MetaADEDB 2.0 @ LMMD
Simethicone
(AMTWCFIAVKBGOD-UHFFFAOYSA-N)
Structure
SMILES
CO[Si](O[Si](C)(C)C)(C)C.O=[Si]=O
Type(s)
Approved
Molecular Formula:
C6H18O4Si3
Molecular Weight:
238.461
Log P:
1.5677
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
52.6
CAS Number(s):
8050-81-5
Synonym(s)
1.
Simethicone
2.
Phazyme 125
External Link(s)
MeSHD012841
PubChem Compound6433516
CHEMBLCHEMBL1200838
DrugBankDB09512
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 8US FAERS
2DyspepsiaFAERS: 4OFFSIDES
US FAERS
3Expired drug administeredFAERS: 4US FAERS
4Feeling abnormalFAERS: 4US FAERS
5Cerebrovascular accidentFAERS: 3US FAERS
6Diabetes MellitusFAERS: 3US FAERS
7Incorrect dose administeredFAERS: 3US FAERS
8VomitingFAERS: 3US FAERS
9Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
10AphasiaFAERS: 2US FAERS
11Blood glucose increasedFAERS: 2US FAERS
12ChokingFAERS: 2US FAERS
13DisorientationFAERS: 2US FAERS
14DizzinessFAERS: 2OFFSIDES
US FAERS
15FlatulenceFAERS: 2OFFSIDES
US FAERS
16HypersensitivityFAERS: 2US FAERS
17MalaiseFAERS: 2US FAERS
18Product quality issueFAERS: 2US FAERS
19Product tamperingFAERS: 2US FAERS
20Wrong technique in product usage processFAERS: 2US FAERS
21AbasiaFAERS: 1US FAERS
22AmnesiaFAERS: 1OFFSIDES
US FAERS
23Atrial FibrillationFAERS: 1US FAERS
24Back PainFAERS: 1US FAERS
25Cardiac ArrestFAERS: 1US FAERS
26Chest PainFAERS: 1OFFSIDES
US FAERS
27Concomitant disease aggravatedFAERS: 1US FAERS
28DementiaFAERS: 1US FAERS
29DiplopiaFAERS: 1US FAERS
30Disease recurrenceFAERS: 1US FAERS
31DiverticulitisFAERS: 1US FAERS
32Drug DependenceFAERS: 1US FAERS
33ErythemaFAERS: 1US FAERS
34Extra dose administeredFAERS: 1US FAERS
35Facial PainFAERS: 1US FAERS
36FatigueFAERS: 1OFFSIDES
US FAERS
37FlushingFAERS: 1US FAERS
38GastritisFAERS: 1US FAERS
39GlaucomaFAERS: 1US FAERS
40GoutFAERS: 1OFFSIDES
US FAERS
41Incorrect drug administration durationFAERS: 1US FAERS
42Intercepted drug dispensing errorFAERS: 1US FAERS
43Joint injuryFAERS: 1US FAERS
44Large intestine perforationFAERS: 1OFFSIDES
US FAERS
45Medication residue presentFAERS: 1US FAERS
46Memory impairmentFAERS: 1US FAERS
47Muscle strainFAERS: 1US FAERS
48Myocardial InfarctionFAERS: 1US FAERS
49NauseaFAERS: 1OFFSIDES
US FAERS
50NephrolithiasisFAERS: 1US FAERS
51NervousnessFAERS: 1US FAERS
52OverdoseFAERS: 1US FAERS
53PainFAERS: 1OFFSIDES
US FAERS
54Pancreatic carcinomaFAERS: 1US FAERS
55Product physical consistency issueFAERS: 1US FAERS
56Product solubility abnormalFAERS: 1US FAERS
57Rash erythematousFAERS: 1US FAERS
58SinusitisFAERS: 1OFFSIDES
US FAERS
59Slow response to stimuliFAERS: 1US FAERS
60StressFAERS: 1US FAERS
61Therapeutic response unexpectedFAERS: 1US FAERS
62Throat irritationFAERS: 1US FAERS
63ToothacheFAERS: 1US FAERS
64Toxicity to various agentsFAERS: 1US FAERS
65Urine flow decreasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
66Abdominal PainOFFSIDES
67Abdominal tendernessOFFSIDES
68Acid refluxOFFSIDES
69Actinic keratosisOFFSIDES
70Activities of daily living impairedOFFSIDES
71Acute graft versus host disease in liverOFFSIDES
72Acute myocardial infarctionOFFSIDES
73Acute sinusitisOFFSIDES
74Anal FissureOFFSIDES
75Anal sphincterotomyOFFSIDES
76AnhidrosisOFFSIDES
77AnorexiaOFFSIDES
78Antiviral drug level above therapeuticOFFSIDES
79AnxietyOFFSIDES
80Aortic AneurysmOFFSIDES
81Aortic valve calcificationOFFSIDES
82Application site pustulesOFFSIDES
83Application site rashOFFSIDES
84ArteriosclerosisOFFSIDES
85ArthritisOFFSIDES
86AscitesOFFSIDES
87Aspiration PneumoniaOFFSIDES
88AstheniaOFFSIDES
89AsthmaOFFSIDES
90AtaxiaOFFSIDES
91AtelectasisOFFSIDES
92Atrial FlutterOFFSIDES
93Atrial tachycardiaOFFSIDES
94Benign Prostatic HyperplasiaOFFSIDES
95Bipolar DisorderOFFSIDES
96Blood GlucoseOFFSIDES
97Blood albumin decreasedOFFSIDES
98Blood alkaline phosphatase increasedOFFSIDES
99Blood chloride decreasedOFFSIDES
100Blood chloride increasedOFFSIDES
101Blood cholesterol abnormalOFFSIDES
102Blood creatinine increasedOFFSIDES
103Blood glucose abnormalOFFSIDES
104Blood glucose decreasedOFFSIDES
105Blood potassium decreasedOFFSIDES
106Blood potassium increasedOFFSIDES
107Blood sodiumOFFSIDES
108Bone painOFFSIDES
109BradycardiaOFFSIDES
110Brain natriuretic peptide increasedOFFSIDES
111Breast tendernessOFFSIDES
112BronchitisOFFSIDES
113BronchopneumoniaOFFSIDES
114Bulbar palsyOFFSIDES
115Burning sensationOFFSIDES
116Cardioactive drug level increasedOFFSIDES
117CellulitisOFFSIDES
118Cerebral ArteriosclerosisOFFSIDES
119Choking sensationOFFSIDES
120Circumstance or information capable of leading to medication errorOFFSIDES
121Clostridium difficile colitisOFFSIDES
122ColitisOFFSIDES
123Compression fractureOFFSIDES
124Conjunctival depositOFFSIDES
125Contact DermatitisOFFSIDES
126CystitisCanada Vigilance: 1Canada Vigilance
127DebridementOFFSIDES
128DehydrationOFFSIDES
129DemyelinationOFFSIDES
130Dentofacial anomalyOFFSIDES
131Device FailureOFFSIDES
132Device leakageOFFSIDES
133DiabetesOFFSIDES
134Diabetes mellitus inadequate controlOFFSIDES
135DiarrheaOFFSIDES
136Drug abuserOFFSIDES
137Drug addictOFFSIDES
138Drug screen positiveOFFSIDES
139Drug toxicityOFFSIDES
140Drug withdrawal headacheOFFSIDES
141Duodenal Ulcer7352543CTD
142DuodenitisOFFSIDES
143DysmenorrheaOFFSIDES
144Dysthymic DisorderOFFSIDES
145DystoniaOFFSIDES
146DysuriaOFFSIDES
147Economic problemOFFSIDES
148Ejection Fraction DecreasedOFFSIDES
149Electrocardiogram ST segment abnormalOFFSIDES
150Electrocardiogram ST-T changeOFFSIDES
151Embolic strokeOFFSIDES
152Emotional distressOFFSIDES
153Endodontic procedureOFFSIDES
154Engraftment syndromeOFFSIDES
155EnteritisOFFSIDES
156EpistaxisOFFSIDES
157Erectile dysfunctionOFFSIDES
158Erosive gastritisOFFSIDES
159Esophageal StenosisOFFSIDES
160Exposure to toxic agentOFFSIDES
161Failure to ThriveOFFSIDES
162Febrile NeutropeniaOFFSIDES
163Fluid overloadOFFSIDES
164GalactorrheaOFFSIDES
165GangreneOFFSIDES
166GastroduodenitisOFFSIDES
167GastroenteritisOFFSIDES
168Gastrointestinal perforationOFFSIDES
169Gingival erythemaOFFSIDES
170GlobulinuriaOFFSIDES
171GlomerulonephritisOFFSIDES
172GranulocytosisOFFSIDES
173Heparin-induced thrombocytopeniaOFFSIDES
174Hepatic Vein ThrombosisOFFSIDES
175Hepatojugular refluxOFFSIDES
176HypokinesiaOFFSIDES
177Incorrect product administration durationCanada Vigilance: 1Canada Vigilance
178InfectionOFFSIDES
179Injection site erythemaOFFSIDES
180Injection site massOFFSIDES
181Injection site noduleOFFSIDES
182Injection site stingingOFFSIDES
183Intention tremorOFFSIDES
184Intervertebral Disc DegenerationOFFSIDES
185Intervertebral disc disorderOFFSIDES
186Intestinal ObstructionOFFSIDES
187Intestinal PerforationOFFSIDES
188Intracranial AneurysmOFFSIDES
189Irritable Bowel Syndrome20003095CTD
190Joint sprainOFFSIDES
191Jugular vein distensionOFFSIDES
192Kidney FailureOFFSIDES
193Lactose IntoleranceOFFSIDES
194LethargyOFFSIDES
195Leukopenia neonatalOFFSIDES
196Life expectancy shortenedOFFSIDES
197Light chain analysis increasedOFFSIDES
198Liver transplant rejectionOFFSIDES
199Lumbar radiculopathyOFFSIDES
200Lung consolidationOFFSIDES
201Lymphocyte count decreasedOFFSIDES
202Mastication disorderOFFSIDES
203Mechanical ventilationOFFSIDES
204Medication residueOFFSIDES
205Meningitis enterococcalOFFSIDES
206Mental status changesOFFSIDES
207Mesenteric artery stenosisOFFSIDES
208Mitral Valve StenosisOFFSIDES
209Mixed Connective Tissue DiseaseOFFSIDES
210Multiple MyelomaOFFSIDES
211Multiple drug overdoseOFFSIDES
212Musculoskeletal PainOFFSIDES
213Musculoskeletal stiffnessOFFSIDES
214Neurogenic BowelOFFSIDES
215Neutrophil count abnormalOFFSIDES
216NocturiaOFFSIDES
217Oropharyngeal painOFFSIDES
218OsteolysisOFFSIDES
219OsteopeniaOFFSIDES
220OverweightOFFSIDES
221PalpitationsCanada Vigilance: 1Canada Vigilance
222Pathogen resistanceOFFSIDES
223Perineal operationOFFSIDES
224Periodontal operationOFFSIDES
225Physical examination abnormalOFFSIDES
226PlasmacytomaOFFSIDES
227PneumopericardiumOFFSIDES
228PneumoperitoneumOFFSIDES
229PneumothoraxOFFSIDES
230Portal HypertensionOFFSIDES
231Protein total decreasedOFFSIDES
232PruritusCanada Vigilance: 1Canada Vigilance
233Pulmonary arterial pressure increasedOFFSIDES
234Pulmonary congestionOFFSIDES
235Rectal polypectomyOFFSIDES
236Renal Artery StenosisOFFSIDES
237Renal tubular necrosisOFFSIDES
238Respiratory FailureOFFSIDES
239Respiratory tract congestionOFFSIDES
240RhinorrheaOFFSIDES
241Right atrial dilatationOFFSIDES
242Risus sardonicusOFFSIDES
243Septic ShockOFFSIDES
244SequestrectomyOFFSIDES
245Shoulder PainOFFSIDES
246Skin lacerationOFFSIDES
247Sputum culture positiveOFFSIDES
248Status EpilepticusOFFSIDES
249StridorOFFSIDES
250Superior Vena Cava SyndromeOFFSIDES
251UlcerOFFSIDES
252Unresponsive to stimuliOFFSIDES
253Urge IncontinenceOFFSIDES
254Violence-related symptomOFFSIDES
255Visual disturbanceOFFSIDES
256Weight GainOFFSIDES
257Wound InfectionOFFSIDES
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