MetaADEDB 2.0 @ LMMD
Adapalene
(LZCDAPDGXCYOEH-UHFFFAOYSA-N)
Structure
SMILES
COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O
Type(s)
Approved
ATC code(s)
D10AD03; D10AD53
Molecular Formula:
C28H28O3
Molecular Weight:
412.520
Log P:
6.6814
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
46.53
CAS Number(s):
106685-40-9
Synonym(s)
1.
Adapalene
2.
6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid
3.
Adaferin
4.
CD 271
5.
CD-271
6.
CD271
7.
Differin
8.
Differine
9.
271, CD
External Link(s)
MeSHD000068816
PubChem Compound60164
BindingDB50048280
50290084
ChEBI31174
CHEMBLCHEMBL1265
DrugBankDB00210
DrugCentral87
IUPHAR/BPS Guide to PHARMACOLOGY5429
KEGGdr:D01112
Therapeutic Target DatabaseD0JC9N
ZINC3784182
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AcneFAERS: 119
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
2Drug ineffectiveFAERS: 96
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
3Dry skinFAERS: 91
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
4ErythemaFAERS: 84
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
5Pain of skinFAERS: 46SIDER
US FAERS
6PruritusFAERS: 45SIDER
US FAERS
7Skin irritationFAERS: 36SIDER
US FAERS
8Product use in unapproved indicationFAERS: 16US FAERS
9Inappropriate schedule of drug administrationFAERS: 15US FAERS
10HypersensitivityFAERS: 13SIDER
US FAERS
11AlopeciaFAERS: 11OFFSIDES
US FAERS
12Rash erythematousFAERS: 11US FAERS
13UrticariaFAERS: 10SIDER
US FAERS
14ScabFAERS: 8US FAERS
15Skin reactionFAERS: 8US FAERS
16DermatitisFAERS: 7SIDER
US FAERS
17Intentional product use issueFAERS: 6US FAERS
18OverdoseFAERS: 6US FAERS
19Skin tightnessFAERS: 6US FAERS
20Inappropriate schedule of product administrationFAERS: 5US FAERS
21Product use issueFAERS: 5US FAERS
22Skin discomfortFAERS: 5SIDER
US FAERS
23Therapeutic response unexpectedFAERS: 5US FAERS
24Chemical burn of skinFAERS: 4US FAERS
25Burning sensationFAERS: 3SIDER
US FAERS
26Drug exposure during pregnancyFAERS: 3OFFSIDES
US FAERS
27NauseaFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
28PainFAERS: 321743808CTD
SIDER
US FAERS
29Accidental exposure to productFAERS: 2US FAERS
30Adverse eventFAERS: 2US FAERS
31Application site painFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
32Application site vesiclesFAERS: 2US FAERS
33CystFAERS: 2US FAERS
34Dandy-Walker SyndromeFAERS: 2OFFSIDES
US FAERS
35Depressed moodFAERS: 2OFFSIDES
US FAERS
36Dilated poresFAERS: 2US FAERS
37Drug ineffective for unapproved indicationFAERS: 2US FAERS
38Emotional distressFAERS: 2US FAERS
39Eye irritationFAERS: 2US FAERS
40Eyelid irritationFAERS: 2SIDER
US FAERS
41HeadacheFAERS: 2US FAERS
42Intentional product misuseFAERS: 2US FAERS
43Maternal exposure during pregnancyFAERS: 2US FAERS
44Medication residue presentFAERS: 2US FAERS
45PregnancyFAERS: 2US FAERS
46Skin UlcerFAERS: 2US FAERS
47Skin lesionFAERS: 2US FAERS
48SunburnFAERS: 2SIDER
US FAERS
49Therapy non-responderFAERS: 2US FAERS
50Abdominal PainFAERS: 1OFFSIDES
US FAERS
51Alopecia effluviumFAERS: 1US FAERS
52AngioedemaFAERS: 1SIDER
US FAERS
53AnxietyFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
54Application site burnFAERS: 1US FAERS
55Application site drynessFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
56Application site erythemaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
57Application site exfoliationFAERS: 1US FAERS
58Application site irritationFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
59Application site pruritusFAERS: 1US FAERS
60Application site rashFAERS: 1US FAERS
61Application site reactionFAERS: 1US FAERS
62AstheniaFAERS: 1US FAERS
63Basal cell carcinomaFAERS: 1US FAERS
64BlepharitisFAERS: 1US FAERS
65Chemical injuryFAERS: 1US FAERS
66Chest PainFAERS: 1US FAERS
67ChloasmaFAERS: 1US FAERS
68DeformityFAERS: 1US FAERS
69DizzinessFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
70Drug administered to patient of inappropriate ageFAERS: 1US FAERS
71Drug exposure before pregnancyFAERS: 1US FAERS
72Drug prescribing errorFAERS: 1US FAERS
73DyspepsiaFAERS: 1US FAERS
74Erythema MultiformeFAERS: 1US FAERS
75Expired product administeredFAERS: 1US FAERS
76Exposure via direct contactFAERS: 1US FAERS
77Eye painFAERS: 1SIDER
US FAERS
78Eyelid exfoliationFAERS: 1US FAERS
79Eyelid painFAERS: 1US FAERS
80Facial PainFAERS: 1US FAERS
81FatigueFAERS: 1OFFSIDES
US FAERS
82GlomerulonephritisFAERS: 1US FAERS
83HyperkeratosisFAERS: 1US FAERS
84Incorrect route of drug administrationFAERS: 1US FAERS
85InflammationFAERS: 19557255
9990413
21743808		CTD
US FAERS
86KeratitisFAERS: 1SIDER
US FAERS
87Maternal exposure before pregnancyFAERS: 1US FAERS
88Musculoskeletal stiffnessFAERS: 1OFFSIDES
US FAERS
89Pregnancy test positiveFAERS: 1US FAERS
90Pregnancy with contraceptive deviceFAERS: 1US FAERS
91Secretion dischargeFAERS: 1OFFSIDES
US FAERS
92Similar reaction on previous exposure to drugFAERS: 1US FAERS
93Skin ErosionFAERS: 1US FAERS
94Skin IndurationFAERS: 1US FAERS
95Skin indentationFAERS: 1US FAERS
96Skin weepingFAERS: 1US FAERS
97StressFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
98SyncopeFAERS: 1US FAERS
99Thermal burnFAERS: 1US FAERS
100ThrombocytopeniaFAERS: 1US FAERS
101Urine alcohol test positiveFAERS: 1US FAERS
102Vulvovaginal painFAERS: 1US FAERS
103Wrong technique in drug usage processFAERS: 1US FAERS
104furuncleFAERS: 1US FAERS
105Abdominal discomfortOFFSIDES
106Acne Vulgaris

View details

8396608
9557255
9990413
12207595
15891249
17166623
17518990
21548569
21864882
 		CTD
107Acquired night blindnessOFFSIDES
108Activated partial thromboplastin time shortenedOFFSIDES
109Alanine Aminotransferase IncreasedOFFSIDES
110Anal FissureOFFSIDES
111Analgesic drug level increasedOFFSIDES
112AngerOFFSIDES
113Ankle FractureOFFSIDES
114Ankylosing spondylitisOFFSIDES
115Aphthous StomatitisOFFSIDES
116AppendicitisOFFSIDES
117Application site infectionCanada Vigilance: 1Canada Vigilance
118Application site papulesCanada Vigilance: 1Canada Vigilance
119Application site scarCanada Vigilance: 1Canada Vigilance
120AscitesOFFSIDES
121AsthmaOFFSIDES
122Atrial tachycardiaOFFSIDES
123BelligerenceOFFSIDES
124Biliary DyskinesiaOFFSIDES
125Blood alkaline phosphatase increasedOFFSIDES
126Blood cholesterolOFFSIDES
127Blood creatinine increasedOFFSIDES
128Blood phosphorus decreasedOFFSIDES
129Blood testosterone decreasedOFFSIDES
130Blood triglycerides increasedOFFSIDES
131Brain ConcussionOFFSIDES
132Breast CystOFFSIDES
133BronchitisOFFSIDES
134Bulbar palsyOFFSIDES
135Choking sensationOFFSIDES
136ChromaturiaOFFSIDES
137Complications of transplant surgeryOFFSIDES
138Congenital heart diseaseOFFSIDES
139Congenital heart valve disorderOFFSIDES
140ConjunctivitisSIDER
141Contact DermatitisOFFSIDES
142Coronary artery insufficiencyOFFSIDES
143Culture positiveOFFSIDES
144Decreased LibidoOFFSIDES
145DemyelinationOFFSIDES
146Dental cariesOFFSIDES
147DextrocardiaOFFSIDES
148Disturbance in sexual arousalOFFSIDES
149DrowsinessOFFSIDES
150Drug withdrawal headacheOFFSIDES
151Ectopic kidneyOFFSIDES
152EczemaOFFSIDES
SIDER
153EmbolismOFFSIDES
154EnterocolitisOFFSIDES
155Euphoric moodOFFSIDES
156ExcoriationSIDER
157Eyelids pruritusSIDER
158Facial NeuralgiaOFFSIDES
159Feeding disorder neonatalOFFSIDES
160Feeling abnormalOFFSIDES
161Flat affectOFFSIDES
162Gastrointestinal inflammationOFFSIDES
163GlobulinuriaOFFSIDES
164GoiterOFFSIDES
165HepatitisSIDER
166Herpes LabialisSIDER
167HoarsenessOFFSIDES
168HostilityOFFSIDES
169Hypocoagulable stateOFFSIDES
170HypospadiasOFFSIDES
171Infusion site mobility decreasedOFFSIDES
172Instillation site painSIDER
173IntertrigoOFFSIDES
174Intervertebral Disc DegenerationOFFSIDES
175Joint stiffnessOFFSIDES
176Keratitis siccaOFFSIDES
177KeratoconjunctivitisSIDER
178Lactose IntoleranceOFFSIDES
179LethargyOFFSIDES
180Limb injuryOFFSIDES
181Lip swellingSIDER
182Liver transplant rejectionOFFSIDES
183Lumbar puncture abnormalOFFSIDES
184NasopharyngitisOFFSIDES
185Neonatal tachycardiaOFFSIDES
186Neoplasms21864882CTD
187Nervous tensionOFFSIDES
188NeuralgiaOFFSIDES
189NeurodermatitisOFFSIDES
190Neutropenic sepsisOFFSIDES
191Occult blood positiveOFFSIDES
192Ocular icterusOFFSIDES
193Optic NeuritisSIDER
194Oropharyngeal painOFFSIDES
195OsteomyelitisOFFSIDES
196PeriodontitisOFFSIDES
197Persistent left superior vena cavaOFFSIDES
198Personality ChangeOFFSIDES
199Pharyngolaryngeal PainOFFSIDES
200PhototoxicitySIDER
201Pregnancy on oral contraceptiveOFFSIDES
202Protein total decreasedOFFSIDES
203Psoriasis21864882CTD
204Pulmonary malformationOFFSIDES
205RednessSIDER
206Respiratory tract congestionOFFSIDES
207RhabdomyolysisOFFSIDES
208Risus sardonicusOFFSIDES
209SacroiliitisOFFSIDES
210Scimitar SyndromeOFFSIDES
211SclerodermaOFFSIDES
212ScreamingOFFSIDES
213Semen volume decreasedOFFSIDES
214Sensation of warmthSIDER
215Sinus headacheOFFSIDES
216SinusitisOFFSIDES
217SnoringOFFSIDES
218Swelling of eyelidSIDER
219SynovitisOFFSIDES
220Temperature intoleranceCanada Vigilance: 1Canada Vigilance
221Unevaluable eventOFFSIDES
222Vesiculobullous rashSIDER
223Weight GainOFFSIDES
224XerosisOFFSIDES
225diagnostic procedureOFFSIDES
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