MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Theophylline

(ZFXYFBGIUFBOJW-UHFFFAOYSA-N)

Structure

SMILES: Cn1c(=O)n(C)c2c(c1=O)[nH]cn2
Type(s): Approved
ATC code(s): R03DA04; R03DA20; R03DA54; R03DA74; R03DB04
Molecular Formula:: C7H8N4O2
Molecular Weight:: 180.164
Log P:: -1.0397
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 1
TPSA:: 72.68
CAS Number(s):: 58-55-9; 75448-53-2

Synonym(s)

Theophylline

1,3-Dimethylxanthine

3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

Accurbron

Aerobin

Aerolate

Afonilum Retard

Aquaphyllin

Armophylline

10.

Bronchoparat

11.

Bronkodyl

12.

Constant-T

13.

Elixophyllin

14.

Euphylong

15.

Glycine Theophyllinate

16.

Lodrane

17.

Monospan

18.

Nuelin

19.

Nuelin S.A.

20.

Quibron T-SR

21.

Slo-Phyllin

22.

Somophyllin-T

23.

Sustaire

24.

Synophylate

25.

Theo Von Ct

26.

Theo-24

27.

Theo-Dur

28.

Theobid

29.

Theocin

30.

Theoconfin Continuous

31.

Theodur

32.

Theolair

33.

Theolix

34.

Theon

35.

Theonite

36.

Theopek

37.

Theophylline Anhydrous

38.

Theophylline Sodium Glycinate

39.

Theospan

40.

Theostat

41.

Theovent

42.

Uniphyl

43.

Uniphyllin

44.

Uniphylline

45.

1,3 Dimethylxanthine

46.

Anhydrous, Theophylline

47.

Constant T

48.

ConstantT

49.

Ct, Theo Von

50.

Glycinate, Theophylline Sodium

51.

Quibron T SR

52.

Quibron TSR

53.

Slo Phyllin

54.

SloPhyllin

55.

Sodium Glycinate, Theophylline

56.

Somophyllin T

57.

SomophyllinT

58.

Theo 24

59.

Theo Dur

60.

Theo24

61.

Theophyllinate, Glycine

62.

Von Ct, Theo

External Link(s)

MeSH	D013806
PubChem Compound	2153
BindingDB	10847 82053
ChEBI	28177
CHEMBL	CHEMBL190
DrugBank	DB00277
DrugCentral	2620
IUPHAR/BPS Guide to PHARMACOLOGY	413
KEGG	cpd:C07130 dr:D00371
Therapeutic Target Database	D0F8RA
ZINC	18043251

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Status Epilepticus	FAERS: 63	View details 108053 637435 1541177 2038423 11605782 18634420 19911151	CTD SIDER US FAERS
2	Toxicity to various agents	FAERS: 51		US FAERS
3	Vomiting	FAERS: 45 Canada Vigilance: 5	View details 2218006 3074291 6625253 8346082 8888546 16868215	CTD SIDER Canada Vigilance US FAERS
4	Overdose	FAERS: 43		SIDER US FAERS
5	Medication Error	FAERS: 33		US FAERS
6	Nausea	FAERS: 33 Canada Vigilance: 11	View details 2218006 3074291 3537092 6506685 16868215	CTD OFFSIDES SIDER Canada Vigilance US FAERS
7	Drug toxicity	FAERS: 32		OFFSIDES US FAERS
8	Hypotension	FAERS: 32	View details 1746998 3706053 3994078 6506685 16595736	CTD SIDER US FAERS
9	Tachycardia	FAERS: 31 Canada Vigilance: 3	View details 2623258 2856947 3408637 4014092 6625253 6751238 7270562 8346082 8888546 10230855 11408986 16868215	CTD SIDER Canada Vigilance US FAERS
10	Drug level increased	FAERS: 24 Canada Vigilance: 12		Canada Vigilance US FAERS
11	Supraventricular tachycardia	FAERS: 24		OFFSIDES SIDER US FAERS
12	Tremor	FAERS: 23 Canada Vigilance: 1	View details 1424400 3074291 6288396 6313028 6506685 6586482 7140872 8017343	CTD SIDER Canada Vigilance US FAERS
13	Intubation	FAERS: 21		US FAERS
14	Metabolic acidosis	FAERS: 21		OFFSIDES US FAERS
15	nervous system disorder	FAERS: 21		SIDER US FAERS
16	Glaucoma	FAERS: 20		US FAERS
17	Drug exposure during pregnancy	FAERS: 19		US FAERS
18	Respiratory Failure	FAERS: 19		OFFSIDES US FAERS
19	Drug level above therapeutic	FAERS: 18		US FAERS
20	Palpitations	FAERS: 18 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
21	Suicide attempt	FAERS: 18		US FAERS
22	Cerebral atrophy	FAERS: 17		OFFSIDES US FAERS
23	Blood creatine phosphokinase increased	FAERS: 16		US FAERS
24	Antasthmatic drug level above therapeutic	FAERS: 14		US FAERS
25	Rhabdomyolysis	FAERS: 14	2858780 7826681 10441997	CTD OFFSIDES SIDER US FAERS
26	Sinus Tachycardia	FAERS: 14		SIDER US FAERS
27	Completed Suicide	FAERS: 13 Canada Vigilance: 3		Canada Vigilance US FAERS
28	Depressed Level of Consciousness	FAERS: 12		OFFSIDES US FAERS
29	Acute kidney injury	FAERS: 10	1956491 2858780 10441997	CTD US FAERS
30	Blood potassium decreased	FAERS: 10		US FAERS
31	Multiple drug overdose	FAERS: 10		US FAERS
32	Accidental overdose	FAERS: 9		US FAERS
33	Agitation	FAERS: 8 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
34	Cardiac Arrest	FAERS: 8 Canada Vigilance: 3		Canada Vigilance US FAERS
35	Dizziness	FAERS: 8 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
36	Drug ineffective	FAERS: 8 Canada Vigilance: 2		Canada Vigilance US FAERS
37	Headache	FAERS: 8 Canada Vigilance: 4	6386511 6838301	CTD SIDER Canada Vigilance US FAERS
38	Malaise	FAERS: 8 Canada Vigilance: 1		Canada Vigilance US FAERS
39	Ventricular Fibrillation	FAERS: 8 Canada Vigilance: 1		Canada Vigilance US FAERS
40	Blood glucose increased	FAERS: 7		US FAERS
41	Asthenia	FAERS: 6 Canada Vigilance: 1	8237803	CTD OFFSIDES Canada Vigilance US FAERS
42	Atrial Fibrillation	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
43	Central nervous system lesion	FAERS: 6		US FAERS
44	Dyspepsia	FAERS: 6 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
45	Incorrect dose administered	FAERS: 6		US FAERS
46	Intentional drug misuse	FAERS: 6		US FAERS
47	Pneumonia	FAERS: 6	1541177	CTD US FAERS
48	Unresponsive to stimuli	FAERS: 6		US FAERS
49	Abdominal Pain	FAERS: 5 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
50	Accidental exposure to product by child	FAERS: 5		US FAERS
51	Epilepsy	FAERS: 5		US FAERS
52	Fatigue	FAERS: 5	3769383	CTD US FAERS
53	Mental retardation severity unspecified	FAERS: 5		US FAERS
54	Restlessness	FAERS: 5		US FAERS
55	Tachyarrhythmia	FAERS: 5		US FAERS
56	Unevaluable event	FAERS: 5		US FAERS
57	Urticaria	FAERS: 5 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
58	Ventricular arrhythmia	FAERS: 5		SIDER US FAERS
59	Hyperpyrexia	FAERS: 4		US FAERS
60	Interleukin level increased	FAERS: 4		US FAERS
61	Mental status changes	FAERS: 4		OFFSIDES US FAERS
62	Myoglobin blood increased	FAERS: 4		US FAERS
63	Pharmaceutical product complaint	FAERS: 4		US FAERS
64	Product substitution issue	FAERS: 4		US FAERS
65	Rash erythematous	FAERS: 4		US FAERS
66	Thirst	FAERS: 4		US FAERS
67	Abdominal tenderness	FAERS: 3		US FAERS
68	Accidental exposure	FAERS: 3		US FAERS
69	Acute myocardial infarction	FAERS: 3		US FAERS
70	Altered state of consciousness	FAERS: 3		US FAERS
71	Amnesia	FAERS: 3		US FAERS
72	Asthma	FAERS: 3 Canada Vigilance: 1	View details 208429 1424400 1758745 2496015 2578971 2828249 3025113 3074291 3109801 3523664 3537092 3707814 6586482 7140872 7148765 7235434 7312482 7332913 7437783 8162974 8346082 8760775 9701106 9878995 10596698 10916367 11758890 11951074 12070353 12113382 12355682 12734767 15370247 15645133 16083514 16270722 16430859 16569937 17130682 17943569	CTD OFFSIDES Canada Vigilance US FAERS
73	Blood chloride decreased	FAERS: 3		US FAERS
74	Blood creatinine increased	FAERS: 3		US FAERS
75	Blood glucose decreased	FAERS: 3		OFFSIDES US FAERS
76	Cerebral hypoperfusion	FAERS: 3		US FAERS
77	Chest Pain	FAERS: 3	12498299 15238202	CTD OFFSIDES US FAERS
78	Chest discomfort	FAERS: 3		US FAERS
79	Electroencephalogram abnormal	FAERS: 3		US FAERS
80	Electrolyte imbalance	FAERS: 3		US FAERS
81	Excitability	FAERS: 3		US FAERS
82	Feeling Cold	FAERS: 3		US FAERS
83	Flushing	FAERS: 3		SIDER US FAERS
84	Gastrointestinal sounds abnormal	FAERS: 3		US FAERS
85	Hemiparesis	FAERS: 3		OFFSIDES US FAERS
86	Hyperventilation	FAERS: 3		US FAERS
87	Influenza	FAERS: 3		US FAERS
88	Leukocytosis	FAERS: 3	20940509	CTD US FAERS
89	Mental impairment	FAERS: 3		US FAERS
90	Nerve injury	FAERS: 3		US FAERS
91	Poisoning	FAERS: 3		SIDER US FAERS
92	Polyuria	FAERS: 3		SIDER US FAERS
93	Sepsis	FAERS: 3		US FAERS
94	Shock	FAERS: 3		SIDER US FAERS
95	Somnolence	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
96	Therapy non-responder	FAERS: 3		OFFSIDES US FAERS
97	Adverse event	FAERS: 2		OFFSIDES US FAERS
98	Anorexia	FAERS: 2		OFFSIDES SIDER US FAERS
99	Anuria	FAERS: 2		US FAERS
100	Anxiety	FAERS: 2		SIDER US FAERS
101	Atelectasis	FAERS: 2		US FAERS
102	Atrial Flutter	FAERS: 2		US FAERS
103	Autoimmune thyroiditis	FAERS: 2		US FAERS
104	Blood pH decreased	FAERS: 2		US FAERS
105	Blood sodium decreased	FAERS: 2		US FAERS
106	Blood sodium increased	FAERS: 2		US FAERS
107	Cerebral Infarction	FAERS: 2		US FAERS
108	Disorientation	FAERS: 2		SIDER US FAERS
109	Drug Dependence	FAERS: 2		US FAERS
110	Enteritis	FAERS: 2		US FAERS
111	Hypersensitivity	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
112	Hypocalciuria	FAERS: 2		US FAERS
113	Incontinence	FAERS: 2		OFFSIDES US FAERS
114	Intentional misuse	FAERS: 2		US FAERS
115	Leukopenia	FAERS: 2		US FAERS
116	Medication residue present	FAERS: 2		US FAERS
117	PCO2 decreased	FAERS: 2		US FAERS
118	Peripheral swelling	FAERS: 2		US FAERS
119	Respiratory distress	FAERS: 2		US FAERS
120	Therapeutic response unexpected with drug substitution	FAERS: 2		US FAERS
121	Thrombophlebitis	FAERS: 2		OFFSIDES US FAERS
122	Troponin increased	FAERS: 2		US FAERS
123	Urinary tract infection	FAERS: 2		US FAERS
124	Abasia	FAERS: 1		OFFSIDES US FAERS
125	Abdominal discomfort	FAERS: 1		OFFSIDES US FAERS
126	Acute respiratory failure	FAERS: 1		OFFSIDES US FAERS
127	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
128	Amino acid level decreased	FAERS: 1		US FAERS
129	Amnestic Disorder	FAERS: 1		US FAERS
130	Angina Pectoris	FAERS: 1		US FAERS
131	Angioedema	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
132	Aphasia	FAERS: 1		US FAERS
133	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
134	Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome	FAERS: 1		US FAERS
135	Atrial tachycardia	FAERS: 1		OFFSIDES SIDER US FAERS
136	Bedridden	FAERS: 1		US FAERS
137	Blood creatine phosphokinase MB increased	FAERS: 1		US FAERS
138	Blood creatine phosphokinase abnormal	FAERS: 1		US FAERS
139	Blood lactate dehydrogenase increased	FAERS: 1		US FAERS
140	Blood magnesium decreased	FAERS: 1		US FAERS
141	Blood osmolarity decreased	FAERS: 1		US FAERS
142	Blood phosphorus decreased	FAERS: 1		US FAERS
143	Bronchiolitis	FAERS: 1		US FAERS
144	Cardiomyopathy neonatal	FAERS: 1		US FAERS
145	Cerebrovascular accident	FAERS: 1		US FAERS
146	Complex partial seizures	FAERS: 1		US FAERS
147	Crying	FAERS: 1		US FAERS
148	Delirium	FAERS: 1	6506685	CTD US FAERS
149	Depression suicidal	FAERS: 1		US FAERS
150	Diabetes mellitus inadequate control	FAERS: 1		US FAERS
151	Diabetic Ketoacidosis	FAERS: 1		US FAERS
152	Drug effect delayed	FAERS: 1		US FAERS
153	Drug level below therapeutic	FAERS: 1		US FAERS
154	Drug level fluctuating	FAERS: 1		US FAERS
155	Drug screen positive	FAERS: 1		US FAERS
156	Drug withdrawal syndrome	FAERS: 1		US FAERS
157	Dysgeusia	FAERS: 1		US FAERS
158	Electrocardiogram ST-T segment depression	FAERS: 1		US FAERS
159	Endocardial Fibroelastosis	FAERS: 1		US FAERS
160	Erythema	FAERS: 1		OFFSIDES US FAERS
161	Eye pain	FAERS: 1		OFFSIDES US FAERS
162	Feeling abnormal	FAERS: 1		US FAERS
163	Flatulence	FAERS: 1		US FAERS
164	General physical health deterioration	FAERS: 1		US FAERS
165	Hemiplegia	FAERS: 1		US FAERS
166	Hepatitis C	FAERS: 1		US FAERS
167	Histiocytosis haematophagic	FAERS: 1		US FAERS
168	Incorrect product dosage form administered	FAERS: 1		US FAERS
169	Infantile apnoeic attack	FAERS: 1		US FAERS
170	Intelligence test abnormal	FAERS: 1		US FAERS
171	Intentional product misuse	FAERS: 1		US FAERS
172	Interleukin-2 receptor increased	FAERS: 1		US FAERS
173	Joint swelling	FAERS: 1		US FAERS
174	Late metabolic acidosis of newborn	FAERS: 1		US FAERS
175	Maternal exposure during pregnancy	FAERS: 1		US FAERS
176	Medication residue	FAERS: 1		US FAERS
177	Memory impairment	FAERS: 1		US FAERS
178	Metabolic alkalosis	FAERS: 1		US FAERS
179	Monoparesis	FAERS: 1		OFFSIDES US FAERS
180	Monoplegia	FAERS: 1		US FAERS
181	Multiple drug overdose intentional	FAERS: 1		US FAERS
182	Mydriasis	FAERS: 1		US FAERS
183	Myocardial Infarction	FAERS: 1		US FAERS
184	Neonatal anuria	FAERS: 1		US FAERS
185	Neonatal disorder	FAERS: 1		US FAERS
186	Neonatal respiratory failure	FAERS: 1		US FAERS
187	Neonatal tachycardia	FAERS: 1		US FAERS
188	Nervousness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
189	Neurological examination abnormal	FAERS: 1		US FAERS
190	Oral administration complication	FAERS: 1		US FAERS
191	PO2 decreased	FAERS: 1		OFFSIDES US FAERS
192	PO2 increased	FAERS: 1		US FAERS
193	Pallor	FAERS: 1		US FAERS
194	Pancreatitis	FAERS: 1		US FAERS
195	Pericardial effusion	FAERS: 1		US FAERS
196	Plasmapheresis	FAERS: 1		US FAERS
197	Pleocytosis	FAERS: 1		US FAERS
198	Poor peripheral circulation	FAERS: 1		US FAERS
199	Post procedural complication	FAERS: 1		US FAERS
200	Pregnancy	FAERS: 1		US FAERS
201	Presyncope	FAERS: 1		US FAERS
202	Product dispensing error	FAERS: 1		US FAERS
203	Product dose omission	FAERS: 1		US FAERS
204	Product label issue	FAERS: 1		US FAERS
205	Product physical issue	FAERS: 1		US FAERS
206	Product taste abnormal	FAERS: 1		US FAERS
207	Product use in unapproved indication	FAERS: 1		US FAERS
208	Quadriplegia	FAERS: 1		US FAERS
209	Rales	FAERS: 1		US FAERS
210	Respiratory arrest	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
211	Sinus bradycardia	FAERS: 1		US FAERS
212	Slow response to stimuli	FAERS: 1		US FAERS
213	Stupor	FAERS: 1		US FAERS
214	Supraventricular tachyarrhythmia	FAERS: 1		US FAERS
215	Syncope	FAERS: 1		US FAERS
216	Therapy cessation	FAERS: 1		US FAERS
217	Therapy change	FAERS: 1		US FAERS
218	Thrombosis	FAERS: 1		US FAERS
219	Tinnitus	FAERS: 1		US FAERS
220	Urinary Retention	FAERS: 1	6187071 7235434 7469216	CTD SIDER US FAERS
221	Urine osmolarity increased	FAERS: 1		US FAERS
222	Vascular occlusion	FAERS: 1		US FAERS
223	Venous angioma of brain	FAERS: 1		US FAERS
224	Vitamin B6 decreased	FAERS: 1		US FAERS
225	Wheelchair user	FAERS: 1		OFFSIDES US FAERS
226	Wrong drug administered	FAERS: 1		US FAERS
227	Wrong technique in product usage process	FAERS: 1		US FAERS
228	treatment failure	FAERS: 1		US FAERS
229	ACTH stimulation test abnormal			OFFSIDES
230	Abdominal sepsis			OFFSIDES
231	Acid reflux			OFFSIDES
232	Acidosis		3769383 6506685	CTD
233	Acne	Canada Vigilance: 1		Canada Vigilance
234	Acute bronchitis			OFFSIDES
235	Acute left ventricular failure			OFFSIDES
236	Acute overdose			SIDER
237	Adenitis			OFFSIDES
238	Agraphia			OFFSIDES
239	Airway Obstruction		8760775	CTD
240	Albuminuria			SIDER
241	Allergy to animal			OFFSIDES
242	Alopecia	Canada Vigilance: 2		Canada Vigilance SIDER
243	Anaphylactic shock			SIDER
244	Anaphylactoid Reaction	Canada Vigilance: 1		Canada Vigilance SIDER
245	Anastomotic stenosis			OFFSIDES
246	Anastomotic ulcer			OFFSIDES
247	Anhidrosis			OFFSIDES
248	Antasthmatic drug level below therapeutic			OFFSIDES
249	Aortic Diseases		2251542	CTD
250	Apnea		View details 22592 683202 718247 723879 4014092 7055114 7398750	CTD
251	Arteritis		8572928 9879811 12180796	CTD
252	Ascites			OFFSIDES
253	Aspiration Pneumonia			OFFSIDES
254	Axillary vein thrombosis			OFFSIDES
255	Benign Prostatic Hyperplasia			OFFSIDES
256	Biliary dilatation			OFFSIDES
257	Blepharospasm			OFFSIDES
258	Blood 1,25-dihydroxycholecalciferol decreased			OFFSIDES
259	Blood amylase increased			OFFSIDES
260	Blood cholesterol			OFFSIDES
261	Blood corticotrophin			OFFSIDES
262	Blood cortisol decreased			OFFSIDES
263	Blood potassium increased			OFFSIDES
264	Blood sodium			OFFSIDES
265	Blood urine present			OFFSIDES
266	Bone Resorption		26851681	CTD
267	Borderline mental impairment			OFFSIDES
268	Bradycardia			OFFSIDES
269	Brain Diseases		8517990	CTD
270	Brain Injuries		10565195	CTD
271	Breast Microcalcification			OFFSIDES
272	Bronchial Obstruction			OFFSIDES
273	Bronchitis, Chronic		18326306	CTD
274	Bronchitis		3025113	CTD OFFSIDES
275	Bruxism			OFFSIDES
276	Bursitis			OFFSIDES
277	Carcinoembryonic antigen increased			OFFSIDES
278	Cardiac Death			OFFSIDES
279	Cardiac Flutter			SIDER
280	Cardiomyopathies		2432914	CTD
281	Cardiovascular Diseases		1835291	CTD
282	Carotid artery occlusion			OFFSIDES
283	Catalepsy		View details 1865993 3167148 9407998 9566031 10199625 10591873 11734184 20713114	CTD
284	Cataract			OFFSIDES
285	Catheter sepsis			OFFSIDES
286	Catheter site infection			OFFSIDES
287	Cellulitis			OFFSIDES
288	Cerebral Hemorrhage		3949080	CTD
289	Cerebral artery occlusion			OFFSIDES
290	Chemotherapeutic drug level increased			OFFSIDES
291	Child Behavior Disorders		1758745	CTD
292	Choking sensation			OFFSIDES
293	Choking			OFFSIDES
294	Chorea		1424400	CTD
295	Chronic Obstructive Airway Disease			OFFSIDES
296	Chronic left ventricular failure			OFFSIDES
297	Clostridium colitis			OFFSIDES
298	Clostridium difficile colitis			OFFSIDES
299	Cocaine-Related Disorders		11927167	CTD
300	Colitis			OFFSIDES
301	Community-Acquired Infections		1541177	CTD
302	Confabulation			OFFSIDES
303	Confusion		637435 3769383 6625253	CTD
304	Cor pulmonale			OFFSIDES
305	Creatinine renal clearance decreased			OFFSIDES
306	Cyanosis			OFFSIDES
307	Deafness Neurosensory			OFFSIDES
308	Delusional disorder, unspecified type			OFFSIDES
309	Demyelination			OFFSIDES
310	Dental abscess			OFFSIDES
311	Depressive disorder		7437783	CTD
312	Dermatitis			SIDER
313	Diabetes			OFFSIDES
314	Diarrhea			OFFSIDES
315	Disease recurrence			OFFSIDES
316	Disruptive, Impulse Control, and Conduct Disorders		6093179	CTD
317	Diuresis			SIDER
318	Double Outlet Right Ventricle		2251542	CTD
319	Drowsiness			OFFSIDES
320	Drug Overdose		View details 108053 10326941 10565195 11605782	CTD
321	Drug Tolerance			OFFSIDES
322	Drug abuser			OFFSIDES
323	Drug addict			OFFSIDES
324	Drug administration error			OFFSIDES
325	Drug withdrawal headache			OFFSIDES
326	Duodenitis			OFFSIDES
327	Dyskinesia, Drug-Induced		6625253	CTD
328	Dyspnea		6858124	CTD
329	Dyspnoea exacerbated			OFFSIDES
330	Dysthymic Disorder			OFFSIDES
331	Dysuria			OFFSIDES
332	Edema		22982570	CTD
333	Embolic stroke			OFFSIDES
334	Emotional disorder			OFFSIDES
335	Endodontic procedure			OFFSIDES
336	Epigastric discomfort			SIDER
337	Epigastric pain			SIDER
338	Epistaxis			OFFSIDES
339	Erectile dysfunction			OFFSIDES
340	Escherichia sepsis			OFFSIDES
341	Esophageal Diseases		12498299	CTD
342	Essential Tremor		1946576	CTD
343	Extravasation of Diagnostic and Therapeutic Materials		11522602	CTD
344	Extravasation			SIDER
345	Facial Neuralgia			OFFSIDES
346	Fever		20940509	CTD
347	Flat affect			OFFSIDES
348	Fluid overload			SIDER
349	Foaming at mouth			OFFSIDES
350	Food craving			OFFSIDES
351	Gastric irritation			SIDER
352	Gastritis	Canada Vigilance: 1		Canada Vigilance
353	Gastrointestinal Diseases		1835291 7826681 9164358	CTD
354	Gastrointestinal Pain			SIDER
355	General physical condition			OFFSIDES
356	Globulinuria			OFFSIDES
357	Glycosuria		718247	CTD
358	Hallucinations		17516267	CTD
359	Heart Block		1874263	CTD
360	Hemorrhage		22982570	CTD
361	Hepatitis, Alcoholic		20578267	CTD
362	House dust allergy			OFFSIDES
363	Hydronephrosis			OFFSIDES
364	Hyperalgesia		7908645	CTD
365	Hyperandrogenism			OFFSIDES
366	Hypercalcemia		3013062 17578191	CTD
367	Hypercalciuria		8407166	CTD
368	Hyperemia		2348231 19496111	CTD
369	Hyperglycemia		718247 1445173 6506685	CTD
370	Hypertrophy		16651698	CTD
371	Hypoaesthesia facial			OFFSIDES
372	Hypokalemia		View details 2596942 2973024 3330186 3408637 3662713 3707814 3940495 6506685 8177851 18724532	CTD
373	Hypokinesia		11734184	CTD
374	Hyponatremia		8177851 12086552	CTD
375	Hypophosphatemia		6506685	CTD
376	Impaired gastric emptying			OFFSIDES
377	Incisional hernia			OFFSIDES
378	Increased bronchial secretion			OFFSIDES
379	Infant, Premature, Diseases		View details 22592 660340 7398750 11605782	CTD
380	Infection			SIDER
381	Inflammation		12065913 12070353	CTD
382	Intention tremor			OFFSIDES
383	Internal injury			OFFSIDES
384	Intestinal infarction			OFFSIDES
385	Intoxication			SIDER
386	Iron Overload			OFFSIDES
387	Joint sprain			OFFSIDES
388	Joint warmth			OFFSIDES
389	Kidney Diseases		View details 7892462 12745095 12836095 16714461	CTD
390	Kidney Failure			OFFSIDES
391	Kidney Neoplasm			OFFSIDES
392	Lethargy		3769383	CTD
393	Lumbar radiculopathy			OFFSIDES
394	Lung Diseases, Obstructive		7053695	CTD
395	Lung Neoplasms		17459420	CTD
396	Lymphangioma			OFFSIDES
397	Male sexual dysfunction			OFFSIDES
398	Malignant neoplasm progression			OFFSIDES
399	Memory Disorders		15351080	CTD
400	Metabolic Diseases		15012710	CTD
401	Mitral valve sclerosis			OFFSIDES
402	Mood Disorders		3537092	CTD
403	Mouth Breathing			OFFSIDES
404	Multifocal atrial tachycardia			SIDER
405	Murine Acquired Immunodeficiency Syndrome		11694023	CTD
406	Muscle Rigidity		8865732	CTD
407	Myelodysplasia			OFFSIDES
408	Myocardial Ischemia		3257531	CTD
409	Myoglobinuria		8865732	CTD
410	Neoplasm Metastasis		11095404	CTD
411	Neoplasms, Experimental		11095404	CTD
412	Nervous tension			OFFSIDES
413	Neutropenic infection			OFFSIDES
414	Nicotine Dependence			OFFSIDES
415	Nocturia			OFFSIDES
416	Non-cardiac chest pain			OFFSIDES
417	Obsessive thoughts			OFFSIDES
418	Obstruction			OFFSIDES
419	Olfaction Disorders		9754114	CTD
420	Oliguria		15840666	CTD OFFSIDES
421	Onycholysis			OFFSIDES
422	Oropharyngeal pain			OFFSIDES
423	Pain			OFFSIDES
424	Pancreatic Pseudocyst			OFFSIDES
425	Paranoia			OFFSIDES
426	Pathogen resistance			OFFSIDES
427	Penile Diseases		8745169	CTD
428	Peptic Ulcer			SIDER
429	Periodontitis			OFFSIDES
430	Persistent vomiting			SIDER
431	Phlebitis			SIDER
432	Pneumoconiosis			OFFSIDES
433	Polysubstance dependence			OFFSIDES
434	Postictal headache			OFFSIDES
435	Prenatal Exposure Delayed Effects		2251542	CTD
436	Procedural complication			OFFSIDES
437	Product residue present	Canada Vigilance: 1		Canada Vigilance
438	Productive Cough			OFFSIDES
439	Pruritus	Canada Vigilance: 2		Canada Vigilance SIDER
440	Psychiatric symptom			OFFSIDES
441	Psychomotor Agitation		6288396	CTD
442	Pulmonary Hypertension			OFFSIDES
443	Pulmonary congestion			OFFSIDES
444	Pulmonary function test decreased			SIDER
445	Radicular pain			OFFSIDES
446	Rectal Prolapse			OFFSIDES
447	Rectal polyp			OFFSIDES
448	Renal Insufficiency		3494838	CTD
449	Renal cyst			OFFSIDES
450	Reperfusion Injury		16410406	CTD
451	Respiration Disorders		2636852	CTD
452	Respiratory Depression			SIDER
453	Respiratory Paralysis		12821393	CTD
454	Restrictive pulmonary disease			OFFSIDES
455	Rhinitis			OFFSIDES
456	Rhonchi			OFFSIDES
457	Seizures		View details 237450 637435 1312320 1438500 1676814 1866026 1901667 2079649 2087497 2222089 2496015 2600817 2623258 2786601 2965587 2969553 3177989 3188359 3225766 3494838 3626650 3723646 3922683 3994071 6646925 6858124 7148765 7270562 7824546 8007033 8046614 8048709 8179767 8192750 8346082 8437130 8540225 8799489 9294318 9339868 9717943 10211593 10230855 10326941 10401785 10819670 10874349 10916367 11734184 16715938 17072109 17671412 17784538 18279214 18326306 18520175 19589454 20940509	CTD
458	Sensation of blood flow			OFFSIDES
459	Sequestrectomy			OFFSIDES
460	Shoulder Pain			OFFSIDES
461	Sinus headache			OFFSIDES
462	Sinusitis			OFFSIDES
463	Sleep Wake Disorders		1776216 2520495	CTD
464	Sneezing		2417477 2431021	CTD
465	Spasm		9658871	CTD
466	Sphincter of Oddi Dysfunction		9658871	CTD
467	Spinal Cord Injuries		12426040 12821393 14992338	CTD
468	Spinal column stenosis			OFFSIDES
469	Splenomegaly		11694023	CTD
470	Sputum retention			OFFSIDES
471	Stevens-Johnson Syndrome			OFFSIDES
472	Stomatitis	Canada Vigilance: 1		Canada Vigilance
473	Stridor			OFFSIDES
474	Stuttering		7312482 7882883 9756159	CTD
475	Substance Withdrawal Syndrome		7055114	CTD
476	Sudden death			OFFSIDES
477	Suture rupture			OFFSIDES
478	Tachycardia, Paroxysmal		660340	CTD
479	Tenosynovitis			OFFSIDES
480	Tension			SIDER
481	Tetany			OFFSIDES
482	Thoracic vertebral fracture			OFFSIDES
483	Thrombosis in device			OFFSIDES
484	Tolosa-Hunt Syndrome			OFFSIDES
485	Transposition of Great Vessels		2251542	CTD
486	Underweight			OFFSIDES
487	Urinary Incontinence		3769383	CTD
488	Uterine Cancer			OFFSIDES
489	Venous Thrombosis			SIDER
490	Vestibular Neuronitis			OFFSIDES
491	Visual disturbance			OFFSIDES
492	Vulvovaginal mycotic infection			OFFSIDES
493	Walking aid user			OFFSIDES
494	Weight Gain			OFFSIDES
495	angiogram			OFFSIDES

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