MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Floxacillin

(UIOFUWFRIANQPC-JKIFEVAISA-N)

Structure

SMILES: O=C1[C@@H](NC(=O)c2c(C)onc2c2c(F)cccc2Cl)[C@@H]2N1[C@@H](C(=O)O)C(S2)(C)C
Type(s): Approved; Investigational
ATC code(s): J01CF05; J01CR50
Molecular Formula:: C19H17ClFN3O5S
Molecular Weight:: 453.872
Log P:: 3.0166
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 2
TPSA:: 138.04
CAS Number(s):: 1847-24-1; 5250-39-5

Synonym(s)

Floxacillin

Flucloxacillin

Fluorochloroxacillin

External Link(s)

MeSH	D005436
PubChem Compound	21319
BindingDB	50370590 50292246
ChEBI	5098
CHEMBL	CHEMBL222645
DrugBank	DB00301
DrugCentral	1183
KEGG	cpd:C11748 dr:D04196
Therapeutic Target Database	D0Q2AT
ZINC	4102187

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal Pain		SIDER
2	Abdominal tenderness		OFFSIDES
3	Acute kidney injury	19142275	CTD
4	Acute prerenal failure		OFFSIDES
5	Ageusia		OFFSIDES
6	Agranulocytosis		SIDER
7	Alanine Aminotransferase Increased		OFFSIDES
8	Anaphylactic shock		SIDER
9	Anemia, Hemolytic	3713580	CTD
10	Angioedema		SIDER
11	Angioplasty		OFFSIDES
12	Angle Closure Glaucoma		OFFSIDES
13	Anosmia		OFFSIDES
14	Anticonvulsant drug level increased		OFFSIDES
15	Anuria		OFFSIDES
16	Apathy		OFFSIDES
17	Arthralgia		SIDER
18	Ataxia		OFFSIDES
19	Bacteremia	17661075	CTD
20	Bacterial Infections	19483685	CTD
21	Blood albumin decreased		OFFSIDES
22	Blood amylase increased		OFFSIDES
23	Blood and lymphatic system disorders		SIDER
24	Blood chloride increased		OFFSIDES
25	Blood creatine phosphokinase increased		OFFSIDES
26	Blood fibrinogen increased		OFFSIDES
27	Blood glucose fluctuation		OFFSIDES
28	Body Temperature		OFFSIDES
29	Breast tenderness		OFFSIDES
30	Bronchopneumonia		OFFSIDES
31	Bronchospasm		SIDER
32	Burning sensation		OFFSIDES
33	Catheter related infection		OFFSIDES
34	Catheter site related reaction		OFFSIDES
35	Cellulitis		OFFSIDES
36	Central line infection		OFFSIDES
37	Chemical and Drug Induced Liver Injury	View details 7997079 8201211 8265236 12505292 15674093 16165719 18793693 19483685 24085192 24652713 30993380	CTD
38	Cholangiolitis		OFFSIDES
39	Cholangitis	7997079	CTD
40	Cholestasis	View details 8201211 8265236 10570561 19694748 24652713	CTD
41	Chronic left ventricular failure		OFFSIDES
42	Coagulation factor VIII level decreased		OFFSIDES
43	Coagulation factor X level increased		OFFSIDES
44	Colitis		OFFSIDES SIDER
45	Community-Acquired Infections	17554568	CTD
46	Constipation		SIDER
47	Dehydration		OFFSIDES
48	Depression suicidal		OFFSIDES
49	Dermatitis		SIDER
50	Device breakage		OFFSIDES
51	Device dislocation		OFFSIDES
52	Device malfunction		OFFSIDES
53	Discomfort		SIDER
54	Distal intestinal obstruction syndrome		OFFSIDES
55	Dizziness		SIDER
56	Drug exposure during pregnancy		OFFSIDES
57	Drug exposure via breast milk		OFFSIDES
58	Dysgeusia		SIDER
59	Dyspepsia		SIDER
60	Electrocardiogram T wave peaked		OFFSIDES
61	Empyema		OFFSIDES
62	Enterovesical Fistula		OFFSIDES
63	Eosinophilia		SIDER
64	Eosinophilic myocarditis		OFFSIDES
65	Erythema Multiforme		SIDER
66	Erythema Nodosum	15701135	CTD SIDER
67	Erythema		OFFSIDES
68	Exfoliative rash		OFFSIDES
69	Factor VIII inhibition		OFFSIDES
70	Feeling Cold		OFFSIDES
71	Feeling abnormal		SIDER
72	Gastrointestinal Pain		SIDER
73	General physical health deterioration		OFFSIDES
74	Glasgow coma scale		OFFSIDES
75	Globulinuria		OFFSIDES
76	Granulocytosis		OFFSIDES
77	Headache		SIDER
78	Heartburn		SIDER
79	Hepatitis	10570561	CTD OFFSIDES SIDER
80	Hepatotoxicity		OFFSIDES
81	Hypersensitivity		SIDER
82	Hyperventilation		OFFSIDES
83	Induration		OFFSIDES
84	Infection		OFFSIDES
85	Infusion site mobility decreased		OFFSIDES
86	Intentional self-injury		OFFSIDES
87	Jaundice, Obstructive	7751579	CTD
88	Kidney Failure		OFFSIDES
89	Lethargy		OFFSIDES
90	Leukopenia		SIDER
91	Lipids abnormal		OFFSIDES
92	Live Birth		OFFSIDES
93	Liver Failure	15773973	CTD
94	Malaise		SIDER
95	Meningitis, Bacterial	17554568	CTD
96	Metabolic acidosis		OFFSIDES
97	Muscle Weakness		OFFSIDES
98	Musculoskeletal discomfort		SIDER
99	Myalgia		SIDER
100	Myoglobin blood increased		OFFSIDES
101	Nausea		SIDER
102	Nephritis, Interstitial	7624012 16943303	CTD
103	Nephritis	6851267	CTD SIDER
104	Neutropenia	15773973	CTD SIDER
105	Neutropenic sepsis		OFFSIDES
106	Neutrophil count decreased		OFFSIDES
107	Nystagmus		OFFSIDES
108	Oral candidiasis		SIDER
109	Oropharyngeal discomfort		SIDER
110	Oropharyngeal pain		SIDER
111	Ototoxicity		OFFSIDES
112	Ovulation disorder		OFFSIDES
113	Paraparesis		OFFSIDES
114	Phlebitis	7447412	CTD
115	Pneumonia, Bacterial	17661075	CTD
116	Porokeratosis		OFFSIDES
117	Postoperative Complications	17554568	CTD
118	Pregnancy with injectable contraceptive		OFFSIDES
119	Proteinuria	16943303	CTD
120	Pruritus Vulvae		SIDER
121	Pruritus	2593915 8265236	CTD
122	Purpura		SIDER
123	Pyomyositis	17661075	CTD
124	Pyroglutamate increased		OFFSIDES
125	Pyuria		OFFSIDES
126	Quadriparesis		OFFSIDES
127	Reaction gastrointestinal		SIDER
128	Red man syndrome		OFFSIDES
129	Renal tubular necrosis		OFFSIDES
130	Respiratory Failure		OFFSIDES
131	Rhabdomyolysis		OFFSIDES
132	Salmonella		OFFSIDES
133	Schizophrenia		OFFSIDES
134	Serum Sickness		SIDER
135	Skin laceration		OFFSIDES
136	Splenic Infarction		OFFSIDES
137	Staphylococcal Infections	View details 9257737 15773973 15963097 17554568 17661075	CTD
138	Staphylococcal abscess		OFFSIDES
139	Stevens-Johnson Syndrome		OFFSIDES SIDER
140	Tardive Dyskinesia		OFFSIDES
141	Tenosynovitis		OFFSIDES
142	Tetany		OFFSIDES
143	Thoracotomy		OFFSIDES
144	Thrombocytopenia		SIDER
145	Thrombocytopenic purpura		SIDER
146	Toxic Epidermal Necrolysis		SIDER
147	Troponin I increased		OFFSIDES
148	Troponin T		OFFSIDES
149	Type II hypersensitivity		OFFSIDES
150	Urticaria		SIDER
151	Uterine Rupture		OFFSIDES
152	Vascular purpura		SIDER
153	Vasculitic rash		OFFSIDES
154	Vomiting		SIDER
155	Vulvovaginal pruritus		SIDER
156	bad taste		SIDER
157	jaundice	View details 3573873 3992199 8265236 8443520	CTD SIDER
158	nervous system disorder		SIDER
159	pseudomembranous colitis		SIDER
160	treatment failure		OFFSIDES

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