MetaADEDB 2.0 @ LMMD
Chloroquine
(WHTVZRBIWZFKQO-UHFFFAOYSA-N)
Structure
SMILES
CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC
Type(s)
Approved; Investigational; Vet_approved
ATC code(s)
P01BA01
Molecular Formula:
C18H26ClN3
Molecular Weight:
319.872
Log P:
4.8836
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
28.16
CAS Number(s):
54-05-7; 19851
Synonym(s)
1.
Chloroquine
2.
Aralen
3.
Arechine
4.
Arequin
5.
Chingamin
6.
Chlorochin
7.
Chloroquine Sulfate
8.
Chloroquine Sulphate
9.
Khingamin
10.
Nivaquine
11.
Sulfate, Chloroquine
12.
Sulphate, Chloroquine
External Link(s)
MeSHD002738
PubChem Compound2719
BindingDB22985
ChEBI3638
CHEMBLCHEMBL76
DrugBankDB00608
DrugCentral607
IUPHAR/BPS Guide to PHARMACOLOGY5535
KEGGcpd:C07625
dr:D02366
Therapeutic Target DatabaseD09EGZ
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Toxicity to various agentsFAERS: 10US FAERS
2CardiotoxicityFAERS: 7OFFSIDES
US FAERS
3FatigueFAERS: 5
Canada Vigilance: 2		1628552CTD
Canada Vigilance
US FAERS
4VomitingFAERS: 5
Canada Vigilance: 1		4603136CTD
SIDER
Canada Vigilance
US FAERS
5DizzinessFAERS: 41628552CTD
US FAERS
6PallorFAERS: 4US FAERS
7SyncopeFAERS: 4

View details

1628552
4441014
4719849
9523387
11966675
12163948
 		CTD
US FAERS
8Ventricular hypertrophyFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
9Visual ImpairmentFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
10Abdominal PainFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
11BlindnessFAERS: 31628552
5090782		CTD
US FAERS
12Cardiac ArrestFAERS: 3US FAERS
13NauseaFAERS: 3
Canada Vigilance: 3		12962582CTD
SIDER
Canada Vigilance
US FAERS
14Optic AtrophyFAERS: 3US FAERS
15Retinal toxicityFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
16Accidental overdoseFAERS: 2US FAERS
17Acute kidney injuryFAERS: 2
Canada Vigilance: 2

View details

734759
4794122
7325735
15526909
17076682
 		CTD
Canada Vigilance
US FAERS
18Angina PectorisFAERS: 2US FAERS
19Atrioventricular BlockFAERS: 2

View details

1535141
3576825
3627179
9523387
10381062
12163948
12407800
16527175
17150283
17202178
17590456
18692276
 		CTD
US FAERS
20Bifascicular blockFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
21Blood magnesium decreasedFAERS: 2US FAERS
22Blood potassium decreasedFAERS: 2US FAERS
23BradycardiaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
24Brain DeathFAERS: 2US FAERS
25Disseminated Intravascular CoagulationFAERS: 2US FAERS
26Drug ineffectiveFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
27HypotensionFAERS: 2

View details

3054558
4603136
8453873
11966675
 		CTD
SIDER
US FAERS
28HypoxiaFAERS: 22290474CTD
US FAERS
29Intentional self-injuryFAERS: 2US FAERS
30Macular pigmentationFAERS: 2US FAERS
31MalaiseFAERS: 2US FAERS
32ParanoiaFAERS: 2US FAERS
33Retinal pigment epitheliopathyFAERS: 2US FAERS
34ScotomaFAERS: 23857780
18974527		CTD
OFFSIDES
SIDER
US FAERS
35Transaminases increasedFAERS: 2US FAERS
36Ventricular FibrillationFAERS: 22290474
9604078		CTD
US FAERS
37AgitationFAERS: 1SIDER
US FAERS
38Blood creatine phosphokinase increasedFAERS: 1US FAERS
39Blood pH decreasedFAERS: 1US FAERS
40BronchitisFAERS: 1US FAERS
41CardiomegalyFAERS: 111245140CTD
US FAERS
42Chest PainFAERS: 1US FAERS
43ChillsFAERS: 1US FAERS
44Depressed Level of ConsciousnessFAERS: 1US FAERS
45Diabetes MellitusFAERS: 1US FAERS
46Drug toxicityFAERS: 1US FAERS
47Electroencephalogram abnormalFAERS: 1US FAERS
48Hallucinations, mixedFAERS: 1OFFSIDES
US FAERS
49HypersensitivityFAERS: 1US FAERS
50Impaired work abilityFAERS: 1US FAERS
51IncoherentFAERS: 1US FAERS
52Intentional product misuseFAERS: 1US FAERS
53Joint swellingFAERS: 1US FAERS
54KeratopathyFAERS: 1US FAERS
55Kidney congestionFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
56LeukopeniaFAERS: 1US FAERS
57Maternal exposure during pregnancyFAERS: 1US FAERS
58Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
59Musculoskeletal PainFAERS: 1US FAERS
60Myasthenic SyndromeFAERS: 1US FAERS
61Myocardial InfarctionFAERS: 1US FAERS
62MyopathyFAERS: 1SIDER
US FAERS
63NeutropeniaFAERS: 1SIDER
US FAERS
64Ocular ToxicityFAERS: 1US FAERS
65Optic NeuritisFAERS: 1US FAERS
66OtotoxicityFAERS: 1OFFSIDES
US FAERS
67OverdoseFAERS: 1US FAERS
68Oxygen saturation abnormalFAERS: 1US FAERS
69PainFAERS: 11029911
9523387		CTD
OFFSIDES
US FAERS
70Pathogen resistanceFAERS: 1US FAERS
71Plasmodium falciparum infectionFAERS: 1US FAERS
72Post-Traumatic Stress DisorderFAERS: 1US FAERS
73Product use issueFAERS: 1US FAERS
74RalesFAERS: 1OFFSIDES
US FAERS
75Retinal depigmentationFAERS: 1US FAERS
76Sinus TachycardiaFAERS: 1US FAERS
77Skin lesionFAERS: 1OFFSIDES
US FAERS
78StrabismusFAERS: 1US FAERS
79TachycardiaFAERS: 1US FAERS
80TinnitusFAERS: 1SIDER
US FAERS
81TremorFAERS: 1US FAERS
82Troponin increasedFAERS: 1US FAERS
83Urinary IncontinenceFAERS: 1US FAERS
84VertigoFAERS: 1US FAERS
85Visual acuity tests abnormalFAERS: 1US FAERS
86VitiligoFAERS: 1US FAERS
87Weight decreasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
88White blood cell morphology abnormalFAERS: 1US FAERS
89AbasiaOFFSIDES
90Abdominal Compartment SyndromeOFFSIDES
91Abdominal CrampsSIDER
92Abdominal discomfortCanada Vigilance: 1Canada Vigilance
93Abnormal visionOFFSIDES
94Abnormalities, Drug-Induced8638253CTD
95Acute psychosisOFFSIDES
96AgranulocytosisSIDER
97Alanine Aminotransferase IncreasedOFFSIDES
98Albumin globulin ratio abnormalOFFSIDES
99AlopeciaOFFSIDES
SIDER
100Altered state of consciousnessOFFSIDES
101Amnesia2266380CTD
OFFSIDES
102AmphetaminesOFFSIDES
103Anaphylactic shockSIDER
104Anaphylactoid ReactionSIDER
105Anemia, Hemolytic4794122CTD
106Anemia, Megaloblastic18057166CTD
107Angioedema18343736CTD
SIDER
108Angle Closure GlaucomaOFFSIDES
109AnisocoriaOFFSIDES
110AnorexiaSIDER
111Antiviral drug level above therapeuticOFFSIDES
112AnuriaOFFSIDES
113AnxietySIDER
114ApathyOFFSIDES
115Arthritis12954536CTD
OFFSIDES
116ArthropathyOFFSIDES
117AscitesOFFSIDES
118AstheniaOFFSIDES
SIDER
119Atrial FibrillationCanada Vigilance: 2Canada Vigilance
120Auricular swellingOFFSIDES
121Bacteria stool identifiedOFFSIDES
122Basal Ganglia Diseases457222CTD
123Bipolar Disorder1888972
8175247
19555804		CTD
124Bipolar I disorderOFFSIDES
125Blood brain barrier defectOFFSIDES
126Blood chloride decreasedOFFSIDES
127Blood creatinine decreasedOFFSIDES
128Blood human chorionic gonadotropin increasedOFFSIDES
129Blood immunoglobulin EOFFSIDES
130Blood sodiumOFFSIDES
131Blood uric acidOFFSIDES
132Bone erosionOFFSIDES
133Bone painOFFSIDES
134Brain AbscessOFFSIDES
135Brain Diseases11245140CTD
136Breast discomfortOFFSIDES
137BronchopneumopathyOFFSIDES
138Bullous impetigoOFFSIDES
139Bullous lung diseaseOFFSIDES
140Bundle-Branch Block1628552
17202178		CTD
141Carcinoma, Ehrlich Tumor24751611CTD
142Cardiomyopathies

View details

920266
3796692
3826099
4253656
7886019
8281631
12163948
12407800
16923761
18061791
 		CTD
143Catalepsy8005645CTD
144CellulitisOFFSIDES
145Cerebellar AtaxiaOFFSIDES
146Cerebral ArteriosclerosisOFFSIDES
147Cerebral atrophyOFFSIDES
148Cerebral ventricle dilatationOFFSIDES
149Chemical and Drug Induced Liver Injury22331495
23607047		CTD
150Chemotherapeutic drug level increasedOFFSIDES
151Choking sensationOFFSIDES
152CholangiolitisOFFSIDES
153ChromaturiaOFFSIDES
154Coagulation factor VIII level decreasedOFFSIDES
155Cogwheel RigidityOFFSIDES
156ConfabulationOFFSIDES
157Connective Tissue Diseases2831692
19560616		CTD
158Corneal Diseases5229994
11245140		CTD
159Corneal OpacitySIDER
160Corneal abscessOFFSIDES
161Creutzfeldt-Jakob diseaseOFFSIDES
162CystOFFSIDES
163Cytolytic hepatitisOFFSIDES
164Deafness NeurosensorySIDER
165Delirium12493616CTD
SIDER
166Demyelinating Diseases2831692CTD
167Depressive disorder12493616CTD
168DermabrasionOFFSIDES
169Dermatitis, Photoallergic18170732CTD
170Dermatitis10612109CTD
171Device FailureOFFSIDES
172Device dislocationOFFSIDES
173Device migrationOFFSIDES
174Device related infectionOFFSIDES
175DiarrheaOFFSIDES
176Diplopia5229994CTD
177Disease recurrenceOFFSIDES
178Drug Overdose1774400CTD
179Dry skinOFFSIDES
180Dyspnea1628552CTD
181Dystonia3371193CTD
182Ear Diseases8638253CTD
183Ejection fraction abnormalOFFSIDES
184Electrocardiogram QRS complexSIDER
185Electrocardiogram changeSIDER
186EndophthalmitisOFFSIDES
187EosinophiliaSIDER
188EpilepsyOFFSIDES
189Erythema MultiformeSIDER
190ErythemaOFFSIDES
191Eye InfectionOFFSIDES
192Factor V Leiden mutationOFFSIDES
193Fatty Liver3965448
19393257		CTD
OFFSIDES
194Febrile NeutropeniaOFFSIDES
195Febrile bone marrow aplasiaOFFSIDES
196Feeling ColdOFFSIDES
197Feeling abnormalSIDER
198Fetal Growth Retardation8638253
19393257		CTD
199Gait Disorders, Neurologic3361992CTD
200Gamma-Glutamyltransferase IncreasedOFFSIDES
201Gastric ulcerOFFSIDES
202Gastrointestinal Diseases11130385
12170684		CTD
203General physical health deteriorationOFFSIDES
204Gingival graftOFFSIDES
205Glioblastoma15727424CTD
206GoiterOFFSIDES
207GranulocytosisOFFSIDES
208GranulomaOFFSIDES
209Hallucinations7310924CTD
210HeadacheCanada Vigilance: 1851793
12962582		CTD
SIDER
Canada Vigilance
211Hearing Loss851793CTD
212Heart Block

View details

2764802
3796692
7398569
8253245
9922366
10172409
10874768
11245140
15846170
16804295
19560616
 		CTD
213Heart Diseases9632091
12361838		CTD
214Heart failure

View details

1535141
1628552
3796692
9922366
14761774
15846170
16804295
19784824
23274061
 		CTD
215Hepatitis ACanada Vigilance: 1Canada Vigilance
216HepatitisCanada Vigilance: 15694600CTD
SIDER
Canada Vigilance
217HepatotoxicityOFFSIDES
218HydronephrosisOFFSIDES
219Hypercalcemia10638776CTD
220HyperkeratosisOFFSIDES
221Hyperpigmentation9523387
11245140		CTD
222HypochondriasisOFFSIDES
223Hypoglycemia8162653CTD
224Hypokalemia7564673
16142151		CTD
225HyporeflexiaOFFSIDES
226Hypotension, Orthostatic3125918CTD
227Iatrogenic injuryOFFSIDES
228Iliac artery occlusionOFFSIDES
229Increased upper airway secretionOFFSIDES
230Inflammation2051527CTD
231Injection site cellulitisOFFSIDES
232Intermittent ClaudicationOFFSIDES
233Intermittent headacheSIDER
234JC virus infectionOFFSIDES
235Keratitis5297866CTD
236Kidney FailureOFFSIDES
237LegionellaOFFSIDES
238Leprosy9715604CTD
239LethargyCanada Vigilance: 2Canada Vigilance
240Lichen PlanusSIDER
241Liver Abscess, Amebic38383
4603136		CTD
242Long QT Syndrome16178046
17590456		CTD
243Low set earsOFFSIDES
244Lupus Erythematosus, Cutaneous7873836CTD
245Lupus Erythematosus, Discoid

View details

3796692
5297866
10381062
16804295
18692276
 		CTD
246Lupus Erythematosus, Systemic

View details

1828574
4076494
7873836
9922366
11245140
11966675
12361838
12739036
14740170
15846170
17590456
18692276
 		CTD
247Lupus pneumonitisOFFSIDES
248Lymphatic obstructionOFFSIDES
249Macular degenerationSIDER
250Malaria, Falciparum

View details

3054558
3125918
12735648
15215119
 		CTD
251Malaria, Vivax12041544
16242740
20140453		CTD
252Malaria

View details

200890
457222
851793
1029911
1486619
1665944
1888972
2051527
2831692
3029852
3371193
4776885
4864652
6335683
6366489
7310924
7325735
7762925
8099690
8772850
9632091
11130385
11675058
12962582
17202178
17341043
17667217
18061791
18343736
18720672
19198858
19393257
19784824
24781711
 		CTD
253MastectomyOFFSIDES
254Mechanical ventilationOFFSIDES
255Medical device complicationOFFSIDES
256MegacolonOFFSIDES
257Methemoglobinemia3537620CTD
258Mood Disorders7310924CTD
259Mucinoses2650665CTD
260Muscle Weakness

View details

4298052
5090782
5297866
12739036
15605079
16096334
 		CTD
OFFSIDES
261Muscle strainOFFSIDES
262Muscular Atrophy4776885
12739036		CTD
263Musculoskeletal Diseases4253656CTD
264Musculoskeletal chest painOFFSIDES
265Myasthenia Gravis

View details

1665944
2650665
3750012
7327092
8709903
10612109
 		CTD
266MyelocytosisOFFSIDES
267Myocardial necrosis marker increasedCanada Vigilance: 1Canada Vigilance
268Nail InfectionOFFSIDES
269Necrosis

View details

2051527
5128208
19393257
23211037
25445804
 		CTD
270Nephrosclerosis12673565CTD
271Nervous tensionOFFSIDES
272Neural Tube Defects8638253CTD
273Neural hearing lossSIDER
274NeuralgiaOFFSIDES
275Neurobehavioral Manifestations7762925CTD
276Neuromuscular Diseases

View details

227093
920266
4076494
4712543
4718071
6095877
10686640
12954536
 		CTD
277Neuromuscular Junction Diseases2650665
3343986		CTD
278Neuromuscular Manifestations3029852
9781573		CTD
279Open woundOFFSIDES
280OsteopeniaOFFSIDES
281OtosclerosisOFFSIDES
282Pancytopenia273209
18057166		CTD
SIDER
283Papilledema7120869CTD
284Parasitemia16494867CTD
285Parasitic Diseases, Animal17649381CTD
286Paresis12652413CTD
287PeriarthritisOFFSIDES
288Peripheral Nervous System Diseases

View details

175101
200890
2831692
6095877
 		CTD
289Personality ChangeSIDER
290PhimosisOFFSIDES
291PhlebitisOFFSIDES
292Platelet count abnormalOFFSIDES
293Poisoning7564673CTD
294PolymyositisOFFSIDES
295PolyneuritisSIDER
296PolyneuropathyOFFSIDES
SIDER
297Porphyria non-acuteOFFSIDES
298Pre-EclampsiaOFFSIDES
299Prealbumin decreasedOFFSIDES
300Prenatal Exposure Delayed Effects19393257CTD
301Prenatal Injuries8638253CTD
302Protein total increasedOFFSIDES
303Pruritus851793
6335683		CTD
SIDER
304Psychiatric symptomOFFSIDES
305Psychomotor skills impairedOFFSIDES
306Psychoses, Substance-Induced

View details

1381902
2138305
2208904
2361706
3243651
4603136
7310924
12493616
17667217
18720672
19326713
19555804
 		CTD
307Psychotic Disorders5338485CTD
308Pulmonary HypertensionOFFSIDES
309Purpura12735648CTD
310Rash erythematousCanada Vigilance: 1Canada Vigilance
311Reaction gastrointestinalSIDER
312Rectal tenesmusOFFSIDES
313Reflex, Abnormal4776885
12652413		CTD
314Renal Insufficiency15605079CTD
315Retinal DegenerationOFFSIDES
316Retinal Diseases

View details

227093
463998
677653
851793
920266
1628552
1665944
2001908
2764802
5090782
5297866
5964922
7065730
8253245
9295226
9632091
10172409
10664060
11245140
15017107
18974527
19165421
 		CTD
317Retinal VasculitisOFFSIDES
318Retinal damageSIDER
319Retinogram abnormalOFFSIDES
320RhabdomyolysisOFFSIDES
321SalmonellaOFFSIDES
322Sarcoidosis4253656CTD
323SclerodermaOFFSIDES
324Seizures

View details

734231
1639237
2089211
2514385
3139186
8471829
 		CTD
325Septic ShockOFFSIDES
326Serum SicknessOFFSIDES
327Shock, Cardiogenic1774400CTD
328SigmoiditisOFFSIDES
329Sinoatrial BlockOFFSIDES
330Sinus bradycardiaOFFSIDES
331Sjogren's SyndromeOFFSIDES
332Skin necrosisOFFSIDES
333Skin test positiveOFFSIDES
334Sleep Wake Disorders12962582CTD
335Sleep disorder due to general medical condition, insomnia typeOFFSIDES
336Staphylococcal impetigoOFFSIDES
337Status Epilepticus7762925CTD
338Stevens-Johnson SyndromeCanada Vigilance: 1Canada Vigilance
SIDER
339Substance-Related Disorders2764802
8253245		CTD
340Superficial ThrombophlebitisOFFSIDES
341Synovial CystOFFSIDES
342Systemic mycosisOFFSIDES
343Tachycardia, Ventricular38383
4441014
17590456		CTD
344Temperature intoleranceOFFSIDES
345TenosynovitisOFFSIDES
346ThrombocytopeniaSIDER
347Tongue dysplasiaOFFSIDES
348TonsillitisOFFSIDES
349Tooth ExtractionOFFSIDES
350Torsades de Pointes16178046CTD
351TorticollisSIDER
352Toxic Epidermal NecrolysisSIDER
353Trigeminal Nerve DisorderOFFSIDES
354Ultrasound antenatal screenOFFSIDES
355Urethral Diseases1029911CTD
356Urethral StenosisOFFSIDES
357UrticariaSIDER
358Vacuolar myopathy

View details

200890
2759144
3343986
4247107
5297866
7359173
8332133
8616629
8787835
9690670
9704973
15712280
19296457
 		CTD
359Vascular stent insertionOFFSIDES
360Vasculitis, Leukocytoclastic, Cutaneous12735648CTD
361Ventricular Remodeling23274061CTD
362Vision Disorders23567313CTD
363Visual disturbanceSIDER
364Vitamin A DeficiencyOFFSIDES
365Vulvovaginal drynessOFFSIDES
366Weight GainOFFSIDES
367effusionOFFSIDES
368furuncleOFFSIDES
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