MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Triamterene

(FNYLWPVRPXGIIP-UHFFFAOYSA-N)

Structure

SMILES: Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
Type(s): Approved
ATC code(s): C03DB02
Molecular Formula:: C12H11N7
Molecular Weight:: 253.263
Log P:: 2.5770
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 3
TPSA:: 129.62
CAS Number(s):: 396-01-0

Synonym(s)

Triamterene

Dyrenium

Dytac

Urocaudal

External Link(s)

MeSH	D014223
PubChem Compound	5546
BindingDB	6644
ChEBI	9671
CHEMBL	CHEMBL585
DrugBank	DB00384
DrugCentral	2728
IUPHAR/BPS Guide to PHARMACOLOGY	4329
KEGG	dr:D00386
Therapeutic Target Database	D00NKB
ZINC	120286

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Blood creatinine increased	FAERS: 2		OFFSIDES US FAERS
2	Anisocytosis	FAERS: 1		US FAERS
3	Blood lactate dehydrogenase increased	FAERS: 1		US FAERS
4	Drug effect incomplete	FAERS: 1		US FAERS
5	Electrocardiogram abnormal	FAERS: 1		US FAERS
6	Erythema	FAERS: 1		US FAERS
7	Flushing	FAERS: 1		US FAERS
8	Nephrolithiasis	FAERS: 1	View details 496113 2231920 2496337 2903714 3728117 3958920 6515076 7230485 7265370 7301028 7356247	CTD SIDER US FAERS
9	Pallor	FAERS: 1		US FAERS
10	Palmar erythema	FAERS: 1		US FAERS
11	Pancytopenia	FAERS: 1		US FAERS
12	Poikilocytosis	FAERS: 1		US FAERS
13	Sunburn	FAERS: 1		US FAERS
14	Urticaria	FAERS: 1		US FAERS
15	jaundice	FAERS: 1		SIDER US FAERS
16	Abasia			OFFSIDES
17	Abdominal Pain			OFFSIDES
18	Abdominal discomfort			OFFSIDES
19	Abscess			OFFSIDES
20	Accidental exposure			OFFSIDES
21	Accidental needle stick			OFFSIDES
22	Accidental overdose			OFFSIDES
23	Acid reflux			OFFSIDES
24	Activities of daily living impaired			OFFSIDES
25	Acute Coronary Syndrome			OFFSIDES
26	Acute bronchitis			OFFSIDES
27	Acute endocarditis			OFFSIDES
28	Acute interstitial nephritis			SIDER
29	Acute kidney injury		View details 493878 3727353 4000350 6589647 6949485	CTD
30	Acute myocardial infarction			OFFSIDES
31	Acute respiratory failure			OFFSIDES
32	Adrenal mass			OFFSIDES
33	Adverse event	Canada Vigilance: 1		Canada Vigilance OFFSIDES
34	Agraphia			OFFSIDES
35	Alveolitis			OFFSIDES
36	Alveoloplasty			OFFSIDES
37	Amenorrhea			OFFSIDES
38	Amnesia			OFFSIDES
39	Anaphylactic shock			SIDER
40	Anemia, Megaloblastic		313333 5455994 16187172	CTD
41	Angiodysplasia			OFFSIDES
42	Anhedonia			OFFSIDES
43	Animal scratch			OFFSIDES
44	Ankle Fracture			OFFSIDES
45	Anorexia			OFFSIDES
46	Anoxia			OFFSIDES
47	Anxiety			OFFSIDES
48	Aortic Aneurysm			OFFSIDES
49	Arteriosclerosis			OFFSIDES
50	Arteriovenous fistula site complication			OFFSIDES
51	Arthritis			OFFSIDES
52	Arthropathy			OFFSIDES
53	Ascites		6476994	CTD
54	Asthenia			OFFSIDES SIDER
55	Asymptomatic bacteriuria			OFFSIDES
56	Atelectasis			OFFSIDES
57	Atherosclerosis			OFFSIDES
58	Atrial Flutter			OFFSIDES
59	Atrial natriuretic peptide increased			OFFSIDES
60	Atrial tachycardia			OFFSIDES
61	Aura			OFFSIDES
62	Back disorder			OFFSIDES
63	Band neutrophil count increased			OFFSIDES
64	Basal cell carcinoma			OFFSIDES
65	Benign Prostatic Hyperplasia			OFFSIDES
66	Bladder prolapse			OFFSIDES
67	Blood Glucose			OFFSIDES
68	Blood amylase decreased			OFFSIDES
69	Blood blister			OFFSIDES
70	Blood chloride decreased			OFFSIDES
71	Blood cholesterol			OFFSIDES
72	Blood creatinine decreased			OFFSIDES
73	Blood insulin			OFFSIDES
74	Blood magnesium decreased			OFFSIDES
75	Blood phosphorus decreased			OFFSIDES
76	Blood potassium decreased			OFFSIDES
77	Blood potassium increased			OFFSIDES
78	Blood potassium			OFFSIDES
79	Blood sodium			OFFSIDES
80	Blood triglycerides increased			OFFSIDES
81	Blood urea increased			OFFSIDES SIDER
82	Blurred vision			OFFSIDES
83	Bone marrow depression			OFFSIDES
84	Bradycardia			OFFSIDES
85	Brain natriuretic peptide increased			OFFSIDES
86	Breast Cyst			OFFSIDES
87	Breast cancer recurrent			OFFSIDES
88	Breast tenderness			OFFSIDES
89	Bronchitis			OFFSIDES
90	Bruxism			OFFSIDES
91	Burning sensation			OFFSIDES
92	Bursitis			OFFSIDES
93	Carcinoma in situ of skin			OFFSIDES
94	Cardiac Death			OFFSIDES
95	Cardiac stress test abnormal			OFFSIDES
96	Cardiac valve sclerosis			OFFSIDES
97	Cardioactive drug level above therapeutic			OFFSIDES
98	Cardioactive drug level increased			OFFSIDES
99	Carotidynia			OFFSIDES
100	Cataract operation			OFFSIDES
101	Cataract			OFFSIDES
102	Catheter site infection			OFFSIDES
103	Cellulitis			OFFSIDES
104	Cervicobrachial syndrome			OFFSIDES
105	Chest Pain			OFFSIDES
106	Chills	Canada Vigilance: 1		Canada Vigilance
107	Choking sensation			OFFSIDES
108	Choking			OFFSIDES
109	Chondromalacia			OFFSIDES
110	Chondroplasty			OFFSIDES
111	Chronic Obstructive Airway Disease			OFFSIDES
112	Chronic respiratory failure			OFFSIDES
113	Chronic sinusitis			OFFSIDES
114	Circumstance or information capable of leading to medication error			OFFSIDES
115	Coagulation factor VIII level increased			OFFSIDES
116	Cold sweat			OFFSIDES
117	Compression fracture			OFFSIDES
118	Concomitant disease progression			OFFSIDES
119	Confabulation			OFFSIDES
120	Congenital tricuspid valve incompetence			OFFSIDES
121	Conjunctival deposit			OFFSIDES
122	Croup infectious			OFFSIDES
123	Culture positive			OFFSIDES
124	Debridement			OFFSIDES
125	Demyelination			OFFSIDES
126	Dermatitis			SIDER
127	Diabetes			OFFSIDES
128	Diabetic Nephropathy			OFFSIDES
129	Diaphragmatic Hernia			OFFSIDES
130	Diarrhea			OFFSIDES
131	Disease complication			OFFSIDES
132	Disease recurrence			OFFSIDES
133	Diverticular perforation			OFFSIDES
134	Diverticulum			OFFSIDES
135	Dizziness			OFFSIDES SIDER
136	Drowsiness			OFFSIDES
137	Drug administration error			OFFSIDES
138	Drug dispensing error			OFFSIDES
139	Drug screen positive			OFFSIDES
140	Drug toxicity			OFFSIDES
141	Drug withdrawal headache			OFFSIDES
142	Dry skin			OFFSIDES
143	Duodenal Ulcer			OFFSIDES
144	Duodenitis			OFFSIDES
145	Dysgeusia	Canada Vigilance: 1		Canada Vigilance
146	Dyspepsia			OFFSIDES
147	Dysphonia			OFFSIDES
148	Ear discomfort			OFFSIDES
149	Early satiety			OFFSIDES
150	Economic problem			OFFSIDES
151	Ejection Fraction Decreased			OFFSIDES
152	Electrocardiogram ST-T change			OFFSIDES
153	Electrocardiogram ST-T segment abnormal			OFFSIDES
154	Electromechanical dissociation			OFFSIDES
155	Emotional disorder			OFFSIDES
156	Emotional distress			OFFSIDES
157	Encephalomalacia			OFFSIDES
158	Endometrial hypertrophy			OFFSIDES
159	Enterocele			OFFSIDES
160	Enuresis			OFFSIDES
161	Episcleritis			OFFSIDES
162	Epistaxis			OFFSIDES
163	Eschar			OFFSIDES
164	Escherichia infection			OFFSIDES
165	Escherichia urinary tract infection			OFFSIDES
166	Exfoliative rash	Canada Vigilance: 1		Canada Vigilance
167	Expired drug administered			OFFSIDES
168	Eye Infection			OFFSIDES
169	Eye pain			OFFSIDES
170	Facial Neuralgia			OFFSIDES
171	Fatigue			OFFSIDES SIDER
172	Feeling abnormal			OFFSIDES
173	Feelings of worthlessness			OFFSIDES
174	Flank Pain			OFFSIDES
175	Flatulence			OFFSIDES
176	Fluid overload			OFFSIDES
177	Foaming at mouth			OFFSIDES
178	Gambling			OFFSIDES
179	Gastroduodenitis			OFFSIDES
180	Gastrointestinal infection			OFFSIDES
181	Gastrointestinal inflammation			OFFSIDES
182	Genital Herpes			OFFSIDES
183	Gingival erythema			OFFSIDES
184	Glaucoma			OFFSIDES
185	Globulinuria			OFFSIDES
186	Glossitis			OFFSIDES
187	Gout			OFFSIDES
188	Graft infection			OFFSIDES
189	Granulocytosis			OFFSIDES
190	Hallucinations, mixed			OFFSIDES
191	Hay fever			OFFSIDES
192	Headache	Canada Vigilance: 1		Canada Vigilance SIDER
193	Hemiparesis			OFFSIDES
194	Heparin-induced thrombocytopenia			OFFSIDES
195	Hydronephrosis			OFFSIDES
196	Hyperkeratosis			OFFSIDES
197	Hyperparathyroidism			OFFSIDES
198	Hypersensitivity			SIDER
199	Hypertensive heart disease			OFFSIDES
200	Hyperventilation			OFFSIDES
201	Hypokalemia		View details 2209135 2596940 3045028 3727353 6195908	CTD
202	Hypokalemic periodic paralysis		7031501	CTD
203	Impaired gastric emptying			OFFSIDES
204	Inappropriate schedule of drug administration			OFFSIDES
205	Incoherent			OFFSIDES
206	Incontinence			OFFSIDES
207	Incorrect dose administered			OFFSIDES
208	Incorrect drug administration duration			OFFSIDES
209	Infection			OFFSIDES
210	Infusion site mobility decreased			OFFSIDES
211	Injection site stinging			OFFSIDES
212	Intentional drug misuse			OFFSIDES
213	Intermittent Claudication			OFFSIDES
214	Intervertebral Disc Degeneration			OFFSIDES
215	Intervertebral disc disorder			OFFSIDES
216	Intestinal Perforation			OFFSIDES
217	Intracranial Aneurysm			OFFSIDES
218	Intraocular pressure test			OFFSIDES
219	Irreversible renal failure			SIDER
220	Joint prosthesis user			OFFSIDES
221	Kidney Calculi		View details 2321916 3999199 4057369 7037980 7144994	CTD
222	Kidney Diseases		19761811	CTD
223	Laceration			OFFSIDES
224	Latex allergy			OFFSIDES
225	Lethargy			OFFSIDES
226	Lichenification			OFFSIDES
227	Life expectancy shortened			OFFSIDES
228	Limb discomfort			OFFSIDES
229	Lip exfoliation			OFFSIDES
230	Lipase			OFFSIDES
231	Liver neoplasms		25058030	CTD
232	Lumbar spine flattening			OFFSIDES
233	Lymphoma			OFFSIDES
234	Malaise	Canada Vigilance: 3		Canada Vigilance
235	Mastication disorder			OFFSIDES
236	Meniscus removal			OFFSIDES
237	Mental impairment			OFFSIDES
238	Mental status changes			OFFSIDES
239	Metastatic uterine cancer			OFFSIDES
240	Middle insomnia			OFFSIDES
241	Migraine with Aura			OFFSIDES
242	Mononeuritis			OFFSIDES
243	Morbid thoughts			OFFSIDES
244	Multiple Myeloma			OFFSIDES
245	Multiple Sclerosis			OFFSIDES
246	Multiple allergies			OFFSIDES
247	Muscle tightness			OFFSIDES
248	Musculoskeletal Pain			OFFSIDES
249	Musculoskeletal chest pain			OFFSIDES
250	Musculoskeletal stiffness			OFFSIDES
251	Nasal discomfort			OFFSIDES
252	Nausea	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
253	Nephritis, Interstitial		6119586 6339355	CTD
254	Nervousness	Canada Vigilance: 1		Canada Vigilance
255	Neuralgia			OFFSIDES
256	Neurodermatitis			OFFSIDES
257	Nocturia			OFFSIDES
258	Nodule			OFFSIDES
259	Non-cardiac chest pain			OFFSIDES
260	Ocular vascular disorder			OFFSIDES
261	Open reduction of fracture			OFFSIDES
262	Open wound			OFFSIDES
263	Oral polypectomy			OFFSIDES
264	Oral torus			OFFSIDES
265	Osteolysis			OFFSIDES
266	Osteomyelitis			OFFSIDES
267	Osteopenia			OFFSIDES
268	Osteoporosis			OFFSIDES
269	Osteosclerosis			OFFSIDES
270	Overdose			OFFSIDES
271	Pain			OFFSIDES
272	Pancreatobiliary sphincterotomy			OFFSIDES
273	Pedal pulse decreased			OFFSIDES
274	Pelvic fluid collection			OFFSIDES
275	Penile size reduced			OFFSIDES
276	Periarthritis			OFFSIDES
277	Periodontitis			OFFSIDES
278	Petechiae	Canada Vigilance: 1		Canada Vigilance
279	Pharmaceutical product complaint			OFFSIDES
280	Physical disability			OFFSIDES
281	Plasmacytosis			OFFSIDES
282	Polymenorrhea			OFFSIDES
283	Polyuria			OFFSIDES
284	Poor personal hygiene			OFFSIDES
285	Post procedural complication			OFFSIDES
286	Postoperative ileus			OFFSIDES
287	Postoperative infection			OFFSIDES
288	Primary sequestrum			OFFSIDES
289	Product substitution issue	Canada Vigilance: 1		Canada Vigilance
290	Prostatism			OFFSIDES
291	Pulmonary Hypertension			OFFSIDES
292	Pulmonary congestion			OFFSIDES
293	Pulmonary function test decreased			OFFSIDES
294	Punctate keratitis			OFFSIDES
295	Purpura	Canada Vigilance: 1		Canada Vigilance
296	Purulent discharge			OFFSIDES
297	QRS axis abnormal			OFFSIDES
298	Radiation Pneumonitis			OFFSIDES
299	Rales			OFFSIDES
300	Renal Insufficiency		1819215 6339355	CTD
301	Renal cyst			OFFSIDES
302	Respiratory tract irritation			OFFSIDES
303	Rhinitis			OFFSIDES
304	Schizoaffective Disorder			OFFSIDES
305	Scleritis			OFFSIDES
306	Sick Sinus Syndrome			OFFSIDES
307	Sinus bradycardia			OFFSIDES
308	Sinus headache			OFFSIDES
309	Sinus operation			OFFSIDES
310	Sinus polyp			OFFSIDES
311	Sinusitis			OFFSIDES
312	Skin Induration			OFFSIDES
313	Skin laceration			OFFSIDES
314	Skin lesion			OFFSIDES
315	Skin tightness			OFFSIDES
316	Snoring			OFFSIDES
317	Spinal column stenosis			OFFSIDES
318	Spinal haemangioma			OFFSIDES
319	Spirometry abnormal			OFFSIDES
320	Splenic cyst			OFFSIDES
321	Squamous cell carcinoma of skin			OFFSIDES
322	Stasis dermatitis			OFFSIDES
323	Submandibular mass			OFFSIDES
324	Sudden Cardiac Death			OFFSIDES
325	Sudden death			OFFSIDES
326	Superficial spreading melanoma stage I			OFFSIDES
327	Supraventricular tachycardia			OFFSIDES
328	Swelling	Canada Vigilance: 1		Canada Vigilance
329	Synovial Cyst			OFFSIDES
330	Systolic hypertension			OFFSIDES
331	Tardive Dyskinesia			OFFSIDES
332	Temperature regulation disorder			OFFSIDES
333	Tenosynovitis			OFFSIDES
334	Terminal state			OFFSIDES
335	Therapeutic reaction time decreased			OFFSIDES
336	Therapy non-responder			OFFSIDES
337	Thrombocytopenia	Canada Vigilance: 1		Canada Vigilance SIDER
338	Thrombophlebitis			OFFSIDES
339	Tinnitus			OFFSIDES
340	Tobacco user			OFFSIDES
341	Toe operation			OFFSIDES
342	Tongue biting			OFFSIDES
343	Tooth Extraction			OFFSIDES
344	Tooth Loss			OFFSIDES
345	Umbilical hernia			OFFSIDES
346	Unevaluable event			OFFSIDES
347	Unresponsive to stimuli			OFFSIDES
348	Urethral Stenosis			OFFSIDES
349	Urinary Calculi		6139048	CTD
350	Urinary tract infection pseudomonal			OFFSIDES
351	Urolithiasis		3946031	CTD
352	Uterine Polyp			OFFSIDES
353	Uterine Prolapse			OFFSIDES
354	Uterine stenosis			OFFSIDES
355	Vascular insufficiency			OFFSIDES
356	Venous Insufficiency			OFFSIDES
357	Ventricular Fibrillation			OFFSIDES
358	Viral pharyngitis			OFFSIDES
359	Visual disturbance			OFFSIDES
360	Vitreous Detachment			OFFSIDES
361	Vomiting			SIDER
362	Vulvovaginal pruritus			OFFSIDES
363	Weight Gain			OFFSIDES
364	Xanthopsia			OFFSIDES
365	kyphosis			OFFSIDES
366	prostatitis			OFFSIDES

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