MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Etoricoxib

(MNJVRJDLRVPLFE-UHFFFAOYSA-N)

Structure

SMILES: Clc1cnc(c(c1)c1ccc(cc1)S(=O)(=O)C)c1ccc(nc1)C
Type(s): Approved; Investigational
ATC code(s): M01AH05
Molecular Formula:: C18H15ClN2O2S
Molecular Weight:: 358.842
Log P:: 5.2567
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 0
TPSA:: 68.3
CAS Number(s):: 202409-33-4; 850896-71-8

Synonym(s)

Etoricoxib

Arcoxia

L-791456

MK 0663

MK-0663

L 791456

L791456

MK0663

External Link(s)

MeSH	D000077613
PubChem Compound	123619
BindingDB	50072064
ChEBI	6339
CHEMBL	CHEMBL416146
DrugBank	DB01628
DrugCentral	1113
IUPHAR/BPS Guide to PHARMACOLOGY	2896
KEGG	cpd:C11718 dr:D03710
Therapeutic Target Database	D09MGR
ZINC	579472

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Chest Pain	FAERS: 3		SIDER US FAERS
2	Dizziness	FAERS: 3	19443681	CTD SIDER US FAERS
3	Vomiting	FAERS: 3		SIDER US FAERS
4	Abdominal Pain	FAERS: 2		SIDER US FAERS
5	Atrial Fibrillation	FAERS: 2		SIDER US FAERS
6	Chest discomfort	FAERS: 2		US FAERS
7	Drug ineffective	FAERS: 2		OFFSIDES US FAERS
8	Drug prescribing error	FAERS: 2		US FAERS
9	Flushing	FAERS: 2		SIDER US FAERS
10	Nausea	FAERS: 2	19443681	CTD SIDER US FAERS
11	Pruritus	FAERS: 2		SIDER US FAERS
12	Respiratory Failure	FAERS: 2		US FAERS
13	Skin lesion	FAERS: 2		US FAERS
14	Swelling	FAERS: 2		US FAERS
15	Tachycardia	FAERS: 2		US FAERS
16	Visual Impairment	FAERS: 2		SIDER US FAERS
17	Abdominal discomfort	FAERS: 1		SIDER US FAERS
18	Acute respiratory failure	FAERS: 1		US FAERS
19	Adverse event	FAERS: 1		US FAERS
20	Angina Pectoris	FAERS: 1		SIDER US FAERS
21	Angioedema	FAERS: 1		SIDER US FAERS
22	Asphyxia	FAERS: 1		OFFSIDES US FAERS
23	Asthenia	FAERS: 1		SIDER US FAERS
24	Asthma	FAERS: 1		US FAERS
25	Cardiac Arrest	FAERS: 1		SIDER US FAERS
26	Cerebrovascular accident	FAERS: 1		SIDER US FAERS
27	Colitis	FAERS: 1		OFFSIDES US FAERS
28	Coronary Artery Disease	FAERS: 1		SIDER US FAERS
29	Deep Vein Thrombosis	FAERS: 1		US FAERS
30	Diplopia	FAERS: 1		US FAERS
31	Exposure via breast milk	FAERS: 1		US FAERS
32	Fatigue	FAERS: 1	19443681	CTD SIDER US FAERS
33	Fixed eruption	FAERS: 1		US FAERS
34	Flatulence	FAERS: 1		SIDER US FAERS
35	Gastritis	FAERS: 1		SIDER US FAERS
36	Hypersensitivity	FAERS: 1		SIDER US FAERS
37	Hypotension	FAERS: 1		US FAERS
38	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
39	Inappropriate schedule of product administration	FAERS: 1		US FAERS
40	Incorrect dose administered	FAERS: 1		US FAERS
41	Joint swelling	FAERS: 1		US FAERS
42	Leukopenia	FAERS: 1		US FAERS
43	Limb discomfort	FAERS: 1		US FAERS
44	Lip pruritus	FAERS: 1		US FAERS
45	Lip swelling	FAERS: 1		US FAERS
46	Muscle enzyme increased	FAERS: 1		US FAERS
47	Muscle tightness	FAERS: 1		US FAERS
48	Myalgia	FAERS: 1		US FAERS
49	Oropharyngeal pain	FAERS: 1		OFFSIDES US FAERS
50	Peripheral swelling	FAERS: 1		US FAERS
51	Pharyngeal erosion	FAERS: 1		US FAERS
52	Prescription drug used without a prescription	FAERS: 1		US FAERS
53	Product prescribing error	FAERS: 1		US FAERS
54	Product use in unapproved indication	FAERS: 1		US FAERS
55	Proteinuria	FAERS: 1		SIDER US FAERS
56	Quadriplegia	FAERS: 1		US FAERS
57	Respiratory distress	FAERS: 1		US FAERS
58	Restlessness	FAERS: 1		US FAERS
59	Rhonchi	FAERS: 1		US FAERS
60	Skin Ulcer	FAERS: 1		SIDER US FAERS
61	Suicide attempt	FAERS: 1		US FAERS
62	Thrombosis	FAERS: 1	View details 17113426 17265571 17304660 18084859 19223284	CTD US FAERS
63	Tongue blistering	FAERS: 1		US FAERS
64	Tuberculosis	FAERS: 1		US FAERS
65	Wheezing	FAERS: 1		US FAERS
66	jaundice	FAERS: 1		SIDER US FAERS
67	Abdominal Infection			OFFSIDES
68	Abdominal mass			OFFSIDES
69	Abdominal sepsis			OFFSIDES
70	Abuse			OFFSIDES
71	Acute Coronary Syndrome			SIDER
72	Adenitis			OFFSIDES
73	Ageusia			OFFSIDES
74	Agitation			SIDER
75	Alanine Aminotransferase Increased			SIDER
76	Alanine aminotransferase abnormal			OFFSIDES
77	Alcohol abuse			OFFSIDES
78	Alopecia			SIDER
79	Alveolar Bone Loss		17225004	CTD
80	Alveolitis			SIDER
81	Anal abscess			OFFSIDES
82	Anaphylactic shock			SIDER
83	Anaphylactoid Reaction			SIDER
84	Aneurysm			OFFSIDES
85	Anhidrosis			OFFSIDES
86	Ankle Fracture			OFFSIDES
87	Ankylosing spondylitis			OFFSIDES
88	Anorexia			SIDER
89	Anosmia			OFFSIDES
90	Antiphospholipid Antibodies			OFFSIDES
91	Anuria			OFFSIDES
92	Anxiety			SIDER
93	Aphonia			OFFSIDES
94	Aphthous Stomatitis			SIDER
95	Appendectomy			OFFSIDES
96	Arthralgia			SIDER
97	Arthritis			OFFSIDES
98	Arthrodesis			OFFSIDES
99	Aseptic Meningitis			OFFSIDES
100	Aspartate Aminotransferase Increased			SIDER
101	Aspartate aminotransferase abnormal			OFFSIDES
102	Atrial Flutter			SIDER
103	Atrial tachycardia			OFFSIDES
104	Autoimmune thrombocytopenia			OFFSIDES
105	Avascular necrosis			OFFSIDES
106	Bacterial Endocarditis			OFFSIDES
107	Bacterial test positive			OFFSIDES
108	Basal cell carcinoma			SIDER
109	Benign Prostatic Hyperplasia			OFFSIDES
110	Bladder neck obstruction			OFFSIDES
111	Bladder pain			SIDER
112	Bladder tamponade			OFFSIDES
113	Bloated feeling			SIDER
114	Blood alkaline phosphatase increased			OFFSIDES SIDER
115	Blood and lymphatic system disorders			SIDER
116	Blood creatine increased			OFFSIDES
117	Blood creatine phosphokinase increased			SIDER
118	Blood creatinine decreased			OFFSIDES
119	Blood creatinine increased			OFFSIDES SIDER
120	Blood lactate dehydrogenase increased			OFFSIDES
121	Blood magnesium decreased			OFFSIDES
122	Blood phosphorus increased			OFFSIDES
123	Blood potassium increased			OFFSIDES
124	Blood urea increased			SIDER
125	Blood urine present			SIDER
126	Bone formation decreased			OFFSIDES
127	Bone swelling			OFFSIDES
128	Bronchitis			SIDER
129	Bronchopneumonia			OFFSIDES
130	Bronchospasm			SIDER
131	Bursitis			SIDER
132	Cardioactive drug level increased			OFFSIDES
133	Cardiovascular insufficiency			OFFSIDES
134	Cartilage injury			OFFSIDES
135	Cataract			SIDER
136	Catheter site pain			OFFSIDES
137	Cellulitis			SIDER
138	Cerebral Infarction		17238877	CTD
139	Cerebral atrophy			OFFSIDES
140	Cervical spine flattening			OFFSIDES
141	Choking sensation			OFFSIDES
142	Cholecystitis			SIDER
143	Chronic left ventricular failure			OFFSIDES
144	Chronic pain			SIDER
145	Cirrhosis			OFFSIDES
146	Clostridium colitis			OFFSIDES
147	Clostridium difficile colitis			OFFSIDES
148	Conjunctivitis			SIDER
149	Constipation			SIDER
150	Cor pulmonale			OFFSIDES
151	Creatine Phosphokinase Increased			SIDER
152	Cystitis		17638016	CTD SIDER
153	Cyst			SIDER
154	Depressed Level of Consciousness			OFFSIDES
155	Dermatitis			SIDER
156	Device related infection			OFFSIDES
157	Diabetes Mellitus			SIDER
158	Diabetes mellitus inadequate control			OFFSIDES
159	Diabetic Foot			OFFSIDES
160	Diarrhea		19443681	CTD OFFSIDES
161	Diastolic hypertension			SIDER
162	Diffuse alveolar damage			OFFSIDES
163	Dissociative Amnesia			OFFSIDES
164	Distress gastrointestinal			SIDER
165	Drug Eruptions		17304885 18084859	CTD
166	Duodenal Ulcer			OFFSIDES
167	Duodenal ulcer perforation			OFFSIDES
168	Dysgeusia			SIDER
169	Dyspepsia		19443681	CTD SIDER
170	Dysphasia			OFFSIDES
171	Ear and labyrinth disorders			SIDER
172	Ecchymosis			SIDER
173	Eczema			SIDER
174	Edema		17965424 18084859	CTD
175	Encephalitis			OFFSIDES
176	Endometriosis			OFFSIDES
177	Epigastric discomfort			SIDER
178	Epistaxis			SIDER
179	Erosive gastritis			OFFSIDES
180	Erysipelas			OFFSIDES
181	Erythema Multiforme			SIDER
182	Erythema			SIDER
183	Escherichia urinary tract infection			OFFSIDES
184	Facial Neuralgia			OFFSIDES
185	Factor VIII inhibition			OFFSIDES
186	Fatty Liver			OFFSIDES
187	Feeding and Eating Disorders		19443681	CTD
188	Feeling abnormal			SIDER
189	Fistula repair			OFFSIDES
190	Fixed drug eruption			SIDER
191	Folliculitis			SIDER
192	Foot pain			SIDER
193	Gamma-Glutamyltransferase Increased			OFFSIDES SIDER
194	Gastric ulcer			OFFSIDES
195	Gastroenteritis			SIDER
196	Gastrointestinal Hemorrhage		18084859	CTD
197	Gastrointestinal Pain			SIDER
198	General physical health deterioration			OFFSIDES
199	Glycosuria			SIDER
200	Gout		18084859	CTD
201	Granuloma			OFFSIDES
202	Headache		19443681	CTD SIDER
203	Heart failure		18084859 19380329	CTD
204	Heartburn			SIDER
205	Hemiparesis			OFFSIDES
206	Hemorrhage		17638016	CTD
207	Hepatitis B DNA increased			OFFSIDES
208	Hepatitis B positive			OFFSIDES
209	Hepatitis B			OFFSIDES
210	Hepatitis			SIDER
211	Hepatotoxicity			SIDER
212	Hydronephrosis			OFFSIDES
213	Hydrothorax			OFFSIDES
214	Hypertensive crisis			SIDER
215	Hypertensive heart disease			OFFSIDES
216	Hyperventilation			OFFSIDES
217	Hypoaesthesia facial			OFFSIDES
218	Hyporeflexia			SIDER
219	Increased thirst			SIDER
220	Infection			OFFSIDES SIDER
221	Infestation			SIDER
222	Infusion site mobility decreased			OFFSIDES
223	Intestinal Perforation			OFFSIDES
224	Intestinal infarction			OFFSIDES
225	Intracranial Thrombosis		17238877	CTD
226	Intraocular inflammation			OFFSIDES
227	Irritable Bowel Syndrome			SIDER
228	Knee sprain			SIDER
229	Laceration			SIDER
230	Laryngitis			SIDER
231	Left Ventricular Hypertrophy			OFFSIDES
232	Left atrial dilatation			OFFSIDES
233	Lipodystrophy acquired			OFFSIDES
234	Low Back Pain		18084859	CTD
235	Lumbar radiculopathy			SIDER
236	Lupus-like syndrome			OFFSIDES
237	Lymphoplasmacytoid lymphoma/immunocytoma			OFFSIDES
238	Malnutrition			SIDER
239	Memory impairment			SIDER
240	Mental disorder due to a general medical condition			OFFSIDES
241	Mixed Connective Tissue Disease			OFFSIDES
242	Monocyte count increased			SIDER
243	Multiple drug overdose			OFFSIDES
244	Muscle strain			SIDER
245	Musculoskeletal Pain			SIDER
246	Musculoskeletal chest pain			OFFSIDES
247	Musculoskeletal discomfort			SIDER
248	Musculoskeletal stiffness			OFFSIDES
249	Myocardial Infarction		17457957	CTD SIDER
250	Neck Pain			SIDER
251	Nephrotic Syndrome			SIDER
252	Neurodermatitis			OFFSIDES
253	Neuropathy			SIDER
254	Nocturia			SIDER
255	Onychomycosis			SIDER
256	Oral lesion			SIDER
257	Osteoporosis			OFFSIDES
258	Ovarian germ cell cancer stage III			OFFSIDES
259	Pain			SIDER
260	Palpitations			SIDER
261	Pancreatitis			SIDER
262	Pelvic venous thrombosis			OFFSIDES
263	Peptic Ulcer			SIDER
264	Performance status decreased			OFFSIDES
265	Perianal abscess			OFFSIDES
266	Periarthritis			SIDER
267	Pericarditis			OFFSIDES
268	Periodontitis		17225004	CTD
269	Pharyngitis			SIDER
270	Pleurisy			OFFSIDES
271	Pneumocystis jiroveci pneumonia			OFFSIDES
272	Pneumonia			SIDER
273	Pneumothorax			OFFSIDES
274	Polyneuropathy			OFFSIDES
275	Postoperative wound complication			OFFSIDES
276	Postrenal failure			OFFSIDES
277	Productive Cough			OFFSIDES
278	Protein urine present			SIDER
279	Pubic pain			OFFSIDES
280	Pulmonary hilar enlargement			OFFSIDES
281	Purulent discharge			OFFSIDES
282	Pustular psoriasis			OFFSIDES
283	Rales			SIDER
284	Renal tubular disorder			OFFSIDES
285	Renal tubular necrosis			OFFSIDES
286	Reticulocyte count decreased			OFFSIDES
287	Rheumatoid Nodule			OFFSIDES
288	Rheumatoid Vasculitis			OFFSIDES
289	Rosacea			SIDER
290	Sciatica			SIDER
291	Septic Shock			OFFSIDES
292	Serology abnormal			OFFSIDES
293	Shock			SIDER
294	Shoulder Pain			SIDER
295	Sinusitis			SIDER
296	Sjogren's Syndrome			SIDER
297	Skin Induration			OFFSIDES
298	Skin necrosis			OFFSIDES
299	Skin nodule			SIDER
300	Somnolence			SIDER
301	Spinal column stenosis			OFFSIDES
302	Stevens-Johnson Syndrome			SIDER
303	Stomatitis			SIDER
304	Subileus			OFFSIDES
305	Sudden death			OFFSIDES
306	Sunburn			SIDER
307	Synovectomy			OFFSIDES
308	Syphilis			OFFSIDES
309	Taste Disorders		19443681	CTD
310	Tenosynovitis			SIDER
311	Thirst			SIDER
312	Thoracic vertebral fracture			OFFSIDES
313	Thrombocytopenia			SIDER
314	Thrombophlebitis			OFFSIDES
315	Tinea Pedis			SIDER
316	Tinnitus			SIDER
317	Tooth Avulsion			OFFSIDES
318	Toothache			SIDER
319	Toxic Epidermal Necrolysis			SIDER
320	Traumatic arthropathy			SIDER
321	Trauma			SIDER
322	Tremor			SIDER
323	Ulcer			OFFSIDES
324	Umbilical hernia			OFFSIDES
325	Uric acid increased			SIDER
326	Urinary tract infection			SIDER
327	Urticaria		17304885	CTD SIDER
328	Vascular insufficiency			OFFSIDES
329	Visual disturbance			SIDER
330	Vitamin B12 abnormal			OFFSIDES
331	White blood cell count decreased			SIDER
332	effusion			OFFSIDES
333	nervous system disorder			SIDER

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