MetaADEDB 2.0 @ LMMD
Diltiazem
(HDRXZJPWHTXQRI-BHDTVMLSSA-N)
Structure
SMILES
COc1ccc(cc1)[C@@H]1Sc2ccccc2N(C(=O)[C@@H]1OC(=O)C)CCN(C)C.Cl
Molecular Formula:
C22H27ClN2O4S
Molecular Weight:
450.979
Log P:
4.2355
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
1
TPSA:
84.38
CAS Number(s):
33286-22-5; 38411-61-9; 103532-26-9
Synonym(s)
1.
Diltiazem
2.
Aldizem
3.
CRD-401
4.
Cardil
5.
Cardizem
6.
Dilacor
7.
Dilacor XR
8.
Dilren
9.
Diltiazem Hydrochloride
10.
Diltiazem Malate
11.
Dilzem
12.
Tiazac
13.
CRD 401
14.
CRD401
External Link(s)
MeSHD004110
PubChem Compound657259
44659717
62920
ChEBI645509
CHEMBLCHEMBL1697
KEGGdr:D00616
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Completed SuicideFAERS: 117
Canada Vigilance: 1
Canada Vigilance
US FAERS
2Drug ineffectiveFAERS: 60
Canada Vigilance: 5
Canada Vigilance
US FAERS
3HypotensionFAERS: 58
Canada Vigilance: 4
Canada Vigilance
US FAERS
4BradycardiaFAERS: 55
Canada Vigilance: 4
Canada Vigilance
US FAERS
5DizzinessFAERS: 51
Canada Vigilance: 8
Canada Vigilance
US FAERS
6HeadacheFAERS: 45
Canada Vigilance: 6
Canada Vigilance
US FAERS
7OverdoseFAERS: 45
Canada Vigilance: 1
Canada Vigilance
US FAERS
8NauseaFAERS: 39
Canada Vigilance: 1
Canada Vigilance
US FAERS
9Toxicity to various agentsFAERS: 37
Canada Vigilance: 2
Canada Vigilance
US FAERS
10VomitingFAERS: 36US FAERS
11Product substitution issueFAERS: 34
Canada Vigilance: 1
Canada Vigilance
US FAERS
12Cardiac ArrestFAERS: 29
Canada Vigilance: 1
Canada Vigilance
US FAERS
13FatigueFAERS: 29
Canada Vigilance: 6
Canada Vigilance
US FAERS
14AstheniaFAERS: 26
Canada Vigilance: 1
Canada Vigilance
US FAERS
15Medication ErrorFAERS: 26US FAERS
16ShockFAERS: 25
Canada Vigilance: 2
Canada Vigilance
US FAERS
17Suicide attemptFAERS: 24US FAERS
18Metabolic acidosisFAERS: 23US FAERS
19Pharmaceutical product complaintFAERS: 23US FAERS
20Medication residue presentFAERS: 22US FAERS
21PoisoningFAERS: 21US FAERS
22MalaiseFAERS: 20US FAERS
23PruritusFAERS: 19
Canada Vigilance: 3
Canada Vigilance
US FAERS
24Atrial FibrillationFAERS: 18US FAERS
25Chest PainFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
26Joint swellingFAERS: 17
Canada Vigilance: 1
Canada Vigilance
US FAERS
27Product quality issueFAERS: 17US FAERS
28PalpitationsFAERS: 16US FAERS
29TachycardiaFAERS: 16
Canada Vigilance: 3
Canada Vigilance
US FAERS
30UrticariaFAERS: 16
Canada Vigilance: 3
Canada Vigilance
US FAERS
31Wrong technique in product usage processFAERS: 13US FAERS
32Abdominal discomfortFAERS: 12
Canada Vigilance: 2
Canada Vigilance
US FAERS
33Atrioventricular BlockFAERS: 12
Canada Vigilance: 3
Canada Vigilance
US FAERS
34Chest discomfortFAERS: 12US FAERS
35Peripheral swellingFAERS: 12US FAERS
36Aspartate Aminotransferase IncreasedFAERS: 11US FAERS
37ErythemaFAERS: 11
Canada Vigilance: 3
Canada Vigilance
US FAERS
38HypersensitivityFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
39TremorFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
40Alanine Aminotransferase IncreasedFAERS: 10US FAERS
41AlopeciaFAERS: 10US FAERS
42AnuriaFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
43FlushingFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
44HypoxiaFAERS: 10US FAERS
45SwellingFAERS: 10US FAERS
46Blood glucose increasedFAERS: 9US FAERS
47Therapeutic response unexpected with drug substitutionFAERS: 9US FAERS
48Acute kidney injuryFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
49Drug dispensing errorFAERS: 8US FAERS
50Feeling abnormalFAERS: 8
Canada Vigilance: 2
Canada Vigilance
US FAERS
51HepatotoxicityFAERS: 8US FAERS
52Incorrect dose administeredFAERS: 8US FAERS
53Product use in unapproved indicationFAERS: 8US FAERS
54Respiratory arrestFAERS: 8US FAERS
55SomnolenceFAERS: 8US FAERS
56Abdominal PainFAERS: 7
Canada Vigilance: 2
Canada Vigilance
US FAERS
57ConstipationFAERS: 7
Canada Vigilance: 2
Canada Vigilance
US FAERS
58Respiratory FailureFAERS: 7US FAERS
59Sinus bradycardiaFAERS: 7US FAERS
60Ventricular FibrillationFAERS: 7US FAERS
61Accidental drug intake by childFAERS: 6US FAERS
62Accidental overdoseFAERS: 6US FAERS
63AcidosisFAERS: 6US FAERS
64Blood pressure inadequately controlledFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
65DyspepsiaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
66Erythema MultiformeFAERS: 6US FAERS
67Exposure via ingestionFAERS: 6US FAERS
68Multi-organ disorderFAERS: 6US FAERS
69OliguriaFAERS: 6US FAERS
70Stevens-Johnson SyndromeFAERS: 6US FAERS
71TinnitusFAERS: 6
Canada Vigilance: 3
Canada Vigilance
US FAERS
72AnxietyFAERS: 5US FAERS
73Back PainFAERS: 5US FAERS
74Blood lactate dehydrogenase increasedFAERS: 5US FAERS
75Cerebrovascular accidentFAERS: 5US FAERS
76DermatitisFAERS: 5US FAERS
77Intentional product misuseFAERS: 5US FAERS
78Medication residueFAERS: 5US FAERS
79Mucosal erosionFAERS: 5US FAERS
80Product taste abnormalFAERS: 5US FAERS
81Product use complaintFAERS: 5US FAERS
82Product use issueFAERS: 5US FAERS
83SyncopeFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
84Adverse eventFAERS: 4US FAERS
85Anaphylactic shockFAERS: 4US FAERS
86AngioedemaFAERS: 4US FAERS
87Blood alkaline phosphatase increasedFAERS: 4US FAERS
88Blood creatinine increasedFAERS: 4US FAERS
89Burning sensationFAERS: 4US FAERS
90CyanosisFAERS: 4US FAERS
91Drug dose omissionFAERS: 4US FAERS
92Eye irritationFAERS: 4US FAERS
93General physical health deteriorationFAERS: 4US FAERS
94HypoperfusionFAERS: 4US FAERS
95Mental status changesFAERS: 4US FAERS
96No adverse eventFAERS: 4US FAERS
97PainFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
98PresyncopeFAERS: 4US FAERS
99Product size issueFAERS: 4US FAERS
100Skin test positiveFAERS: 4US FAERS
101Vasoplegia syndromeFAERS: 4US FAERS
102VertigoFAERS: 4US FAERS
103Accidental exposureFAERS: 3US FAERS
104ConjunctivitisFAERS: 3US FAERS
105CryingFAERS: 3US FAERS
106Drug exposure during pregnancyFAERS: 3US FAERS
107DysarthriaFAERS: 3US FAERS
108DysphoniaFAERS: 3US FAERS
109EpistaxisFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
110Eye painFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
111Foreign body traumaFAERS: 3US FAERS
112Intentional misuseFAERS: 3US FAERS
113LeukocytosisFAERS: 3US FAERS
114Lip swellingFAERS: 3US FAERS
115PancytopeniaFAERS: 3US FAERS
116Rash erythematousFAERS: 3
Canada Vigilance: 2
Canada Vigilance
US FAERS
117SluggishnessFAERS: 3US FAERS
118Supraventricular tachycardiaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
119Unevaluable eventFAERS: 3US FAERS
120Visual ImpairmentFAERS: 3US FAERS
121Abdominal Compartment SyndromeFAERS: 2US FAERS
122Acute Lung InjuryFAERS: 2US FAERS
123AgranulocytosisFAERS: 2US FAERS
124AmnesiaFAERS: 2US FAERS
125AnorexiaFAERS: 2US FAERS
126Aortic AneurysmFAERS: 2US FAERS
127ArthralgiaFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
128Blood cholesterol increasedFAERS: 2US FAERS
129Blood creatine increasedFAERS: 2US FAERS
130CataractFAERS: 2US FAERS
131Caustic injuryFAERS: 2US FAERS
132ChokingFAERS: 2US FAERS
133CholestasisFAERS: 2US FAERS
134Cytolytic hepatitisFAERS: 2US FAERS
135DeafnessFAERS: 2US FAERS
136DehydrationFAERS: 2US FAERS
137DemyelinationFAERS: 2US FAERS
138Depressed Level of ConsciousnessFAERS: 2US FAERS
139Device capturing issueFAERS: 2US FAERS
140Diabetic KetoacidosisFAERS: 2US FAERS
141DiverticulumFAERS: 2US FAERS
142Drug abuseFAERS: 2US FAERS
143Drug administration errorFAERS: 2US FAERS
144Electrolyte imbalanceFAERS: 2US FAERS
145Epigastric discomfortFAERS: 2US FAERS
146ExtravasationFAERS: 2US FAERS
147FlatulenceFAERS: 2US FAERS
148GastritisFAERS: 2US FAERS
149HepatitisFAERS: 2US FAERS
150HypothyroidismFAERS: 2US FAERS
151Iatrogenic injuryFAERS: 2US FAERS
152Idiosyncratic drug reactionFAERS: 2US FAERS
153Intentional drug misuseFAERS: 2US FAERS
154Intentional self-injuryFAERS: 2US FAERS
155LethargyFAERS: 2US FAERS
156Mood swingsFAERS: 2US FAERS
157Musculoskeletal PainFAERS: 2US FAERS
158Musculoskeletal stiffnessFAERS: 2US FAERS
159Oropharyngeal painFAERS: 2US FAERS
160Pharmaceutical product counterfeitFAERS: 2US FAERS
161PneumoniaFAERS: 2US FAERS
162Poor quality drug administeredFAERS: 2US FAERS
163Prescribed overdoseFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
164Product preparation errorFAERS: 2US FAERS
165Product residue presentFAERS: 2US FAERS
166Reaction to excipientFAERS: 2US FAERS
167Sinoatrial BlockFAERS: 2US FAERS
168Sinus TachycardiaFAERS: 2US FAERS
169Skin lesionFAERS: 2US FAERS
170SneezingFAERS: 2US FAERS
171Therapeutic response unexpectedFAERS: 2US FAERS
172Therapy cessationFAERS: 2US FAERS
173Therapy non-responderFAERS: 2US FAERS
174Throat irritationFAERS: 2US FAERS
175ThrombocytopeniaFAERS: 2US FAERS
176Weight decreasedFAERS: 2US FAERS
177WheezingFAERS: 2US FAERS
178White blood cell count decreasedFAERS: 2US FAERS
179Wrong drug administeredFAERS: 2US FAERS
180nervous system disorderFAERS: 2US FAERS
181treatment failureFAERS: 2US FAERS
182Accidental exposure to productFAERS: 1US FAERS
183AcneFAERS: 1US FAERS
184Acute prerenal failureFAERS: 1US FAERS
185AdactylyFAERS: 1US FAERS
186Adams-Stokes SyndromeFAERS: 1US FAERS
187AgeusiaFAERS: 1US FAERS
188AgitationFAERS: 1US FAERS
189Allergy to arthropod stingFAERS: 1US FAERS
190Amylase increasedFAERS: 1US FAERS
191Anal FissureFAERS: 1US FAERS
192Anal spasmFAERS: 1US FAERS
193AneurysmFAERS: 1US FAERS
194AngerFAERS: 1US FAERS
195Angina PectorisFAERS: 1US FAERS
196AnhidrosisFAERS: 1US FAERS
197ApathyFAERS: 1US FAERS
198ArthropathyFAERS: 1US FAERS
199Arthropod stingFAERS: 1US FAERS
200AsthmaFAERS: 1US FAERS
201AtaxiaFAERS: 1US FAERS
202Atrial FlutterFAERS: 1US FAERS
203Auricular swellingFAERS: 1US FAERS
204Blister ruptureFAERS: 1US FAERS
205Blood creatine phosphokinase increasedFAERS: 1US FAERS
206Blood glucose abnormalFAERS: 1US FAERS
207Blood glucose decreasedFAERS: 1US FAERS
208Blood immunoglobulin M decreasedFAERS: 1US FAERS
209Blood potassium decreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
210Blood potassium increasedFAERS: 1US FAERS
211Blood pressure fluctuationFAERS: 1US FAERS
212Blood sodium decreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
213Bone painFAERS: 1US FAERS
214Bowel movement irregularityFAERS: 1US FAERS
215Capsule physical issueFAERS: 1US FAERS
216Carbon Monoxide PoisoningFAERS: 1US FAERS
217Cardiac FlutterFAERS: 1US FAERS
218CardiomegalyFAERS: 1US FAERS
219CardiotoxicityFAERS: 1US FAERS
220Cerebral InfarctionFAERS: 1US FAERS
221Cerebral atrophyFAERS: 1US FAERS
222CheilitisFAERS: 1US FAERS
223ChillsFAERS: 1US FAERS
224Cluster HeadacheFAERS: 1US FAERS
225Colonic Pseudo-ObstructionFAERS: 1US FAERS
226Coma scale abnormalFAERS: 1US FAERS
227CrystalluriaFAERS: 1US FAERS
228Depressed moodFAERS: 1US FAERS
229Device computer issueFAERS: 1US FAERS
230Device malfunctionFAERS: 1US FAERS
231Device use issueFAERS: 1US FAERS
232Diabetes MellitusFAERS: 1US FAERS
233DiplopiaFAERS: 1US FAERS
234DiscomfortFAERS: 1US FAERS
235Drug effect incompleteFAERS: 1US FAERS
236Drug ineffective for unapproved indicationFAERS: 1US FAERS
237Drug level increasedFAERS: 1US FAERS
238Drug prescribing errorFAERS: 1US FAERS
239Drug toxicityFAERS: 1US FAERS
240DysgeusiaFAERS: 1US FAERS
241DystoniaFAERS: 1US FAERS
242EczemaFAERS: 1US FAERS
243Ejection Fraction DecreasedFAERS: 1US FAERS
244Electrocardiogram ST segment abnormalFAERS: 1US FAERS
245Emotional disorderFAERS: 1US FAERS
246Emotional distressFAERS: 1US FAERS
247Epidermal necrosisFAERS: 1US FAERS
248EructationFAERS: 1US FAERS
249Exfoliation SyndromeFAERS: 1US FAERS
250ExophthalmosFAERS: 1US FAERS
251Facial ParesisFAERS: 1US FAERS
252Food AllergyFAERS: 1US FAERS
253Frustration tolerance decreasedFAERS: 1US FAERS
254Gait inabilityFAERS: 1US FAERS
255Gastrointestinal inflammationFAERS: 1US FAERS
256Genital HerpesFAERS: 1US FAERS
257Genital erosionFAERS: 1US FAERS
258GlaucomaFAERS: 1US FAERS
259HELLP SyndromeFAERS: 1US FAERS
260Hepatic necrosisFAERS: 1US FAERS
261Hepatitis CFAERS: 1US FAERS
262HordeolumFAERS: 1US FAERS
263Human herpes virus 6 serology positiveFAERS: 1US FAERS
264Hypertensive crisisFAERS: 1US FAERS
265HypokinesiaFAERS: 1US FAERS
266Idiopathic Pulmonary FibrosisFAERS: 1US FAERS
267Impaired gastric emptyingFAERS: 1US FAERS
268Inappropriate schedule of product administrationFAERS: 1US FAERS
269Incorrect route of drug administrationFAERS: 1US FAERS
270Increased tendency to bruiseFAERS: 1US FAERS
271InflammationFAERS: 1US FAERS
272Infusion site erythemaFAERS: 1US FAERS
273Injection Site ReactionFAERS: 1US FAERS
274Intentional product use issueFAERS: 1US FAERS
275Intercepted drug dispensing errorFAERS: 1US FAERS
276Lupus-like syndromeFAERS: 1US FAERS
277LymphadenopathyFAERS: 1US FAERS
278Macular degenerationFAERS: 1US FAERS
279MaculeFAERS: 1US FAERS
280Mechanical ventilationFAERS: 1US FAERS
281Medication tamperingFAERS: 1US FAERS
282Memory impairmentFAERS: 1US FAERS
283Mental impairmentFAERS: 1US FAERS
284Middle insomniaFAERS: 1US FAERS
285Migraine with AuraFAERS: 1US FAERS
286Multiple drug overdoseFAERS: 1US FAERS
287Muscle RigidityFAERS: 1US FAERS
288Musculoskeletal chest painFAERS: 1US FAERS
289MyalgiaFAERS: 1US FAERS
290Myocardial InfarctionFAERS: 1US FAERS
291NephrolithiasisFAERS: 1US FAERS
292NervousnessFAERS: 1US FAERS
293NocturiaFAERS: 1US FAERS
294OsteopeniaFAERS: 1US FAERS
295Pain of skinFAERS: 1US FAERS
296PallorFAERS: 1US FAERS
297PetechiaeFAERS: 1US FAERS
298PhotophobiaFAERS: 1US FAERS
299PneumothoraxFAERS: 1US FAERS
300Postoperative infectionFAERS: 1US FAERS
301Product availability issueFAERS: 1US FAERS
302Product comminglingFAERS: 1US FAERS
303Product compounding quality issueFAERS: 1US FAERS
304Product container issueFAERS: 1US FAERS
305Product dispensing errorFAERS: 1US FAERS
306Product dose omissionFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
307Product formulation issueFAERS: 1US FAERS
308Product label issueFAERS: 1US FAERS
309Product physical consistency issueFAERS: 1US FAERS
310Product physical issueFAERS: 1US FAERS
311Product prescribing errorFAERS: 1US FAERS
312Product solubility abnormalFAERS: 1US FAERS
313Product supply issueFAERS: 1US FAERS
314Productive CoughFAERS: 1US FAERS
315ProteinuriaFAERS: 1US FAERS
316Pulmonary EmbolismFAERS: 1US FAERS
317Reaction to drug excipientsFAERS: 1US FAERS
318Renal Artery StenosisFAERS: 1US FAERS
319Residual urineFAERS: 1US FAERS
320Respiratory distressFAERS: 1US FAERS
321Restless Legs SyndromeFAERS: 1US FAERS
322RetchingFAERS: 1US FAERS
323RhabdomyolysisFAERS: 1US FAERS
324Rheumatoid ArthritisFAERS: 1US FAERS
325Sick Sinus SyndromeFAERS: 1US FAERS
326Sinus ArrhythmiaFAERS: 1US FAERS
327SinusitisFAERS: 1US FAERS
328Skin ErosionFAERS: 1US FAERS
329Skin necrosisFAERS: 1US FAERS
330Skin tightnessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
331Soft tissue necrosisFAERS: 1US FAERS
332Stoma site irritationFAERS: 1US FAERS
333StomatitisFAERS: 1US FAERS
334StressFAERS: 1US FAERS
335Sudden deathFAERS: 1US FAERS
336Swelling of eyelidFAERS: 1US FAERS
337TetanyFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
338Therapeutic product ineffectiveFAERS: 1US FAERS
339Throat cancerFAERS: 1US FAERS
340ThrombosisFAERS: 1US FAERS
341Toxic Epidermal NecrolysisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
342Tracheal painFAERS: 1US FAERS
343Transcription medication errorFAERS: 1US FAERS
344Traumatic fractureFAERS: 1US FAERS
345TrichorrhexisFAERS: 1US FAERS
346Troponin increasedFAERS: 1US FAERS
347Unresponsive to stimuliFAERS: 1US FAERS
348Vascular purpuraFAERS: 1US FAERS
349Venous ThrombosisFAERS: 1US FAERS
350Ventricular arrhythmiaFAERS: 1US FAERS
351Ventricular hypertrophyFAERS: 1US FAERS
352Wrong doseFAERS: 1US FAERS
353Wrong product administeredFAERS: 1US FAERS
354jaundiceFAERS: 1US FAERS
355BlindnessCanada Vigilance: 1Canada Vigilance
356Eyelid painCanada Vigilance: 1Canada Vigilance
357Joint stiffnessCanada Vigilance: 1Canada Vigilance
358OsteoporosisCanada Vigilance: 1Canada Vigilance
359PancreatitisCanada Vigilance: 1Canada Vigilance
360Pathological fractureCanada Vigilance: 1Canada Vigilance
361Retinal DetachmentCanada Vigilance: 1Canada Vigilance
362Urinary RetentionCanada Vigilance: 1Canada Vigilance
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