linaclotide
(KXGCNMMJRFDFNR-WDRJZQOASA-N)
Structure
- SMILES
- OC(=O)CC[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](C)NC(=O)[C@H]4N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC3=O)[C@H](O)C)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CSSC[C@@H](C(=O)N2)N)CC(=O)N)CCC4
- Type(s)
- Approved
- ATC code(s)
- A06AX04
- Molecular Formula:
- C59H79N15O21S6
- Molecular Weight:
- 1526.740
- Log P:
- -0.5930
- Hydrogen Bond Acceptor:
- 42
- Hydrogen Bond Donor:
- 19
- TPSA:
- 725.71
- CAS Number(s):
- 851199-59-2
Synonym(s)
1.
linaclotide
2.
ASP-0456
3.
ASP0456
4.
Linaclotide Acetate
5.
Linzess
6.
MD-1100
7.
MD-1100 acetate
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 1422 | US FAERS | |
| 2 | Abdominal Pain | FAERS: 307 | SIDER US FAERS | |
| 3 | Intentional product misuse | FAERS: 247 | US FAERS | |
| 4 | Constipation | FAERS: 226 | US FAERS | |
| 5 | Inappropriate schedule of drug administration | FAERS: 208 | US FAERS | |
| 6 | Flatulence | FAERS: 192 | SIDER US FAERS | |
| 7 | Nausea | FAERS: 141 | US FAERS | |
| 8 | Drug dose omission | FAERS: 122 | US FAERS | |
| 9 | Wrong technique in product usage process | FAERS: 102 | US FAERS | |
| 10 | Product storage error | FAERS: 98 | US FAERS | |
| 11 | Dizziness | FAERS: 95 | SIDER US FAERS | |
| 12 | Abdominal discomfort | FAERS: 74 | US FAERS | |
| 13 | Headache | FAERS: 67 | SIDER US FAERS | |
| 14 | Incorrect dose administered | FAERS: 62 | US FAERS | |
| 15 | Drug dispensing error | FAERS: 60 | US FAERS | |
| 16 | Drug ineffective for unapproved indication | FAERS: 58 | US FAERS | |
| 17 | Malaise | FAERS: 51 | US FAERS | |
| 18 | Drug prescribing error | FAERS: 49 | US FAERS | |
| 19 | Vomiting | FAERS: 48 | SIDER US FAERS | |
| 20 | Fatigue | FAERS: 43 | SIDER US FAERS | |
| 21 | Bowel movement irregularity | FAERS: 41 | US FAERS | |
| 22 | Dehydration | FAERS: 41 | SIDER US FAERS | |
| 23 | Pain | FAERS: 40 | US FAERS | |
| 24 | Asthenia | FAERS: 39 | SIDER US FAERS | |
| 25 | Weight decreased | FAERS: 38 | US FAERS | |
| 26 | Expired product administered | FAERS: 35 | US FAERS | |
| 27 | Gastrointestinal motility disorder | FAERS: 32 | US FAERS | |
| 28 | Pruritus | FAERS: 32 | US FAERS | |
| 29 | Unevaluable event | FAERS: 32 | US FAERS | |
| 30 | Feeling abnormal | FAERS: 29 | US FAERS | |
| 31 | Back Pain | FAERS: 28 | US FAERS | |
| 32 | Alopecia | FAERS: 27 | US FAERS | |
| 33 | Product packaging quantity issue | FAERS: 25 | US FAERS | |
| 34 | Palpitations | FAERS: 24 | US FAERS | |
| 35 | Dyspepsia | FAERS: 23 | SIDER US FAERS | |
| 36 | Urticaria | FAERS: 23 | SIDER US FAERS | |
| 37 | Adverse event | FAERS: 16 | US FAERS | |
| 38 | Medication Error | FAERS: 16 | US FAERS | |
| 39 | Product physical issue | FAERS: 15 | US FAERS | |
| 40 | Product quality issue | FAERS: 15 | US FAERS | |
| 41 | Chest Pain | FAERS: 14 | US FAERS | |
| 42 | Discomfort | FAERS: 13 | US FAERS | |
| 43 | Diverticulitis | FAERS: 13 | US FAERS | |
| 44 | Infrequent bowel movements | FAERS: 13 | US FAERS | |
| 45 | Somnolence | FAERS: 13 | US FAERS | |
| 46 | Anxiety | FAERS: 12 | US FAERS | |
| 47 | Dyschezia | FAERS: 12 | US FAERS | |
| 48 | Eructation | FAERS: 12 | US FAERS | |
| 49 | Hypersensitivity | FAERS: 12 | SIDER US FAERS | |
| 50 | Product use in unapproved indication | FAERS: 12 | US FAERS | |
| 51 | Syncope | FAERS: 12 | US FAERS | |
| 52 | Gastrointestinal Pain | FAERS: 11 | SIDER US FAERS | |
| 53 | Gastrointestinal sounds abnormal | FAERS: 11 | US FAERS | |
| 54 | Incorrect product storage | FAERS: 11 | US FAERS | |
| 55 | Intentional dose omission | FAERS: 11 | US FAERS | |
| 56 | Intestinal Obstruction | FAERS: 11 | US FAERS | |
| 57 | Peripheral swelling | FAERS: 11 | US FAERS | |
| 58 | Drug effect delayed | FAERS: 10 | US FAERS | |
| 59 | Myalgia | FAERS: 10 | US FAERS | |
| 60 | Swelling | FAERS: 10 | US FAERS | |
| 61 | Tremor | FAERS: 10 | US FAERS | |
| 62 | Nervousness | FAERS: 9 | US FAERS | |
| 63 | Therapeutic response unexpected | FAERS: 9 | US FAERS | |
| 64 | Anorectal discomfort | FAERS: 8 | US FAERS | |
| 65 | Chills | FAERS: 8 | US FAERS | |
| 66 | Drug effect incomplete | FAERS: 8 | US FAERS | |
| 67 | Rectal tenesmus | FAERS: 8 | US FAERS | |
| 68 | Accidental exposure to product | FAERS: 7 | US FAERS | |
| 69 | Accidental overdose | FAERS: 7 | US FAERS | |
| 70 | Blood glucose increased | FAERS: 7 | US FAERS | |
| 71 | Burning sensation | FAERS: 7 | US FAERS | |
| 72 | Electrolyte imbalance | FAERS: 7 | US FAERS | |
| 73 | Gastric Dilatation | FAERS: 7 | US FAERS | |
| 74 | Hypotension | FAERS: 7 | US FAERS | |
| 75 | Joint swelling | FAERS: 7 | US FAERS | |
| 76 | Prescription drug used without a prescription | FAERS: 7 | US FAERS | |
| 77 | Product use issue | FAERS: 7 | US FAERS | |
| 78 | Acne | FAERS: 6 | US FAERS | |
| 79 | Arthralgia | FAERS: 6 | US FAERS | |
| 80 | Chest discomfort | FAERS: 6 | US FAERS | |
| 81 | Clostridium difficile infection | FAERS: 6 | US FAERS | |
| 82 | Colitis | FAERS: 6 | US FAERS | |
| 83 | Drug effect variable | FAERS: 6 | US FAERS | |
| 84 | Dysuria | FAERS: 6 | US FAERS | |
| 85 | Epistaxis | FAERS: 6 | US FAERS | |
| 86 | Intentional drug misuse | FAERS: 6 | US FAERS | |
| 87 | Intestinal Perforation | FAERS: 6 | US FAERS | |
| 88 | Overdose | FAERS: 6 | US FAERS | |
| 89 | Thirst | FAERS: 6 | US FAERS | |
| 90 | Blood potassium decreased | FAERS: 5 | US FAERS | |
| 91 | Contraindicated drug prescribed | FAERS: 5 | US FAERS | |
| 92 | Dysgeusia | FAERS: 5 | US FAERS | |
| 93 | Erythema | FAERS: 5 | US FAERS | |
| 94 | Feeling Cold | FAERS: 5 | US FAERS | |
| 95 | Flushing | FAERS: 5 | US FAERS | |
| 96 | Irritable Bowel Syndrome | FAERS: 5 | 23330973 | CTD US FAERS |
| 97 | Lip swelling | FAERS: 5 | US FAERS | |
| 98 | Oropharyngeal pain | FAERS: 5 | US FAERS | |
| 99 | Prescribed overdose | FAERS: 5 | US FAERS | |
| 100 | Product packaging issue | FAERS: 5 | US FAERS | |
| 101 | Rectal discharge | FAERS: 5 | US FAERS | |
| 102 | Sinusitis | FAERS: 5 | SIDER US FAERS | |
| 103 | Urinary Incontinence | FAERS: 5 | US FAERS | |
| 104 | Vertigo | FAERS: 5 | US FAERS | |
| 105 | Agitation | FAERS: 4 | US FAERS | |
| 106 | Blood sodium decreased | FAERS: 4 | US FAERS | |
| 107 | Drug administration error | FAERS: 4 | US FAERS | |
| 108 | Gastritis | FAERS: 4 | US FAERS | |
| 109 | Poor quality drug administered | FAERS: 4 | US FAERS | |
| 110 | Presyncope | FAERS: 4 | US FAERS | |
| 111 | Therapeutic response delayed | FAERS: 4 | US FAERS | |
| 112 | Tinnitus | FAERS: 4 | US FAERS | |
| 113 | Visual Impairment | FAERS: 4 | US FAERS | |
| 114 | treatment failure | FAERS: 4 | US FAERS | |
| 115 | Back disorder | FAERS: 3 | US FAERS | |
| 116 | Bladder discomfort | FAERS: 3 | US FAERS | |
| 117 | Bladder pain | FAERS: 3 | US FAERS | |
| 118 | Blood glucose decreased | FAERS: 3 | US FAERS | |
| 119 | Contraindicated product administered | FAERS: 3 | US FAERS | |
| 120 | Dry skin | FAERS: 3 | US FAERS | |
| 121 | Hernia | FAERS: 3 | US FAERS | |
| 122 | Hunger | FAERS: 3 | US FAERS | |
| 123 | Incontinence | FAERS: 3 | US FAERS | |
| 124 | Influenza | FAERS: 3 | US FAERS | |
| 125 | Lethargy | FAERS: 3 | US FAERS | |
| 126 | Mydriasis | FAERS: 3 | US FAERS | |
| 127 | Nasopharyngitis | FAERS: 3 | US FAERS | |
| 128 | Neck Pain | FAERS: 3 | US FAERS | |
| 129 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 130 | Product size issue | FAERS: 3 | US FAERS | |
| 131 | Sneezing | FAERS: 3 | US FAERS | |
| 132 | Sunburn | FAERS: 3 | US FAERS | |
| 133 | Urinary Retention | FAERS: 3 | US FAERS | |
| 134 | Urinary tract infection | FAERS: 3 | US FAERS | |
| 135 | Abdominal rigidity | FAERS: 2 | US FAERS | |
| 136 | Ageusia | FAERS: 2 | US FAERS | |
| 137 | Amnesia | FAERS: 2 | US FAERS | |
| 138 | Anal spasm | FAERS: 2 | US FAERS | |
| 139 | Anaphylactic shock | FAERS: 2 | US FAERS | |
| 140 | Angioedema | FAERS: 2 | US FAERS | |
| 141 | Atrial Fibrillation | FAERS: 2 | US FAERS | |
| 142 | Blood cholesterol increased | FAERS: 2 | US FAERS | |
| 143 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 144 | Chromaturia | FAERS: 2 | US FAERS | |
| 145 | Drug screen positive | FAERS: 2 | US FAERS | |
| 146 | Dysphonia | FAERS: 2 | US FAERS | |
| 147 | Epigastric discomfort | FAERS: 2 | US FAERS | |
| 148 | Extra dose administered | FAERS: 2 | US FAERS | |
| 149 | Eye pain | FAERS: 2 | US FAERS | |
| 150 | Feeling jittery | FAERS: 2 | US FAERS | |
| 151 | Foreign body in respiratory tract | FAERS: 2 | US FAERS | |
| 152 | Gastroenteritis | FAERS: 2 | US FAERS | |
| 153 | Genital infection fungal | FAERS: 2 | US FAERS | |
| 154 | Gluten sensitivity | FAERS: 2 | US FAERS | |
| 155 | Gout | FAERS: 2 | US FAERS | |
| 156 | Hyperchlorhydria | FAERS: 2 | US FAERS | |
| 157 | Ileus | FAERS: 2 | US FAERS | |
| 158 | Impaired gastric emptying | FAERS: 2 | US FAERS | |
| 159 | Incorrect disposal of product | FAERS: 2 | US FAERS | |
| 160 | Incorrect drug administration duration | FAERS: 2 | US FAERS | |
| 161 | Incorrect route of drug administration | FAERS: 2 | US FAERS | |
| 162 | Intentional product use issue | FAERS: 2 | US FAERS | |
| 163 | Large intestine perforation | FAERS: 2 | US FAERS | |
| 164 | Laryngitis | FAERS: 2 | US FAERS | |
| 165 | Loss of personal independence in daily activities | FAERS: 2 | US FAERS | |
| 166 | Memory impairment | FAERS: 2 | US FAERS | |
| 167 | Mouth swelling | FAERS: 2 | US FAERS | |
| 168 | Muscle strain | FAERS: 2 | US FAERS | |
| 169 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 170 | Neuralgia | FAERS: 2 | US FAERS | |
| 171 | Pancreatitis | FAERS: 2 | US FAERS | |
| 172 | Pregnancy | FAERS: 2 | US FAERS | |
| 173 | Product dose omission | FAERS: 2 | US FAERS | |
| 174 | Product solubility abnormal | FAERS: 2 | US FAERS | |
| 175 | Productive Cough | FAERS: 2 | US FAERS | |
| 176 | Renal pain | FAERS: 2 | US FAERS | |
| 177 | Sense of oppression | FAERS: 2 | US FAERS | |
| 178 | Stomatitis | FAERS: 2 | US FAERS | |
| 179 | Stress | FAERS: 2 | US FAERS | |
| 180 | Tachyphylaxis | FAERS: 2 | US FAERS | |
| 181 | Therapy change | FAERS: 2 | US FAERS | |
| 182 | Urine flow decreased | FAERS: 2 | US FAERS | |
| 183 | jaundice | FAERS: 2 | US FAERS | |
| 184 | Abdominal tenderness | FAERS: 1 | US FAERS | |
| 185 | Abnormal weight gain | FAERS: 1 | US FAERS | |
| 186 | Accidental exposure to product by child | FAERS: 1 | US FAERS | |
| 187 | Acute kidney injury | FAERS: 1 | US FAERS | |
| 188 | Acute psychosis | FAERS: 1 | US FAERS | |
| 189 | Ammonia increased | FAERS: 1 | US FAERS | |
| 190 | Anal Fissure | FAERS: 1 | US FAERS | |
| 191 | Anal inflammation | FAERS: 1 | US FAERS | |
| 192 | Anger | FAERS: 1 | US FAERS | |
| 193 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 194 | Anginal equivalent | FAERS: 1 | US FAERS | |
| 195 | Anuria | FAERS: 1 | US FAERS | |
| 196 | Aphthous Stomatitis | FAERS: 1 | US FAERS | |
| 197 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 198 | Ataxia | FAERS: 1 | US FAERS | |
| 199 | Atrioventricular Block | FAERS: 1 | US FAERS | |
| 200 | Autoimmune hepatitis | FAERS: 1 | US FAERS | |
| 201 | Biliary Colic | FAERS: 1 | US FAERS | |
| 202 | Blood chloride decreased | FAERS: 1 | US FAERS | |
| 203 | Blood creatinine decreased | FAERS: 1 | US FAERS | |
| 204 | Blood electrolytes decreased | FAERS: 1 | US FAERS | |
| 205 | Blood iron decreased | FAERS: 1 | US FAERS | |
| 206 | Blood potassium increased | FAERS: 1 | US FAERS | |
| 207 | Blood sodium increased | FAERS: 1 | US FAERS | |
| 208 | Blood urine present | FAERS: 1 | US FAERS | |
| 209 | Blunted affect | FAERS: 1 | US FAERS | |
| 210 | Bone pain | FAERS: 1 | US FAERS | |
| 211 | Breast tenderness | FAERS: 1 | US FAERS | |
| 212 | Butterfly rash | FAERS: 1 | US FAERS | |
| 213 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 214 | Cardiac Flutter | FAERS: 1 | US FAERS | |
| 215 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 216 | Chloasma | FAERS: 1 | US FAERS | |
| 217 | Choking | FAERS: 1 | US FAERS | |
| 218 | Cholecystitis | FAERS: 1 | US FAERS | |
| 219 | Circumstance or information capable of leading to medication error | FAERS: 1 | US FAERS | |
| 220 | Clostridium test positive | FAERS: 1 | US FAERS | |
| 221 | Colectomy | FAERS: 1 | US FAERS | |
| 222 | Contraindicated product prescribed | FAERS: 1 | US FAERS | |
| 223 | Creatinine renal clearance increased | FAERS: 1 | US FAERS | |
| 224 | Cystitis | FAERS: 1 | US FAERS | |
| 225 | Deafness | FAERS: 1 | US FAERS | |
| 226 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 227 | Depressed mood | FAERS: 1 | US FAERS | |
| 228 | Diplopia | FAERS: 1 | US FAERS | |
| 229 | Disability | FAERS: 1 | US FAERS | |
| 230 | Diverticulum | FAERS: 1 | US FAERS | |
| 231 | Drug Dependence | FAERS: 1 | US FAERS | |
| 232 | Drug administered to patient of inappropriate age | FAERS: 1 | US FAERS | |
| 233 | Drug resistance | FAERS: 1 | US FAERS | |
| 234 | Drug screen false positive | FAERS: 1 | US FAERS | |
| 235 | Drug screen negative | FAERS: 1 | US FAERS | |
| 236 | Drug withdrawal syndrome | FAERS: 1 | US FAERS | |
| 237 | Ear discomfort | FAERS: 1 | US FAERS | |
| 238 | Early satiety | FAERS: 1 | US FAERS | |
| 239 | Eating disorder symptom | FAERS: 1 | US FAERS | |
| 240 | Electrolyte depletion | FAERS: 1 | US FAERS | |
| 241 | Emotional disorder | FAERS: 1 | US FAERS | |
| 242 | Emotional distress | FAERS: 1 | US FAERS | |
| 243 | Emotional poverty | FAERS: 1 | US FAERS | |
| 244 | Endometriosis | FAERS: 1 | US FAERS | |
| 245 | Eye irritation | FAERS: 1 | US FAERS | |
| 246 | Eyelid pain | FAERS: 1 | US FAERS | |
| 247 | Facial Pain | FAERS: 1 | US FAERS | |
| 248 | Failure to Thrive | FAERS: 1 | US FAERS | |
| 249 | Food aversion | FAERS: 1 | US FAERS | |
| 250 | Food craving | FAERS: 1 | US FAERS | |
| 251 | Gastric ulcer | FAERS: 1 | US FAERS | |
| 252 | Gastrointestinal carcinoma | FAERS: 1 | US FAERS | |
| 253 | Gastrointestinal hypermotility | FAERS: 1 | US FAERS | |
| 254 | Gastrointestinal hypomotility | FAERS: 1 | US FAERS | |
| 255 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 256 | Gastrointestinal obstruction | FAERS: 1 | US FAERS | |
| 257 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 258 | Genital discomfort | FAERS: 1 | US FAERS | |
| 259 | Hair injury | FAERS: 1 | US FAERS | |
| 260 | Head Banging | FAERS: 1 | US FAERS | |
| 261 | Head discomfort | FAERS: 1 | US FAERS | |
| 262 | Heat Stroke | FAERS: 1 | US FAERS | |
| 263 | Herpes Zoster Oticus | FAERS: 1 | US FAERS | |
| 264 | Hypersomnia | FAERS: 1 | US FAERS | |
| 265 | Hypophagia | FAERS: 1 | US FAERS | |
| 266 | Hysterectomy | FAERS: 1 | US FAERS | |
| 267 | Immune thrombocytopenic purpura | FAERS: 1 | US FAERS | |
| 268 | Impaired work ability | FAERS: 1 | US FAERS | |
| 269 | Increased upper airway secretion | FAERS: 1 | US FAERS | |
| 270 | Inhibitory drug interaction | FAERS: 1 | US FAERS | |
| 271 | Intercepted drug prescribing error | FAERS: 1 | US FAERS | |
| 272 | Intervertebral disc injury | FAERS: 1 | US FAERS | |
| 273 | Intestinal congestion | FAERS: 1 | US FAERS | |
| 274 | Irregular breathing | FAERS: 1 | US FAERS | |
| 275 | Maternal exposure during breast feeding | FAERS: 1 | US FAERS | |
| 276 | Medical diet | FAERS: 1 | US FAERS | |
| 277 | Medication residue present | FAERS: 1 | US FAERS | |
| 278 | Middle insomnia | FAERS: 1 | US FAERS | |
| 279 | Multiple Sclerosis | FAERS: 1 | US FAERS | |
| 280 | Muscular Dystrophy | FAERS: 1 | US FAERS | |
| 281 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 282 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 283 | Myocardial Infarction | FAERS: 1 | US FAERS | |
| 284 | Nasal discomfort | FAERS: 1 | US FAERS | |
| 285 | Night sweats | FAERS: 1 | US FAERS | |
| 286 | Nipple pain | FAERS: 1 | US FAERS | |
| 287 | Nodule | FAERS: 1 | US FAERS | |
| 288 | Non-cardiac chest pain | FAERS: 1 | US FAERS | |
| 289 | Nutritional condition abnormal | FAERS: 1 | US FAERS | |
| 290 | Obesity | FAERS: 1 | US FAERS | |
| 291 | Onychoclasis | FAERS: 1 | US FAERS | |
| 292 | Parenteral Nutrition | FAERS: 1 | US FAERS | |
| 293 | Pelvic Pain | FAERS: 1 | US FAERS | |
| 294 | Penile swelling | FAERS: 1 | US FAERS | |
| 295 | Peripheral motor neuropathy | FAERS: 1 | US FAERS | |
| 296 | Physical disability | FAERS: 1 | US FAERS | |
| 297 | Pneumonia | FAERS: 1 | US FAERS | |
| 298 | Polyuria | FAERS: 1 | US FAERS | |
| 299 | Prescribed underdose | FAERS: 1 | US FAERS | |
| 300 | Proctitis | FAERS: 1 | US FAERS | |
| 301 | Product container issue | FAERS: 1 | US FAERS | |
| 302 | Product contamination physical | FAERS: 1 | US FAERS | |
| 303 | Product formulation issue | FAERS: 1 | US FAERS | |
| 304 | Product use complaint | FAERS: 1 | US FAERS | |
| 305 | Protein total decreased | FAERS: 1 | US FAERS | |
| 306 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 307 | Pyruvate kinase increased | FAERS: 1 | US FAERS | |
| 308 | Rash erythematous | FAERS: 1 | US FAERS | |
| 309 | Reaction to preservatives | FAERS: 1 | US FAERS | |
| 310 | Rectal spasm | FAERS: 1 | US FAERS | |
| 311 | Reduced bladder capacity | FAERS: 1 | US FAERS | |
| 312 | Renal Colic | FAERS: 1 | US FAERS | |
| 313 | Renal cyst | FAERS: 1 | US FAERS | |
| 314 | Restless Legs Syndrome | FAERS: 1 | US FAERS | |
| 315 | Restlessness | FAERS: 1 | US FAERS | |
| 316 | Retching | FAERS: 1 | US FAERS | |
| 317 | Saliva altered | FAERS: 1 | US FAERS | |
| 318 | Secretion discharge | FAERS: 1 | US FAERS | |
| 319 | Sepsis | FAERS: 1 | US FAERS | |
| 320 | Sexual Dysfunction | FAERS: 1 | US FAERS | |
| 321 | Skin Wrinkling | FAERS: 1 | US FAERS | |
| 322 | Skin lesion | FAERS: 1 | US FAERS | |
| 323 | Skin reaction | FAERS: 1 | US FAERS | |
| 324 | Skin tightness | FAERS: 1 | US FAERS | |
| 325 | Somnambulism | FAERS: 1 | US FAERS | |
| 326 | Stoma obstruction | FAERS: 1 | US FAERS | |
| 327 | Suicide attempt | FAERS: 1 | US FAERS | |
| 328 | Tachycardia | FAERS: 1 | US FAERS | |
| 329 | Temperature intolerance | FAERS: 1 | US FAERS | |
| 330 | Tetany | FAERS: 1 | US FAERS | |
| 331 | Therapeutic product ineffective for unapproved indication | FAERS: 1 | US FAERS | |
| 332 | Throat cancer | FAERS: 1 | US FAERS | |
| 333 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 334 | Tongue blistering | FAERS: 1 | US FAERS | |
| 335 | Trichorrhexis | FAERS: 1 | US FAERS | |
| 336 | Trisomy 21 | FAERS: 1 | US FAERS | |
| 337 | Ulcer | FAERS: 1 | US FAERS | |
| 338 | Unresponsive to stimuli | FAERS: 1 | US FAERS | |
| 339 | Urinary hesitation | FAERS: 1 | US FAERS | |
| 340 | Urine output increased | FAERS: 1 | US FAERS | |
| 341 | Vasculitis | FAERS: 1 | US FAERS | |
| 342 | Vitamin D Deficiency | FAERS: 1 | US FAERS | |
| 343 | Vitiligo | FAERS: 1 | US FAERS | |
| 344 | Vitreous floaters | FAERS: 1 | US FAERS | |
| 345 | Vulvovaginal burning sensation | FAERS: 1 | US FAERS | |
| 346 | Vulvovaginal pain | FAERS: 1 | US FAERS | |
| 347 | Wheezing | FAERS: 1 | US FAERS | |
| 348 | Wound Complication | FAERS: 1 | US FAERS | |
| 349 | Yawning | FAERS: 1 | US FAERS | |
| 350 | Dermatitis | SIDER | ||
| 351 | Infection | SIDER | ||
| 352 | Infestation | SIDER | ||
| 353 | Malnutrition | SIDER | ||
| 354 | nervous system disorder | SIDER |
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