MetaADEDB 2.0 @ LMMD
Nisoldipine
(VKQFCGNPDRICFG-UHFFFAOYSA-N)
Structure
SMILES
COC(=O)C1=C(C)NC(=C(C1c1ccccc1[N+](=O)[O-])C(=O)OCC(C)C)C
Type(s)
Approved
ATC code(s)
C08CA07
Molecular Formula:
C20H24N2O6
Molecular Weight:
388.414
Log P:
4.0538
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
110.45
CAS Number(s):
63675-72-9
Synonym(s)
1.
Nisoldipine
2.
Bay K 5552
External Link(s)
MeSHD015737
PubChem Compound4499
BindingDB50227259
50101963
ChEBI76917
CHEMBLCHEMBL3192341
CHEMBL441428
CHEMBL1726
DrugBankDB00401
DrugCentral1942
IUPHAR/BPS Guide to PHARMACOLOGY2524
KEGGcpd:C07699
dr:D00618
Therapeutic Target DatabaseD0S5CU
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HeadacheFAERS: 7

View details

3065058
3661439
9358963
9744143
12944032
17322141
 		CTD
SIDER
US FAERS
2PalpitationsFAERS: 5SIDER
US FAERS
3Product substitution issueFAERS: 5US FAERS
4DizzinessFAERS: 412944032
17322141		CTD
OFFSIDES
SIDER
US FAERS
5Drug ineffectiveFAERS: 4OFFSIDES
US FAERS
6NauseaFAERS: 4OFFSIDES
SIDER
US FAERS
7SyncopeFAERS: 4SIDER
US FAERS
8FatigueFAERS: 3OFFSIDES
US FAERS
9MalaiseFAERS: 3SIDER
US FAERS
10Myocardial InfarctionFAERS: 3

View details

1289100
1464339
3154643
7947377
 		CTD
SIDER
US FAERS
11VomitingFAERS: 3US FAERS
12AnxietyFAERS: 2OFFSIDES
SIDER
US FAERS
13AstheniaFAERS: 2OFFSIDES
US FAERS
14CellulitisFAERS: 2SIDER
US FAERS
15Depressed Level of ConsciousnessFAERS: 2US FAERS
16DyspepsiaFAERS: 2OFFSIDES
SIDER
US FAERS
17EcchymosisFAERS: 2SIDER
US FAERS
18FlushingFAERS: 23065058
3661439		CTD
US FAERS
19HypersensitivityFAERS: 2SIDER
US FAERS
20Peripheral swellingFAERS: 2US FAERS
21Pharmaceutical product complaintFAERS: 2US FAERS
22PruritusFAERS: 2SIDER
US FAERS
23Toxicity to various agentsFAERS: 2US FAERS
24UrticariaFAERS: 2SIDER
US FAERS
25furuncleFAERS: 2US FAERS
26Abdominal PainFAERS: 1US FAERS
27AlopeciaFAERS: 1OFFSIDES
SIDER
US FAERS
28AphasiaFAERS: 1US FAERS
29AsthmaFAERS: 1SIDER
US FAERS
30Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
31Blood pressure fluctuationFAERS: 1OFFSIDES
US FAERS
32Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
33Chest discomfortFAERS: 1SIDER
US FAERS
34ChillsFAERS: 1SIDER
US FAERS
35Drug administration errorFAERS: 1OFFSIDES
US FAERS
36Drug dose omissionFAERS: 1US FAERS
37Dry skinFAERS: 1OFFSIDES
SIDER
US FAERS
38DysarthriaFAERS: 1US FAERS
39DysphoniaFAERS: 1US FAERS
40EpistaxisFAERS: 1SIDER
US FAERS
41Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
42GoutFAERS: 1OFFSIDES
SIDER
US FAERS
43HypotensionFAERS: 18558767CTD
SIDER
US FAERS
44LethargyFAERS: 1OFFSIDES
US FAERS
45Medication ErrorFAERS: 1US FAERS
46Mental status changesFAERS: 1US FAERS
47MyalgiaFAERS: 1SIDER
US FAERS
48Oropharyngeal painFAERS: 1OFFSIDES
US FAERS
49OverdoseFAERS: 1US FAERS
50PeritonitisFAERS: 1US FAERS
51PharyngitisFAERS: 1SIDER
US FAERS
52Product quality issueFAERS: 1US FAERS
53ShockFAERS: 1SIDER
US FAERS
54Sinus bradycardiaFAERS: 1US FAERS
55StressFAERS: 1OFFSIDES
US FAERS
56Therapeutic product ineffectiveFAERS: 1US FAERS
57Therapy regimen changedFAERS: 1US FAERS
58TremorFAERS: 1SIDER
US FAERS
59Unevaluable eventFAERS: 1OFFSIDES
US FAERS
60Visual disturbanceFAERS: 1OFFSIDES
US FAERS
61Abdominal discomfortOFFSIDES
62Abnormal visionSIDER
63Acid refluxOFFSIDES
64Acute Coronary SyndromeSIDER
65Acute kidney injury2441191CTD
66Acute respiratory failureOFFSIDES
67AmblyopiaSIDER
68AmnesiaOFFSIDES
SIDER
69Angina Pectoris

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1927911
2344682
3065058
3450520
11720635
 		CTD
70Angioedema19077729CTD
OFFSIDES
SIDER
71AnhedoniaOFFSIDES
72AnhidrosisOFFSIDES
73AnorexiaSIDER
74AnosmiaOFFSIDES
75Aphthous StomatitisOFFSIDES
76ArthralgiaSIDER
77ArthritisSIDER
78Artificial crown procedureOFFSIDES
79AtaxiaSIDER
80AtelectasisOFFSIDES
81AtherosclerosisOFFSIDES
82Atrial FibrillationSIDER
83Autoimmune hepatitisOFFSIDES
84Bacillus infectionOFFSIDES
85Bile Duct StenosisOFFSIDES
86Biliary dilatationOFFSIDES
87Biopsy gingivalOFFSIDES
88BlepharitisSIDER
89Blood GlucoseOFFSIDES
90Blood lactate dehydrogenase increasedOFFSIDES
91Blood potassium increasedOFFSIDES
92Blood pressure inadequately controlledOFFSIDES
93Blood sodiumOFFSIDES
94Blood urea increasedOFFSIDES
SIDER
95Blood uric acidOFFSIDES
96Bone painOFFSIDES
97BradycardiaOFFSIDES
98BronchopneumoniaOFFSIDES
99Cardiac infectionOFFSIDES
100Cardioactive drug level increasedOFFSIDES
101Cardiomegaly9118169CTD
102Cardiovascular Diseases12578880CTD
103Cartilage injuryOFFSIDES
104Cerebrovascular accidentSIDER
105Chest tightnessSIDER
106Choking sensationOFFSIDES
107CholecystitisOFFSIDES
108Chronic Fatigue SyndromeOFFSIDES
109Chronic Obstructive Airway DiseaseOFFSIDES
110Chronic left ventricular failureOFFSIDES
111Chronic sinusitisOFFSIDES
112Cold sweatOFFSIDES
113ColectomyOFFSIDES
114ColitisSIDER
115ConjunctivitisSIDER
116Cramps of lower extremitiesSIDER
117Cutaneous CandidiasisOFFSIDES
118CystOFFSIDES
119DebridementOFFSIDES
120DemyelinationOFFSIDES
121Dental abscessOFFSIDES
122DermatitisSIDER
123DiabetesOFFSIDES
124Diabetes MellitusSIDER
125DiarrheaOFFSIDES
126DiscomfortSIDER
127Disturbance in sexual arousalSIDER
128DiverticulumOFFSIDES
129Drug withdrawal headacheOFFSIDES
130DysgeusiaOFFSIDES
SIDER
131DysuriaSIDER
132Ear congestionOFFSIDES
133Economic problemOFFSIDES
134Edema

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9056681
9358963
9744143
12944032
17322141
 		CTD
135Electrocardiogram ST segment abnormalOFFSIDES
136Electrocardiogram changeOFFSIDES
137Electrocardiogram poor R-wave progressionOFFSIDES
138Electromechanical dissociationOFFSIDES
139Emotional distressOFFSIDES
140EmpyemaOFFSIDES
141Endotracheal intubation complicationOFFSIDES
142EnteritisOFFSIDES
143Enterococcal sepsisOFFSIDES
144EnterocolitisOFFSIDES
145Enterovesical FistulaOFFSIDES
146Erectile dysfunctionSIDER
147Erythema MultiformeOFFSIDES
148ErythemaOFFSIDES
149Escherichia infectionOFFSIDES
150Extremity contractureOFFSIDES
151Eye painOFFSIDES
152Eyelid irritationOFFSIDES
153Fear of fallingOFFSIDES
154FlatulenceSIDER
155Fluid overloadOFFSIDES
156FormicationOFFSIDES
157GamblingOFFSIDES
158GangreneOFFSIDES
159GastritisSIDER
160Gastrointestinal sounds abnormalOFFSIDES
161Gingival HyperplasiaOFFSIDES
SIDER
162GlaucomaOFFSIDES
SIDER
163GlossitisSIDER
164Heart failure8523445
11720635		CTD
165HemiplegiaOFFSIDES
166HepatomegalySIDER
167HypophagiaOFFSIDES
168HypoxiaOFFSIDES
169Implantable defibrillator insertionOFFSIDES
170IncoherentOFFSIDES
171InfluenzaSIDER
172Intervertebral Disc DegenerationOFFSIDES
173Intestinal Diseases19077729CTD
174Ischemia8742913CTD
175Joint stiffnessOFFSIDES
176KeratitisSIDER
177KeratoconjunctivitisSIDER
178Kidney FailureOFFSIDES
179LaryngitisSIDER
180Left Ventricular HypertrophyOFFSIDES
181LeukopeniaSIDER
182Life expectancy shortenedOFFSIDES
183Limb discomfortOFFSIDES
184LymphocytosisOFFSIDES
185Maxillofacial operationOFFSIDES
186Multiple MyelomaOFFSIDES
187Multiple allergiesOFFSIDES
188Muscle WeaknessOFFSIDES
189Muscle necrosisOFFSIDES
190Musculoskeletal PainOFFSIDES
191Musculoskeletal discomfortSIDER
192Musculoskeletal stiffnessOFFSIDES
193Myocardial Ischemia

View details

2329180
8523445
9649927
10410823
11720635
 		CTD
194MyositisSIDER
195NasopharyngitisOFFSIDES
196NephrolithiasisOFFSIDES
197NervousnessSIDER
198Neutrophil count decreasedOFFSIDES
199NocturiaSIDER
200Non-cardiac chest painOFFSIDES
201OliguriaOFFSIDES
202Oral fungal infectionOFFSIDES
203OrchitisOFFSIDES
204OrthopneaOFFSIDES
205OsteopeniaOFFSIDES
206OsteoporosisOFFSIDES
207Otitis MediaSIDER
208PainOFFSIDES
209PallorOFFSIDES
210PeriarthritisOFFSIDES
211PetechiaeSIDER
212PlasmacytomaOFFSIDES
213PlasmacytosisOFFSIDES
214PleurisyOFFSIDES
215Polymyalgia RheumaticaOFFSIDES
216Post procedural complicationOFFSIDES
217Postmenopausal bleedingOFFSIDES
218Postoperative wound complicationOFFSIDES
219PresbyopiaOFFSIDES
220Prescribed overdoseOFFSIDES
221Prothrombin time abnormalOFFSIDES
222PsoriasisOFFSIDES
223PurulenceOFFSIDES
224RalesOFFSIDES
SIDER
225Respiratory tract congestionOFFSIDES
226Retinal DetachmentSIDER
227RhinitisSIDER
228SYSTOLIC EJECTION MURMURSIDER
229ScotomaOFFSIDES
230Sick Sinus SyndromeOFFSIDES
231Silent myocardial infarctionOFFSIDES
232SinusitisOFFSIDES
SIDER
233Skin UlcerSIDER
234Skin hypertrophyOFFSIDES
235Skin necrosisOFFSIDES
236Skin tightnessOFFSIDES
237Small bowel angioedemaOFFSIDES
238Soft tissue necrosisOFFSIDES
239SomnolenceSIDER
240SpondylolisthesisOFFSIDES
241SpondylosisOFFSIDES
242StomatitisSIDER
243Supraventricular tachycardiaSIDER
244SweatingSIDER
245TachycardiaSIDER
246TenosynovitisSIDER
247TensionSIDER
248Thrombosis9194537CTD
249ThyroiditisSIDER
250TinnitusSIDER
251Tooth ExtractionOFFSIDES
252Unilateral vision lossSIDER
253Unresponsive to stimuliOFFSIDES
254Uterine CancerOFFSIDES
255Uterine ProlapseOFFSIDES
256Vasodilation procedureSIDER
257VasodilationSIDER
258Venous InsufficiencyOFFSIDES
SIDER
259Ventricular Dysfunction, Left3450520
8558767
9060793		CTD
260VertigoSIDER
261Visual ImpairmentSIDER
262Vitamin B 12 DeficiencyOFFSIDES
263Vitreous floatersSIDER
264Walking aid userOFFSIDES
265Weight GainOFFSIDES
266Weight decreasedSIDER
267WheezingSIDER
268Wound necrosisOFFSIDES
269effusionOFFSIDES
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