MetaADEDB 2.0 @ LMMD
Ritonavir
(NCDNCNXCDXHOMX-XGKFQTDJSA-N)
Structure
SMILES
O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1
Type(s)
Approved; Investigational
ATC code(s)
J05AE03; J05AP52; J05AP53; J05AR10; J05AR23
Molecular Formula:
C37H48N6O5S2
Molecular Weight:
720.944
Log P:
7.0779
Hydrogen Bond Acceptor:
13
Hydrogen Bond Donor:
4
TPSA:
202.26
CAS Number(s):
155213-67-5
Synonym(s)
1.
Ritonavir
2.
ABT 538
3.
ABT-538
4.
Norvir
5.
ABT538
External Link(s)
MeSHD019438
PubChem Compound392622
BindingDB520
50088504
ChEBI45409
CHEMBLCHEMBL163
DrugBankDB00503
DrugCentral2391
IUPHAR/BPS Guide to PHARMACOLOGY8804
KEGGcpd:C07240
dr:D00427
Therapeutic Target DatabaseD0ZU9R
ZINC3944422
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 1817976269CTD
SIDER
US FAERS
2HaematotoxicityFAERS: 16
Canada Vigilance: 16		Canada Vigilance
US FAERS
3Drug exposure during pregnancyFAERS: 15US FAERS
4VomitingFAERS: 1010907977
17976269		CTD
SIDER
US FAERS
5HeadacheFAERS: 7SIDER
US FAERS
6Drug dose omissionFAERS: 6US FAERS
7OverdoseFAERS: 6US FAERS
8Abdominal discomfortFAERS: 5US FAERS
9DizzinessFAERS: 5SIDER
US FAERS
10Expired drug administeredFAERS: 5US FAERS
11Incorrect dose administeredFAERS: 5US FAERS
12NephrolithiasisFAERS: 512473836CTD
OFFSIDES
SIDER
US FAERS
13Unevaluable eventFAERS: 5US FAERS
14AlopeciaFAERS: 4US FAERS
15AnxietyFAERS: 4SIDER
US FAERS
16AstheniaFAERS: 4SIDER
US FAERS
17CD4 Lymphocytes DecreasedFAERS: 4OFFSIDES
US FAERS
18DyspepsiaFAERS: 4SIDER
US FAERS
19Hepatitis BFAERS: 410357637CTD
OFFSIDES
US FAERS
20Immune reconstitution syndromeFAERS: 4OFFSIDES
US FAERS
21MalaiseFAERS: 4SIDER
US FAERS
22MalnutritionFAERS: 4SIDER
US FAERS
23Medication residueFAERS: 4US FAERS
24Spina BifidaFAERS: 4US FAERS
25Vertical TalusFAERS: 4US FAERS
26Viral mutation identifiedFAERS: 4US FAERS
27Blood triglycerides increasedFAERS: 3OFFSIDES
SIDER
US FAERS
28Cerebrovascular accidentFAERS: 3US FAERS
29Chest PainFAERS: 3SIDER
US FAERS
30GastrostomyFAERS: 3US FAERS
31Pericardial effusionFAERS: 3US FAERS
32Pneumocystis jiroveci pneumoniaFAERS: 3US FAERS
33PneumoniaFAERS: 3US FAERS
34PruritusFAERS: 3SIDER
US FAERS
35Retinal toxicityFAERS: 3US FAERS
36Therapy cessationFAERS: 3US FAERS
37Trisomy 21FAERS: 3US FAERS
38TuberculosisFAERS: 3US FAERS
39Weight decreasedFAERS: 3SIDER
US FAERS
40treatment failureFAERS: 3US FAERS
41Abdominal PainFAERS: 212473836CTD
SIDER
US FAERS
42Accidental exposureFAERS: 2US FAERS
43Cardiac septal defect residual shuntFAERS: 2US FAERS
44Cerebral ventricle dilatationFAERS: 2US FAERS
45Drug administration errorFAERS: 2US FAERS
46DysgeusiaFAERS: 2SIDER
US FAERS
47FatigueFAERS: 2SIDER
US FAERS
48Foreign body traumaFAERS: 2US FAERS
49Inability to afford medicationFAERS: 2US FAERS
50Incorrect product storageFAERS: 2US FAERS
51Incorrect route of drug administrationFAERS: 2US FAERS
52Incorrect storage of drugFAERS: 2US FAERS
53InfectionFAERS: 2US FAERS
54Left atrial dilatationFAERS: 2US FAERS
55Medication ErrorFAERS: 2US FAERS
56Mitochondrial cytopathyFAERS: 2US FAERS
57MyalgiaFAERS: 2SIDER
US FAERS
58Myocardial InfarctionFAERS: 2SIDER
US FAERS
59PainFAERS: 2SIDER
US FAERS
60Patent ductus arteriosusFAERS: 2US FAERS
61Product expiration date issueFAERS: 2US FAERS
62Product lot number issueFAERS: 2US FAERS
63RegurgitationFAERS: 2US FAERS
64SepsisFAERS: 2US FAERS
65Shunt blood flow excessiveFAERS: 2US FAERS
66Suicide attemptFAERS: 2US FAERS
67Terminal stateFAERS: 2US FAERS
68Wolf-Hirschhorn SyndromeFAERS: 2US FAERS
69Wrong technique in product usage processFAERS: 2US FAERS
70intensive careFAERS: 2US FAERS
71Accidental exposure to productFAERS: 1US FAERS
72AcneFAERS: 1SIDER
US FAERS
73Acquired Immunodeficiency SyndromeFAERS: 18782789
10452668		CTD
US FAERS
74AdactylyFAERS: 1US FAERS
75Adverse eventFAERS: 1US FAERS
76Alcohol IntoleranceFAERS: 1SIDER
US FAERS
77Alcohol poisoningFAERS: 1US FAERS
78Ammonia increasedFAERS: 1US FAERS
79AngioedemaFAERS: 1OFFSIDES
US FAERS
80AnoxiaFAERS: 1US FAERS
81AphagiaFAERS: 1US FAERS
82ArthropathyFAERS: 1SIDER
US FAERS
83AsphyxiaFAERS: 1US FAERS
84Autoantibody positiveFAERS: 1US FAERS
85Bladder spasmFAERS: 1US FAERS
86Blood HIV RNA increasedFAERS: 1US FAERS
87Blood cholesterol increasedFAERS: 1US FAERS
88Blood osmolarity decreasedFAERS: 1US FAERS
89CachexiaFAERS: 1SIDER
US FAERS
90CataractFAERS: 1OFFSIDES
US FAERS
91ChillsFAERS: 1SIDER
US FAERS
92ChokingFAERS: 1US FAERS
93Complications of maternal exposure to therapeutic drugsFAERS: 1US FAERS
94ConstipationFAERS: 1SIDER
US FAERS
95CystitisFAERS: 1SIDER
US FAERS
96DehydrationFAERS: 1SIDER
US FAERS
97Diabetes MellitusFAERS: 1SIDER
US FAERS
98DroolingFAERS: 1US FAERS
99Drug dispensing errorFAERS: 1US FAERS
100Drug resistanceFAERS: 1US FAERS
101Drug screen false positiveFAERS: 1US FAERS
102Dry skinFAERS: 1SIDER
US FAERS
103Economic problemFAERS: 1US FAERS
104Ectopic kidneyFAERS: 1US FAERS
105Endocardial FibroelastosisFAERS: 1US FAERS
106EructationFAERS: 1SIDER
US FAERS
107Essential HypertensionFAERS: 1US FAERS
108Executive dysfunctionFAERS: 1US FAERS
109Expired product administeredFAERS: 1US FAERS
110Eye irritationFAERS: 1US FAERS
111Feeling ColdFAERS: 1OFFSIDES
US FAERS
112General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
113Hip surgeryFAERS: 1OFFSIDES
US FAERS
114HypersensitivityFAERS: 1SIDER
US FAERS
115HyperventilationFAERS: 1US FAERS
116HypotensionFAERS: 1SIDER
US FAERS
117Inappropriate schedule of drug administrationFAERS: 1US FAERS
118Injury asphyxiationFAERS: 1US FAERS
119Joint swellingFAERS: 1US FAERS
120Lactose IntoleranceFAERS: 1US FAERS
121Ligament injuryFAERS: 1US FAERS
122Lipodystrophy acquiredFAERS: 1OFFSIDES
SIDER
US FAERS
123Medical device implantationFAERS: 1US FAERS
124Medication residue presentFAERS: 1US FAERS
125Mental status changesFAERS: 1US FAERS
126Neonatal disorderFAERS: 1US FAERS
127NeutropeniaFAERS: 117378895CTD
SIDER
US FAERS
128Occupational exposure to drugFAERS: 1US FAERS
129Optic NeuritisFAERS: 1US FAERS
130Pancreatogenous diabetesFAERS: 1US FAERS
131PancytopeniaFAERS: 1US FAERS
132Parotid lipomatosisFAERS: 1US FAERS
133Poor quality drug administeredFAERS: 1US FAERS
134Product formulation issueFAERS: 1US FAERS
135Product packaging issueFAERS: 1US FAERS
136Product physical issueFAERS: 1US FAERS
137Product quality issueFAERS: 1US FAERS
138Product residue presentFAERS: 1US FAERS
139Product size issueFAERS: 1US FAERS
140Product solubility abnormalFAERS: 1US FAERS
141Product substitution issueFAERS: 1US FAERS
142Product taste abnormalFAERS: 1US FAERS
143Product use complaintFAERS: 1US FAERS
144Pseudomyxoma PeritoneiFAERS: 1US FAERS
145Pulmonary HypertensionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
146Renal ColicFAERS: 1OFFSIDES
US FAERS
147RhabdomyolysisFAERS: 110452668CTD
US FAERS
148Single umbilical arteryFAERS: 1US FAERS
149Skin IndurationFAERS: 1US FAERS
150SomnolenceFAERS: 1SIDER
US FAERS
151Squamous cell carcinomaFAERS: 1US FAERS
152StressFAERS: 1US FAERS
153Supraventricular tachycardiaFAERS: 1US FAERS
154TachycardiaFAERS: 1SIDER
US FAERS
155Throat cancerFAERS: 1US FAERS
156TinnitusFAERS: 1SIDER
US FAERS
157Toxicity to various agentsFAERS: 1US FAERS
158Transmission of an infectious agent via productFAERS: 1US FAERS
159Urinary IncontinenceFAERS: 1US FAERS
160Urinary tract infectionFAERS: 1SIDER
US FAERS
161UrticariaFAERS: 1SIDER
US FAERS
162Viral load increasedFAERS: 1US FAERS
163Visual ImpairmentFAERS: 1SIDER
US FAERS
164Wrong technique in drug usage processFAERS: 1US FAERS
165hypertensive nephropathyFAERS: 1US FAERS
166AIDS-Related Opportunistic Infections10357637CTD
167Abnormal visionSIDER
168Acidosis, Lactic9786823CTD
169Acidosis12473836CTD
OFFSIDES
170Acute Coronary SyndromeSIDER
171Acute kidney injury8992345
9850700
10452668		CTD
172Acute myocardial infarctionOFFSIDES
173Adrenal cortical hypofunctionSIDER
174AgeusiaSIDER
175AgitationSIDER
176Alanine Aminotransferase IncreasedOFFSIDES
177AlbuminuriaSIDER
178AmblyopiaSIDER
179AmnesiaSIDER
180Anorectal discomfortSIDER
181AnorexiaSIDER
182Antidepressant drug level above therapeuticOFFSIDES
183AphasiaSIDER
184Aphthous StomatitisOFFSIDES
185Arteriosclerosis17879945
19114959
19762785		CTD
186ArthralgiaSIDER
187ArthritisSIDER
188Ascites9786823CTD
OFFSIDES
189Aseptic MeningitisOFFSIDES
190Aspartate Aminotransferase IncreasedSIDER
191Aspiration PneumoniaOFFSIDES
192AsthmaSIDER
193Ataxia11197575CTD
OFFSIDES
SIDER
194AvitaminosisSIDER
195Back PainSIDER
196Bacterial sepsisOFFSIDES
197Basal Ganglia Diseases11978161CTD
198Beta 2 microglobulin urine increasedOFFSIDES
199Biliary dilatationOFFSIDES
200Biliary tract infectionOFFSIDES
201Bipolar Disorder16368918CTD
202Bladder painSIDER
203BlepharitisSIDER
204Blood alkaline phosphatase increasedOFFSIDES
205Blood amylase increasedOFFSIDES
206Blood corticotrophinOFFSIDES
207Blood cortisol decreasedOFFSIDES
208Blood creatine phosphokinase MB increasedOFFSIDES
209Blood creatine phosphokinase increasedSIDER
210Blood glucose fluctuationOFFSIDES
211Blood lactate dehydrogenase decreasedOFFSIDES
212Blood testosterone decreasedOFFSIDES
213Blood urea increasedSIDER
214Blood uric acidOFFSIDES
215Bone painSIDER
216BronchitisSIDER
217CalcinosisOFFSIDES
218Candida serology positiveOFFSIDES
219Cardiac TamponadeOFFSIDES
220Cardiac enzymes increasedOFFSIDES
221Cerebellar AtaxiaOFFSIDES
222Cerebral hypoperfusionOFFSIDES
223CheilitisSIDER
224Chemical and Drug Induced Liver Injury

View details

10907977
12004282
14986274
23956101
24014644
26626330
28437613
 		CTD
225CholangiolitisOFFSIDES
226CholangitisSIDER
227CholecystitisOFFSIDES
228Cholestasis9786823CTD
229Circumoral paresthesiaSIDER
230CirrhosisOFFSIDES
231ColitisOFFSIDES
SIDER
232Confusion11197575CTD
233ConjunctivitisSIDER
234Coronary Artery Disease9848377CTD
235Cramps of lower extremitiesSIDER
236Creatine Phosphokinase IncreasedSIDER
237Cubital Tunnel SyndromeOFFSIDES
238Cytolytic hepatitisOFFSIDES
239Cytomegalovirus test positiveOFFSIDES
240DeafnessSIDER
241DementiaSIDER
242Depressed Level of ConsciousnessSIDER
243DermatitisSIDER
244DiabetesOFFSIDES
245DiarrheaOFFSIDES
246Diffuse Large B-Cell LymphomaOFFSIDES
247Diplopia11197575CTD
SIDER
248DiscomfortSIDER
249Disease recurrenceOFFSIDES
250Disorders of Excessive Somnolence11197575CTD
251Disturbance in sexual arousalSIDER
252Drug ineffectiveCanada Vigilance: 1Canada Vigilance
253Duodenal UlcerOFFSIDES
254DysgraphiaOFFSIDES
255Dyslipidemias27378623CTD
256DysuriaSIDER
257EcchymosisSIDER
258EczemaSIDER
259Electrolyte imbalanceSIDER
260Electroretinogram abnormalSIDER
261Enlargement abdomenSIDER
262Enzyme abnormalitySIDER
263Eosinophilic myocarditisOFFSIDES
264EpistaxisSIDER
265Erectile dysfunctionSIDER
266Erythema MultiformeSIDER
267Escherichia sepsisOFFSIDES
268Euphoric moodSIDER
269External OphthalmoplegiaSIDER
270Eye painSIDER
271Facial PainSIDER
272Facial wastingOFFSIDES
273Factor VIII DeficiencyOFFSIDES
SIDER
274Fanconi Syndrome14689363
18260800		CTD
OFFSIDES
275FastingSIDER
276Fat redistributionSIDER
277Febrile bone marrow aplasiaOFFSIDES
278Feeling abnormalSIDER
279FlatulenceSIDER
280Flight of ideasOFFSIDES
281FlushingSIDER
282Focal glomerulosclerosisOFFSIDES
283FolliculitisSIDER
284FurunculosisSIDER
285Gamma-Glutamyltransferase IncreasedOFFSIDES
286Gastric ulcerOFFSIDES
287GastritisSIDER
288GastroenteritisSIDER
289Gastrointestinal Diseases10093594CTD
290Gastrointestinal PainSIDER
291GingivitisSIDER
292GlomerulonephritisOFFSIDES
293GlycosuriaSIDER
294GoutSIDER
295Granulocyte count decreasedOFFSIDES
296Granulomatous liver diseaseOFFSIDES
297HIV Infections

View details

8992345
9848377
9850700
10625032
11141242
11197575
11363243
11486172
11545549
12389881
12473835
12473836
12799577
14502007
14518700
15388451
16288408
17378895
17461719
17898705
19908326
23548184
 		CTD
298HIV Wasting SyndromeOFFSIDES
299HIV-Associated Lipodystrophy Syndrome18230615CTD
300Hepatic Encephalopathy9786823CTD
301Hepatic necrosisOFFSIDES
302Hepatitis B positiveOFFSIDES
303Hepatitis COFFSIDES
304Hepatitis10452668CTD
OFFSIDES
SIDER
305Hepatomegaly9786823CTD
SIDER
306HepatosplenomegalySIDER
307HepatotoxicitySIDER
308Hormone level abnormalSIDER
309Hyperbilirubinemia11724090
12473836		CTD
310Hypercholesterolemia11545549
12473836
17719200		CTD
311Hyperglycemia12473836CTD
312HyperkinesiaSIDER
313Hyperparathyroidism12131200CTD
314Hypertriglyceridemia

View details

11545549
11794424
12473836
16269669
17719200
 		CTD
315Hypothalamo-pituitary disorderOFFSIDES
316HypoventilationSIDER
317HypoxiaSIDER
318Ileal ulcerOFFSIDES
319IleitisSIDER
320IleusSIDER
321Immunosuppressant drug levelOFFSIDES
322InfluenzaSIDER
323Injection site dermatitisOFFSIDES
324Intermittent ClaudicationOFFSIDES
325IritisSIDER
326Joint injuryOFFSIDES
327Kidney FailureOFFSIDES
328Large intestine perforationOFFSIDES
329Leukopenia neonatalOFFSIDES
330LeukopeniaSIDER
331Lipodystrophy16269669CTD
332LipohypertrophyOFFSIDES
333Live BirthOFFSIDES
334Livedo ReticularisOFFSIDES
335Liver Cirrhosis9786823CTD
336Liver Failure, Acute9786823CTD
337Liver Failure19025478CTD
338Liver diseases20003457CTD
339Local throat irritationSIDER
340LymphadenopathySIDER
341LymphocytosisOFFSIDES
SIDER
342Manic psychosisSIDER
343MenorrhagiaSIDER
344Metabolic acidosisOFFSIDES
345MicrocytosisOFFSIDES
346MicrolithiasisOFFSIDES
347Molluscum ContagiosumSIDER
348Mood swingsSIDER
349Muscle necrosisOFFSIDES
350Musculoskeletal discomfortSIDER
351Musculoskeletal stiffnessSIDER
352Myasthenia Gravis9572258CTD
353Mycobacterium Infections21442799CTD
354Mycobacterium avium complex immune restoration diseaseOFFSIDES
355MyelocytosisOFFSIDES
356MyoglobinaemiaOFFSIDES
357MyopathySIDER
358MyositisSIDER
359Neck PainSIDER
360Neck stiffnessSIDER
361Neonatal aspirationOFFSIDES
362Neoplasms, Experimental16551874CTD
363NervousnessSIDER
364NeuralgiaOFFSIDES
SIDER
365NeuropathySIDER
366Neutrophil count decreasedOFFSIDES
367NocturiaSIDER
368Nuchal RigiditySIDER
369Nutritional condition abnormalOFFSIDES
370OnychomycosisSIDER
371OphthalmoplegiaSIDER
372Opioid-Related Disorders10641980CTD
373Oral candidiasisSIDER
374Oropharyngeal painSIDER
375OsteoporosisOFFSIDES
376Oxygen consumption decreasedOFFSIDES
377Palmar erythemaOFFSIDES
378PalpitationsSIDER
379Pancreatic Pseudocyst9848377CTD
380Pancreatitis9848377CTD
OFFSIDES
SIDER
381Parkinsonian Disorders19908326CTD
382Pelvic PainSIDER
383Perirectal abscessOFFSIDES
384PeritonitisOFFSIDES
385PharyngitisSIDER
386PhlebitisSIDER
387PhotophobiaSIDER
388Pneumococcal sepsisOFFSIDES
389PolyuriaSIDER
390Portal HypertensionOFFSIDES
391Portal Vein ThrombosisOFFSIDES
392Portal hypertensive gastropathyOFFSIDES
393Post procedural infectionOFFSIDES
394Pressure of speechOFFSIDES
395ProctocolitisSIDER
396Productive CoughOFFSIDES
397Protein-losing gastroenteropathyOFFSIDES
398PsoriasisSIDER
399Pulmonary Embolism10625032CTD
400Pus in stoolOFFSIDES
401PyelonephritisOFFSIDES
SIDER
402Rebound effectOFFSIDES
403Rectal tenesmusSIDER
404Renal Insufficiency8782789
9831435		CTD
405Renal painSIDER
406Renal tubular disorderOFFSIDES
407Renal tubular necrosisOFFSIDES
408Respiratory FailureSIDER
409Retinal Vein OcclusionOFFSIDES
410Retinogram abnormalSIDER
411Retrosternal painSIDER
412RhinitisSIDER
413ScotomaSIDER
414Septic ShockOFFSIDES
415Severe Acute Respiratory SyndromeOFFSIDES
416ShockSIDER
417Sick Sinus SyndromeOFFSIDES
418SinusitisSIDER
419Skin hypertrophySIDER
420Status Epilepticus20851280CTD
421Stevens-Johnson Syndrome25811541CTD
422StomatitisSIDER
423StuporSIDER
424Substance Withdrawal Syndrome10641980CTD
425SweatingSIDER
426SyncopeSIDER
427T-lymphocyte count increasedOFFSIDES
428TensionSIDER
429ThirstSIDER
430Throat irritationSIDER
431ThrombocytopeniaSIDER
432ThrombosisSIDER
433Toxic Epidermal NecrolysisSIDER
434ToxoplasmosisOFFSIDES
435TracheitisOFFSIDES
436Transaminases increasedOFFSIDES
437TremorSIDER
438Urethritis noninfectiveSIDER
439UrethritisSIDER
440Urinary RetentionSIDER
441Urine output increasedSIDER
442UveitisSIDER
443Vasodilation procedureSIDER
444VasodilationSIDER
445VasospasmOFFSIDES
SIDER
446Venous Thrombosis10625032CTD
447Vertigo10907977
11197575		CTD
SIDER
448Vesiculobullous rashSIDER
449Visual disturbanceOFFSIDES
450XanthomatosisSIDER
451furuncleSIDER
452jaundiceSIDER
453nervous system disorderSIDER
454pseudomembranous colitisSIDER
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