
18488994
18533134
18550034
18571097
18572151
18585369
18587450
18671295
18672383
18695509
18708038
18722515
18760902
18772502
18774262
18804094
18808451
18815271
18845420
18853423
18929683
18949272
18988310
19010416
19025771
19054409
19055492
19068237
19099125
19111409
19125849
19138473
19138675
19220408
19222700
19272430
19298597
19306853
19320047
19321966
19356691
19368833
19371260
19371577
19397936
19402951
19403808
19430551
19474175
19490431
19493016
19497871
19500573
19505798
19535596
19553465
19559095
19563803
19570321
19607878
19616071
19631748
19669875
19674083
19686240
19694724
19695311
19767176
19800952
19811616
19909730
19951488
20004712
20015615
20018232
20026136
20034063
20034406
20064661
20080419
20149694
20206232
20211740
20347349
20384764
20437568
20443057
20498848
20553876
20592767
20599541
20600929
20633040
20660766
20682341
20691264
20732386
20801723
20880321
20886625
20888801
20971086
20971094
21070218
21075125
21087489
21147076
21177194
21204826
21219332
21269288
21307269
21366554
21429313
21905079
22824136
23211629
24911645
25715797
28174044
29545205
CTD
312Stevens-Johnson SyndromeOFFSIDES
313StomatitisSIDER
314StridorSIDER
315SweatingSIDER
316SympathectomyOFFSIDES
317TenosynovitisSIDER
318TensionSIDER
319Therapeutic product effect decreasedCanada Vigilance: 3Canada Vigilance
320Thoracic cavity drainageOFFSIDES
321ThrombocytopeniaSIDER
322ThrombocytosisSIDER
323ThrombosisSIDER
324TinnitusSIDER
325Tooth ExtractionOFFSIDES
326Transaminases increasedOFFSIDES
327UlcerOFFSIDES
328Ultrasound pelvisOFFSIDES
329Umbilical herniaOFFSIDES
330Unresponsive to stimuliOFFSIDES
331Urinary Incontinence3769383CTD
SIDER
332Urinary tract infection enterococcalOFFSIDES
333Urinary tract infectionSIDER
334Urine cytology abnormalOFFSIDES
335Vesiculobullous rashSIDER
336Vision Disorders3737129
8280687
CTD
337VitritisOFFSIDES
338Vulvovaginal mycotic infectionSIDER
339Wound InfectionOFFSIDES
340Wound dehiscenceOFFSIDES
341Wound infection staphylococcalOFFSIDES
342Xerostomia3306552
3476633
17241436
CTD
343YawningSIDER
344effusionOFFSIDES
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